-
2
-
-
79952801293
-
Effect of low-, moderate-, and high-fat meals on raltegravir pharmacokinetics
-
Brainard DM, et al. 2011. Effect of low-, moderate-, and high-fat meals on raltegravir pharmacokinetics. J. Clin. Pharmacol. 51:422-427.
-
(2011)
J. Clin. Pharmacol.
, vol.51
, pp. 422-427
-
-
Brainard, D.M.1
-
3
-
-
80053271242
-
Clinical pharmacology profile of raltegravir, an HIV-1 integrase strand transfer inhibitor
-
Brainard DM, Wenning LA, Stone JA, Wagner JA, Iwamoto M. 2011. Clinical pharmacology profile of raltegravir, an HIV-1 integrase strand transfer inhibitor. J. Clin. Pharmacol. 51:1376-1402.
-
(2011)
J. Clin. Pharmacol.
, vol.51
, pp. 1376-1402
-
-
Brainard, D.M.1
Wenning, L.A.2
Stone, J.A.3
Wagner, J.A.4
Iwamoto, M.5
-
4
-
-
47949114939
-
Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
-
Cooper DA, et al. 2008. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N. Engl. J. Med. 359:355-365.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 355-365
-
-
Cooper, D.A.1
-
5
-
-
33748113778
-
Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients
-
DOI 10.1097/01.qai.0000233308.82860.2f, PII 0012633420060900000001
-
DeJesus E, et al. 2006. Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naïve and treatment-experienced patients. J. Acquir. Immune Defic. Syndr. 43:1-5. (Pubitemid 44306480)
-
(2006)
Journal of Acquired Immune Deficiency Syndromes
, vol.43
, Issue.1
, pp. 1-5
-
-
DeJesus, E.1
Berger, D.2
Markowitz, M.3
Cohen, C.4
Hawkins, T.5
Ruane, P.6
Elion, R.7
Farthing, C.8
Zhong, L.9
Cheng, A.K.10
McColl, D.11
Kearney, B.P.12
-
6
-
-
81855166275
-
Raltegravir once daily or twice daily in previously untreated patients with HIV-1: A randomised, active-controlled, phase 3 non-inferiority trial
-
Eron JJ, Jr, et al. 2011. Raltegravir once daily or twice daily in previously untreated patients with HIV-1: a randomised, active-controlled, phase 3 non-inferiority trial. Lancet Infect. Dis. 11:907-915.
-
(2011)
Lancet Infect. Dis.
, vol.11
, pp. 907-915
-
-
Eron Jr., J.J.1
-
7
-
-
77949381837
-
Long-term efficacy and safety of the HIV integrase inhibitor raltegravir in patients with limited treatment options in a phase II study
-
Gatell JM, et al. 2010. Long-term efficacy and safety of the HIV integrase inhibitor raltegravir in patients with limited treatment options in a phase II study. J. Acquir. Immune Defic. Syndr. 53:456-463.
-
(2010)
J. Acquir. Immune Defic. Syndr.
, vol.53
, pp. 456-463
-
-
Gatell, J.M.1
-
8
-
-
34147136222
-
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
-
DOI 10.1016/S0140-6736(07)60597-2, PII S0140673607605972
-
Grinsztejn B, et al. 2007. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet 369:1261-1269. (Pubitemid 46553846)
-
(2007)
Lancet
, vol.369
, Issue.9569
, pp. 1261-1269
-
-
Grinsztejn, B.1
Nguyen, B.-Y.2
Katlama, C.3
Gatell, J.M.4
Lazzarin, A.5
Vittecoq, D.6
Gonzalez, C.J.7
Chen, J.8
Harvey, C.M.9
Isaacs, R.D.10
-
9
-
-
38349194563
-
Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects
-
Iwamoto M, et al. 2008. Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects. Clin. Pharmacol. Ther. 83:293-299.
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 293-299
-
-
Iwamoto, M.1
-
10
-
-
69449101785
-
Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naïve patients with HIV-1 infection: A multicentre, double-blind randomized controlled trial
-
Lennox JL, et al. 2009. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naïve patients with HIV-1 infection: a multicentre, double-blind randomized controlled trial. Lancet 374:796-806.
-
(2009)
Lancet
, vol.374
, pp. 796-806
-
-
Lennox, J.L.1
-
11
-
-
77956646683
-
Raltegravir versus efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses
-
Lennox JL, et al. 2010. Raltegravir versus efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses. J. Acquir. Immune Defic. Syndr. 55:39-48.
-
(2010)
J. Acquir. Immune Defic. Syndr.
, vol.55
, pp. 39-48
-
-
Lennox, J.L.1
-
12
-
-
33845366857
-
Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
-
DOI 10.1097/QAI.0b013e31802b4956, PII 0012633420061215000002
-
Markowitz M, et al. 2006. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J. Acquir. Immune Defic. Syndr. 43:509-515. (Pubitemid 44885615)
-
(2006)
Journal of Acquired Immune Deficiency Syndromes
, vol.43
, Issue.5
, pp. 509-515
-
-
Markowitz, M.1
Morales-Ramirez, J.O.2
Nguyen, B.-Y.3
Kovacs, C.M.4
Steigbigel, R.T.5
Cooper, D.A.6
Liporace, R.7
Schwartz, R.8
Isaacs, R.9
Gilde, L.R.10
Wenning, L.11
Zhao, J.12
Teppler, H.13
Tsoukas, C.14
Galpin, J.15
Hicks, C.16
Brown, S.17
Chen, J.18
Miller, M.19
Hazuda, D.20
Vacca, J.21
Iwamoto, M.22
Rowley, M.23
Summa, V.24
more..
-
13
-
-
34748860363
-
Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
-
DOI 10.1097/QAI.0b013e318157131c, PII 0012633420071001000001
-
Markowitz M, et al. 2007. Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J. Acquir. Immune Defic. Syndr. 46:125-133. (Pubitemid 47482607)
-
(2007)
Journal of Acquired Immune Deficiency Syndromes
, vol.46
, Issue.2
, pp. 125-133
-
-
Markowitz, M.1
Nguyen, B.-Y.2
Gotuzzo, E.3
Mendo, F.4
Ratanasuwan, W.5
Kovacs, C.6
Prada, G.7
Morales-Ramirez, J.O.8
Crumpacker, C.S.9
Isaacs, R.D.10
Gilde, L.R.11
Wan, H.12
Miller, M.D.13
Wenning, L.A.14
Teppler, H.15
Baker, D.16
Bloch, M.17
Bodsworth, N.18
Cooper, D.19
Workman, C.20
Kovacs, C.21
Tsoukas, C.22
Afani, A.23
Perez, J.24
Cortes, J.25
Prada, G.26
Gotuzzo, E.27
Mendo, F.28
Ratanasuwan, W.29
Thitivichianlert, S.30
Brown, S.31
Crumpacker, C.32
Galpin, J.33
Hicks, C.34
Kumar, P.35
Lichtenstein, K.36
Little, S.37
Liporace, R.38
Markowitz, M.39
Morales-Ramirez, J.40
Santana-Bagur, J.41
Schwartz, R.42
Steigbigel, R.43
Tashima, K.44
more..
-
14
-
-
70350558421
-
Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection
-
Markowitz M, et al. 2009. Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection. J. Acquir. Immune Defic. Syndr. 52:350-356.
-
(2009)
J. Acquir. Immune Defic. Syndr.
, vol.52
, pp. 350-356
-
-
Markowitz, M.1
-
15
-
-
84861172161
-
-
Merck & Co., Inc. Merck & Co., Inc., Whitehouse Station, NJ
-
Merck & Co., Inc. 2009. Isentress (raltegravir) prescribing information. Merck & Co., Inc., Whitehouse Station, NJ.
-
(2009)
Isentress (Raltegravir) Prescribing Information
-
-
-
16
-
-
34548384292
-
Determination of the HIV integrase inhibitor, MK-0518 (raltegravir), in human plasma using 96-well liquid-liquid extraction and HPLC-MS/MS
-
DOI 10.1016/j.jchromb.2007.06.032, PII S157002320700459X
-
Merschman SA, Vallano PT, Wenning LA, Matuszewski BK, Woolf EJ. 2007. Determination of the HIV integrase inhibitor, MK-0518 (raltegravir), in human plasma using 96-well liquid-liquid extraction and HPLC-MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 857:15-24. (Pubitemid 47362852)
-
(2007)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
, vol.857
, Issue.1
, pp. 15-24
-
-
Merschman, S.A.1
Vallano, P.T.2
Wenning, L.A.3
Matuszewski, B.K.4
Woolf, E.J.5
-
17
-
-
80052905594
-
Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naïve human immunodeficiency virus-1-infected patients: 156-Week results from STARTMRK
-
Rockstroh JK, et al. 2011. Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naïve human immunodeficiency virus-1-infected patients: 156-week results from STARTMRK. Clin. Infect. Dis. 53:807-816.
-
(2011)
Clin. Infect. Dis.
, vol.53
, pp. 807-816
-
-
Rockstroh, J.K.1
-
18
-
-
84873063704
-
Pharmacokinetic (PK) and pharmacodynamic (PD) relationship of S/GSK1349572, a next generation integrase inhibitor (INI), in HIV-1 infected patients
-
abstr. WEPEB250
-
Song I, et al. 2009. Pharmacokinetic (PK) and pharmacodynamic (PD) relationship of S/GSK1349572, a next generation integrase inhibitor (INI), in HIV-1 infected patients, abstr. WEPEB250. Abstr. Int. AIDS Soc. 5th Conf. HIV Pathog. Treatment Prev. International AIDS Society, Geneva, Switzerland.
-
(2009)
Abstr. Int. AIDS Soc. 5th Conf. HIV Pathog. Treatment Prev. International AIDS Society, Geneva, Switzerland
-
-
Song, I.1
-
19
-
-
47949120697
-
Raltegravir with optimized background therapy for resistant HIV-1 infection
-
Steigbigel RT, et al. 2008. Raltegravir with optimized background therapy for resistant HIV-1 infection. N. Engl. J. Med. 359:339-354.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 339-354
-
-
Steigbigel, R.T.1
-
20
-
-
75749107023
-
Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: Week 96 results of the BENCH-MRK 1 and 2 phase III trials
-
Steigbigel RT, et al. 2010. Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: week 96 results of the BENCH-MRK 1 and 2 phase III trials. Clin. Infect. Dis. 50:605-612.
-
(2010)
Clin. Infect. Dis.
, vol.50
, pp. 605-612
-
-
Steigbigel, R.T.1
-
21
-
-
80051809442
-
Pharmacokinetic modeling of plasma and intracellular concentrations of raltegravir in healthy volunteers
-
Wang L, et al. 2011. Pharmacokinetic modeling of plasma and intracellular concentrations of raltegravir in healthy volunteers. Antimicrob. Agents Chemother. 55:4090-4095.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 4090-4095
-
-
Wang, L.1
-
22
-
-
72249121096
-
Pharmacokinetic/pharmacodynamic (PK/PD) analyses for raltegravir (RAL) in phase II and III studies in treatment experienced HIV-infected patients
-
abstr. O21
-
Wenning L, et al. 2008. Pharmacokinetic/pharmacodynamic (PK/PD) analyses for raltegravir (RAL) in phase II and III studies in treatment experienced HIV-infected patients, abstr. O21. Abstr. 9th Int. Workshop Clin. Pharmacol. HIV Ther., New Orleans, LA, 7 to 9 April 2008.
-
(2008)
Abstr. 9th Int. Workshop Clin. Pharmacol. HIV Ther., New Orleans, LA, 7 to 9 April 2008
-
-
Wenning, L.1
|