Structural identifiability analysis and reparameterisation (parameter reduction) of a cardiovascular feedback model

European Journal of Pharmaceutical Sciences

Volumn 46, Issue 4, 2012, Pages 259-271

  Cheung, S Y Amy ^a   Majid, Oneeb ^b   Yates, James W T ^a   Aarons, Leon ^c  

^a ASTRAZENECA   (United Kingdom)

^b EISAI CO LTD   (Japan)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cardiovascular PKPD model; NONMEM; Parameter estimation; Reparameterisation (parameter list reduction); Simulation; Structural identifiability analysis

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT;

ARTICLE; CARDIOVASCULAR SYSTEM; FEEDBACK MODEL REPARAMETERIZATION; HEART OUTPUT; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; PHARMACOKINETICS; PRIORITY JOURNAL; PULSATILE FLOW; SIMULATION; STRUCTURAL IDENTIFIABILITY ANALYSIS; URINE INCONTINENCE; VASCULAR RESISTANCE;

ADRENERGIC ALPHA-1 RECEPTOR AGONISTS; ANIMALS; COMPUTER SIMULATION; DRUG PARTIAL AGONISM; FEEDBACK; HUMANS; MODELS, CARDIOVASCULAR; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SYSTEMS BIOLOGY; URETHRA; URINARY INCONTINENCE, STRESS; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 84861196277     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.12.017     Document Type: Article

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