The anti-atherosclerotic di-peptide, Trp-His, inhibits the phosphorylation of voltage-dependent L-type Ca 2+ channels in rat vascular smooth muscle cells

FEBS Open Bio

Volumn 2, Issue , 2012, Pages 83-88

  Kobayashi, Yutaro ^a   Fukuda, Toshihiko ^a   Tanaka, Mitsuru ^a   Matsui, Toshiro ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Calmodulin dependent kinase II; Di peptide; Intracellular Ca 2+; L type Ca 2+ channel; Phos tag

Indexed keywords

ANGIOTENSIN II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL L TYPE; PHOSPHOLIPASE C; TRYPTOPHYL HISTIDINE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE; VASODILATATION;

MUS; PHOS; RATTUS;

EID: 84861218549     PISSN: 22115463     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fob.2012.04.005     Document Type: Article

References (21)

1. Tanaka M., Tokuyasu M., Matsui T., Matsumoto K. Endothelium-independent vasodilation effect of di- and tri-peptides in thoracic aorta of Sprague-Dawley rats. Life Sci. 2008, 82:869-875.
2. 2+ influx. Peptides 2009, 30:1502-1507.
3. 2+ channels. Peptides 2010, 31:2060-2066.
4. Miguel M., Alvarez Y., Lopez-Fandino R., Alonso M.J., Salaices M. Vasodilator effects of peptides derived from egg white proteins. Regul. Pept. 2007, 140:131-135.
5. Erdmann K., Grosser N., Schipporeit K., Schroder H. The ACE inhibitory dipeptide Met-Tyr diminishes free radical formation in human endothelial cells via induction of heme oxygenase-1 and ferritin. J. Nutr. 2006, 136:2148-2152.
6. Schmidt-Ott K.M., Kagiyama S., Phillips M.I. The multiple actions of angiotensin II in atherosclerosis. Regul. Pept. 2000, 93:65-77.
7. Matsui T., Sato M., Tanaka M., Yamada Y., Watanabe S., Fujimoto Y., Imaizumi K., Matsumoto K. Vasodilating dipeptide Trp-His can prevent atherosclerosis in apo E-deficient mice. Br. J. Nutr. 2010, 103:309-313.
8. Touyz R.M., Schiffrin E.L. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol. Rev. 2000, 52:639-672.
9. Timmermans P.B., Wong P.C., Chiu A.T., Herblin W.F., Benfield P., Carini D.J., Lee R.J., Wexler R.R., Saye J.A., Smith R.D. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol. Rev. 1993, 45:205-251.
10. Bae Y.S., Lee T.G., Park J.C., Hur J.H., Kim Y., Heo K., Kwak J.Y., Suh P.G., Ryu S.H. Identification of a compound that directly stimulates phospholipase C activity. Mol. Pharmacol. 2003, 63:1043-1050.
11. Lee D.L., Webb R.C., Jin L. Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature. Hypertension 2004, 44:796-799.
12. Wynne B.M., Chiao C.W., Webb R.C. Vascular smooth muscle cell signaling mechanisms for contraction to angiotensin II and endothelin-1. J. Am. Soc. Hypertens. 2009, 3:84-95.
13. Dzhura I., Wu Y., Colbran R.J., Balser J.R., Anderson M.E. Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat. Cell Biol. 2000, 2:173-177.
14. Lee T.S., Karl R., Moosmang S., Lenhardt P., Klugbauer N., Hofmann F., Kleppisch T., Welling A. Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: identification of the phosphorylation sites. J. Biol. Chem. 2006, 281:25560-25567.
15. Mant A., Elliott D., Eyers P.A., O'Kelly I.M. Protein kinase A is central for forward transport of two pore domain potassium channels K(2P)3.1 and K(2P)9.1. J. Biol. Chem. 2011, 286:14110-14119.
16. McCarron J.G., McGeown J.G., Reardon S., Ikebe M., Fay F.S., Walsh J.V. Calcium-dependent enhancement of calcium current in smooth muscle by calmodulin-dependent protein kinase II. Nature 1992, 357:74-77.
17. Ishida A., Shigeri Y., Tatsu Y., Uegaki K., Kameshita I., Okuno S., Kitani T., Yumoto N., Fujisawa H. Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin-dependent protein kinase II. FEBS Lett. 1998, 427:115-118.
18. Li H., Aluko R.E. Kinetics of the inhibition of calcium/calmodulin-dependent protein kinase II by pea protein-derived peptides. J. Nutr. Biochem. 2005, 16:656-662.
19. Yang L., Doshi D., Morrow J., Katchman A., Chen X., Marx S.O. Protein kinase C isoforms differentially phosphorylate Cav1.2 alpha1c. Biochemistry 2009, 48:6674-6683.
20. Vetter S.W., Leclerc E. Novel aspects of calmodulin target recognition and activation. Eur. J. Biochem. 2003, 270:404-414.
21. Dawson R.M.C., Elliott D.C., Elliott W.H., Jones K.M. Data for Biochemical Research 1986, Oxford University Press, NY. third ed.