Comparative effects of angiotensin receptor blockade and ACE inhibition on the fibrinolytic and inflammatory responses to cardiopulmonary bypass

Clinical Pharmacology and Therapeutics

Volumn 91, Issue 6, 2012, Pages 1065-1073

  Billings, F T ^a   Balaguer, J M ^a,b   Yu, C ^a   Wright, P ^a   Petracek, M R ^a   Byrne, J G ^a   Brown, N J ^a   Pretorius, M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Tennessee Valley Healthcare System   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; CANDESARTAN; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; RAMIPRIL; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; CARDIOPULMONARY BYPASS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; FIBRINOLYSIS; HOSPITALIZATION; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; PLASMA TRANSFUSION; PRIORITY JOURNAL; RECEPTOR BLOCKING;

AGED; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BENZIMIDAZOLES; BLOOD TRANSFUSION; BRADYKININ; CARDIOPULMONARY BYPASS; ENDPOINT DETERMINATION; FEMALE; FIBRINOLYSIS; HEMATOCRIT; HOSPITAL MORTALITY; HUMANS; INFLAMMATION; INTERLEUKINS; LENGTH OF STAY; MALE; MIDDLE AGED; MONITORING, INTRAOPERATIVE; PERIOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS; RAMIPRIL; TETRAZOLES; TREATMENT OUTCOME;

EID: 84861345271     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.356     Document Type: Article

References (33)

1. Chandler, W.L. et al. Individual variations in the fibrinolytic response during and after cardiopulmonary bypass. Thromb Haemost 74, 1293-1297 (1995).
2. Pretorius, M., Murphey, L.J., McFarlane, J.A., Vaughan, D.E. & Brown, N.J. Angiotensin-converting enzyme inhibition alters the fibrinolytic response to cardiopulmonary bypass. Circulation 108, 3079-3083 (2003). (Pubitemid 38031795)
3. Suleiman, M.S., Zacharowski, K. & Angelini, G.D. Inflammatory response and cardioprotection during open-heart surgery: the importance of anaesthetics. Br. J. Pharmacol. 153, 21-33 (2008).
4. Kawamura, T., Wakusawa, R., Okada, K. & Inada, S. Elevation of cytokines during open heart surgery with cardiopulmonary bypass: participation of interleukin 8 and 6 in reperfusion injury. Can. J. Anaesth. 40, 1016-1021 (1993). (Pubitemid 23356329)
5. Pretorius, M., Donahue, B.S., Yu, C., Greelish, J.P., Roden, D.M. & Brown, N.J. Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass. Circulation 116, I1-I7 (2007). (Pubitemid 47480763)
6. Sander, M. et al. Increased interleukin-6 after cardiac surgery predicts infection. Anesth. Analg. 102, 1623-1629 (2006). (Pubitemid 43799826)
7. Liu, K.D. et al. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit. Care 13, R104 (2009).
8. Fliser, D., Buchholz, K. & Haller, H.; EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis (EUTOPIA) Investigators. Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation. Circulation 110, 1103-1107 (2004). (Pubitemid 39319009)
9. Flammer, A.J. et al. Angiotensin-converting enzyme inhibition improves vascular function in rheumatoid arthritis. Circulation 117, 2262-2269 (2008).
10. Fleming, G.A., Billings, F.T. 4th, Klein, T.M., Bichell, D.P., Christian, K.G. & Pretorius, M. Angiotensin-converting enzyme inhibition alters the inflammatory and fibrinolytic response to cardiopulmonary bypass in children. Pediatr. Crit. Care Med. 12, 532-538 (2011).
11. Ridker, P.M., Gaboury, C.L., Conlin, P.R., Seely, E.W., Williams, G.H. & Vaughan, D.E. Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Evidence of a potential interaction between the reninangiotensin system and fibrinolytic function. Circulation 87, 1969-1973 (1993). (Pubitemid 23165641)
12. Brown, N.J., Nadeau, J.H. & Vaughan, D.E. Selective stimulation of tissuetype plasminogen activator (t-PA) in vivo by infusion of bradykinin. Thromb. Haemost. 77, 522-525 (1997). (Pubitemid 27121020)
13. Huang, C.D., Tliba, O., Panettieri, R.A. Jr & Amrani, Y. Bradykinin induces interleukin-6 production in human airway smooth muscle cells: modulation by Th2 cytokines and dexamethasone. Am. J. Respir. Cell Mol. Biol. 28, 330-338 (2003). (Pubitemid 36238010)
14. Campbell, D.J., Krum, H. & Esler, M.D. Losartan increases bradykinin levels in hypertensive humans. Circulation 111, 315-320 (2005). (Pubitemid 40165338)
15. Tsutsumi, Y. et al. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J. Clin. Invest. 104, 925-935 (1999). (Pubitemid 29536342)
16. Brull, D.J., Sanders, J., Rumley, A., Lowe, G.D., Humphries, S.E (Pubitemid 34177681)
17. Radaelli, A. et al. Inflammatory activation during coronary artery surgery and its dose-dependent modulation by statin/ACE-inhibitor combination. Arterioscler. Thromb. Vasc. Biol. 27, 2750-2755 (2007). (Pubitemid 350158932)
18. Trevelyan, J., Brull, D.J., Needham, E.W., Montgomery, H.E., Morris, A. & Mattu, R.K. Effect of enalapril and losartan on cytokines in patients with stable angina pectoris awaiting coronary artery bypass grafting and their interaction with polymorphisms in the interleukin-6 gene. Am. J. Cardiol. 94, 564-569 (2004). (Pubitemid 39165833)
19. Kwapisz, M.M. et al. The effect of intravenous quinaprilat on plasma cytokines and hemodynamic variables during cardiac surgery. J. Cardiothorac. Vasc. Anesth. 18, 53-58 (2004). (Pubitemid 38240761)
20. Ruddy, M.C. & Mroczek, W.J. Comparison of ramipril and enalapril in patients with essential hypertension. Pharmacotherapy 13, 224-228 (1993). (Pubitemid 23162475)
21. Fogari, R. & Zoppi, A. Antihypertensive drugs and fibrinolytic function. Am. J. Hypertens. 19, 1293-1299 (2006).
22. Pahor, M. et al. Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1. Circulation 105, 457-461 (2002). (Pubitemid 34141702)
23. Vaughan, D.E., Rouleau, J.L., Ridker, P.M., Arnold, J.M., Menapace, F.J. & Pfeffer, M.A. Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. HEART Study Investigators. Circulation 96, 442-447 (1997). (Pubitemid 27329418)
24. Kerins, D.M., Hao, Q. & Vaughan, D.E. Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV. J. Clin. Invest. 96, 2515-2520 (1995).
25. Hayashi, R. et al. Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK-and p38 MAPK-dependent mechanisms. Eur. Respir. J. 16, 452-458 (2000).
26. Gainer, J.V., Morrow, J.D., Loveland, A., King, D.J. & Brown, N.J. Effect of bradykinin-receptor blockade on the response to angiotensin- convertingenzyme inhibitor in normotensive and hypertensive subjects. N. Engl. J. Med. 339, 1285-1292 (1998). (Pubitemid 28496194)
27. Pretorius, M., McFarlane, J.A., Vaughan, D.E., Brown, N.J. & Murphey, L.J. Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass. Clin. Pharmacol. Ther. 76, 379-387 (2004). (Pubitemid 39313129)
28. Rady, M.Y. & Ryan, T. The effects of preoperative therapy with angiotensinconverting enzyme inhibitors on clinical outcome after cardiovascular surgery. Chest 114, 487-494 (1998). (Pubitemid 28387528)
29. Miceli, A. et al. Effects of angiotensin-converting enzyme inhibitor therapy on clinical outcome in patients undergoing coronary artery bypass grafting. J. Am. Coll. Cardiol. 54, 1778-1784 (2009).
30. Belluzzi, F., Sernesi, L., Preti, P., Salinaro, F., Fonte, M.L. & Perlini, S. Prevention of recurrent lone atrial fibrillation by the angiotensin-II converting enzyme inhibitor ramipril in normotensive patients. J. Am. Coll. Cardiol. 53, 24-29 (2009).
31. Mehta, R.L. et al.; Acute Kidney Injury Network. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit. Care 11, R31 (2007).
32. Macedo, E., Malhotra, R., Claure-Del Granado, R., Fedullo, P. & Mehta, R.L. Defining urine output criterion for acute kidney injury in critically ill patients. Nephrol. Dial. Transplant. 26, 509-515 (2011).
33. Ridker, P.M. et al. Baseline fibrinolytic state and the risk of future venous thrombosis. A prospective study of endogenous tissue-type plasminogen activator and plasminogen activator inhibitor. Circulation 85, 1822-1827 (1992).