Controlled-pH tissue cleanup protocol for signal enhancement of small molecule drugs analyzed by MALDI-MS imaging

Analytical Chemistry

Volumn 84, Issue 10, 2012, Pages 4603-4607

  Shariatgorji, Mohammadreza ^a   Källback, Patrik ^a   Gustavsson, Lena ^b,c   Schintu, Nicoletta ^d   Svenningsson, Per ^d   Goodwin, Richard J A ^a,e   Andren, Per E ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

^e ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER SOLUTIONS; BUFFERED SOLUTIONS; DELOCALIZATIONS; IN-SITU; LIMIT OF DETECTION; LOW-MOLECULAR WEIGHT; MALDI-MS; MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY; PHARMACEUTICAL COMPOUNDS; PROTEASE INHIBITOR; SIGNAL ENHANCEMENT; SMALL-MOLECULE DRUGS; TARGET ANALYTES; TARGET COMPOUND; TISSUE SECTIONS; WASHING PROCEDURES; WASHING SOLUTION;

TISSUE;

WASHING;

CIMETIDINE; DRUG; IMIPRAMINE;

ANIMAL; ARTICLE; BRAIN; ISOLATION AND PURIFICATION; MALE; MASS SPECTROMETRY; METABOLISM; MOUSE; PH; RAT; WISTAR RAT;

ANIMALS; BRAIN; CIMETIDINE; HYDROGEN-ION CONCENTRATION; IMIPRAMINE; MALE; MICE; PHARMACEUTICAL PREPARATIONS; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84861168071     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac203322q     Document Type: Article

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