Design, synthesis and biological evaluation of potent NAD +-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3699-3703

  Wang, Tiansheng ^a   Duncan, Leonard ^a   Gu, Wenxin ^a   O'Dowd, Hardwin ^a   Wei, Yunyi ^a   Perola, Emanuele ^a   Parsons, Jonathan ^a   Gross, Christian H ^a   Moody, Cameron Stuver ^a   Ryan Arends, S J ^a   Charifson, Paul S ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

Antibiotics; DNA ligase; Inhibitor; NAD; Pyridopyrimidinone

Indexed keywords

4 AMINO PYRIDO 2,3 D PYRIMIDIN 5 8 H ONES; ANTIINFECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; GRAM POSITIVE BACTERIUM; NONHUMAN; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DNA LIGASES; DRUG DESIGN; ENZYME INHIBITORS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; NAD; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

POSIBACTERIA;

EID: 84861184745     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.038     Document Type: Article

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