-
1
-
-
80051804221
-
Population pharmacokinetics of raltegravir in HIV positive and healthy subjects
-
oral abstr. O15
-
Arab-Alameddine, M., et al. 2011. Population pharmacokinetics of raltegravir in HIV positive and healthy subjects, oral abstr. O15. Twelfth Int. Workshop Clin. Pharmacol. HIV Ther., Miami, FL, 13 to 15 April 2011.
-
(2011)
Twelfth Int. Workshop Clin. Pharmacol. HIV Ther., Miami, FL, 13 to 15 April 2011
-
-
Arab-Alameddine, M.1
-
2
-
-
77955790197
-
Raltegravir: A review of its pharmacokinetics, pharmacology and clinical studies
-
Burger, D M 2010. Raltegravir: A review of its pharmacokinetics, pharmacology and clinical studies. Expert Opin. Drug Metab. Toxicol. 6:1151-1160.
-
(2010)
Expert Opin. Drug Metab. Toxicol.
, vol.6
, pp. 1151-1160
-
-
Burger, D.M.1
-
4
-
-
80051827954
-
-
An exploratory analysis to determine the feasibility of raltegravir population pharmacokinetics in HIV-infected patients and healthy volunteers, poster P10.
-
Dickinson, L., et al. 2009. An exploratory analysis to determine the feasibility of raltegravir population pharmacokinetics in HIV-infected patients and healthy volunteers, poster P10. Tenth Int. Workshop Clin. Pharmacol. HIV Ther., Amsterdam, The Netherlands, 15 to 17 April 2009.
-
(2009)
Tenth Int. Workshop Clin. Pharmacol. HIV Ther., Amsterdam, the Netherlands, 15 to 17 April 2009
-
-
Dickinson, L.1
-
5
-
-
84856036493
-
QDMRK, a phase III study of the safety & efficacy of once daily (QD) versus twice daily (BID) raltegravir in combination therapy for treatment-naïve HIV-infected patients
-
abstr. 150LB
-
Eron, J E, et al. 2011. QDMRK, a phase III study of the safety & efficacy of once daily (QD) versus twice daily (BID) raltegravir in combination therapy for treatment-naïve HIV-infected patients, abstr. 150LB. Eighteenth Conf. Retroviruses Opportun. Infect., Boston, MA, 27 February to 2 March 2011.
-
(2011)
Eighteenth Conf. Retroviruses Opportun. Infect., Boston, MA, 27 February to 2 March 2011
-
-
Eron, J.E.1
-
6
-
-
34147136222
-
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
-
DOI 10.1016/S0140-6736(07)60597-2, PII S0140673607605972
-
Grinsztejn, B., et al. 2007. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial. Lancet 369:1261-1269. (Pubitemid 46553846)
-
(2007)
Lancet
, vol.369
, Issue.9569
, pp. 1261-1269
-
-
Grinsztejn, B.1
Nguyen, B.-Y.2
Katlama, C.3
Gatell, J.M.4
Lazzarin, A.5
Vittecoq, D.6
Gonzalez, C.J.7
Chen, J.8
Harvey, C.M.9
Isaacs, R.D.10
-
7
-
-
80051817455
-
Effect of atazanavir and ritonavir on raltegravir pharmacokinetics in HIV patients is similar to results obtained in healthy subjects
-
Hanley, W D, et al. 2008. Effect of atazanavir and ritonavir on raltegravir pharmacokinetics in HIV patients is similar to results obtained in healthy subjects. Clin. Pharmacol. Ther. 83(Suppl. 1):S32.
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, Issue.SUPPL. 1
-
-
Hanley, W.D.1
-
8
-
-
38349182976
-
Lack of a pharmacokinetic effect of raltegravir on midazolam: In vitro/in vivo correlation
-
Iwamoto, M., et al. 2008. Lack of a pharmacokinetic effect of raltegravir on midazolam: In vitro/in vivo correlation. J. Clin. Pharmacol. 48:209-214.
-
(2008)
J. Clin. Pharmacol.
, vol.48
, pp. 209-214
-
-
Iwamoto, M.1
-
9
-
-
58749102754
-
Effects of omeprazole on plasma levels of raltegravir
-
Iwamoto, M., et al. 2009. Effects of omeprazole on plasma levels of raltegravir. Clin. Infect. Dis. 48:489-492.
-
(2009)
Clin. Infect. Dis.
, vol.48
, pp. 489-492
-
-
Iwamoto, M.1
-
10
-
-
20044388655
-
Population pharmacokinetics of efavirenz in an unselected cohort of HIV-1-infected individuals
-
DOI 10.2165/00003088-200544080-00006
-
Kappelhoff, B S, et al. 2005. Population pharmacokinetics of efavirenz in an unselected cohort of HIV-1-infected individuals. Clin. Pharmacokinet. 44:849-861. (Pubitemid 41126932)
-
(2005)
Clinical Pharmacokinetics
, vol.44
, Issue.8
, pp. 849-861
-
-
Kappelhoff, B.S.1
Huitema, A.D.R.2
Yalvac, Z.3
Prins, J.M.4
Mulder, J.W.5
Meenhorst, P.L.6
Beijnen, J.H.7
-
11
-
-
34548065793
-
Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme
-
DOI 10.1124/dmd.107.016196
-
Kassahun, K., et al. 2007. Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme. Drug Metab. Dispos. 35:1657-1663. (Pubitemid 47296061)
-
(2007)
Drug Metabolism and Disposition
, vol.35
, Issue.9
, pp. 1657-1663
-
-
Kassahun, K.1
McIntosh, I.2
Cui, D.3
Hreniuk, D.4
Merschman, S.5
Lasseter, K.6
Azrolan, N.7
Iwamoto, M.8
Wagner, J.A.9
Wenning, L.A.10
-
12
-
-
69449101785
-
Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: A multicentre, double-blind randomised controlled trial
-
Lennox, J L, et al. 2009. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: A multicentre, double-blind randomised controlled trial. Lancet 374:796-806.
-
(2009)
Lancet
, vol.374
, pp. 796-806
-
-
Lennox, J.L.1
-
13
-
-
33845366857
-
Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
-
DOI 10.1097/QAI.0b013e31802b4956, PII 0012633420061215000002
-
Markowitz, M., et al. 2006. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J. Acquir. Immune Defic. Syndr. 43:509-515. (Pubitemid 44885615)
-
(2006)
Journal of Acquired Immune Deficiency Syndromes
, vol.43
, Issue.5
, pp. 509-515
-
-
Markowitz, M.1
Morales-Ramirez, J.O.2
Nguyen, B.-Y.3
Kovacs, C.M.4
Steigbigel, R.T.5
Cooper, D.A.6
Liporace, R.7
Schwartz, R.8
Isaacs, R.9
Gilde, L.R.10
Wenning, L.11
Zhao, J.12
Teppler, H.13
Tsoukas, C.14
Galpin, J.15
Hicks, C.16
Brown, S.17
Chen, J.18
Miller, M.19
Hazuda, D.20
Vacca, J.21
Iwamoto, M.22
Rowley, M.23
Summa, V.24
more..
-
15
-
-
78650673812
-
Plasma and intracellular (peripheral blood mononuclear cells) pharmacokinetics of once-daily raltegravir (800 milligrams) in HIV-infected patients
-
Molto, J., et al. 2011. Plasma and intracellular (peripheral blood mononuclear cells) pharmacokinetics of once-daily raltegravir (800 milligrams) in HIV-infected patients. Antimicrob. Agents Chemother. 55:72-75.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 72-75
-
-
Molto, J.1
-
17
-
-
79956329914
-
Evaluation of the mean corpuscular volume of peripheral blood mononuclear cells of HIV patients by a Coulter counter to determine intracellular drug concentrations
-
Simiele, M., et al. 2011. Evaluation of the mean corpuscular volume of peripheral blood mononuclear cells of HIV patients by a Coulter counter to determine intracellular drug concentrations. Antimicrob. Agents Chemother. 55:2976-2978.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 2976-2978
-
-
Simiele, M.1
-
18
-
-
47949120697
-
Raltegravir with optimized background therapy for resistant HIV-1 infection
-
Steigbigel, R T, et al. 2008. Raltegravir with optimized background therapy for resistant HIV-1 infection. N. Engl. J. Med. 359:339-354.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 339-354
-
-
Steigbigel, R.T.1
-
19
-
-
77950641037
-
Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pretreated HIV-infected patients
-
Ter Heine, R., et al. 2010. Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pretreated HIV-infected patients. Br. J. Clin. Pharmacol. 69:475-483.
-
(2010)
Br. J. Clin. Pharmacol.
, vol.69
, pp. 475-483
-
-
Ter Heine, R.1
-
20
-
-
79951670921
-
Simultaneous determination of raltegravir and raltegravir glucuronide in human plasma by liquid chromatography-tandem mass spectrometric method
-
Wang, L Z, et al. 2011. Simultaneous determination of raltegravir and raltegravir glucuronide in human plasma by liquid chromatography-tandem mass spectrometric method. J. Mass Spectrom. 46:202-208.
-
(2011)
J. Mass Spectrom.
, vol.46
, pp. 202-208
-
-
Wang, L.Z.1
-
21
-
-
80051807678
-
-
Investigating variability in reported intracellular raltegravir concentrations: contribution of PBMC isolation methodology, poster P01
-
Watson, V., et al. 2011. Investigating variability in reported intracellular raltegravir concentrations: contribution of PBMC isolation methodology, poster P01. Twelfth Int. Workshop Clin. Pharmacol. HIV Ther., Miami, FL, 13 to 15 April 2011.
-
(2011)
Twelfth Int. Workshop Clin. Pharmacol. HIV Ther., Miami, FL, 13 to 15 April 2011
-
-
Watson, V.1
-
22
-
-
67349217885
-
Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms
-
Wenning, L A, et al. 2009. Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms. Clin. Pharmacol. Ther. 85:623-627.
-
(2009)
Clin. Pharmacol. Ther.
, vol.85
, pp. 623-627
-
-
Wenning, L.A.1
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