Alstiphyllanines I-O, ajmaline type alkaloids from Alstonia macrophylla showing vasorelaxant activity

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 11, 2012, Pages 3454-3459

  Arai, Hiroko ^a   Zaima, Kazumasa ^a   Mitsuta, Erika ^a   Tamamoto, Haruka ^a   Saito, Aiko ^a   Hirasawa, Yusuke ^a   Rahman, Abdul ^b   Kusumawati, Idha ^b   Zaini, Noor Cholies ^b   Morita, Hiroshi ^a  

^a HOSHI UNIVERSITY   (Japan)

^b AIRLANGGA UNIVERSITY   (Indonesia)

Author keywords

Ajmaline type alkaloids; Alstiphyllanines I O; Alstonia macrophylla; Indole alkaloids; Nitric oxide; ROCs; SAR; Vasorelaxant activity; VDCs

Indexed keywords

ALKALOID; ALSTIPHYLLANINE A; ALSTIPHYLLANINE H; ALSTIPHYLLANINE I; ALSTIPHYLLANINE J; ALSTIPHYLLANINE K; ALSTIPHYLLANINE L; ALSTIPHYLLANINE M; ALSTIPHYLLANINE N; ALSTIPHYLLANINE O; ALSTONIA MACROPHYLLA EXTRACT; CALCIUM CHANNEL; CALCIUM ION; NITRIC OXIDE; PHENYLEPHRINE; PLANT EXTRACT; RECEPTOR OPERATED CALCIUM CHANNEL; UNCLASSIFIED DRUG; VASODILATOR AGENT; VINCAMAJINE; VINCAMAJINE 17 O 3',4',5' TRIMETHOXYBENZOATE; VINCAMAJINE 17 O VERATRATE; VINCAMEDINE; VOLTAGE GATED CALCIUM CHANNEL;

ALSTONIA; ALSTONIA MACROPHYLLA; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENDOTHELIUM CELL; EX VIVO STUDY; MALE; NONHUMAN; PLANT LEAF; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VASCULAR RING; VASODILATATION;

AJMALINE; ALSTONIA; ANIMALS; AORTA; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENDOTHELIAL CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR STRUCTURE; NITRIC OXIDE; PHENYLEPHRINE; RATS; RATS, WISTAR; SECOLOGANIN TRYPTAMINE ALKALOIDS; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATION; VASODILATOR AGENTS;

ALSTONIA MACROPHYLLA; RATTUS;

EID: 84861197474     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.013     Document Type: Article

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