-
1
-
-
33750694608
-
Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance
-
Battini L, Fedorova E, Macip S, Li X, Wilson PD, Gusella GL. Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance. J Am Soc Nephrol 17: 3049-3058, 2006.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 3049-3058
-
-
Battini, L.1
Fedorova, E.2
Macip, S.3
Li, X.4
Wilson, P.D.5
Gusella, G.L.6
-
2
-
-
76949097377
-
Novel targets for the treatment of autosomal dominant polycystic kidney disease
-
Belibi FA, Edelstein CL. Novel targets for the treatment of autosomal dominant polycystic kidney disease. Expert Opin Investig Drugs 19: 315-328, 2010.
-
(2010)
Expert Opin Investig Drugs
, vol.19
, pp. 315-328
-
-
Belibi, F.A.1
Edelstein, C.L.2
-
3
-
-
49149097608
-
Strategies to inhibit cyst formation in ADPKD
-
Calvet JP. Strategies to inhibit cyst formation in ADPKD. Clin J Am Soc Nephrol 3: 1205-1211, 2008.
-
(2008)
Clin J Am Soc Nephrol
, vol.3
, pp. 1205-1211
-
-
Calvet, J.P.1
-
4
-
-
0035083551
-
The genetics and physiology of polycystic kidney disease
-
Calvet JP, Grantham JJ. The genetics and physiology of polycystic kidney disease. Semin Nephrol 21: 107-123, 2001.
-
(2001)
Semin Nephrol
, vol.21
, pp. 107-123
-
-
Calvet, J.P.1
Grantham, J.J.2
-
5
-
-
0035170552
-
Kinase regulates branching morphogenesis in the developing mouse kidney
-
Fisher CE, Michael L, Barnett MW, Davies JA. Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney. Development 128: 4329-4338, 2001.
-
(2001)
Development
, vol.128
, pp. 4329-4338
-
-
Fisher, C.E.1
Michael, L.2
Barnett, M.W.3
Davies, J.A.4
Erk, M.A.P.5
-
6
-
-
0035933577
-
Green fluorescent protein-based halide indicators with improved chloride and iodide affinities
-
Galietta LJ, Haggie PM, Verkman AS. Green fluorescent protein-based halide indicators with improved chloride and iodide affinities. FEBS Let 499: 220-224, 2001.
-
(2001)
FEBS Let
, vol.499
, pp. 220-224
-
-
Galietta, L.J.1
Haggie, P.M.2
Verkman, A.S.3
-
7
-
-
78951470663
-
Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathways
-
Gao J, Zhou H, Lei T, Zhou L, Li W, Li X, Yang B. Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathways. Eur J Pharmacol 654: 92-99, 2011.
-
(2011)
Eur J Pharmacol
, vol.654
, pp. 92-99
-
-
Gao, J.1
Zhou, H.2
Lei, T.3
Zhou, L.4
Li, W.5
Li, X.6
Yang, B.7
-
8
-
-
0024445798
-
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
-
Gonzalez MV, Montminy MR. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59: 611-617, 1989.
-
(1989)
Cell
, vol.59
, pp. 611-617
-
-
Gonzalez, M.V.1
Montminy, M.R.2
-
9
-
-
0024792158
-
Net fluid secretion by mammalian renal epithelial cells: Stimulation by cAMP in polarized cultures derived from established renal cells and from normal and polycystic kidneys
-
Grantham JJ, Mangoo-Karim R, Uchic ME, Grant M, Shumate WA, Park CH, Calvet JP. Net fluid secretion by mammalian renal epithelial cells: Stimulation by cAMP in polarized cultures derived from established renal cells and from normal and polycystic kidneys. Trans Assoc Am Physicians 102: 158-162, 1989.
-
(1989)
Trans Assoc Am Physicians
, vol.102
, pp. 158-162
-
-
Grantham, J.J.1
Mangoo-Karim, R.2
Uchic, M.E.3
Grant, M.4
Shumate, W.A.5
Park, C.H.6
Calvet, J.P.7
-
11
-
-
2942744532
-
Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2 gamma2L GABAA receptors
-
Huang SH, Duke RK, Chebib M, Sasaki K, Wada K, Johnston GA. Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2 gamma2L GABAA receptors. Eur J Pharmacol 494: 131-138, 2004.
-
(2004)
Eur J Pharmacol
, vol.494
, pp. 131-138
-
-
Huang, S.H.1
Duke, R.K.2
Chebib, M.3
Sasaki, K.4
Wada, K.5
Johnston, G.A.6
-
12
-
-
0032191933
-
2+ stimulation of CREB-dependent transcription and ERK nuclear translocation
-
2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron 21: 869-883, 1998.
-
(1998)
Neuron
, vol.21
, pp. 869-883
-
-
Impey, S.1
Obrietan, K.2
Wong, S.T.3
Poser, S.4
Yano, S.5
Wayman, G.6
Deloulme, J.C.7
Chan, G.8
Storm, D.R.9
-
13
-
-
0034061227
-
Role of fibronectin deposition in branching morphogenesis of Madin-Darby canine kidney cells
-
Jiang ST, Chuang WJ, Tang MJ. Role of fibronectin deposition in branching morphogenesis of Madin-Darby canine kidney cells. Kidney Int 57: 1860-1867, 2000.
-
(2000)
Kidney Int
, vol.57
, pp. 1860-1867
-
-
Jiang, S.T.1
Chuang, W.J.2
Tang, M.J.3
-
14
-
-
33744771933
-
Effects of ginkgolide on the development of NOS and AChE positive neurons in the embryonic basal forebrain
-
Jin GH, Huang Z, Tan XF, Tian ML, Zhang XH, Qin JB, Xu HJ, Yew DT, Mak YT. Effects of ginkgolide on the development of NOS and AChE positive neurons in the embryonic basal forebrain. Cell Biol Int 30: 500-504, 2006.
-
(2006)
Cell Biol Int
, vol.30
, pp. 500-504
-
-
Jin, G.H.1
Huang, Z.2
Tan, X.F.3
Tian, M.L.4
Zhang, X.H.5
Qin, J.B.6
Xu, H.J.7
Yew, D.T.8
Mak, Y.T.9
-
15
-
-
79955780675
-
Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: In vivo evidence from a Pkd1-deletion model
-
Leonhard WN, van der Wal A, Novalic Z, Kunnen SJ, Gansevoort RT, Breuning MH, de Heer E, Peters DJ. Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model. Am J Physiol Renal Physiol 300: F1193-F1202, 2011.
-
(2011)
Am J Physiol Renal Physiol
, vol.300
-
-
Leonhard, W.N.1
van der Wal, A.2
Novalic, Z.3
Kunnen, S.J.4
Gansevoort, R.T.5
Breuning, M.H.6
de Heer, E.7
Peters, D.J.8
-
16
-
-
54749087598
-
Triptolide reduces cystogenesis in a model of ADPKD
-
Leuenroth SJ, Bencivenga N, Igarashi P, Somlo S, Crews CM. Triptolide reduces cystogenesis in a model of ADPKD. J Am Soc Nephrol 19: 1659-1662, 2008.
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 1659-1662
-
-
Leuenroth, S.J.1
Bencivenga, N.2
Igarashi, P.3
Somlo, S.4
Crews, C.M.5
-
18
-
-
34248350004
-
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
-
Leuenroth SJ, Okuhara D, Shotwell JD, Markowitz GS, Yu Z, Somlo S, Crews CM. Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease. Proc Natl Acad Sci USA 104: 4389-4394, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 4389-4394
-
-
Leuenroth, S.J.1
Okuhara, D.2
Shotwell, J.D.3
Markowitz, G.S.4
Yu, Z.5
Somlo, S.6
Crews, C.M.7
-
19
-
-
67749139804
-
Ginkgolide B suppresses intercellular adhesion molecule-1 expression via blocking nuclear factorkappa B activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein
-
Li R, Chen B, Wu W, Bao L, Li J, Qi R. Ginkgolide B suppresses intercellular adhesion molecule-1 expression via blocking nuclear factorkappa B activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein. J Pharmacol Sci 110: 362-369, 2009.
-
(2009)
J Pharmacol Sci
, vol.110
, pp. 362-369
-
-
Li, R.1
Chen, B.2
Wu, W.3
Bao, L.4
Li, J.5
Qi, R.6
-
20
-
-
33845265926
-
-, co-transporter-dependent cystic dilation
-
-, co-transporter-dependent cystic dilation. J Am Soc Nephrol 17: 3424-3437, 2006.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 3424-3437
-
-
Magenheimer, B.S.1
St John, P.L.2
Isom, K.S.3
Abrahamson, D.R.4
de Lisle, R.C.5
Wallace, D.P.6
Maser, R.L.7
Grantham, J.J.8
Calvet, J.P.9
-
21
-
-
1642422306
-
In vitro effects of astaxanthin combined with ginkgolide B on T lymphocyte activation in peripheral blood mononuclear cells from asthmatic subjects
-
Mahmoud FF, Haines DD, Abul HT, Abal AT, Onadeko BO, Wise JA. In vitro effects of astaxanthin combined with ginkgolide B on T lymphocyte activation in peripheral blood mononuclear cells from asthmatic subjects. J Pharmacol Sci 94: 129-136, 2004.
-
(2004)
J Pharmacol Sci
, vol.94
, pp. 129-136
-
-
Mahmoud, F.F.1
Haines, D.D.2
Abul, H.T.3
Abal, A.T.4
Onadeko, B.O.5
Wise, J.A.6
-
22
-
-
33947315462
-
Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5=-cyclic monophosphate
-
Masyuk TV, Masyuk AI, Torres VE, Harris PC, Larusso NF. Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5=-cyclic monophosphate. Gastroenterology 132: 1104-1116, 2007.
-
(2007)
Gastroenterology
, vol.132
, pp. 1104-1116
-
-
Masyuk, T.V.1
Masyuk, A.I.2
Torres, V.E.3
Harris, P.C.4
Larusso, N.F.5
-
23
-
-
0022986829
-
Scanning electron microscopy of kidney cells in culture: Surface features of polarized epithelia
-
McAteer JA, Dougherty GS, Gardner KD Jr, Evan AP. Scanning electron microscopy of kidney cells in culture: surface features of polarized epithelia. Scan Electron Microsc Pt 3: 1135-1150, 1986.
-
(1986)
Scan Electron Microsc Pt
, vol.3
, pp. 1135-1150
-
-
McAteer, J.A.1
Dougherty, G.S.2
Gardner Jr., K.D.3
Evan, A.P.4
-
24
-
-
0023759388
-
Polarized epithelial cysts in vitro: A review of cell and explant culture systems that exhibit epithelial cyst formation
-
McAteer JA, Dougherty GS, Gardner KD Jr, Evan AP. Polarized epithelial cysts in vitro: a review of cell and explant culture systems that exhibit epithelial cyst formation. Scanning Microsc 2: 1739-1763, 1988.
-
(1988)
Scanning Microsc
, vol.2
, pp. 1739-1763
-
-
McAteer, J.A.1
Dougherty, G.S.2
Gardner Jr., K.D.3
Evan, A.P.4
-
25
-
-
0023139296
-
Morphogenetic clonal growth of kidney epithelial cell line, MDCK
-
McAteer JA, Evan AP, Gardner KD. Morphogenetic clonal growth of kidney epithelial cell line, MDCK. Anat Rec 217: 229-239, 1987.
-
(1987)
Anat Rec
, vol.217
, pp. 229-239
-
-
McAteer, J.A.1
Evan, A.P.2
Gardner, K.D.3
-
26
-
-
20444409680
-
4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and DeltaF508 CFTR
-
Murthy M, Pedemonte N, MacVinish L, Galietta L, Cuthbert A. 4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and DeltaF508 CFTR. Eur J Pharmacol 516: 118-124, 2005.
-
(2005)
Eur J Pharmacol
, vol.516
, pp. 118-124
-
-
Murthy, M.1
Pedemonte, N.2
Macvinish, L.3
Galietta, L.4
Cuthbert, A.5
-
27
-
-
79960105492
-
Polycystic kidney disease and therapeutic approaches
-
Park EY, Woo YM, Park JH. Polycystic kidney disease and therapeutic approaches. BMB Rep 44: 359-368, 2011.
-
(2011)
BMB Rep
, vol.44
, pp. 359-368
-
-
Park, E.Y.1
Woo, Y.M.2
Park, J.H.3
-
28
-
-
63849273195
-
Advances in the pathogenesis and treatment of polycystic kidney disease
-
Patel V, Chowdhury R, Igarashi P. Advances in the pathogenesis and treatment of polycystic kidney disease. Curr Opin Nephrol Hypertens 18: 99-106, 2009.
-
(2009)
Curr Opin Nephrol Hypertens
, vol.18
, pp. 99-106
-
-
Patel, V.1
Chowdhury, R.2
Igarashi, P.3
-
29
-
-
0032387652
-
Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis
-
Pollack AL, Runyan RB, Mostov KE. Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis. Dev Biol 204: 64-79, 1998.
-
(1998)
Dev Biol
, vol.204
, pp. 64-79
-
-
Pollack, A.L.1
Runyan, R.B.2
Mostov, K.E.3
-
30
-
-
24344470833
-
Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease
-
Ruggenenti P, Remuzzi A, Ondei P, Fasolini G, Antiga L, Ene- Iordache B, Remuzzi G, Epstein FH. Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease. Kidney Int 68: 206-216, 2005.
-
(2005)
Kidney Int
, vol.68
, pp. 206-216
-
-
Ruggenenti, P.1
Remuzzi, A.2
Ondei, P.3
Fasolini, G.4
Antiga, L.5
Ene- iordache, B.6
Remuzzi, G.7
Epstein, F.H.8
-
31
-
-
0025267015
-
The regulation and function of c-fos and other immediate early genes in the nervous system
-
Sheng M, Greenberg ME. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4: 477-485, 1990.
-
(1990)
Neuron
, vol.4
, pp. 477-485
-
-
Sheng, M.1
Greenberg, M.E.2
-
32
-
-
44349088262
-
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1
-
Shibazaki S, Yu Z, Nishio S, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S. Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet 17: 1505-1516, 2008.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 1505-1516
-
-
Shibazaki, S.1
Yu, Z.2
Nishio, S.3
Thomson, R.B.4
Mitobe, M.5
Louvi, A.6
Velazquez, H.7
Ishibe, S.8
Cantley, L.G.9
Igarashi, P.10
Somlo, S.11
-
33
-
-
79958126807
-
Drug discovery for polycystic kidney disease
-
Sun Y, Zhou H, Yang B. Drug discovery for polycystic kidney disease. Acta Pharmacol Sin 32: 805-816, 2011.
-
(2011)
Acta Pharmacol Sin
, vol.32
, pp. 805-816
-
-
Sun, Y.1
Zhou, H.2
Yang, B.3
-
34
-
-
0029974642
-
Human simple renal cyst fluid contains a cyst formation-promoting activity for Madin-Darby canine kidney cells cultured in collagen gel
-
Taide M, Kanda S, Igawa T, Eguchi J, Kanetake H, Saito Y. Human simple renal cyst fluid contains a cyst formation-promoting activity for Madin-Darby canine kidney cells cultured in collagen gel. Eur J Clin Invest 26: 506-513, 1996.
-
(1996)
Eur J Clin Invest
, vol.26
, pp. 506-513
-
-
Taide, M.1
Kanda, S.2
Igawa, T.3
Eguchi, J.4
Kanetake, H.5
Saito, Y.6
-
35
-
-
4344560344
-
Cyclic AMP, at the hub of the cystic cycle
-
Torres VE. Cyclic AMP, at the hub of the cystic cycle. Kidney Int 66: 1283-1285, 2004.
-
(2004)
Kidney Int
, vol.66
, pp. 1283-1285
-
-
Torres, V.E.1
-
36
-
-
44349084391
-
Vasopressin antagonists in polycystic kidney disease
-
Torres VE. Vasopressin antagonists in polycystic kidney disease. Semin Nephrol 28: 306-317, 2008.
-
(2008)
Semin Nephrol
, vol.28
, pp. 306-317
-
-
Torres, V.E.1
-
37
-
-
70350070383
-
Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model
-
Tradtrantip L, Sonawane ND, Namkung Verkman AS W. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem 52: 6447-6455, 2009.
-
(2009)
J Med Chem
, vol.52
, pp. 6447-6455
-
-
Tradtrantip, L.1
Sonawane, N.D.2
Namkung Verkman, A.S.W.3
-
38
-
-
19344374972
-
A constituent of Ginkgo biloba, facilitates glutamate exocytosis from rat hippocampal nerve terminals
-
Wang SJ, Chen HH. Ginkgolide B, a constituent of Ginkgo biloba, facilitates glutamate exocytosis from rat hippocampal nerve terminals. Eur J Pharmacol 514: 141-149, 2005.
-
(2005)
Eur J Pharmacol
, vol.514
, pp. 141-149
-
-
Wang, S.J.1
Chen, H.H.2
Ginkgolide, B.3
-
39
-
-
2942534582
-
Polycystic kidney disease: New understanding in the pathogenesis
-
Wilson PD. Polycystic kidney disease: new understanding in the pathogenesis. Int J Biochem Cell Biol 36: 1868-1873, 2004.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 1868-1873
-
-
Wilson, P.D.1
-
40
-
-
34249780094
-
Pharmacological action and mechanisms of ginkgolide B
-
Xia SH, Fang DC. Pharmacological action and mechanisms of ginkgolide B. Chin Med J (Engl) 120: 922-928, 2007.
-
(2007)
Chin Med J (Engl)
, vol.120
, pp. 922-928
-
-
Xia, S.H.1
Fang, D.C.2
-
41
-
-
0029789643
-
Coupling of the Ras-MAPK pathway to gene activation by RSK2, a growth factor regulated CREB kinase
-
Xing J, Ginty DD, Greenberg ME. Coupling of the Ras-MAPK pathway to gene activation by RSK2, a growth factor regulated CREB kinase. Science 273: 959-963, 1996.
-
(1996)
Science
, vol.273
, pp. 959-963
-
-
Xing, J.1
Ginty, D.D.2
Greenberg, M.E.3
-
42
-
-
33645456243
-
Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells
-
Yamaguchi T, Hempson SJ, Reif GA, Hedge AM, Wallace DP. Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells. J Am Soc Nephrol 17: 178-187, 2006.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 178-187
-
-
Yamaguchi, T.1
Hempson, S.J.2
Reif, G.A.3
Hedge, A.M.4
Wallace, D.P.5
-
43
-
-
0037513435
-
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys
-
Yamaguchi T, Nagao S, Wallace DP, Belibi FA, Cowley BD, Pelling JC, Grantham JJ. Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. Kidney Int 63: 1983-1994, 2003.
-
(2003)
Kidney Int
, vol.63
, pp. 1983-1994
-
-
Yamaguchi, T.1
Nagao, S.2
Wallace, D.P.3
Belibi, F.A.4
Cowley, B.D.5
Pelling, J.C.6
Grantham, J.J.7
-
44
-
-
4644367485
-
Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growthstimulated phenotype
-
Yamaguchi T, Wallace DP, Magenheimer BS, Hempson SJ, Grantham JJ, Calvet JP. Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growthstimulated phenotype. J Biol Chem 279: 40419-40430, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 40419-40430
-
-
Yamaguchi, T.1
Wallace, D.P.2
Magenheimer, B.S.3
Hempson, S.J.4
Grantham, J.J.5
Calvet, J.P.6
-
45
-
-
48149087107
-
Smallmolecule CFTR inhibitors slow cyst growth in polycystic kidney disease
-
Yang B, Sonawane ND, Zhao D, Somlo S, Verkman AS. Smallmolecule CFTR inhibitors slow cyst growth in polycystic kidney disease. J Am Soc Nephrol 19: 1300-1310, 2008.
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 1300-1310
-
-
Yang, B.1
Sonawane, N.D.2
Zhao, D.3
Somlo, S.4
Verkman, A.S.5
-
46
-
-
34247249322
-
Ginkgo biloba and ovarian cancer prevention: Epidemiological and biological evidence
-
Ye B, Aponte M, Dai Y, Li L, Ho MC, Vitonis A, Edwards D, Huang TN, Cramer DW. Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Cancer Lett 251: 43-52, 2007.
-
(2007)
Cancer Lett
, vol.251
, pp. 43-52
-
-
Ye, B.1
Aponte, M.2
Dai, Y.3
Li, L.4
Ho, M.C.5
Vitonis, A.6
Edwards, D.7
Huang, T.N.8
Cramer, D.W.9
|