Generation of Th17 from human naive CD4+ T cells preferentially occurs from FOXP3+ Tregs upon costimulation via CD28 or CD5

Blood

Volumn 119, Issue 20, 2012, Pages 4810-4812

  Ayyoub, Maha ^a   Raffin, Caroline ^a   Valmori, Danila ^a,b  

^a UMR INSERM U892 CNRS 6299   (France)

^b UNIVERSITÉ DE NANTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD5 ANTIGEN; CYSTEINE; INTERLEUKIN 6; MONOCLONAL ANTIBODY CD28; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL ISOLATION; CELL SELECTION; HUMAN; IN VITRO STUDY; LETTER; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TH17 CELL;

EID: 84861219901     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-02-409722     Document Type: Letter

References (5)

1. de Wit J, Souwer Y, van Beelen AJ, et al. CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation. Blood. 2011;118(23):6107-6114.
2. Valmori D, Merlo A, Souleimanian NE, Hesdorffer CS, Ayyoub M. A peripheral circulating compartment of natural naive CD4 Tregs. J Clin Invest. 2005;115(7): 1953-1962. (Pubitemid 40979735)
3. Valmori D, Raffin C, Raimbaud I, Ayyoub M. Human RORgamma t+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineagespecific polarizing factors. Proc Natl Acad Sci U S A. 2010;107(45):19402-19407.
4. Chung Y, Chang SH, Martinez GJ, et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity. 2009;30(4):576-587.
5. Raffin C, Raimbaud I, Valmori D, Ayyoub M. Ex vivo IL-1 receptor type I expression in human CD4+ T cells identifies an early intermediate in the differentiation of Th17 from FOXP3+ naive regulatory T cells. J Immunol. 2011;187(10): 5196-5202.