Evolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation. A clinical-physiologic study

Journal of Critical Care

Volumn 27, Issue 3, 2012, Pages 283-288

  Hernandez, Glenn ^a   Pedreros, Cesar ^a   Veas, Enrique ^a   Bruhn, Alejandro ^a   Romero, Carlos ^b   Rovegno, Maximiliano ^a   Neira, Rodolfo ^b   Bravo, Sebastian ^a   Castro, Ricardo ^a   Kattan, Eduardo ^a   Ince, Can ^c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Lactate; Peripheral perfusion; Resuscitation; Septic shock

Indexed keywords

ADULT; AGED; ANALYTICAL PARAMETERS; ARTICLE; CHILE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LACTATE BLOOD LEVEL; MALE; METABOLIC PERFUSION PARAMETERS; OBSERVATIONAL STUDY; OXYGEN SATURATION; PERFUSION; PERIPHERAL PERFUSION PARAMETERS; PROSPECTIVE STUDY; RESUSCITATION; SEPTIC SHOCK; STATISTICAL ANALYSIS;

AGED; CHILE; EXTREMITIES; FEMALE; FLUID THERAPY; HUMANS; LACTIC ACID; MALE; MICROCIRCULATION; MIDDLE AGED; MONITORING, PHYSIOLOGIC; MULTIVARIATE ANALYSIS; PROSPECTIVE STUDIES; REGIONAL BLOOD FLOW; SHOCK, SEPTIC; SKIN TEMPERATURE; TOES;

EID: 84861203020     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2011.05.024     Document Type: Article

References (27)

1. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992, 20:864-874. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference.
2. Dellinger R.P., Levy M.M., Carlet J.M., Bion J., Parker M.M., Jaeschke R., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008, 34:17-60.
3. Antonelli M., Levy M., Andrews P.J., Chastre J., Hudson L.D., Manthous C., et al. Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006. Intensive Care Med 2007, 33:575-590.
4. Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377.
5. Hernandez G., Peña H., Cornejo R., Rovegno M., Retamal J., Navarro J.L., et al. Impact of emergency intubation on central venous oxygen saturation in critically ill patients: a multicenter observational study. Crit Care 2009, 13:R63.
6. Vallée F., Vallet B., Mathe O., Parraguette J., Mari A., Silva S., et al. Central venous-to-arterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock?. Intensive Care Med 2008, 34:2218-2225.
7. Bracht H., Hänggi M., Jeker B., Wegmüller N., Porta F., Tüller D., et al. Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study. Crit Care 2007, 11:R2.
8. Spronk P.E., Zandstra D.F., Ince C. Bench-to-bedside review: sepsis is a disease of the microcirculation. Crit Care 2004, 8:462-468.
9. Howell M.D., Donnino M., Clardy P., Talmor D., Shapiro N.I. Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med 2007, 33:1892-1899.
10. Joly H.R., Weil M.H. Temperature of the great toe as an indication of the severity of shock. Circulation 1969, 39:131-138.
11. Kaplan L.J., McPartland K., Santora T.A., Trooskin S.Z. Start with a subjective assessment of skin temperature to identify hypoperfusion in intensive care unit patients. J Trauma 2001, 50:620-627.
12. Lima A., Jansen T.C., van Bommel J., Ince C., Bakker J. The prognostic value of the subjective assessment of peripheral perfusion in critically ill patients. Crit Care Med 2009, 37:934-938.
13. Levy M.M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003, 31:1250-1256.
14. Hernandez G., Bruhn A., Romero C., Javier Larrondo F., De La Fuente R., Castillo L., et al. Management of septic shock with a norepinephrine-based haemodynamic algorithm. Resuscitation 2005, 66:63-69.
15. Hernandez G., Bruhn A., Romero C., Larrondo F.J., De La Fuente R., Cornejo R., et al. Implementation of a norepinephrine-based protocol for management of septic shock: a pilot feasibility study. J Trauma 2006, 60:77-81.
16. Cornejo R., Downey P., Castro R., Romero C., Regueira T., Vega J., et al. High-volume hemofiltration as salvage therapy in severe hyperdynamic septic shock. Intensive Care Med 2006, 32:713-722.
17. Castro R., Regueira T., Aguirre M.L., Llanos O.P., Bruhn A., Bugedo G., et al. An evidence-based resuscitation algorithm applied from the emergency room to the ICU improves survival of severe septic shock. Minerva Anestesiol 2008, 74:223-231.
18. Boerma E.C., Kuiper M.A., Kingma W.P., Egbers P.H., Gerritsen R.T., Ince C. Disparity between skin perfusion and sublingual microcirculatory alterations in severe sepsis and septic shock: a prospective observational study. Intensive Care Med 2008, 34:1294-1298.
19. Lima A., Bakker J. Noninvasive monitoring of peripheral perfusion. Intensive Care Med 2005, 31:1316-1326.
20. Levy B., Gibot S., Franck P., Cravoisy A., Bollaert P.E. Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study. Lancet 2005, 365:871-875.
21. Anderson B., Kelly A.M., Kerr D., Clooney M., Jolley D. Impact of patient and environmental factors on capillary refill time in adults. Am J Emerg Med 2008, 26:62-65.
22. Sevransky J. Clinical assessment of hemodynamically unstable patients. Curr Opin Crit Care 2009, 15:234-238.
23. Arnold R.C., Shapiro N.I., Jones A.E., Schorr C., Pope J., Casner E., et al. Multi-center study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 2009, 32:35-39.
24. Bakker J., Gris P., Coffernils M., Kahn R.J., Vincent J.L. Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg 1996, 171:221-226.
25. Boerma E.C., Ince C. The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. Intensive Care Med 2010, 36:2004-2018.
26. Lima A., van Bommel J., Jansen T.C., Ince C., Bakker J. Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients. Crit Care 2009, 13(Suppl 5):S13.
27. Hernandez G., Castro R., Romero C.M., De la Hoz C., Angulo D., Aranguiz I., et al. Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock?. J Crit Care 2010, [Epub ahead of print].