A novel nano-structured porous polycaprolactone scaffold improves hyaline cartilage repair in a rabbit model compared to a collagen type I/III scaffold: In vitro and in vivo studies

Knee Surgery, Sports Traumatology, Arthroscopy

Volumn 20, Issue 6, 2012, Pages 1192-1204

  Christensen, Bjørn Borsøe ^a   Foldager, Casper Bindzus ^a   Hansen, Ole Møller ^a   Kristiansen, Asger Albæk ^b   Le, Dang Quang Svend ^b   Nielsen, Agnete Desirée ^c   Nygaard, Jens Vinge ^b   Bünger, Cody Erik ^a   Lind, Martin ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c SILKEBORG REGIONAL HOSPITAL   (Denmark)

Author keywords

Articular cartilage repair; Cell free scaffold; Chondrocyte transplantation; Polycaprolactone; Rabbit model

Indexed keywords

AGGRECAN; BIOLOGICAL MARKER; COLLAGEN TYPE 1; COLLAGEN TYPE 3; NANOMATERIAL; POLYCAPROLACTONE; POLYESTER; TISSUE SCAFFOLD; TRANSCRIPTION FACTOR SOX9;

ANIMAL; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; COMPARATIVE STUDY; CYTOLOGY; EVALUATION; INJURY; INSTRUMENTATION; MALE; METABOLISM; PHYSIOLOGY; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; TISSUE REGENERATION; TRANSPLANTATION; WOUND HEALING;

AGGRECANS; ANIMALS; BIOLOGICAL MARKERS; CARTILAGE, ARTICULAR; CHONDROCYTES; COLLAGEN TYPE I; COLLAGEN TYPE III; GUIDED TISSUE REGENERATION; MALE; MODELS, ANIMAL; NANOSTRUCTURES; POLYESTERS; RABBITS; REAL-TIME POLYMERASE CHAIN REACTION; SOX9 TRANSCRIPTION FACTOR; TISSUE SCAFFOLDS; WOUND HEALING;

EID: 84861344807     PISSN: 09422056     EISSN: 14337347     Source Type: Journal    
DOI: 10.1007/s00167-011-1692-9     Document Type: Article

References (32)

1. Behrens P, Bitter T, Kurz B, Russlies M (2006) Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI): 5-year follow-up. Knee 13: 194-202.
2. Behrens P, Bosch U, Bruns J, Erggelet C, Esenwein SA, Gaissmaier C, Krackhardt T, Lohnert J, Marlovits S, Meenen NM, Mollenhauer J, Nehrer S, Niethard FU, Noth U, Perka C, Richter W, Schafer D, Schneider U, Steinwachs M, Weise K (2004) Indications and implementation of recommendations of the working group "tissue regeneration and tissue substitutes" for autologous chondrocyte transplantation (ACT). Z Orthop Ihre Grenzgeb 142: 529-539.
3. Benthien JP, Behrens P (2010) Autologous matrix-induced chondrogenesis (AMIC). A one-step procedure for retropatellar articular resurfacing. Acta Orthop Belg 76: 260-263.
4. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331: 889-895.
5. Buckwalter JA, Mankin HJ (1998) Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 47: 487-504.
6. Discher DE, Janmey P, Wang YL (2005) Tissue cells feel and respond to the stiffness of their substrate. Science 310: 1139-1143.
7. Ehlers EM, Fuss M, Rohwedel J, Russlies M, Kuhnel W, Behrens P (1999) Development of a biocomposite to fill out articular cartilage lesions. Light, scanning and transmission electron microscopy of sheep chondrocytes cultured on a collagen I/III sponge. Ann Anat 181: 513-518.
8. Engler AJ, Sen S, Sweeney HL, Discher DE (2006) Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689.
9. Haddo O, Mahroof S, Higgs D, David L, Pringle J, Bayliss M, Cannon SR, Briggs TW (2004) The use of chondrogide membrane in autologous chondrocyte implantation. Knee 11: 51-55.
10. Hall FM, Wyshak G (1980) Thickness of articular cartilage in the normal knee. J Bone Jt Surg Am 62: 408-413.
11. Hattori T, Muller C, Gebhard S, Bauer E, Pausch F, Schlund B, Bosl MR, Hess A, Surmann-Schmitt C, von der Mark H, de Crombrugghe B, von der Mark K (2010) SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification. Development 137: 901-911.
12. Ho ST, Hutmacher DW, Ekaputra AK, Hitendra D, Hui JH (2010) The evaluation of a biphasic osteochondral implant coupled with an electrospun membrane in a large animal model. Tiss Eng Part A 16: 1123-1141.
13. Hunziker EB (2002) Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartil 10: 432-463.
14. Kon E, Filardo G, Condello V, Collarile M, Di Martino A, Zorzi C, Marcacci M (2011) Second-generation autologous chondrocyte implantation: results in patients older than 40 years. Am J Sports Med 39: 1668-1675.
15. Krishnan SP, Skinner JA, Carrington RW, Flanagan AM, Briggs TW, Bentley G (2006) Collagen-covered autologous chondrocyte implantation for osteochondritis dissecans of the knee: 2-7-year results. J Bone Jt Surg Br 88: 203-205.
16. Kubo S, Cooper GM, Matsumoto T, Phillippi JA, Corsi KA, Usas A, Li G, Fu FH, Huard J (2009) Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells. Arthritis Rheum 60: 155-165.
17. Lam CX, Hutmacher DW, Schantz JT, Woodruff MA, Teoh SH (2009) Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo. J Biomed Mater Res A 90: 906-919.
18. Maehara H, Sotome S, Yoshii T, Torigoe I, Kawasaki Y, Sugata Y, Yuasa M, Hirano M, Mochizuki N, Kikuchi M, Shinomiya K, Okawa A (2010) Repair of large osteochondral defects in rabbits using porous hydroxyapatite/collagen (HAp/Col) and fibroblast growth factor-2 (FGF-2). J Orthop Res 28: 677-686.
19. Martinez-Diaz S, Garcia-Giralt N, Lebourg M, Gomez-Tejedor JA, Vila G, Caceres E, Benito P, Pradas MM, Nogues X, Ribelles JL, Monllau JC (2010) In vivo evaluation of 3-D polycaprolactone scaffolds for cartilage repair in rabbits. Am J Sports Med 38: 509-519.
20. Minas T, Nehrer S (1997) Current concepts in the treatment of articular cartilage defects. Orthopedics 20: 525-538.
21. Mrosek EH, Schagemann JC, Chung HW, Fitzsimmons JS, Yaszemski MJ, Mardones RM, O'Driscoll SW, Reinholz GG (2010) Porous tantalum and poly-epsilon-caprolactone biocomposites for osteochondral defect repair: preliminary studies in rabbits. J Orthop Res 28: 141-148.
22. Ng KW, Hutmacher DW, Schantz JT, Ng CS, Too HP, Lim TC, Phan TT, Teoh SH (2001) Evaluation of ultra-thin poly(epsilon-caprolactone) films for tissue-engineered skin. Tiss Eng 7: 441-455.
23. Niemeyer P, Pestka JM, Kreuz PC, Erggelet C, Schmal H, Suedkamp NP, Steinwachs M (2008) Characteristic complications after autologous chondrocyte implantation for cartilage defects of the knee joint. Am J Sports Med 36: 2091-2099.
24. O'Driscoll SW, Keeley FW, Salter RB (1988) Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. A follow-up report at 1 year. J Bone Jt Surg Am 70: 595-606.
25. Pfaffl MW, Tichopad A, Prgomet C, Neuvians TP (2004) Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: best keeper-excel-based tool using pair-wise correlations. Biotechnol Lett 26: 509-515.
26. Pitt CG, Gratzl MM, Kimmel GL, Surles J, Schindler A (1981) Aliphatic polyesters II. The degradation of poly (dl-lactide), poly (epsilon-caprolactone), and their copolymers in vivo. Biomaterials 2: 215-220.
27. Reinholz GG, Lu L, Saris DB, Yaszemski MJ, O'Driscoll SW (2004) Animal models for cartilage reconstruction. Biomaterials 25: 1511-1521.
28. Russlies M, Ruther P, Koller W, Stomberg P, Behrens P (2003) Biomechanical properties of cartilage repair tissue after different cartilage repair procedures in sheep. Z Orthop Ihre Grenzgeb 141: 465-471.
29. Shao XX, Hutmacher DW, Ho ST, Goh JC, Lee EH (2006) Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits. Biomaterials 27: 1071-1080.
30. Steinert AF, Ghivizzani SC, Rethwilm A, Tuan RS, Evans CH, Noth U (2007) Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res Ther 9: 213.
31. Woodward SC, Brewer PS, Moatamed F, Schindler A, Pitt CG (1985) The intracellular degradation of poly(epsilon-caprolactone). J Biomed Mater Res 19: 437-444.
32. Yamashita S, Andoh M, Ueno-Kudoh H, Sato T, Miyaki S, Asahara H (2009) Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes. Exp Cell Res 315: 2231-2240.