Variability in the analysis of 25-hydroxyvitamin D by liquid chromatography-tandem mass spectrometry: The devil is in the detail

Clinica Chimica Acta

Volumn 413, Issue 15-16, 2012, Pages 1239-1243

  Couchman, Lewis ^a   Benton, Christopher M ^a   Moniz, Cajetan F ^a  

^a KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

25 Hydroxyvitamin D; DEQAS; LC MS MS; Standardisation

Indexed keywords

25 HYDROXYVITAMIN D; 3 EPI 25 HYDROXYVITAMIN D; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; ELECTROSPRAY; HEALTH SURVEY; HYPERBARISM; LABORATORY TEST; LIQUID CHROMATOGRAPHY; OBSERVER VARIATION; PHASE TRANSITION; PRIORITY JOURNAL; QUESTIONNAIRE; TANDEM MASS SPECTROMETRY; VITAMIN D EXTERNAL QUALITY ASSESSMENT SCHEME; WATER LOSS;

CALIBRATION; CHROMATOGRAPHY, LIQUID; CLINICAL LABORATORY TECHNIQUES; DATA COLLECTION; HUMANS; QUALITY CONTROL; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; VITAMIN D;

EID: 84861331797     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2012.04.003     Document Type: Article

References (33)

1. Seamans K.M., Cashman K.D. Existing and potentially novel functional markers of vitamin D status: a systematic review. Am J Clin Nutr 2009, 89:1997S-2008S.
2. United Kingdom Department of Health Nutrition and bone health with particular reference to calcium and vitamin D: report of the Subgroup on Bone Health. (Working Group on the Nutritional Status of the Population) of the Committee on Medical Aspects of Food and Nutrition Policy 1998, http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_4005936 (Accessed February 2012).
3. Vogeser M. Quantification of circulating 25-hydroxyvitamin D by liquid chromatography-tandem mass spectrometry. J Steroid Biochem Mol Biol 2010, 121:565-573.
4. Holick M.F. Vitamin D status: measurement, interpretation and clinical application. Ann Epidemiol 2009, 19:73-78.
5. El-Khoury J.M., Reineks E.Z., Wang S. Progress of liquid chromatography-mass spectrometry in measurement of vitamin D metabolites and analogues. Clin Biochem 2011, 44:66-76.
6. Carter G.D. Accuracy of 25-hydroxyvitamin D assays: confronting the issues. Curr Drug Targets 2011, 12:19-28.
7. Haddad J.C., Chyu K.J. Competitive protein-binding radioassay for 25-hydroxycholecalciferol. J Clin Endocrinol Metab 1971, 33:992-995.
8. Mayer E., Schmidt-Gayk H. Inter-laboratory comparison of 25-hydroxyvitamin D determination. Clin Chem 1984, 30:1199-1204.
9. Carter G.D., Carter C.R., Gunter E., et al. Measurement of vitamin D metabolites: an international perspective on methodology and clinical interpretation. J Steroid Biochem Mol Biol 2004, 89-90:467-471.
10. Carter G.D., Carter R., Jones J., Berry J. How accurate are assays for 25-hydroxyvitamin D? Data from the international vitamin D external quality assessment scheme. Clin Chem 2004, 50:2195-2197.
11. Binkley N., Krueger D., Cowgill C.S., et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardisation. J Clin Endocrinol Metab 2004, 89:3152-3157.
12. Hollis B.W. Editorial: the determination of circulating 25-hydroxyvitamin D: no easy task. J Clin Endocrinol Metab 2004, 89:3149-3151.
13. Dooley K.C. Tandem mass spectrometry in the clinical chemistry laboratory. Clin Biochem 2003, 36:471-481.
14. Watson D., Setchell K.D.R., Ross R. Analysis of vitamin D and its metabolites using thermospray liquid chromatography/mass spectrometry. Biomed Chrom 1991, 5:153-160.
15. Roth H.J., Schmidt-Gayk H., Weber H., Niederau C. Accuracy and clinical implications of seven 25-hydroxyvitamin D methods compared with liquid chromatography-tandem mass spectrometry as a reference. Ann Clin Biochem 2008, 45:153-159.
16. Zerwekh J.E. Blood biomarkers of vitamin D status. Am J Clin Nutr 2008, 87:1087S-1091S.
17. Carter G.D. 25-hydroxyvitamin D assays: the quest for accuracy. Clin Chem 2009, 55:1300-1302.
18. De la Hunty A., Wallace A.M., Gibson S., Viljakainen H., Lamberg-Allardt C., Ashwell M. UK Food Standards Agency workshop consensus report: the choice of method for measuring 25-hydroxyvitamin D to estimate vitamin D status for the UK National Diet and Nutrition Survey. Br J Nutr 2010, 104:612-619.
19. Carter G.D., Jones J. Use of a common standard improves the performance of liquid chromatography-tandem mass spectrometry methods for serum 25-hydroxyvitamin-D. Ann Clin Biochem 2009, 46:79-81.
20. Chen H., McCoy L.F., Schleicher R.L., Pfeiffer C.M. Measurement of 25-hydroxyvitamin D3 (25OHD3) and 25-hydroxyvitamin D2 (25OHD2) in human serum using liquid chromatography-tandem mass spectrometry and its comparison to a radioimmunassay method. Clin Chim Acta 2008, 391:6-12.
21. Healy M.J.R. Outliers in clinical chemistry quality control schemes. Clin Chem 1979, 25:675-677.
22. Guo T., Taylor R.L., Singh R.J., Soldin S.J. Simultaneous determination of 12 steroids by isotope dilution liquid chromatography-photospray ionization tandem mass spectrometry. Clin Chim Acta 2006, 372:76-82.
23. Herrmann M., Harwood T., Gaston-Parry O., et al. A new quantitative LC tandem mass spectrometry assay for serum 25-hydroxyvitamin D. Steroids 2010, 75:1106-1112.
24. Annesley T.M. Ion suppression in mass spectrometry. Clin Chem 2003, 49:1041-1044.
25. Bonfiglio R., King R.C., Olah T.V., Merkle K. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commum Mass Spectrom 1999, 13:1175-1185.
26. Matuzewski B.K., Constanzer M.L., Chavez-Eng C.M. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 2003, 75:3019-3030.
27. Dams R., Huestis M.A., Lambert W.A., Murphy C.M. Matrix effect in bioanalysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid. J Am Soc Mass Spectrom 2003, 14:1290-1294.
28. Matuzewski B.K. Standard line slopes as a measure of relative matrix effect in quantitative HPLC-MS bioanalysis. J Chromatogr B Analyt Technol Biomed Life Sci 2006, 830:293-300.
29. Iwasaki Y., Nakano Y., Mochizuki K., et al. A new strategy for ionization enhancement by derivatization for mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2011, 879:1159-1165.
30. Norgdren H.K., Holmgren P., Liljeberg P., Eriksson N., Beck O. Application of direct urine LC-MS/MS analysis for screening of novel substances in drug abusers. J Anal Toxicol 2005, 29:234-239.
31. Singh R.J., Taylor R.L., Satyanarayana R., Grebe S.K.G. C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. J Clin Endocrinol Metab 2006, 91:3055-3061.
32. Stepman H.C.M., Vanderroost A., Stockl D., Thienpont L.M. Full-scan mass spectral evidence for 3-epi-25-hydroxyvitamin D(3) in serum of infants and adults. Clin Chem Lab Med 2011, 49:253-256.
33. Shah I., James R., Barker J., Petroczi A., Naughton D.P. Misleading measures in vitamin D analysis: a novel LC-MS/MS assay to account for epimers and isobars. Nutr J 2011, 10:46-55.