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Volumn 153, Issue 6, 2012, Pages 2623-2632

Intestinotrophic glucagon-like peptide-2 (GLP-2) activates intestinal gene expression and growth factor-dependent pathways independent of the vasoactive intestinal peptide gene in mice

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLUCAGON LIKE PEPTIDE 2; RNA; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST;

EID: 84861309089     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1069     Document Type: Article
Times cited : (33)

References (46)
  • 1
    • 0036158954 scopus 로고    scopus 로고
    • Biological actions and therapeutic potential of the glucagon-like peptides
    • Drucker DJ 2002 Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122:531-544 (Pubitemid 34117003)
    • (2002) Gastroenterology , vol.122 , Issue.2 , pp. 531-544
    • Drucker, D.J.1
  • 2
    • 0023008693 scopus 로고
    • Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing
    • Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF 1986 Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 261:11880-11889 (Pubitemid 17206117)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.25 , pp. 11880-11889
    • Mojsov, S.1    Heinrich, G.2    Wilson, I.B.3
  • 3
    • 0023470507 scopus 로고
    • Pancreatic and intestinal processing of proglucagon in man
    • Orskov C, Holst JJ, Poulsen SS, Kirkegaard P 1987 Pancreatic and intestinal processing of proglucagon in man. Diabetologia 30:874-881 (Pubitemid 18003670)
    • (1987) Diabetologia , vol.30 , Issue.11 , pp. 874-881
    • Orskov, C.1    Holst, J.J.2    Seier, P.S.3    Kirkegaard, P.4
  • 4
    • 78650774089 scopus 로고    scopus 로고
    • The gut-brain axis: A major glucoregulatory player
    • Burcelin R 2010 The gut-brain axis: a major glucoregulatory player. Diabetes Metab 36(Suppl 3):S54-S58
    • (2010) Diabetes Metab , vol.36 , Issue.SUPPL. 3
    • Burcelin, R.1
  • 5
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin JA, Drucker DJ 2009 Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 5:262-269
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 6
    • 0030795767 scopus 로고    scopus 로고
    • Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2
    • Brubaker PL, Izzo A, Hill M, Drucker DJ 1997 Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2. Am J Physiol 272:E1050-E1058
    • (1997) Am J Physiol , vol.272
    • Brubaker, P.L.1    Izzo, A.2    Hill, M.3    Drucker, D.J.4
  • 10
    • 0037665189 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 and common therapeutics in a murine model of ulcerative colitis
    • DOI 10.1124/jpet.103.051771
    • L'Heureux MC, Brubaker PL 2003 Glucagon-like peptide-2 and common therapeutics in a murine model of ulcerative colitis. J Pharmacol Exp Ther 306:347-354 (Pubitemid 36734391)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.306 , Issue.1 , pp. 347-354
    • L'Heureux, M.-C.1    Brubaker, P.L.2
  • 12
    • 1542408629 scopus 로고    scopus 로고
    • Glucagonlike peptide-2 analogue: A possible new approach in the management of inflammatory bowel disease
    • discussion 448-452
    • Arthur GL, Schwartz MZ, Kuenzler KA, Birbe R 2004 Glucagonlike peptide-2 analogue: a possible new approach in the management of inflammatory bowel disease. J Pediatr Surg 39:448-452; discussion 448-452
    • (2004) J Pediatr Surg , vol.39 , pp. 448-452
    • Arthur, G.L.1    Schwartz, M.Z.2    Kuenzler, K.A.3    Birbe, R.4
  • 13
    • 0032714919 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis
    • Boushey RP, Yusta B, Drucker DJ 1999 Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis. Am J Physiol 277:E937-E947
    • (1999) Am J Physiol , vol.277
    • Boushey, R.P.1    Yusta, B.2    Drucker, D.J.3
  • 14
    • 0035863327 scopus 로고    scopus 로고
    • Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor
    • Boushey RP, Yusta B, Drucker DJ 2001 Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor. Cancer Res 61:687-693 (Pubitemid 32128634)
    • (2001) Cancer Research , vol.61 , Issue.2 , pp. 687-693
    • Boushey, R.P.1    Yusta, B.2    Drucker, D.J.3
  • 16
    • 79958187560 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
    • Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B, O'Keefe SJ 2011 Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome. Gut 60:902-914
    • (2011) Gut , vol.60 , pp. 902-914
    • Jeppesen, P.B.1    Gilroy, R.2    Pertkiewicz, M.3    Allard, J.P.4    Messing, B.5    O'Keefe, S.J.6
  • 17
    • 77952679996 scopus 로고    scopus 로고
    • Teduglutide, a novel mucosally active analog of glucagon-like peptide- 2 (GLP-2) for the treatment of moderate to severe Crohn's disease
    • Buchman AL, Katz S, Fang JC, Bernstein CN, Abou-Assi SG 2010 Teduglutide, a novel mucosally active analog of glucagon-like peptide- 2 (GLP-2) for the treatment of moderate to severe Crohn's disease. Inflamm Bowel Dis 16:962-973
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 962-973
    • Buchman, A.L.1    Katz, S.2    Fang, J.C.3    Bernstein, C.N.4    Abou-Assi, S.G.5
  • 20
    • 8444230951 scopus 로고    scopus 로고
    • GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors
    • Ørskov C, Hartmann B, Poulsen SS, Thulesen J, Hare KJ, Holst JJ 2005 GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors. Regul Pept 124:105-112
    • (2005) Regul Pept , vol.124 , pp. 105-112
    • Ørskov, C.1    Hartmann, B.2    Poulsen, S.S.3    Thulesen, J.4    Hare, K.J.5    Holst, J.J.6
  • 21
    • 33746524497 scopus 로고    scopus 로고
    • The Essential Role of Insulin-Like Growth Factor-1 in the Intestinal Tropic Effects of Glucagon-Like Peptide-2 in Mice
    • DOI 10.1053/j.gastro.2006.05.055, PII S001650850601208X
    • Dubé PE, Forse CL, Bahrami J, Brubaker PL 2006 The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice. Gastroenterology 131:589-605 (Pubitemid 44142460)
    • (2006) Gastroenterology , vol.131 , Issue.2 , pp. 589-605
    • Dube, P.E.1    Forse, C.L.2    Bahrami, J.3    Brubaker, P.L.4
  • 23
    • 60849086453 scopus 로고    scopus 로고
    • VPAC and PAC receptors: From ligands to function
    • Dickson L, Finlayson K 2009 VPAC and PAC receptors: From ligands to function. Pharmacol Ther 121:294-316
    • (2009) Pharmacol Ther , vol.121 , pp. 294-316
    • Dickson, L.1    Finlayson, K.2
  • 25
    • 78650835129 scopus 로고    scopus 로고
    • VIP and PACAP: Recent insights into their functions/roles in physiology and disease from molecular and genetic studies
    • Moody TW, Ito T, Osefo N, Jensen RT 2011 VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies. Curr Opin Endocrinol Diabetes Obes 18:61-67
    • (2011) Curr Opin Endocrinol Diabetes Obes , vol.18 , pp. 61-67
    • Moody, T.W.1    Ito, T.2    Osefo, N.3    Jensen, R.T.4
  • 29
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • Cooper HS, Murthy SN, Shah RS, Sedergran DJ 1993 Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69:238-249
    • (1993) Lab Invest , vol.69 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.2    Shah, R.S.3    Sedergran, D.J.4
  • 30
    • 77952721309 scopus 로고    scopus 로고
    • ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel
    • Bahrami J, Yusta B, Drucker DJ 2010 ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel. Gastroenterology 138:2447-2456
    • (2010) Gastroenterology , vol.138 , pp. 2447-2456
    • Bahrami, J.1    Yusta, B.2    Drucker, D.J.3
  • 31
    • 54249088472 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells
    • Koehler JA, Harper W, Barnard M, Yusta B, Drucker DJ 2008 Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. Cancer Research 68:7897-7904
    • (2008) Cancer Research , vol.68 , pp. 7897-7904
    • Koehler, J.A.1    Harper, W.2    Barnard, M.3    Yusta, B.4    Drucker, D.J.5
  • 33
    • 0029035530 scopus 로고
    • Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors
    • Potten CS, Owen G, Hewitt D, Chadwick CA, Hendry H, Lord BI,Woolford LB 1995 Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors. Gut 36:864-873
    • (1995) Gut , vol.36 , pp. 864-873
    • Potten, C.S.1    Owen, G.2    Hewitt, D.3    Chadwick, C.A.4    Hendry, H.5    Lord, B.I.6    Woolford, L.B.7
  • 34
    • 84863115292 scopus 로고    scopus 로고
    • Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis
    • Lee SJ, Lee J, Li KK, Holland D, Maughan H, Guttman DS, Yusta B, Drucker DJ 2012 Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis. Endocrinology 153:1141-1151
    • (2012) Endocrinology , vol.153 , pp. 1141-1151
    • Lee, S.J.1    Lee, J.2    Li, K.K.3    Holland, D.4    Maughan, H.5    Guttman, D.S.6    Yusta, B.7    Drucker, D.J.8
  • 35
    • 79954915318 scopus 로고    scopus 로고
    • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
    • Bevins CL, Salzman NH 2011 Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 9:356-368
    • (2011) Nat Rev Microbiol , vol.9 , pp. 356-368
    • Bevins, C.L.1    Salzman, N.H.2
  • 36
    • 34548388348 scopus 로고    scopus 로고
    • Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: A model for the study of intestinal ileus and Hirschsprung's disease
    • DOI 10.1016/j.peptides.2007.05.006, PII S0196978107001714
    • Lelievre V, Favrais G, Abad C, Adle-Biassette H, Lu Y, Germano PM, Cheung-Lau G, Pisegna JR, Gressens P, Lawson G, Waschek JA 2007 Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and Hirschsprung's disease. Peptides 28:1688-1699 (Pubitemid 47361426)
    • (2007) Peptides , vol.28 , Issue.9 , pp. 1688-1699
    • Lelievre, V.1    Favrais, G.2    Abad, C.3    Adle-Biassette, H.4    Lu, Y.5    Germano, P.M.6    Cheung-Lau, G.7    Pisegna, J.R.8    Gressens, P.9    Lawson, G.10    Waschek, J.A.11
  • 37
    • 78650588402 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis
    • Abad C, Tan YV, Lopez R, Nobuta H, Dong H, Phan P, Feng JM, Campagnoni AT, Waschek JA 2010 Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 107:19555-19560
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 19555-19560
    • Abad, C.1    Tan, Y.V.2    Lopez, R.3    Nobuta, H.4    Dong, H.5    Phan, P.6    Feng, J.M.7    Campagnoni, A.T.8    Waschek, J.A.9
  • 41
    • 79751526267 scopus 로고    scopus 로고
    • VPAC1 (vasoactive intestinal peptide (VIP) receptor type 1)Gprotein-coupled receptor mediation of VIP enhancement of murine experimental colitis
    • Yadav M, Huang MC, Goetzl EJ 2011 VPAC1 (vasoactive intestinal peptide (VIP) receptor type 1)Gprotein-coupled receptor mediation of VIP enhancement of murine experimental colitis. Cell Immunol 267:124-132
    • (2011) Cell Immunol , vol.267 , pp. 124-132
    • Yadav, M.1    Huang, M.C.2    Goetzl, E.J.3
  • 42
    • 77955521850 scopus 로고    scopus 로고
    • Comparison of intestinal cold preservation injury on pituitary adenylate cyclase-activating polypeptide in knockout and wild-type mice
    • Ferencz A, Nedvig K, Fekecs T, Rácz B, Wéber G, Hashimoto H, Baba A, Helyes Z, Reglödi D 2010 Comparison of intestinal cold preservation injury on pituitary adenylate cyclase-activating polypeptide in knockout and wild-type mice. Transplant Proc 42:2290-2292
    • (2010) Transplant Proc , vol.42 , pp. 2290-2292
    • Ferencz, A.1    Nedvig, K.2    Fekecs, T.3    Rácz, B.4    Wéber, G.5    Hashimoto, H.6    Baba, A.7    Helyes, Z.8    Reglödi, D.9
  • 45
    • 0024404952 scopus 로고
    • Vasoactive intestinal peptide potentiates sexual behavior: Inhibition by novel antagonist
    • Gozes I, Meltzer E, Rubinrout S, Brenneman DE, Fridkin M 1989 Vasoactive intestinal peptide potentiates sexual behavior: inhibition by novel antagonist. Endocrinology 125:2945-2949 (Pubitemid 20010669)
    • (1989) Endocrinology , vol.125 , Issue.6 , pp. 2945-2949
    • Gozes, I.1    Meltzer, E.2    Rubinrout, S.3    Brenneman, D.E.4    Fridkin, M.5
  • 46
    • 0024780534 scopus 로고
    • VIP: Molecular biology and neurobiological function
    • Gozes I, Brenneman DE 1989 VIP: molecular biology and neurobiological function. Mol Neurobiol 3:201-236
    • (1989) Mol Neurobiol , vol.3 , pp. 201-236
    • Gozes, I.1    Brenneman, D.E.2


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