Polymethoxyflavonoids from Kaempferia parviflora induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 5, 2012, Pages 686-692

  Horikawa, Takumi ^a,b   Shimada, Tsutomu ^c   Okabe, Yui ^b   Kinoshita, Kaoru ^b   Koyama, Kiyotaka ^b   Miyamoto, Ken Ichi ^a   Ichinose, Koji ^c   Takahashi, Kunio ^b   Aburada, Masaki ^c  

^a KANAZAWA UNIVERSITY   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^c MUSASHINO UNIVERSITY   (Japan)

Author keywords

3T3 L1 cell; Adipogenesis; Adiponectin; Kaempferia parviflora; Polymethoxyflavonoid

Indexed keywords

ACETIC ACID ETHYL ESTER; ADIPONECTIN; CCAAT ENHANCER BINDING PROTEIN BETA; FLAVONOID; KAEMPFERIA PARVIFLORA EXTRACT; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; POLYMETHOXYFLAVONOID; UNCLASSIFIED DRUG;

ADIPOGENESIS; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION REGULATION; KAEMPFERIA PARVIFLORA; LIGAND BINDING; LIPID STORAGE; NONHUMAN; PROADIPOCYTE; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; ZINGIBERACEAE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ADIPONECTIN; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CCAAT-ENHANCER-BINDING PROTEIN-BETA; FLAVONES; GATA TRANSCRIPTION FACTORS; LIPID METABOLISM; METABOLIC DISEASES; MICE; PLANT EXTRACTS; PPAR GAMMA; RNA, MESSENGER; TRANSCRIPTION FACTORS; ZINGIBERACEAE;

EID: 84861215767     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.686     Document Type: Article

References (31)

1. Rajala MW, Scherer PE. Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology, 144, 3765-3773 (2003).
2. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab., 280, E745-E751 (2001).
3. Suganami T, Nishida J, Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler. Thromb. Vasc. Biol., 25, 2062-2068 (2005).
4. Suganami T, Tanimoto-Koyama K, Nishida J, Itoh M, Yuan X, Mizuarai S, Kotani H, Yamaoka S, Miyake K, Aoe S, Kamei Y, Ogawa Y. Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler. Thromb. Vasc. Biol., 27, 84-91 (2007).
5. Kim YK, Choi HY, Kim NH, Lee W, Seo DW, Kang DW, Lee HY, Han JW, Park SW, Kim SN. Reversine stimulates adipocyte differentiation and downregulates Akt and p70 (s6k) signaling pathways in 3T3-L1 cells. Biochem. Biophys. Res. Commun., 358, 553-558 (2007).
6. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr. Rev., 26, 439-451 (2005).
7. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest., 116, 1784-1792 (2006).
8. Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell, 4, 611-617 (1999).
9. Hamm JK, Park BH, Farmer SR. A role for C/EBPbeta in regulating peroxisome proliferator-activated receptor gamma activity during adipogenesis in 3T3-L1 preadipocytes. J. Biol. Chem., 276, 18464-18471 (2001).
10. Suh JM, Gao X, McKay J, McKay R, Salo Z, Graff JM. Hedgehog signaling plays a conserved role in inhibiting fat formation. Cell Metab., 3, 25-34 (2006).
11. Farmer SR. Transcriptional control of adipocyte formation. Cell Metab., 4, 263-273 (2006).
12. Rujjanawate C, Kanjanapothi D, Amornlerdpison D, Pojanagaroon S. Anti-gastric ulcer effect of Kaempferia parviflora. J. Ethnopharmacol., 102, 120-122 (2005).
13. Kusirisin W, Srichairatanakool S, Lerttrakarnnon P, Lailerd N, Suttajit M, Jaikang C, Chaiyasut C. Antioxidative activity, polyphenolic content and anti-glycation effect of some Thai medicinal plants traditionally used in diabetic patients. Med. Chem., 5, 139-147 (2009).
14. Sutthanut K, Sripanidkulchai B, Yenjai C, Jay M. Simultaneous identification and quantitation of 11 flavonoid constituents in Kaempferia parviflora by gas chromatography. J. Chromatogr. A, 1143, 227-233 (2007).
15. Sawasdee P, Sabphon C, Sitthiwongwanit D, Kokpol U. Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora. Phytother. Res., 23, 1792-1794 (2009).
16. Azuma T, Tanaka Y, Kikuzaki H. Phenolic glycosides from Kaempferia parviflora. Phytochemistry, 69, 2743-2748 (2008).
17. Panthong A, Tassaneeyakul W, Kanjanapothi D, Tantiwachwuttikul P, Reutrakul V. Anti-inflammatory activity of 5,7-dimethoxyflavone. Planta Med., 55, 133-136 (1989).
18. Yenjai C, Prasanphen K, Daodee S, Wongpanich V, Kittakoop P. Bioactive flavonoids from Kaempferia parviflora. Fitoterapia, 75, 89-92 (2004).
19. Tuchinda P, Reutrakul V, Claeson P, Pongprayoon U, Sematong T, Santisuk T, Taylor WC. Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata. Phytochemistry, 59, 169-173 (2002).
20. Akase T, Shimada T, Terabayashi S, Ikeya Y, Sanada H, Aburada M. Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice. J. Nat. Med., 65, 73-80 (2011).
21. Shimada T, Horikawa T, Ikeya Y, Matsuo H, Kinoshita K, Taguchi T, Ichinose K, Takahashi K, Aburada M. Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polymethoxyflavonoid on metabolic diseases. Fitoterapia, 82, 1272-1278 (2011).
22. Wang Y, Hamburger M, Gueho J, Hostettmann K. Antimicrobial flavonoids from Psiadia trinervia and their methylated and acetylated derivatives. Phytochemistry, 28, 2323-2327 (1989).
23. Gnabre J, Huang RCC, Bates RB, Burns JJ, Caldera S, Malcomson ME, McClure KJ. Characterization of anti-HIV lignans. Tetrahedron, 51, 12203-12210 (1995).
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951).
25. Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev., 5, 1538-1552 (1991).
26. Saito T, Abe D, Sekiya K. Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun., 357, 371-376 (2007).
27. Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science, 290, 134-138 (2000).
28. Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS. Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol. Cell. Biol., 25, 706-715 (2005).
29. Saito T, Abe D, Sekiya K. Sakuranetin induces adipogenesis of 3T3-L1 cells through enhanced expression of PPARgamma2. Biochem. Biophys. Res. Commun., 372, 835-839 (2008).
30. Tang QQ, Otto TC, Lane MD. CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc. Natl. Acad. Sci. U.S.A., 100, 850-855 (2003).
31. Zhang JW, Tang QQ, Vinson C, Lane MD. Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc. Natl. Acad. Sci. U.S.A., 101, 43-47 (2004).