Diastereoselective synthesis of fluorinated piperidine quinazoline spirocycles as iNOS selective inhibitors

Tetrahedron Letters

Volumn 53, Issue 24, 2012, Pages 2942-2947

  Walpole, Chris ^a   Liu, Ziping ^a   Lee, Ernest E ^b   Yang, Hua ^a   Zhou, Fei ^a   MacKintosh, Nicole ^a   Sjogren, Magnus ^c   Taylor, David ^a   Shen, Jinyu ^b   Batey, Robert A ^b  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF TORONTO   (Canada)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Difluorobenzamidine; Lewis acid; Piperidine; Piperidone; Spirocycle

Indexed keywords

BENZAMIDINE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR; LEWIS ACID; OXYGENASE INHIBITOR; PIPERIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CHEMICAL REACTION; FLUORINATION; STEREOCHEMISTRY; SYNTHESIS;

EID: 84861190222     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2012.03.050     Document Type: Article

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