Fixing the "broken Heart": Pharmacologic implications

American Journal of Therapeutics

Volumn 19, Issue 3, 2012, Pages

  Shah, Rachit M ^a   Kodumuri, Vamsi K ^a   Bhuriya, Rohit ^a   Singh, Param P ^a   Adigopula, Sashikanth ^a   Khosla, Sandeep ^a   Arora, Rohit R ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

ACE inhibitors; acute coronary syndrome; aspirin; beta blockers; broken heart syndrome; catecholamines; left ventricular apical ballooning syndrome; Takotsubo cardiomyopathy

Indexed keywords

ACETYLSALICYLIC ACID; ANTIARRHYTHMIC AGENT; ANTICOAGULANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA METHYLIODOPHENYLPENTADECANOIC ACID I 123; BRAIN NATRIURETIC PEPTIDE; CALCIUM CHANNEL BLOCKING AGENT; CATECHOLAMINE; CREATINE KINASE MB; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; DOBUTAMINE; FLUORODEOXYGLUCOSE F 18; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPERTENSIVE AGENT; INOTROPIC AGENT; LEVOSIMENDAN; NICORANDIL; NITRIC ACID DERIVATIVE; PHENYLEPHRINE; RADIOPHARMACEUTICAL AGENT; TROPONIN I; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; AKINESIA; ANGIOCARDIOGRAPHY; ANTICOAGULANT THERAPY; BACKACHE; BLOOD SAMPLING; CARDIOGENIC SHOCK; CARDIOMYOPATHY; CATECHOLAMINE BLOOD LEVEL; CLINICAL FEATURE; COMPLETE HEART BLOCK; CORONARY ARTERY DILATATION; CORONARY ARTERY OBSTRUCTION; CORONARY ARTERY SPASM; CORONARY MICROVASCULAR DYSFUNCTION; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DIURETIC THERAPY; DOPPLER ECHOCARDIOGRAPHY; DRUG EFFICACY; DYSPNEA; ECG ABNORMALITY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FATIGUE; HEART ARRHYTHMIA; HEART CATHETERIZATION; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE THROMBOSIS; HUMAN; HYPERKINESIA; HYPOTENSION; LEFT VENTRICULAR MURAL THROMBUS; LOW DRUG DOSE; MEDLINE; MITRAL VALVE REGURGITATION; MULTICENTER STUDY (TOPIC); MYOCARDIAL DISEASE; NAUSEA; NEUROGENIC MYOCARDIAL STUNNING; PATHOPHYSIOLOGY; PHYSICAL STRESS; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; PROVOCATION TEST; REVIEW; RISK FACTOR; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STABLE ANGINA PECTORIS; STUNNED HEART MUSCLE; SYMPTOM; SYNCOPE; SYSTEMATIC REVIEW; TAKOTSUBO CARDIOMYOPATHY; THORAX PAIN; TREATMENT INDICATION; TREATMENT RESPONSE; VASOCONSTRICTION;

ACUTE CORONARY SYNDROME; ANIMALS; CHEST PAIN; ELECTROCARDIOGRAPHY; HUMANS; STRESS, PSYCHOLOGICAL; TAKOTSUBO CARDIOMYOPATHY;

EID: 84861197033     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e3181f2ab74     Document Type: Review

References (81)

1. Dote K, Sato H, Tateishi H, et al. Myocardial stunning due to simultaneous multivessel coronary spasm: a review of 5 cases. J Cardiol. 1991;21:203-214.
2. Kawai S, Suzuki H, Tanaka K, et al. Ampulla cardiomyopathy ('Takotusbo' cardiomyopathy)\-reversible left ventricular dysfunction: with ST segment elevation. Jpn Circ J. 2000;64:156-159. (Pubitemid 30136933)
3. Inoue M, Shimizu M, Ino H, et al. Differentiation between patients with takotsubo cardiomyopathy and those with anterior acute myocardial infarction. Circ J. 2005;69:89-94. (Pubitemid 40139615)
4. Akashi YJ, Nakazawa K, Sakakibara M, et al. 1231-MIBG myocardial scintigraphy in patients with 'takotsubo' cardiomyopathy. J Nucl Med. 2004;45:1121-1127. (Pubitemid 47616042)
5. Kurisu S, Inoue I, Kawagoe T, et al. Time course of electrocardiographic changes in patients with tako-tsubo syndrome: comparison with acute myocardial infarction with minimal enzymatic release. Circ J. 2004;68:77-81. (Pubitemid 38139941)
6. Matsuoka K, Okubo S, Fujii E, et al. Evaluation of the arrhythmogenicity of stress-induced 'takotsubo cardiomyopathy' from the time course of the 12 lead surface electrocardiogram. Am J Cardiol. 2003;92;230-233. (Pubitemid 36835980)
7. Ito K, Sugihara H, Katoh S, et al. Assessment of Takotsubo (Ampulla) cardiomyopathy using 99mTc-tetroformin myocardial SPECT\-comparison with acute coronary syndrome. Ann Nucl Med. 2003;67;687-690.
8. Ogura R, Hiasa Y, Takahashi T, et al. Specific findings of the standard 12-lead ECG in patients with 'Takotsubo' cardiomyopathy: comparison with the findings if acute anterior mycordial infarction. Circ J. 2003;67:687-690. (Pubitemid 36950785)
9. Abe Y, Kondo M, Matsuoka R, et al. Assessment of clinical features in transient left ventricular apical ballooning. J Am Coll Cardiol. 2003;41:737-742. (Pubitemid 36308378)
10. Tsuchihashi K, Ueshima K, Uchida T, et al. Angina pectoris-myocardial infarction investigations in Japan. Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. Angina pectoris-myocardial infarction investigation in Japan. J Am coll Cardiol. 2001;38:11-18. (Pubitemid 32613822)
11. Wittstein IS, Thiemann DR, Lima JA, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005;352:539-548. (Pubitemid 40204667)
12. Sharkey SW, Lesser JR, Zenovich AG, et al. Acute and reversible cardiomyoopathy provoked by stress in women from the United States. Circulation. 2005;111: 472-479. (Pubitemid 40204432)
13. Bybee KA, Prasad A, Barsness GW, et al. Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am J Cardiol. 2004;94: 343-346. (Pubitemid 38962701)
14. Desmet WJ, Adriaenssens BF, Dens JA. Apical ballooning of the left ventricle: first series in white patients. Heart. 2003;89:1027-1031. (Pubitemid 37046837)
15. Ibanez B, Navarro F, Cordoba M, et al. Tako-tsubo transient left ventricular apical ballooning: is intravascular ultrasound the key to resolve the enigma? Heart. 2005; 91:102-104. (Pubitemid 39665011)
16. Maron BJ, Towbin JA, Thiene G, et al. American Heart Association contemporary definitions and classification of the cardiomyopathies, American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation. 2006;113:1807-1816.
17. Akashi YJ, Nakazawa K, Sakakibara M, et al. The clinical features of takotsubo cardiomyopathy. Quart J Med. 2003; 96:563-573. (Pubitemid 36987255)
18. Kurowaski V, Kaiser A, von Hof K, et al. Apical and midventricular transient left ventricular dysfunction syndrome (tako-tsubo cardiomyopathy): frequency, mechanism, and prognosis. Chest. 2007;132:809-816.
19. Shimizu M, Kato Y, Masai H, et al. Recurrent episodes of Takotsubo-like-transient apical ballooning occurring in different regions: a case report. J Cardiol. 2006;48:101-107.
20. Baybee KA, Kara T, Prasad A, Lerman A. Transient left ventricular apical ballooning: a syndrome that mimics ST elevation myocardial infarction. Ann Intern Med. 2004; 141:858-865. (Pubitemid 39601180)
21. Lacy CR, Contrada RJ, Robbins ML, et al. Coronary vasoconstriction induced by mental stress (simulated public speaking). Am J Cardiol. 1995;75:503-505.
22. Yoshida T, Hibino T, Kako N, et al. A pathophysiologic study of tako-tsubo cardiomyopathy with F-18 flurodeox-yglucose positron emission tomography. Eur Heart J. 2007; 28:2598-2604. (Pubitemid 350071529)
23. Gupta R, Sech C, Lazzara R, et al. Transient cardiac ballooning\-the syndrome. Clin Cardiol. 2009;32:614-620.
24. Akashi YJ, Goldstein D, Ueyama, T. Takotsubo cardio-myopathy. A new form of acute, reversible heart failure. Circulation. 2008;118:2754-2762.
25. Kume T, Akasaka T, Kawamoto T, et al. Relationship between coronary flow reserve and recovery of regional left ventricular dysfunction in patients with tako-tsubo like transient left ventricular dysfunction. J Cardiol. 2004; 43:123-129. (Pubitemid 40756180)
26. Gibson CM, Cannon CP, Daley WL, et al. TIMI Frame account: a quantitative method of assessing coronary artery flow. Circulation. 1996;96:879-888. (Pubitemid 26074824)
27. Elesber A, Lerman A, Bybee KA, et al. Myocardial perfusion in apical ballooning syndrome: correlates of myocardial injury. Am Heart J. 2006;152:469.e9-13.
28. Meimoun P, Malaquin D, Sayah S, et al. The coronary flow reserve is transiently impaired in tako-tsubo cardiomyopathy: a prospective study using serial Dopp-ler transthoracic echocardiography. J Am Soc Echocardiogr. 2008;21:72-77.
29. Goldstein DS, Eisenhofer G, Kopin IJ. Sources and significance of plasma levels of catechols and their metabolites in humans. J Pharmacol Exp Ther. 2003;305: 800-811. (Pubitemid 36617954)
30. Wilkenfeld C, Cohen M, Lansman Sl, et al. Heart transplantation for end-stage cardiomyopathy caused by an occult phechromocytoma. J Heart Lung Transplant. 1992;11:363-366.
31. Neil-Dwyer G, Walter P, Cruckshank JM, et al. Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage. Br Med J. 1978;2: 990-992. (Pubitemid 9029929)
32. Movahed A, Reeves WC, Mehta PM, et al. Norepineph-rine-induced left ventricular dysfunction in anesthetized and conscious, sedated dogs. Int J Cardiol. 1994;45:23-33. (Pubitemid 124012951)
33. Frustaci A, Loperfido F, Gentiloni N, et al. Catechol-amine-induced cardiomyopathy in multiple endocrine neoplasia: a histologic, ultrastructural, and biochemical study. Chest. 1991;99:382-385.
34. Mann DL, Kent RL, Parsons B, et al. Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation. 1995;85:790-804.
35. Singal PK, Kanpur N, Dhillon KS, et al. Role of free radicals in catecholamine-induced cardiomyopathy. Can J Physiol Pharmacol. 1982;60:1390-1397. (Pubitemid 13209544)
36. Bolli R, Marbán E. Molecular and cellular mechanisms of myocardial stunning. Physiol Rev. 1999;79:609-634. (Pubitemid 29210931)
37. Ueyama T, Hano T, Kasamatsu K, et al. Emotional stress induces transient left ventricular hypokinesis in the rat via activation of the cardiac adrenoceptors: a possible animal model of ''tako-tsubo'' cardiomyopathy. Circ J. 2002;66:712-713.
38. Bybee KA, Murphy J, Prasad A, et al. Acute impairment of regional myocardial glucose utilization in the apical ballooning (Takotsubo) syndrome. J Nuc Cardiol. 2006:13: 244-250.
39. Pierpont Gl, DeMaster EG, Cohn JN. Regional differences in adrenergic function within the left ventricle. Am J Physiol. 1984;246:H824-H829. (Pubitemid 14077783)
40. Kawano H, Okada R, Yano K. Histological study on the distribution of autonomic nerves in the human heart. Heart Vessels. 2003;18:32-39. (Pubitemid 36442904)
41. Mori H, Ishikawa S, Kojima S, et al. Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli. Cardiovasc Res. 1993;27:192-198. (Pubitemid 23070327)
42. Lyon AR, Rees PS, Prasad S, et al. Stress (Takotsubo) cardiomyopathy; a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med. 2008;5:22-29.
43. Sader MA, Celermajer DS. Endothelial function, vascular reactivity and gender differences in the cardiovascular system. Cardiovasc Res. 2002;53:597-604. (Pubitemid 34175252)
44. Hinojosa-Laborde C, Chapa I, Lange D, et al. Gender differences in sympathetic nervous system regulation. Clin Exp Pharmacol Physiol. 1999;26:122-126.
45. Frankenhaeuser M, Dunne E, Lundberg U. Sex differences in sympathetic-adrenal medullary reactions induced by different stressors. Psychopharmacology (Berl). 1976;47:1-5.
46. Kneale BJ, Chowienczyk PJ, Brett SE, et al. Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol. 2000;36: 1233-1238.
47. Anderson Jl, Andams CD, Antman EM, et al. American College of Cardiology; American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients with Unstable Angina/Non-ST-Elevation Myo-cardial Infarction); American College of Emergency Physicians; Society for Cardiovascular Angiography and Interventions; Society of Thoracic Surgeons; American
48. Association of Cardiovascular and Pulmonary Rehabilitation; Society for Academic Emergency Medicine. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocar-dial infarction. J Am Coll Cardiol. 2007;50:el-el57.
49. Gianni M, Denatali F, Grandi AM, et al. Apical ballooning syndrome or takotsubo cardiomypathy: a systematic review. Eur Heart J. 2006;27:1523-14529.
50. Yamabe H, Hanaoka J, Funakoshi T, et al. Deep negative Twaves and abnormal cardiac sympathetic image (1231-MIBG) after the great hanshin earthquake of 1995. Am J Med Sci. 1996; 311:221-224.
51. Watanabe H, Kodama M, Okura Y, et al. Impact of earthquakes on takotsubo cardiomyopathy. JAMA. 2005;294:305-307.
52. Jensen JB, Malouf JF. Takotsubo cardiomyopathy following cholecystectomy a poorly recognized cause of acute reversible left ventricular dysfunction. Int J Cardiol. 2006; 106:390-391. (Pubitemid 41766643)
53. Berman M, Saute M, Porat E, et al. Takotsubo cardiomy-opathy: expanding the differential diagnosis in cardio-thoracic surgery. Ann Thorac Surg. 2007;83:295-298. (Pubitemid 44932145)
54. Akashi YJ, Sakakibara M, Miyake F. Reversible left ventricular dysfunction ''takotsubo'' cardiomyopathy associated with pneumothorax. Heart. 2002;87:E1.
55. Arai M, Ukigai H, Miyata H. A case of transient left ventricular ballooning (''Takotsubo''- shaped cardiomyopathy) developed during plasmapheresis for treatment of myasthenic crisis [Japanese]. Rinsho Shinkeigaku. 2004;44:207-210. (Pubitemid 38855865)
56. Maruyama S, Nomura Y, Fukushige T, et al. Suspected takotsubo cardiomyopathy caused by withdrawal of bupirenophine in a child. Circ J. 2006;70:509-511.
57. Saito Y. Hypoglycemic attack: a rare triggering factor for takotsubo cardiomyopathy. Intern Med. 2005;44:171-172. (Pubitemid 40575891)
58. Suzuki K, Osada N, Akasi YJ, et al. An atypical case of ''Takotsubo cardiomyopathy'' during alcohol withdrawal: abnormality in the transient left ventricular wall motion and a remarkable elevation in the ST segment. Intern Med. 2004;43:300-305. (Pubitemid 38678805)
59. Bybee KA, Motiei A, Syed I, et al. Electrocardiography cannot reliably differentiate transient left ventricular apical ballooning syndrome from anterior St-segment elevation myocardial infarction. J Electrocardiol. 2007;40:el-e6.
60. Bahit MC, Criger DA, Ohman EM, et al. Thresholds for the electrocardiographics change range of biochemical markers of acute myocardial infarction (GUSTO-IIa data). Am J Cardiol. 2002:90:233-237. (Pubitemid 34804556)
61. Ennezat PV, Pesenti-Rossi D, Aubert JM, et al. Transient left ventricular basal dysfunction without coronary stenosis in acute cerebral disorders: a novel heart syndrome (inverted Takotsubo). Echocardiography. 2005;22:599-602. (Pubitemid 41603167)
62. Sanchez-Recalda A, Costero O, Oliver JM, et al. Images in cardiovascular: pheochromocytome-related cardiomyopathy: inverted Takotsubo contractile pattern. Circulation. 2006; 113:e738-e739.
63. Copetti R, Gonano C, Colombo T, et al. ''Inverted Takotsubo'' pattern. Resuscitation. 2007;74:391.
64. Van de Walle SO, Gevaert SA, Gheeraert PJ, et al. Transient stress-induced cardiomyopathy with an ''inverted takotsubo'' contractile pattern. Mayo Clin. 2006;81:1499-1502. (Pubitemid 44685016)
65. Prasad A. Apical ballooning syndrome: an important differential diagnosis of acute myocardial infarction. Circulation. 115:e56-e59.
66. Donahue D, Movahed MR. Clinical characteristics, demographics and prognosis of transient left ventricular apical ballooning syndrome. Heart Fail Rev. 2005;10: 311-316.
67. Lee WL, Miao LF, Chan HW, et al. Takotsubo syndrome with transient complete atrioventricular block. Chin Med J (Engl). 2006;119:73-76.
68. Fazio, G, Pizzuto, C, Barbaro G, et al. Int J Cardiology. 2008;127:121-123.
69. Fazio G, Novo G, Barbaro G, et al. Int J Cardiol. 2008;130: 475-476.
70. Fefer P, Chelvanathan A, Dick AJ, et al. J Int Cardiology. 22: 444-452.
71. Kyuma M, Tsuchihashi K, Shinshi Y, et al. Effect of intravenous propranolol on left ventricular apical ballooning without coronary artery stenosis (ampulla cardiomy-opathy): three cases. Circ J. 2002;66:1181-1184. (Pubitemid 35416331)
72. Chockalingam A, Tejwani L, Aggarwal K, et al. Dynamic left ventricular outflow tract obstruction in acute myocardial infarction with shock: cause, effect, and coincidence. Circulation. 2007;116:e110-e113. (Pubitemid 47450269)
73. Haley JH, Sinak LJ, Tajik AJ, et al. Dynamic left ventricular outflow tract obstruction in acute coronary syndrome. An important cause of new systolic murmur and cardiogenic shock. Mayo Clin Proc. 1999;74:901-906. (Pubitemid 29430359)
74. Merli E, Sutcliffe S, Gori M, et al. Tako-Tsubo cardiomy-opathy: new insights into the possible underlying pathophysiology. Eur J Echocardiogr. 2006;7:53-61. (Pubitemid 43103041)
75. Padayachee L. Levosimendan: the inotrope of choice in cardiogenic shock secondary to Takotsubo cardiomyop-athy. Heart Lung Circ. 2007;16:S65-S70. (Pubitemid 47233292)
76. De Santis V, Vitale D, Tritapepe L, et al. Use of levosimendan for cardiogenic shock in a patient with the apical ballooning syndrome. Ann Intern Med. 2008; 149:365-367.
77. Carreira RS, Monteiro P, Kowaltowski AJ, et al. Nicor-andil protects cardiac mitochondria against permeability transition induced by ischemia-reperfusion. J Bioenerg Biomembr. 2008;40:95-102.
78. Ito K, Sugihara H, and Kawasaki T, et al. Assessment of ampulla (takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and 99mTc-tetrofosmin myocardial single photon emission computed tomography, Ann Nucl Med. 2001;15: 351-355. (Pubitemid 32899573)
79. De Gregorio C, Grimaldi P, Lentini C. Left ventricular thrombus formation and cardioembolic complications in patients with takotsubo-like syndrome: a systematic review. Int J Cardiol. 2008;131:18-24.
80. Can MM, Tanboga IH, Turkyilmaz E, et al. Am J Psychiatry. 2008;165:1052-1053.
81. Kurisu S, Inoue I, Kawagoe T, et al. Int J Cardiol. 2009;134: e120-e123.