PinX1 localizes to telomeres and stabilizes TRF1 at mitosis

Molecular and Cellular Biology

Volumn 32, Issue 8, 2012, Pages 1387-1395

  Yonekawa, Tohru ^a   Yang, Shuqun ^a   Counter, Christopher M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; PINX1 PROTEIN; TELOMERIC REPEAT BINDING FACTOR 1; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL LEVEL; CONTROLLED STUDY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY; TELOMERE;

APOPTOSIS; HELA CELLS; HUMANS; MITOSIS; PROTEIN BINDING; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERIC REPEAT BINDING PROTEIN 1; TUMOR SUPPRESSOR PROTEINS;

EID: 84861321850     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.05641-11     Document Type: Article

References (34)

1. Armbruster BN, Banik SS, Guo C, Smith AC, Counter CM. 2001. N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol. Cell. Biol. 21:7775-7786.
2. Banik SS, Counter CM. 2004. Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. J. Biol. Chem. 279:51745-51748.
3. Barrientos KS, et al. 2008. Distinct functions of POT1 at telomeres. Mol. Cell. Biol. 28:5251-5264.
4. Canudas S, et al. 2007. Protein requirements for sister telomere association in human cells. EMBO J. 26:4867-4878.
5. Chang W, Dynek JN, Smith S. 2003. TRF1 is degraded by ubiquitinmediated proteolysis after release from telomeres. Genes Dev. 17:1328-1333.
6. Chen Y, et al. 2008. A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319:1092-1096.
7. Chong L, et al. 1995. A human telomeric protein. Science 270:1663-1667.
8. Cook BD, Dynek JN, Chang W, Shostak G, Smith S. 2002. Role for the related poly(ADP-ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol. Cell. Biol. 22:332-342.
9. Dynek JN, Smith S. 2004. Resolution of sister telomere association is required for progression through mitosis. Science 304:97-100.
10. Grobelny JV, Godwin AK, Broccoli D. 2000. ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle. J. Cell Sci. 113(Pt 24):4577-4585.
11. Houghtaling BR, Cuttonaro L, Chang W, Smith S. 2004. A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr. Biol. 14:1621-1631.
12. Karlseder J, et al. 2003. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol. 23:6533-6541.
13. Kim SH, Kaminker P, Campisi J. 1999. TIN2, a new regulator of telomere length in human cells. Nat. Genet. 23:405-412.
14. Lee TH, Perrem K, Harper JW, Lu KP, Zhou XZ. 2006. The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. J. Biol. Chem. 281:759-768.
15. Martinez P, Blasco MA. 2011. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat. Rev. Cancer 11:161-176.
16. Martinez P, et al. 2009. Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev. 23:2060-2075.
17. Morgenstern JP, Land H. 1990. A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells. Nucleic Acids Res. 18:1068.
18. Nakamura M, Zhou XZ, Kishi S, Lu KP. 2002. Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett. 514:193-198.
19. Okamoto K, Iwano T, Tachibana M, Shinkai Y. 2008. Distinct roles of TRF1 in the regulation of telomere structure and lengthening. J. Biol. Chem. 283:23981-23988.
20. Palm W, de Lange T. 2008. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42:301-334.
21. Sfeir A, et al. 2009. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell 138:90-103.
22. Smith S, Giriat I, Schmitt A, de Lange T. 1998. Tankyrase, a poly(ADPribose) polymerase at human telomeres. Science 282:1484-1487.
23. Takai KK, Hooper S, Blackwood S, Gandhi R, de Lange T. 2010. In vivo stoichiometry of shelterin components. J. Biol. Chem. 285:1457-1467.
24. Vakifahmetoglu H, Olsson M, Zhivotovsky B. 2008. Death through a tragedy: mitotic catastrophe. Cell Death Differ. 15:1153-1162.
25. van Steensel B, de Lange T. 1997. Control of telomere length by the human telomeric protein TRF1. Nature 385:740-743.
26. Verdun RE, Crabbe L, Haggblom C, Karlseder J. 2005. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol. Cell 20:551-561.
27. Whitfield ML, et al. 2002. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol. Biol. Cell 13: 1977-2000.
28. Ye JZ, de Lange T. 2004. TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat. Genet. 36:618-623.
29. Yoo JE, Oh BK, Park YN. 2009. Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres. J. Mol. Biol. 388:928-940.
30. Yuan K, et al. 2009. PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. J. Biol. Chem. 284:23072-23082.
31. Zeng Z, et al. 2010. Structural basis of selective ubiquitination of TRF1 by SCFFbx4. Dev. Cell 18:214-225.
32. Zhou XZ, et al. 2011. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J. Clin. Invest. 121:1266-1282.
33. Zhou XZ, Lu KP. 2001. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107:347-359.
34. Zhu Q, et al. 2009. GNL3L stabilizes the TRF1 complex and promotes mitotic transition. J. Cell Biol. 185:827-839.