Hypolipidemic effects of Nigella sativa L. seeds oil in healthy volunteers: A randomized, double-blind, placebo-controlled clinical trial

Journal of Medicinal Plants

Volumn 10, Issue 40, 2011, Pages

  Amini, M ^a   Fallah Huseini, H ^b   Mohtashami, R ^a   Sadeqhi, Z ^c   Ghamarchehre, M A ^a  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

^c Human Resource and Management Development Deputy   (Iran)

Author keywords

Black seed oil; Blood lipids; Nigella sativa; Traditional medicine

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTILIPEMIC AGENT; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CREATININE; GLUCOSE; HEMOGLOBIN A; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; NIGELLA SATIVA EXTRACT; PLACEBO; TRIACYLGLYCEROL; VEGETABLE OIL;

ABSENCE OF SIDE EFFECTS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLACK CUMIN; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYPOLIPEMIA; NORMAL HUMAN; PLANT SEED; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

NIGELLA SATIVA;

EID: 84861174155     PISSN: 2717204X     EISSN: 27172058     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. The Lipid Research Clinics Coronary Primary Prevention Trial results. Reduction in incidence of coronary heart disease. JAMA 1984; 251: 351-64.
2. Hoerger TJ, Bala MV. Treatment patterns and distribution of low-density lipoprotein cholesterol levels in treatment-eligible United States adults. Am. J. Cardiol. 1998; 82: 61-5. (Pubitemid 28322036)
3. Lamarche B, Tchernof A, Moorjani S, Cantin B, Dagenais GR. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Circulation 1997; 95 (1): 69-75. (Pubitemid 27029945)
4. Bhardwaj PK, Dasgupta DJ, Prashar BS, Kaushal SS. Control of hyperglycaemia and hyperlipidaemia by plant product. J. Assoc. Physicians India 1994; 42: 33-5.
5. Bohm H, Boeing H, Hempel J, Raab B, Kroke A. Flavonols, flavone and anthocyanins as natural antioxidants of food and their possible role in the prevention of chronic diseases. Z. Ernahrungswiss 1998; 37: 147-63. (Pubitemid 28318357)
6. Hou L, Zhou B, Yang L, Liu ZL. Inhibition of human low density lipoprotein oxidation by flavonols and their glycosides. Chem. Phys. Lipids 2004; 129: 209-19. (Pubitemid 38471972)
7. Mermen LI, Sapinho D, de Bree A, Arnault N, Bertrais S, Galan P. Hercberg S. Consumption of foods rich in flavonoids is related to a decreased cardiovascular risk in apparently healthy French women. J. Nutr. 2004; 134: 923-6. (Pubitemid 38456265)
8. Haji Sharifi A. Black Cumin. In Secretes in Medicinal Plants (3rd ed) Hafez-e-Novin press. Tehran Iran. 2003, pp: 658-61.
9. Jazayeri Gh A. Black Cumin. In Zaban-e-khorakiha, volum 3, Amir kabir press. Tehran Iran. 2004, pp: 53-4.
10. Schleicher P, Saleh M. Black seed cumin: the magical Egyptian herb for allergies, asthma, and immune disorders. Rochester, Vermont Healing Arts Press; 1998, pp: 90.
11. Amirghofran Z, Azadbakht M, Karimi MH. Evaluation of the immunomodulatory effects of five herbal plants. J. Ethnopharmocol. 2000; 72: 167-72.
12. Goreja WG. Black Seed: Nature's Miracle Remedy. New York, NY7 Amazing Herbs Press. 2003, pp: 46.
13. Salehi surmaghi MH. Nigella Sativa. In Herbal Medicine and Herbal Therapy, volum 2, Donyay Taghziah press. Tehran Iran. 2008, pp: 216-9.
14. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother. Res. 2003; 17: 299-305. (Pubitemid 36565330)
15. Dahri AH, Chandiol AM, Rahoo AA, Memon RA. Effect of Nigella sativa (kalonji) on serum cholesterol of albino rats. J. Ayub. Med. Coll. Abbottabad. 2005; 17 (2): 72-4.
16. Meral I, Yener Z, Kahraman T, Mert N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally induced diabetic rabbits. J. Vet. Med. A Physiol. Pathol. Clin. Med. 2001; 48: 593-9. (Pubitemid 33637447)
17. Kanter M, Meral I, Dede S, Gunduz H, Cemek M, Ozbek H. Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CCl4-treated rats. J. Vet. Med. A Physiol. Pathol. Clin. Med. 2003; 50: 264-8. (Pubitemid 41743024)
18. El-Saleh SC, Al-Sagair OA, Al-Khalaf MI. Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats. Int. J. Cardiol. 2004; 93: 19-23. (Pubitemid 38068504)
19. Geng D, Zhang S, Lan J. Analysis on chemical components of volatile oil and determination of thymoquinone from seed of Nigella glandulifera. Zhongguo Zhong Yao Za Zhi 2009; 34 (22): 2887-90.
20. Mehta BK, Pandit V, Gupta M. New principles from seeds of Nigella sativa. Nat. Prod. Res. 2009; 23 (2): 138-48.
21. Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother. Res. 2000; 14 (5): 323-8. (Pubitemid 30655515)
22. Fararh KM, Atoji Y, Shimizu Y, Shiina T, Nikami H, Takewaki T. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocininduced diabetic hamsters. Res. Vet. Sci. 2004; 77: 123-9. (Pubitemid 38950326)
23. Kaleem M, Kirmani D, Asif M, Ahmed Q, Bano B. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J. Exp. Biol. 2006; 44 (9): 745-8. (Pubitemid 44369305)
24. Pari L, Sankaranarayanan C. Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin- nicotinamide induced diabetic rats. Life Sci. 2009; 85 (23-26): 830-4.
25. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Department of Internal Medicine and Cardiology and Medicinal Plant Research Center, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. Fundam. Clin. Pharmacol. 2008; 22 (4): 447-52.
26. Benhaddou-Andaloussi A, Martineau LC, Vallerand D, Haddad Y, Afshar A, Settaf A, Haddad PS. Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells. Diabetes Obes. Metab. 2010; 12 (2): 148-57.