Ergic2, a brain specific interacting partner of Otoferlin

Cellular Physiology and Biochemistry

Volumn 29, Issue 5-6, 2012, Pages 941-948

  Zak, Magdalena ^a   Breß, Andreas ^b   Brandt, Niels ^c   Franz, Christoph ^b   Ruth, Peter ^a   Pfister, Markus ^b   Knipper, Marlies ^b   Blin, Nikolaus ^a,d  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Brain; Cochlea; Ergic2; Interactome; Otoferlin; Vesicle trafficking; Yeast two hybrid

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; NEURONAL CALCIUM SENSOR; PROTEIN ERGIC 2; PROTEIN HYDROLYSATE; PROTEIN OTOFERLIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL MIGRATION; COCHLEA; CONTROLLED STUDY; DNA LIBRARY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HEARING; HEARING IMPAIRMENT; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; TWO HYBRID SYSTEM; WESTERN BLOTTING; YEAST;

MURINAE; RODENTIA;

EID: 84861378565     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000188338     Document Type: Article

References (27)

1. Cohn ES, Kelley PM: Clinical phenotype and mutations in connexin 26 (dfnb1/gjb2), the most common cause of childhood hearing loss. Am J Med Genet 1999;89:130-136. (Pubitemid 30120744)
2. Rodriguez-Ballesteros M, Reynoso R, Olarte M, Villamar M, Morera C, Santarelli R, Arslan E, Meda C, Curet C, Volter C, Sainz-Quevedo M, Castorina P, Ambrosetti U, Berrettini S, Frei K, Tedin S, Smith J, Cruz Tapia M, Cavalle L, Gelvez N, Primignani P, Gomez-Rosas E, Martin M, Moreno-Pelayo MA, Tamayo M, Moreno-Barral J, Moreno F, Del Castillo I: A multicenter study on the prevalence and spectrum of mutations in the otoferlin gene (otof) in subjects with nonsyndromic hearing impairment and auditory neuropathy. Hum Mutat 2008;29:823-831. (Pubitemid 351794133)
3. Yasunaga S, Grati M, Cohen-Salmon M, El-Amraoui A, Mustapha M, Salem N, El-Zir E, Loiselet J, Petit C: A mutation in otof, encoding otoferlin, a fer-1-like protein, causes dfnb9, a nonsyndromic form of deafness. Nat Genet 1999;21:363-369. (Pubitemid 29159571)
4. Schug N, Braig C, Zimmermann U, Engel J, Winter H, Ruth P, Blin N, Pfister M, Kalbacher H, Knipper M: Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat. Eur J Neurosci 2006;24:3372-3380. (Pubitemid 44952603)
5. Roux I, Safieddine S, Nouvian R, Grati M, Simmler MC, Bahloul A, Perfettini I, Le Gall M, Rostaing P, Hamard G, Triller A, Avan P, Moser T, Petit C: Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell 2006;127:277-289. (Pubitemid 44572372)
6. Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N: Rab8b gtpase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. Hum Mol Genet 2008;17:3814-3821.
7. Sahlender DA, Roberts RC, Arden SD, Spudich G, Taylor MJ, Luzio JP, Kendrick-Jones J, Buss F: Optineurin links myosin vi to the golgi complex and is involved in golgi organization and exocytosis. J Cell Biol 2005;169:285-295. (Pubitemid 40656566)
8. + channels in rodent inner hair cells. J Neurosci 2007;27:3174-3186. (Pubitemid 46474116)
9. Kwok SC, Liu X, Daskal I: Molecular cloning, expression, localization, and gene organization of ptx1, a human nuclear protein that is downregulated in prostate cancer. DNA Cell Biol 2001;20:349-357. (Pubitemid 32692438)
10. Breuza L, Halbeisen R, Jeno P, Otte S, Barlowe C, Hong W, Hauri HP: Proteomics of endoplasmic reticulumgolgi intermediate compartment (ergic) membranes from brefeldin a-treated hepg2 cells identifies ergic-32, a new cycling protein that interacts with human erv46. J Biol Chem 2004;279:47242-47253. (Pubitemid 39518381)
11. Otte S, Belden WJ, Heidtman M, Liu J, Jensen ON, Barlowe C: Erv41p and erv46p: New components of copii vesicles involved in transport between the er and golgi complex. J Cell Biol 2001;152:503-518.
12. Otte S, Barlowe C: The erv41p-erv46p complex: Multiple export signals are required in trans for copii-dependent transport from the er. EMBO J 2002;21:6095-6104. (Pubitemid 35415326)
13. Appenzeller-Herzog C, Hauri HP: The er-golgi intermediate compartment (ergic): In search of its identity and function. J Cell Sci 2006;119:2173-2183. (Pubitemid 43960307)
14. Muppirala M, Gupta V, Swarup G: Syntaxin 17 cycles between the er and ergic and is required to maintain the architecture of ergic and golgi. Biol Cell 2011;103:333-350.
15. Longo-Guess C, Gagnon LH, Bergstrom DE, Johnson KR: A missense mutation in the conserved c2b domain of otoferlin causes deafness in a new mouse model of dfnb9. Hear Res 2007;234:21-28. (Pubitemid 350088327)
16. Wilson L, Ching YH, Farias M, Hartford SA, Howell G, Shao H, Bucan M, Schimenti JC: Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Genome Res 2005;15:1095-1105. (Pubitemid 41126865)
17. Knipper M, Bandtlow C, Gestwa L, Kopschall I, Rohbock K, Wiechers B, Zenner HP, Zimmermann U: Thyroid hormone affects schwann cell and oligodendrocyte gene expression at the glial transition zone of the viiith nerve prior to cochlea function. Development 1998;125:3709-3718. (Pubitemid 28469971)
18. 2+ currents in neonatal outer hair cells of mice. J Physiol 2003;553:747-758. (Pubitemid 38035619)
19. Knipper M, Zinn C, Maier H, Praetorius M, Rohbock K, Kopschall I, Zimmermann U: Thyroid hormone deficiency before the onset of hearing causes irreversible damage to peripheral and central auditory systems. J Neurophysiol 2000;83:3101-3112. (Pubitemid 30321497)
20. Karram K, Goebbels S, Schwab M, Jennissen K, Seifert G, Steinhauser C, Nave KA, Trotter J: Ng2-expressing cells in the nervous system revealed by the ng2-eyfp-knockin mouse. Genesis 2008;46:743-757.
21. Heidrych P, Zimmermann U, Kuhn S, Franz C, Engel J, Duncker SV, Hirt B, Pusch CM, Ruth P, Pfister M, Marcotti W, Blin N, Knipper M: Otoferlin interacts with myosin vi: Implications for maintenance of the basolateral synaptic structure of the inner hair cell. Hum Mol Genet 2009;18:2779-2790.
22. Kwok SC, Liu X, Mangel P, Daskal I: Ptx1 (ergic2)-vp22 fusion protein upregulates interferon-beta in prostate cancer cell line pc-3. DNA Cell Biol 2006;25:523-529. (Pubitemid 44763221)
23. Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Buckers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kugler S, Brigande JV, Moser T: Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis. J Neurosci 2011;31:4886-4895.
24. De Bello WM, Betz H, Augustine GJ: Synaptotagmin and neurotransmitter release. Cell 1993;74:947-950. (Pubitemid 23289451)
25. Zheng J, Shen W, He DZ, Long KB, Madison LD, Dallos P: Prestin is the motor protein of cochlear outer hair cells. Nature 2000;405:149-155. (Pubitemid 30313525)
26. Liu X, Daskal I, Kwok SC: Effects of ptx1 expression on growth and tumorigenicity of the prostate cancer cell line pc-3. DNA Cell Biol 2003;22:469-474. (Pubitemid 36981463)
27. Nelson TJ, Alkon DL: Protection against beta-amyloid-induced apoptosis by peptides interacting with beta-amyloid. J Biol Chem 2007;282:31238-31249. (Pubitemid 350044852)