Interpretation and recommended testing for antiphospholipid antibodies

Seminars in Thrombosis and Hemostasis

Volumn 38, Issue 4, 2012, Pages 348-352

  Galli, Monica ^a  

^a OSPEDALI RIUNITI   (Italy)

Author keywords

abortion; antiphospholipid antibodies; antiphospholipid syndrome; thrombosis

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; BLOOD CLOTTING FACTOR 8; CARDIOLIPIN ANTIBODY; EPITOPE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LUPUS ANTICOAGULANT; PEPTIDE; PHOSPHOLIPID ANTIBODY;

ARTERY THROMBOSIS; DIAGNOSTIC ERROR; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; HUMAN; MORBIDITY; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROGNOSIS; RECURRENT DISEASE; REPRODUCIBILITY; REVIEW; RISK FACTOR; SENSITIVITY AND SPECIFICITY; VEIN THROMBOSIS;

ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; RISK FACTORS;

EID: 84861343072     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0032-1304716     Document Type: Review

References (39)

1. Miyakis S, Lockshin MD, Atsumi T., et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost: 2006; 4 2 295 306
2. Pengo V, Tripodi A, Reber G., et al. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. Update of the guidelines for lupus anticoagulant detection. J Thromb Haemost: 2009; 7 10 1737 1740
3. Tincani A, Filippini M, Scarsi M, Galli M, Meroni PL. European attempts for the standardisation of the antiphospholipid antibodies. Lupus: 2009; 18 10 913 919
4. Tincani A, Allegri F, Balestrieri G., et al. Minimal requirements for antiphospholipid antibodies ELISAs proposed by the European Forum on antiphospholipid antibodies. Thromb Res: 2004; 114 5-6 553 558 (Pubitemid 39422591)
5. Wong RCW, Gillis D, Adelstein S., et al. Consensus guidelines on anti-cardiolipin antibody testing and reporting. Pathology: 2004; 36 1 63 68 (Pubitemid 38223415)
6. Reber G, Schousboe I, Tincani A., et al. Inter-laboratory variability of anti-beta2-glycoprotein I measurement. A collaborative study in the frame of the European Forum on Antiphospholipid Antibodies Standardization Group. Thromb Haemost: 2002; 88 1 66 73 (Pubitemid 34752269)
7. Reber G, Tincani A, Sanmarco M, de Moerloose P, Boffa MC.; European Forum on Antiphospholipid Antibodies Standardization Group. Variability of anti-beta2 glycoprotein I antibodies measurement by commercial assays. Thromb Haemost: 2005; 94 3 665 672
8. Reber G, Tincani A, Sanmarco M, de Moerloose P, Boffa MC.; Standardization group of the European Forum on Antiphospholipid Antibodies. Proposals for the measurement of anti-beta2-glycoprotein I antibodies. Standardization group of the European Forum on Antiphospholipid Antibodies. J Thromb Haemost: 2004; 2 10 1860 1862 (Pubitemid 40192732)
9. Cervera R, Font J, Tincani A, Boffa MC. V meeting of the European forum on antiphospholipid antibodies. Autoimmun Rev: 2006; 5 7 499 507 (Pubitemid 44233400)
10. Pengo V, Biasiolo A, Gresele P., et al. Participating Centres of Italian Federation of Thrombosis Centres (FCSA). Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples. J Thromb Haemost: 2007; 5 5 925 930 (Pubitemid 46691720)
11. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci U S A: 1990; 87 11 4120 4124
12. Galli M, Comfurius P, Maassen C., et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet: 1990; 335 8705 1544 1547 (Pubitemid 20189625)
13. Matsuura E, Igarashi Y, Fujimoto M, Ichikawa K, Koike T. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet: 1990; 336 8708 177 178 (Pubitemid 20225005)
14. de Laat BH, Derksen RHWM, van Lummel M, Pennings MT, de Groot PG. Pathogenic anti-2-glycoprotein I antibodies recognize domain I of 2-glycoprotein I only after a conformational change. Blood: 2006; 107 5 1916 1924 (Pubitemid 43289372)
15. de Laat BH, Derksen RHWM, Ubanus R, Roest M, de Groot P. 2GPI-dependent lupus anticoagulant activity highly correlates with thrombosis in the antiphospholipid syndrome. Blood: 2004; 104 3598 3602 (Pubitemid 39564433)
16. de Laat BH, Derksen RHWM, Urbanus RT, de Groot PG. IgG antibodies that recognize epitope Gly40-Arg43 in domain I of 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. Blood: 2005; 105 4 1540 1545 (Pubitemid 40223671)
17. Banzato A, Pozzi N, Frasson R., et al. Antibodies to domain I of (2)Glycoprotein I are in close relation to patients risk categories in antiphospholipid syndrome (APS). Thromb Res: 2011; 128 6 583 586
18. Simmelink MJ, Derksen RHW, Arnout J, De Groot PG. A simple method to discriminate between 2-glycoprotein I- and prothrombin-dependent lupus anticoagulants. J Thromb Haemost: 2003; 1 4 740 747
19. Pengo V, Biasiolo A, Pegoraro C, Iliceto S. A two-step coagulation test to identify antibeta-glycoprotein I lupus anticoagulants. J Thromb Haemost: 2004; 2 5 702 707 (Pubitemid 40185707)
20. Devreese KM. A functional coagulation test to identify anti-2-glycoprotein I dependent lupus anticoagulants. Thromb Res: 2007; 119 6 753 759 (Pubitemid 46441418)
21. Galli M, Beretta G, Daldossi M, Bevers EM, Barbui T. Different anticoagulant and immunological properties of anti-prothrombin antibodies in patients with antiphospholipid antibodies. Thromb Haemost: 1997; 77 3 486 491 (Pubitemid 27121014)
22. Bevers EM, Galli M, Barbui T, Comfurius P, Zwaal RFA. Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin. Thromb Haemost: 1991; 66 6 629 632
23. Horbach DA, van Oort E, Derksen RHWM, de Groot PG. The contribution of anti-prothrombin-antibodies to lupus anticoagulant activitydiscrimination between functional and non-functional anti-prothrombin-antibodies. Thromb Haemost: 1998; 79 4 790 795 (Pubitemid 28163856)
24. Galli M, Finazzi G, Bevers EM, Barbui T. Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and 2-glycoprotein I-dependent antiphospholipid antibodies. Blood: 1995; 86 2 617 623
25. Pengo V, Biasiolo A, Rampazzo P, Brocco T. dRVVT is more sensitive than KCT or TTI for detecting lupus anticoagulant activity of anti-2-glycoprotein I autoantibodies. Thromb Haemost: 1999; 81 2 256 258 (Pubitemid 29078313)
26. Pengo V, Banzato A, Bison E, Denas G, Padayattil Jose S, Ruffatti A. Antiphospholipid syndrome: critical analysis of the diagnostic path. Lupus: 2010; 19 4 428 431
27. Galli M. The antiphospholipid triangle. J Thromb Haemost: 2010; 8 2 234 236
28. Galli M, Luciani D, Bertolini G, Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood: 2003; 101 5 1827 1832 (Pubitemid 36237580)
29. Galli M, Luciani D, Bertolini G, Barbui T. Anti- 2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome. Blood: 2003; 102 8 2717 2723 (Pubitemid 37248837)
30. Opatrny L, David M, Kahn SR, Shrier I, Rey E. Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a metaanalysis. J Rheumatol: 2006; 33 11 2214 2221 (Pubitemid 44749780)
31. Previtali S, Barbui T, Galli M. Anti-2-glycoprotein I and anti-prothrombin antibodies in antiphospholipid-negative patients with thrombosis: a case control study. Thromb Haemost: 2002; 88 5 729 732 (Pubitemid 35345327)
32. Pengo V, Biasiolo A, Pegoraro C, Cucchini U, Noventa F, Iliceto S. Antibody profiles for the diagnosis of antiphospholipid syndrome. Thromb Haemost: 2005; 93 6 1147 1152 (Pubitemid 40823521)
33. Ruffatti A, Tonello M, Del Ross T., et al. Antibody profile and clinical course in primary antiphospholipid syndrome with pregnancy morbidity. Thromb Haemost: 2006; 96 3 337 341 (Pubitemid 44377818)
34. Pengo V, Ruffatti A, Legnani C., et al. Clinical course of high-risk patients diagnosed with antiphospholipid syndrome. J Thromb Haemost: 2010; 8 2 237 242
35. Pengo V, Ruffatti A, Legnani C., et al. Incidence of a first thromboembolic event in asymptomatic carriers of high risk antiphospholipid antibody profile: a multicentre prospective study. Blood: 2011; 118 4714 4718
36. Lee EY, Lee CK, Lee TH., et al. Does the anti-2-glycoprotein I antibody provide additional information in patients with thrombosis? Thromb Res: 2003; 111 1-2 29 32 (Pubitemid 37485922)
37. Male C, Foulon D, Hoogendoorn H., et al. Predictive value of persistent versus transient antiphospholipid antibody subtypes for the risk of thrombotic events in pediatric patients with systemic lupus erythematosus. Blood: 2005; 106 13 4152 4158 (Pubitemid 41775921)
38. Forastiero R, Martinuzzo M, Pombo G., et al. A prospective study of antibodies to 2-glycoprotein I and prothrombin, and risk of thrombosis. J Thromb Haemost: 2005; 3 6 1231 1238 (Pubitemid 41725247)
39. de Laat B, Pengo V, Pabinger I., et al. The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. J Thromb Haemost: 2009; 7 11 1767 1773