Downregulation of gastrokine-1 in gastric cancer tissues and restoration of its expression induced gastric cancer cells to apoptosis

Journal of Experimental and Clinical Cancer Research

Volumn 31, Issue 1, 2012, Pages

  Mao, Wei ^a   Chen, Jie ^a   Peng, Tie Li ^a   Yin, Xiao Fei ^a   Chen, Lian Zhou ^a   Chen, Min Hu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

5 FU; Apoptosis; Cell viability; Gastric cancer; Gastrokine 1; Immunohistochemistry

Indexed keywords

ABL1 PROTEIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BCL2 RELATED PROTEIN A1; BCL2L1 PROTEIN; BCL2L11 PROTEIN; BCLAF1 PROTEIN; BOK PROTEIN; CARD11 PROTEIN; CARD8 PROTEIN; CIDEB PROTEIN; COMPLEMENTARY DNA; DECOY RECEPTOR 3; FLUOROURACIL; GASTROKINE 1; NOL3 PROTEIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 10; TNFRSF10D PROTEIN; TNFRSF1A PROTEIN; TP53BP2 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR 3; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; ATROPHIC GASTRITIS; CANCER CELL; CANCER TISSUE; CELL CYCLE REGULATION; CELL VIABILITY; CHEMOSENSITIVITY; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRECANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; STOMACH MUCOSA; WESTERN BLOTTING;

ADULT; AGED; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; EPITHELIUM; FEMALE; FLUOROURACIL; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; PEPTIDE HORMONES; STOMACH NEOPLASMS;

EID: 84861333028     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-31-49     Document Type: Article

References (21)

1. Surgical outcomes of patients with gastric carcinoma: the importance of primary tumor location and microvessel invasion. Talamonti MS, Kim SP, Yao KA, Wayne JD, Feinglass J, Bennett CL, Rao S, Surgery 2003 134 720 727 discussion 727-729 10.1016/S0039-6060(03)00337-4 14605635 (Pubitemid 37411981)
2. Cancer statistics, 2002. Jemal A, Thomas A, Murray T, Thun M, CA Cancer J Clin 2002 52 23 47 10.3322/canjclin.52.1.23 11814064 (Pubitemid 34110469)
3. Gastric cancer: epidemiology and risk factors. Krejs GJ, Dig Dis 2010 28 600 603 10.1159/000320277 21088409
4. Isolation of two novel genes, down-regulated in gastric cancer. Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I, Jpn J Cancer Res 2000 91 459 463 10.1111/j.1349-7006.2000.tb00967.x 10835488 (Pubitemid 30392314)
5. Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation. Oien KA, McGregor F, Butler S, Ferrier RK, Downie I, Bryce S, Burns S, Keith WN, J Pathol 2004 203 789 797 10.1002/path.1583 15221938 (Pubitemid 38961565)
6. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG, Am J Physiol Gastrointest Liver Physiol 2003 285 332 G343 12851218
7. AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins. Walsh-Reitz MM, Huang EF, Musch MW, Chang EB, Martin TE, Kartha S, Toback FG, Am J Physiol Gastrointest Liver Physiol 2005 289 163 G171 10.1152/ajpgi.00013.2005 15961882 (Pubitemid 40944235)
8. BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer. Sanchez-Pulido L, Devos D, Valencia A, Trends Biochem Sci 2002 27 329 332 10.1016/S0968-0004(02)02134-5 12114016 (Pubitemid 34756511)
9. Gastrokine 1 expression in patients with and without Helicobacter pylori infection. Nardone G, Rippa E, Martin G, Rocco A, Siciliano RA, Fiengo A, Cacace G, Malorni A, Budillon G, Arcari P, Dig Liver Dis 2007 39 122 129 10.1016/j.dld.2006.09.017 17092786 (Pubitemid 46126745)
10. Low-dose aspirin reduces the gene expression of gastrokine-1 in the antral mucosa of healthy subjects. Martin G, Wex T, Treiber G, Malfertheiner P, Nardone G, Aliment Pharmacol Ther 2008 28 782 788 10.1111/j.1365-2036.2008. 03793.x 19145733
11. Molecular expression of Gastrokine 1 in normal mucosa and in Helicobacter pylori-related preneoplastic and neoplastic gastric lesions. Nardone G, Martin G, Rocco A, Rippa E, La Monica G, Caruso F, Arcari P, Cancer Biol Ther 2008 7 1890 1895 18927498
12. Histological assessment of the Sydney classification of endoscopic gastritis. Khakoo SI, Lobo AJ, Shepherd NA, Wilkinson SP, Gut 1994 35 1172 1175 10.1136/gut.35.9.1172 7959220 (Pubitemid 24277326)
13. The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis. Bossenmeyer-Pourie C, Kannan R, Ribieras S, Wendling C, Stoll I, Thim L, Tomasetto C, Rio MC, J Cell Biol 2002 157 761 770 10.1083/jcb200108056 12034770 (Pubitemid 34847814)
14. Inactivation of the Gastrokine 1 gene in gastric adenomas and carcinomas. Yoon JH, Song JH, Zhang C, Jin M, Kang YH, Nam SW, Lee JY, Park WS, J Pathol 2011 223 618 625 10.1002/path.2838 21341273
15. Overexpression of gastrokine 1 in gastric cancer cells induces Fas-mediated apoptosis. Rippa E, La Monica G, Allocca R, Romano MF, De Palma M, Arcari P, J Cell Physiol 2011 226 2571 2578 10.1002/jcp.22601 21792914
16. Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers. Yoon JH, Kang YH, Choi YJ, Park IS, Nam SW, Lee JY, Lee YS, Park WS, J Cancer Res Clin Oncol 2011 137 1697 1704 10.1007/s00432-011-1051-8 21898090
17. Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells. Xing R, Li W, Cui J, Zhang J, Kang B, Wang Y, Wang Z, Liu S, Lu Y, Gut 2012 61 43 52 10.1136/gut.2010.230623 21676900
18. Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cells. Yan GR, Xu SH, Tan ZL, Yin XF, He QY, Proteomics 2011 11 3657 3664 10.1002/pmic.201100215 21751384
19. Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Toback FG, Walsh-Reitz MM, Musch MW, Chang EB, Del Valle J, Ren H, Huang E, Martin TE, Am J Physiol Gastrointest Liver Physiol 2003 285 344 G353 12851219
20. Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis. Moss SF, Lee JW, Sabo E, Rubin AK, Rommel J, Westley BR, May FE, Gao J, Meitner PA, Tavares R, Resnick MB, Clin Cancer Res 2008 14 4161 4167 10.1158/1078-0432.CCR-07-4381 18593995
21. BCL2A1: the underdog in the BCL2 family. Vogler M, Cell Death Differ 2012 19 67 74 10.1038/cdd.2011.158 22075983