Formation of orthopoxvirus cytoplasmic A-type inclusion bodies and embedding of virions are dynamic processes requiring microtubules

Journal of Virology

Volumn 86, Issue 10, 2012, Pages 5905-5914

  Howard, Amanda R ^a   Moss, Bernard ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; MCHERRY FLUORESCENT PROTEIN; RED FLUORESCENT PROTEIN; UNCLASSIFIED DRUG; VIRAL CORE PROTEIN A4; YELLOW FLUORESCENT PROTEIN;

ARTICLE; CELLULAR PARAMETERS; CONFOCAL MICROSCOPY; COWPOX; CYTOPLASMIC A TYPE INCLUSION BODY; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INCLUSION BODY COALESCENCE; INTRACELLULAR TRANSPORT; MICROTUBULE; ORTHOPOXVIRUS; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; VACCINIA VIRUS; VIRION; VIRUS CORE; VIRUS INCLUSION; VIRUS INFECTION; VIRUS RECOMBINANT;

HELA CELLS; HUMANS; INCLUSION BODIES; INCLUSION BODIES, VIRAL; MICROTUBULES; VACCINIA; VACCINIA VIRUS; VIRION;

COWPOX VIRUS; ORTHOPOXVIRUS; VACCINIA VIRUS;

EID: 84861302916     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06997-11     Document Type: Article

References (33)

1. Amegadzie BY, Sisler JR, Moss B. 1992. Frame-shift mutations within the vaccinia virus A-type inclusion protein gene. Virology 186:777-782.
2. Carter GC, et al. 2003. Vaccinia virus cores are transported on microtubules. J. Gen. Virol. 84:2443-2458.
3. Ching Y-C, et al. 2009. Disulfide bond formation at the C termini of vaccinia A26 and A27 proteins does not require viral redox enzymes and suppresses glycosaminoglycan-mediated cell fusion. J. Virol. 83:6464-6476.
4. Chiu W-L, Lin C-L, Yang M-H, Tzou D-L, Chang W. 2007. Vaccinia virus 4c(A26L) protein on intracellular mature virus binds to the extracellular cellular matrix laminin. J. Virol. 81:2149-2157.
5. Condit RC, Moussatche N, Traktman P. 2006. In a nutshell: structure and assembly of the vaccinia virion. Adv. Virus Res. 66:31-124.
6. Cudmore S, Cossart P, Griffiths G, Way M. 1995. Actin-based motility of vaccinia virus. Nature 378:636-638.
7. de Carlos A, Eduardo P. 1991. Isolation and characterization of mutants of vaccinia virus with a modified 94-kDa inclusion protein. Virology 185: 768-778.
8. Downie AW. 1939. A study of the lesions produced experimentally by cowpox virus. J. Pathol. Bacteriol. 48:361-379.
9. Earl PL, Cooper N, Wyatt S, Moss B, Carroll MW. 1998. Preparation of cell cultures and vaccinia virus stocks, p 16.16.1-16.16.3. In Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (ed), Current protocols in molecular biology, vol 2. John Wiley and Sons, New York, NY.
10. Funahashi S, Sato T, Shida H. 1988. Cloning and characterization of the gene encoding the major protein of the A-type inclusion body of cowpox virus. J. General Virology. 69(Pt. 1):35-47.
11. Grimley PM, Rosenblum EN, Mims SJ, Moss B. 1970. Interruption by rifampin of an early stage in vaccinia virus morphogenesis: accumulation of membranes which are precursors of virus envelopes. J. Virol. 6:519-533.
12. Hollinshead M, et al. 2001. Vaccinia virus utilizes microtubules for movement to the cell surface. J. Cell Biol. 154:389-402.
13. Howard AR, Senkevich TG, Moss B. 2008. Vaccinia virus A26 and A27 proteins form a stable complex tethered to mature virions by association with the A17 transmembrane protein. J. Virol. 82:12384-12391.
14. Howard AR, Weisberg AS, Moss B. 2010. Congregation of orthopoxvirus virions in cytoplasmic A-type inclusions is mediated by interactions of a bridging protein (A26p) with a matrix protein (ATIp) and a virion membrane-associated protein (A27p). J. Virol. 84:7592-7602.
15. Ichihashi Y, Dales S. 1973. Biogenesis of poxviruses: relationship between a translation complex and formation of A-type inclusions. Virology 51: 297-319.
16. Ichihashi Y, Matsumoto S, Dales S. 1971. Biogenesis of poxviruses: role of A-type inclusions and host cell membranes in virus dissemination. Virology 46:507-532.
17. Katsafanas GC, Moss B. 2007. Colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions. Cell Host Microbe 2:221-228.
18. Knight JC, et al. 1992. Further analyses of the orthopoxvirus volepox virus and raccoon poxvirus. Virology 190:423-433.
19. Lin YC, Evans DH. 2010. Vaccinia virus particles mix inefficiently, and in a way that would restrict viral recombination, in coinfected cells. J. Virol. 84:2432-2443.
20. Locker JK, et al. 2000. Entry of the two infectious forms of vaccinia virus at the plasma membrane is signaling-dependent for the IMV but not the EEV. Mol. Biol. Cell 11:2497-2511.
21. Marchal J. 1930. Infectious ectromelia. A hitherto undescribed virus disease of mice. J. Pathol. Bacteriol. 33:713-728.
22. McKelvey TA, Andrews SC, Miller SE, Ray CA, Pickup DJ. 2002. Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions. J. Virol. 76:11216-11225.
23. Mercer J, Helenius A. 2008. Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells. Science 320:531-535.
24. Moser TS, Jones RG, Thompson CB, Coyne CB, Cherry S. 2010. A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog. 6:e1000954.
25. Moss B, Rosenblum EN, Katz E, Grimley PM. 1969. Rifampicin: a specific inhibitor of vaccinia virus assembly. Nature 224:1280-1284.
26. Patel D, Pickup D, Joklik W. 1986. Isolation of cowpox virus A-type inclusions and characterization of their major protein component. Virology 149:174-189.
27. Ploubidou A, et al. 2000. Vaccinia virus infection disrupts microtubule organization and centrosome function. EMBO J. 19:3932-3944.
28. Randall CC, Gafford LG, Darlington RW, Hyde J. 1964. Composition of Fowlpox Virus and Inclusion Matrix. J. Bacteriol. 87:939-944.
29. Rietdorf J, et al. 2001. Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus. Nat. Cell Biol. 3:992-1000.
30. Smith GL, Vanderplasschen A, Law M. 2002. The formation and function of extracellular enveloped vaccinia virus. J. Gen. Virol. 83:2915-2931.
31. Ward BM. 2005. Visualization and characterization of the intracellular movement of vaccinia virus intracellular mature virions. J. Virol. 79:4755-4763.
32. Ward BM, Moss B. 2001. Vaccinia virus intracellular movement is associated with microtubules and independent of actin tails. J. Virol. 75: 11651-11663.
33. Yang G, et al. 2005. An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus challenge. J. Virol. 79:13139-13149.