Differential IgG recognition of desmoglein 3 by paraneoplastic pemphigus and pemphigus vulgaris sera

Journal of Investigative Dermatology

Volumn 132, Issue 6, 2012, Pages 1738-1741

  Brandt, Oliver ^a   Rafei, David ^a   Podstawa, Eva ^a   Niedermeier, Andrea ^b   Jonkman, Marcel F ^c   Terra, Jorrit B ^c   Hein, Rüdiger ^d   Hertl, Michael ^a   Pas, Hendri H ^c   Müller, Ralf ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOGLEIN 1; DESMOGLEIN 2; DESMOGLEIN 3; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ADULT; AGED; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; LETTER; MALE; PARANEOPLASTIC PEMPHIGUS; PEMPHIGUS VULGARIS; PRIORITY JOURNAL;

EID: 84861187212     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.1     Document Type: Letter

References (28)

1. Carroll JM, McElwee KJ, King LE Jr et al. (2002) Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J Invest Dermatol 119:392-402 (Pubitemid 35001949)
2. Fraticelli P, Sironi M, Bianchi G et al. (2001) Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses. J Clin Invest 107:1173-81 (Pubitemid 32422914)
3. Freyschmidt-Paul P, McElwee KJ, Hoffmann R et al. (2006) Interferon-gamma-deficient mice are resistant to the development of alopecia areata. Br J Dermatol 155:515-21 (Pubitemid 44215480)
4. Ghoreishi M, Martinka M, Dutz JP (2010) Type 1 interferon signature in the scalp lesions of alopecia areata. Br J Dermatol 163:57-62
5. Groom JR, Luster AD (2011) CXCR3 ligands: redundant, collaborative and antagonistic functions. Immunol Cell Biol 89:207-15
6. Hancock WW, Lu B, Gao W et al. (2000) Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med 192:1515-20
7. Ito T, Ito N, Bettermann A et al. (2004) Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. Am J Pathol 164: 623-34 (Pubitemid 38364677)
8. McElwee KJ, Boggess D, King LE Jr et al. (1998) Experimental induction of alopecia areatalike hair loss in C3H/HeJ mice using full-thickness skin grafts. J Invest Dermatol 111:797-803 (Pubitemid 28509321)
9. McElwee KJ, Freyschmidt-Paul P, Sundberg JP et al. (2003) The pathogenesis of alopecia areata in rodent models. J Investig Dermatol Symp Proc 8:6-11 (Pubitemid 36900483)
10. Paus R, Christoph T, Muller-Rover S (1999) Immunology of the hair follicle: a short journey into terra incognita. J Investig Dermatol Symp Proc 4:226-34 (Pubitemid 30085810)
11. Rotondi M, Chiovato L, Romagnani S et al. (2007) Role of chemokines in endocrine autoimmune disease. Endocr Rev 28: 492-520 (Pubitemid 47236335)
12. Subramanya RD, Coda AB, Sinha AA (2010) Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures. Genomics 96:146-53
13. Sundberg JP, Cordy WR, King LE Jr (1994) Alopecia areata in aging C3H/HeJ mice. J Invest Dermatol 102:847-56 (Pubitemid 24210378)
14. Amagai M, Nishikawa T, Nousari HC et al. (1998) Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. J Clin Invest 102:775-82 (Pubitemid 28399610)
15. Anhalt GJ (2004) Paraneoplastic pemphigus. J Investig Dermatol Symp Proc 9:29-33 (Pubitemid 38096195)
16. Fairley JA, Burnett CT, Fu CL et al. (2007) A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice. J Invest Dermatol 127:2605-11 (Pubitemid 47585071)
17. Futei Y, Amagai M, Hashimoto T et al. (2003) Conformational epitope mapping and IgG subclass distribution of desmoglein 3 in paraneoplastic pemphigus. J Am Acad Dermatol 49:1023-8 (Pubitemid 37475473)
18. Hisamatsu Y, Amagai M, Garrod DR et al. (2004) The detection of IgG and IgA autoantibodies to desmocollins 1-3 by enzyme-linked immunosorbent assays using baculovirusexpressed proteins, in atypical pemphigus but not in typical pemphigus. Br J Dermatol 151:73-83 (Pubitemid 39061282)
19. Lambert J, Bracke S, van Roy F et al. (2010) Serum plakophilin-3 autoreactivity in paraneoplastic pemphigus. Br J Dermatol 163: 630-2
20. Mentink LF, de Jong MC, Kloosterhuis GJ et al. (2007) Coexistence of IgA antibodies to desmogleins 1 and 3 in pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. Br J Dermatol 156: 635-41 (Pubitemid 46452350)
21. Mihai S, Chiriac MT, Herrero-Gonzalez JE et al. (2007) IgG4 autoantibodies induce dermalepidermal separation. J Cell Mol Med 11:1117-28 (Pubitemid 350037053)
22. Muller R, Heber B, Hashimoto T et al. (2009) Autoantibodies against desmocollins in European patients with pemphigus. Clin Exp Dermatol 34:898-903
23. Muller R, Svoboda V, Wenzel E et al. (2008) IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris. Exp Dermatol 17: 35-43 (Pubitemid 350269210)
24. Nagata Y, Karashima T, Watt FM et al. (2001) Paraneoplastic pemphigus sera react strongly with multiple epitopes on the various regions of envoplakin and periplakin, except for the c-terminal homologous domain of periplakin. J Invest Dermatol 116:556-63 (Pubitemid 32299845)
25. Oursler JR, Labib RS, Ariss-Abdo L et al. (1992) Human autoantibodies against desmoplakins in paraneoplastic pemphigus. J Clin Invest 89:1775-82
26. Rafei D, Muller R, Ishii N et al. (2011) IgG autoantibodies against desmocollin 3 in pemphigus sera induce loss of keratinocyte adhesion. Am J Pathol 178:718-23
27. Schepens I, Jaunin F, Begre N et al. (2010) The protease inhibitor alpha-2-macroglobulinlike- 1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human. PLoS ONE 5:e12250
28. Spindler V, Heupel WM, Efthymiadis A et al. (2009) Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus. J Biol Chem 284: 30556-64