Cell therapy in chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): A multicenter randomized trial

Circulation

Volumn 125, Issue 20, 2012, Pages 2454-2461

  Dos Santos, Ricardo Ribeiro ^a   Rassi, Salvador ^b   Feitosa, Gilson ^c   Grecco, Oswaldo T ^d   Rassi, Anis ^e   Da Cunha, Ademir B ^f   De Carvalho, Valéria B ^g   Guarita Souza, Luiz César ^h   De Oliveira, Wilson ⁱ   Tura, Bernardo R ^f   Soares, Milena B P ^a   De Carvalho, Antonio C Campos ^f  

^a San Rafael Hospital   (Brazil)

^b Hospital das Clý nicas de Goiania   (Brazil)

^c HOSPITAL SANTA IZABEL   (Brazil)

^d Instituto de Molestias Cardiovasculares   (Brazil)

^e Hospital do Coração Anis Rassi   (Brazil)

^f INSTITUTO NACIONAL DE CARDIOLOGIA   (Brazil)

^g Hospital Sý rio Libanes   (Brazil)

^h PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

ⁱ Pronto Socorro Cardiológico Universitário de Pernambuco Prof Luiz Tavares   (Brazil)

Author keywords

Cardiomyopathies; Chagas cardiomyopathy; Stem cells; Tissue therapy

Indexed keywords

AMIODARONE; BRAIN NATRIURETIC PEPTIDE; CAPTOPRIL; CARVEDILOL; DIGOXIN; ENALAPRIL; FUROSEMIDE; HYDRALAZINE; HYDROCHLOROTHIAZIDE; ISOSORBIDE MONONITRATE; LOSARTAN; PLACEBO; SPIRONOLACTONE;

ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW DERIVED MONONUCLEAR CELL THERAPY; CELL THERAPY; CHAGAS DISEASE; CHRONIC CHAGASIC CARDIOMYOPATHY; CHRONIC DISEASE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; AGED; BONE MARROW TRANSPLANTATION; CHAGAS CARDIOMYOPATHY; CHRONIC DISEASE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INJECTIONS, INTRALESIONAL; MALE; MIDDLE AGED; MOTOR ACTIVITY; QUALITY OF LIFE; TRANSPLANTATION, AUTOLOGOUS; TREATMENT FAILURE; VENTRICULAR FUNCTION, LEFT; YOUNG ADULT;

EID: 84861335926     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.067785     Document Type: Article

References (23)

1. Rassi A, Rassi A, Marin-Neto JA. Chagas disease. Lancet. 2010;375: 1388-1402.
2. Chagas C. Nova tripanozomiaze humana: estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade morbida do homem. Memórias do Instituto Oswaldo Cruz. 1909;1:159-218.
3. Kierszenbaum F. Where do we stand on the autoimmunity hypothesis of Chagas disease? Trends Parasitol. 2005;21:513-516.
4. Andrade ZA, Andrade SG. Pathogenesis of Chagas' chronic myocarditis; importance of ischemic lesions [in Portuguese]. Arq Bras Med. 1955;45: 279-288.
5. Andrade ZA, Lopes EA. A histochemical study of experimental Chagas' disease. Rev Inst Med Trop São Paulo. 1963;5:236-242.
6. Freitas HFG, Chizzola PR, Paes AT, Lima ACP, Mansur AJ. Risk stratification in a Brazilian hospital-based cohort of 1220 outpatients with heart failure: role of Chagas' heart disease. Int J Cardiol. 2005;102: 239-247.
7. Soares MBP, Lima RS, Rocha LL, Takyia CM, Pontes-de-Carvalho L, de Carvalho ACC, Ribeiro-dos-Santos R. Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice. Am J Pathol. 2004;164:441-447.
8. Vilas-Boas F, Feitosa GS, Soares MBP, Mota A, Pinho-Filho JA, Almeida AJG, Andrade MV, Carvalho HG, Dourado-Oliveira A, Ribeirodos-Santos R. Early results of bone marrow cell transplantation to the myocardium of patients with heart failure due to Chagas disease. Arq Bras Cardiol. 2006;87:159-166.
9. Vilas-Boas F, Feitosa GS, Soares MBP, Pinho-Filho JÁ , Mota A, Almeida AJG, Andrade MS, Carvalho HG, Oliveira AD, Ribeiro-dos-Santos R. Bone marrow cell transplantation in Chagas' disease heart failure: report of the first human experience. Arq Bras Cardiol. 2011;96: 325-331.
10. Theodoropoulos TAD, Bestetti RB, Otaviano AP, Cordeiro JA, Rodrigues VC, Silva AC. Predictors of all-cause mortality in chronic Chagas' heart disease in the current era of heart failure therapy. Int J Cardiol. 2008;128:22-29.
11. Yuen KK. The two sample trimmed t test for unequal population variances. Biometrika. 1974;61:165-170.
12. Wilcox RR. Analyzing repeated measures or randomized block designs using trimmed means. Br J Math Stat Psychol. 1993;46:63-76.
13. Martin-Rendon E, Brunskill SJ, Hyde CJ, Stanworth SJ, Mathur A, Watt SM. Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review. Eur Heart J. 2008;29: 1807-1818.
14. Kang H-J, Kim H-S, Zhang S-Y, Park K-W, Cho H-J, Koo B-K, Kim YJ, Soo Lee D, Sohn DW, Han KS, Oh BH, Lee MM, Park YB. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet. 2004;363:751-756.
15. Assmus B, Walter DH, Lehmann R, Honold J, Martin H, Dimmeler S, Zeiher AM, Schächinger V. Intracoronary infusion of progenitor cells is not associated with aggravated restenosis development or atherosclerotic disease progression in patients with acute myocardial infarction. Eur Heart J. 2006;27:2989-2995.
16. Abdel-Latif A, Bolli R, Zuba-Surma EK, Tleyjeh IM, Hornung CA, Dawn B. Granulocyte colony-stimulating factor therapy for cardiac repair after acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. Am Heart J. 2008;156: 216-226.e9.
17. Higuchi ML. Chagas disease: importance of the parasite in the pathogenesis of the cardiac chronic disease. Arq Bras Cardiol. 1995;64: 251-254.
18. Tanowitz HB, Machado FS, Jelicks LA, Shirani J, de Carvalho ACC, Spray DC, Factor SM, Kirchhoff LV, Weiss LM. Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease). Prog Cardiovasc Dis. 2009;51:524-539.
19. Goldenberg RCS, Jelicks LA, Fortes FSA, Weiss LM, Rocha LL, Zhao D, Carvalho AC, Spray DC, Tanowitz HB. Bone marrow cell therapy ameliorates and reverses chagasic cardiomyopathy in a mouse model. J Infect Dis. 2008;197:544-547.
20. Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, Fichtner S, Korte T, Hornig B, Messinger D, Arseniev L, Hertenstein B, Ganser A, Drexler H. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 2004;364:141-148.
21. Schächinger V, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Hölschermann H, Yu J, Corti R, Mathey DG, Hamm CW, Süselbeck T, Assmus B, Tonn T, Dimmeler S, Zeiher AM; REPAIR-AMI Investigators. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006;355:1210-1221.
22. Janssens S, Dubois C, Bogaert J, Theunissen K, Deroose C, Desmet W, Kalantzi M, Herbots L, Sinnaeve P, Dens J, Maertens J, Rademakers F, Dymarkowski S, Gheysens O, Van Cleemput J, Bormans G, Nuyts J, Belmans A, Mortelmans L, Boogaerts M, Van de Werf F. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet. 2006;367:113-121.
23. Barbosa da Fonseca LM, Xavier SS, Rosado de Castro PH, Lima RSL, Gutfilen B, Goldenberg RCS, Maiolino A, Chagas CL, Pedrosa RC, Campos de Carvalho AC. Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection. Int J Cardiol. 2011;149:310-314.