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The utility of cardiac biomarkers, tissue velocity and strain imaging, and cardiac magnetic resonance imaging in predicting early left ventricular dysfunction in patients with human epidermal growth factor receptor II-positive breast cancer treated with adjuvant trastuzumab therapy
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These investigators were the first to combine multiple biomarkers, echocardiographic indices, and cardiac MRI with gadolinium enhancement for early detection of LVD in patients receiving trastuzumab. A pattern of delayed enhancement was found in the lateral wall of all 10 subjects who developed LVD
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Fallah-Rad N, Walker JR, Wassef A, et al. The utility of cardiac biomarkers, tissue velocity and strain imaging, and cardiac magnetic resonance imaging in predicting early left ventricular dysfunction in patients with human epidermal growth factor receptor II-positive breast cancer treated with adjuvant trastuzumab therapy. J Am Coll Cardiol. 2011;57(22):2263-70. These investigators were the first to combine multiple biomarkers, echocardiographic indices, and cardiac MRI with gadolinium enhancement for early detection of LVD in patients receiving trastuzumab. A pattern of delayed enhancement was found in the lateral wall of all 10 subjects who developed LVD.
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(2011)
J Am Coll Cardiol.
, vol.57
, Issue.22
, pp. 2263-2270
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Fallah-Rad, N.1
Walker, J.R.2
Wassef, A.3
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44
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Prevention of highdose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition
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This study demonstrates the role of TNI to identify patients who will benefit from cardioprotective medication while receiving trastuzumab
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Cardinale D, Colombo A, Sandri MT, et al. Prevention of highdose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition. Circulation. 2006;114(23):2474-81. This study demonstrates the role of TNI to identify patients who will benefit from cardioprotective medication while receiving trastuzumab.
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(2006)
Circulation.
, vol.114
, Issue.23
, pp. 2474-2481
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Cardinale, D.1
Colombo, A.2
Sandri, M.T.3
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45
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79961004271
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Prevention of chemotherapyinduced left ventricular dysfunction with enalapril and carvedilol: Rationale and design of the OVERCOME trial
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These investigators outline their intention to study the role of conventional heart failure therapy to prevent chemotherapy-induced cardiotoxicity in patients with hematological malignancies undergoing autologous stem cell transplant. They will incorporate cardiac MRI, echocardiographic parameters of myocardial deformation, and biomarkers into their serial patient assessment
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Bosch X, Esteve J, Sitges M, et al. Prevention of chemotherapyinduced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial. J Card Fail. 2011;17(8):643-8. These investigators outline their intention to study the role of conventional heart failure therapy to prevent chemotherapy-induced cardiotoxicity in patients with hematological malignancies undergoing autologous stem cell transplant. They will incorporate cardiac MRI, echocardiographic parameters of myocardial deformation, and biomarkers into their serial patient assessment.
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(2011)
J Card Fail.
, vol.17
, Issue.8
, pp. 643-648
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Bosch, X.1
Esteve, J.2
Sitges, M.3
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46
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79960691560
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Rationale and design of the multidisciplinary approach to novel therapies in cardiology oncology research trial (MANTICORE 101-Breast): A randomized, placebo-controlled trial to determine if conventional heart failure pharmacotherapy can prevent trastuzumab-mediated left ventricular remodeling among patients with HER2+ early breast cancer using cardiac MRI
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This study will utilize cardiac MRI and biomarkers to study the effect of cardioprotective medications to prevent LVD in patients treated with trastuzumab
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Pituskin E, Haykowsky M, Mackey JR, et al. Rationale and design of the Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research Trial (MANTICORE 101-Breast): a randomized, placebo-controlled trial to determine if conventional heart failure pharmacotherapy can prevent trastuzumab-mediated left ventricular remodeling among patients with HER2+ early breast cancer using cardiac MRI. BMC Cancer. 2011;11:318. This study will utilize cardiac MRI and biomarkers to study the effect of cardioprotective medications to prevent LVD in patients treated with trastuzumab.
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(2011)
BMC Cancer.
, vol.11
, pp. 318
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Pituskin, E.1
Haykowsky, M.2
Mackey, J.R.3
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