Anti-inflammatory effects of scopoletin and underlying mechanisms

Pharmaceutical Biology

Volumn 46, Issue 12, 2008, Pages 854-860

  Ding, Zuoqi ^a   Dai, Yue ^a   Hao, Haiping ^a   Pan, Rong ^a   Yao, Xiujuan ^a   Wang, Zhengtao ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti inflammatory effect; carrageenan; croton oil; nitric oxide; scopoletin

Indexed keywords

EID: 77956797211     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200802367155     Document Type: Article

References (23)

1. Agudelo CA, Wise CM (2001): Gout: Diagnosis, pathogenesis, and clinical manifestations. Curr Opin Rheumatol 13: 234-239. (Pubitemid 32430078)
2. Blazso G, Gabor M (1994): Anti-edematous action of some H1-receptor antagonists. Agents and Actions 42: 13-18. (Pubitemid 24281696)
3. Bradley PP, Pribat DA, Christensen RD, Rothstein G (1982): Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78: 206-209. (Pubitemid 12171880)
4. Chang WS, Chang YH, Lu FJ, Chiang HC (1994): Inhibitory effects of phenolics on xanthine oxidase. Anticancer Res 14: 501-506.
5. Ding ZQ, Dai Y,Wang ZT (2005): Hypouricemic action of scopoletin arising from xanthine oxidase inhibition and uricosuric activity. Planta Med 71: 183-185.
6. Farah MH, Samuelsson G (1992): Pharmacologically active phenylpropanoids from Senra incana. PlantaMed 58: 14-18.
7. Flint MS, Miller DB, Tinkle SS (2000): Restraint-induced modulation of allergic and irritant contact dermatitis in male and female B6.129 mice. Brain Behav Immun 14: 256-269. (Pubitemid 32060518)
8. Kang TH, Rae HO, Jeong SJ, Yoo JC, Choi BM, Jun CD, Chunq HT,Mivamoto T,Hiquchi R, KimYC (1999): Scopoletin:An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei. Planta Med 65: 400-403.
9. Kim HJ, Jang SI, Kim YJ, Chung HT, Yun YG, Kang TH, Jeong OS, Kim YC (2004): Scopoletin suppresses proinflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells. Fitoterapia 75: 261-266. (Pubitemid 38670554)
10. Liu BL, Dai YY, Tang N, Zhang FL, Wang C (2003): Antiinflammatory activity of chloroform extract of Evodia rutaecarpa on experimental colitis in mice. Pharmacol Clin Chin Mat Med 19: 16-19.
11. Lloret S, Moreno JJ (1995): Effects of an anti-inflammatory peptide (antiflammin 2) on cell influx, eicosanoid biosynthesis and edema formation by arachidonic acid and tetradecanoyl phorbol dermal application. Biochem Pharmacol 50: 347-353.
12. Morita Y, ClemensMG, Miller LS, Rangan U, Kondo S, Miyasaka M, Yoshikawa T, Bulklev GB (1995): Reactive oxidants mediate TNF-alpha-induced leukocyte adhesion to rat mesenteric venular endothelium. Am J Physiol 269: H1833-H1842.
13. Muschietti L, Gorzalczany S, Ferraro G, Acevedo C, Martino V (2001): Phenolic compounds with anti-inflammatory activity from Eupatorium buniifolium. Planta Med 67: 743-744. (Pubitemid 33044482)
14. Ojewole JA, Adesina SK (1983): Mechanism of the hypotensive effect of scopoletin isolated from the fruit of Tetrapleura tetraptera. Planta Med 49: 46-50. (Pubitemid 14241502)
15. Oyanagui Y (1976): Participation of superoxide anions at the prostaglandin phase of carrageenan foot-edema. Biochem Pharmacol 25: 1465-1472.
16. Piguet PF, Grau GE, Hauser C, Vassalli P (1991): Tumor necrosis factor is a critical mediator in hapten-induced irritant and contact hypersensitivity reactions. J Exp Med 173: 673-679.
17. Roubenoff R (1990): Gout and hyperuricemia. Rheum Dis Clin North Am 16: 539-550. (Pubitemid 20330585)
18. Shaw CY, Chen CH, Hsu CC, Chen CC, Tsai YC (2003): Antioxidant properties of scopoletin isolated from Sinomonium acutum. Phytother Res 17: 823-825.
19. Siqueira junior JM, Peters RR, de Brum Fernandes AJ, Riberiro do Valle RM (2003): Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation inmice. Pharmacol Res 48: 437-443. (Pubitemid 37101199)
20. Sosa S, Tubaro A, Kastner U, Glasl S, Jurenitsch J, Della Loggia R (2001): Topical anti-inflammatory activity of a new germacrane derivative from Achillea pannonica. Planta Med 67: 654-658. (Pubitemid 32929578)
21. Williams TJ, Peck MJ (1977): Role of prostaglandin-mediated vasodilation in inflammation. Nature 270: 530-532.
22. Wong RK, Baldwin AL, Heimark RL (1999): Cadherin-5 redistribution at sites of TNF-α and IFN-? induced permeability in mesenteric venules.Am J Physiol 276: H736-H748. (Pubitemid 29100644)
23. Yun BS, Lee IK, Ryoo IJ, Yoo ID (2001): Coumarins with monoamine oxidase inhibitory activity and antioxidative coumarino-lignans from Hibiscus syriacus. J Nat Prod 64: 1238-1240.