Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats

Andrologia

Volumn 44, Issue SUPPL.1, 2012, Pages 396-409

  Nahata, A ^a   Dixit, V K ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

sitosterol; Benign prostatic hyperplasia; Prostate specific antigen; Scopoletin; Urtica dioica

Indexed keywords

ALCOHOL; FINASTERIDE; PETROLEUM ETHER; PROSTATE SPECIFIC ANTIGEN; SCOPOLETIN; SITOSTEROL; TESTOSTERONE; URTICA DIOICA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HISTOPATHOLOGY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MALE; MEDICINAL PLANT; NONHUMAN; ORGAN WEIGHT; PROSTATE HYPERTROPHY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TESTOSTERONE BLOOD LEVEL; ULTRAVIOLET SPECTROSCOPY; URINE VOLUME;

ANIMALS; BODY WEIGHT; CHROMATOGRAPHY, THIN LAYER; FINASTERIDE; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; ORGAN SIZE; PLANT EXTRACTS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC HYPERPLASIA; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TESTOSTERONE; URTICA DIOICA;

EID: 84861192703     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2011.01197.x     Document Type: Article

References (35)

1. Berges RR, Windeler J, Trampisch HJ, Senge T (1995) Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet345:1529-1532.
2. Birkhoff JD (1983) Natural history of benign prostatic hypertrophy. In: Benign Prostatic Hypertrophy. Hinman F (ed). Springer-Verlag, New York5-9.
3. Bombardelli E, Morazzoni P, Small JK (1997) Serenoa repens (13artram). Fitoterapia68:99-113.
4. Bondarenko B, Walther C, Funk P, Schlafke S, Engelmann U (2003) Long-term efficacy and safety of PRO 160/120 (a combination of sabal and urtica extract) in patients with lower urinary tract symptoms (LUTS). Phytomedicine10(Suppl 4):53-55.
5. Braeckman J (1994) The extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a multicenter open study. Curr Ther Res Clin Exp55:776-785.
6. Carbajal D, Arruzazabala ML, Mas R, Molina V, Rodriguez E, Gonzalez V (2004) Effects of D-004, a lipid extract from Cuban royal Palm fruit, on inhibiting prostatic hypertrophy induced with testosterone or dihydrotestosterone in a rat model: a randomized, controlled study. Curr Ther Res Clin Exp65:505-514.
7. Catalona WJ, Smith DS, Wolfert RL, Wang TJ, Rittenhouse HG, Ratliff TL (1995) Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening. JAMA274:1214-1220.
8. Delporte C, Backhouse N, Negrete R, Salinas P, Rivas P, Cassels BK, San Feliciano A (1998) Antipyretic, hypothermic and antiinflammatory activities and metabolites from Solanum ligustrinum Lood. Phytother Res12:118-122.
9. Dhanotiya R, Chauhan NS, Saraf DK, Dixit VK (2009) Effect of Citrullus colocynthis Schard on testosterone-induced Benign Prostatic hyperplasia. J Complement Integr Med6:art 29.
10. Ding Z, Dai Y, Hao H, Pan R, Yao X, Wang Z (2008) Anti-inflammatory effects of scopoletin and underlying mechanisms. Pharmaceut Biol46:854-860.
11. Klippel KF, Hiltl DM, Schipp B (1997) A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto study group. Br J Urol80:427-432.
12. Kumar P, Kumar N, Thakur DS, Patidar A (2010) Male hypogonadism: symptoms and treatment. J Adv Pharm Tech Res1:297-301.
13. Lepor H (1989) Alpha adrenergic antagonists for the treatment of symptomatic benign prostatic hyperplasia. Int J Clin Pharmacol Ther Toxicol27:151-155.
14. Li LX, Liang Z, Lu FX, Kai C, Chu QB (2001) Effect of scopoletin on PC3 cell proliferation and apoptosis. Acta Pharmacol Sin22:929-933.
15. Lichius J, Lenz C, Lindemann P, Muller H, Aumüller G, Konrad L (1999) Antiproliferative effect of a polysaccharide fraction of a 20% methanolic extract of stinging nettle roots upon epithelial cells of the human prostate (LNCaP). Pharmazie54:768-771.
16. Lopatkin N, Sivkov A, Walther C, Schläfke S, Medvedev A, Avdeichuk J, Golubev G, Melnik K, Elenberger N, Engelmann U (2005) Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms - a placebo-controlled, double-blind, multicenter trail. World J Urol23:139-146.
17. Martindale W (1989) In: The Extra Pharmacopoeia, 29th edn. Reynolds JEF (ed). The Pharmaceutical Press, London1203.
18. McConnell JD, Wilson JD, George FW, Geller J, Walsh PC, Ewing LL, Isaacs J, Stoner E (1989) An inhibitor of 5.alpha.-reductase, MK-906, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. AUA Eighty-fourth Annual Meeting (Dallas, May 7-11). J Urol141:239A, abst. 280.
19. Nahata A, Dixit VK (2011a) Ganoderma lucidum is an inhibitor of testosterone induced prostatic hyperplasia in rats. Andrologia44:160-174.
20. Nahata A, Dixit VK (2011b) Sphaeranthus indicus attenuates testosterone induced prostatic hypertrophy in albino rats. Phytother Res 25.
21. Nandecha C, Nahata A, Dixit VK (2010) Effect of Benincasa hispida fruits on testosterone induced prostatic hypertrophy in albino rats. Curr Ther Res Clin Exp71:331-343.
22. Nilsson O, Peter A, Andersson I, Nilsson K, Grundstrom B, Karlsson B (1997) Antigenic determinants of prostate-specific antigen (PSA) and development of assays specific for different forms of PSA. Br J Cancer75:789-797.
23. Organisation for Economic Cooperation and Development 423 (2001) OECD Guideline For Testing Of Chemicals Acute Oral Toxicity - Acute Toxic Class Method Adopted: 17th December 2001. OECD Publishing, a division of OECD Public Affairs and Communications Directorate, London.
24. Paubert-Braquet M, Richardson FO, Servent-Saez N (1996) Effect of Serenoa repens extract (Permixon) on estradiol/testosterone-induced experimental prostate enlargement in the rat. Pharmacol Res34:171-179.
25. Roll R, Höfer-Bosse TH, Kayser D (1986) New perspectives in acute toxicity testing of chemicals. Toxicol Lett31(Suppl):86.
26. Safarinejad MR (2005) Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, doubleblind, placebo-controlled, crossover study. J Herb Pharmacother5:1-11.
27. Schneider T, Rubben H (2004) Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome (BPS). Results of a randomized, double-blind, placebocontrolled mulicenter study after 12months. Urologe A43:302-306.
28. Steers WD (2001) 5α-reductase activity in the prostate. Urology58:17-24.
29. Stoner E (1990) The clinical development of a 5α- reductase inhibitor, finasteride. J Steroid Biochem37:375-378.
30. The Merck Index (2006) Encyclopedia of chemical, drugs, and biologicals. In: Merck Index. An encyclopedia of chemicals, drugs, and biologicals., 14th edn. O'Neil MJ, Heckelman PE, Koch CB, Roman KJ (eds). Merck Research Laboratories, Merck & Co., Whitehouse Station, New Jeresy, USA, p 1475.
31. Wagner H, Willer F, Samtleben R, Boos G (1994) Search for the antiprostatic principle of stinging nettle (Urtica dioica) roots. Phytomedicine1:213-224.
32. Wilt TJ, Ishani A, Stark G, MacDonald R, Lau J, Mulrow C (1998) Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA280:1604-1609.
33. Wilt TJ, MacDonald R, Ishani A (1999) β-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int83:976-983.
34. World Health Organisation (2002) WHO Monographs on Selected Medicinal Plants. Vol. 2. WHO Graphics, Malta.
35. Zhang Q, Li L, Liu L, Li Y, Yuan L, Song L, Wu Z (2008) Effects of the polysaccharide fraction of Urtica fissa on castrated rat prostate hyperplasia induced by testosterone propionate. Phytomedicine15:722-727.