Interfering Transbody-mediated Her2 gene silencing induces apoptosis by G0/G1 cell cycle arrest in her2-overexpressing SK-BR-3 breast cancer cells

Biotechnology and Bioprocess Engineering

Volumn 17, Issue 2, 2012, Pages 413-419

  Kim, Aeyung ^a   Choi, Dong Ki ^a   Sung, Eun Sil ^a   Yun, Jee Sun ^a   Kwon, Myung Hee ^b   Kim, Yong Sung ^a  

^a Ajou University   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

Antibody engineering; Apoptosis; Cell cycle arrest; Cell penetration; Gene silencing

Indexed keywords

AKT PHOSPHORYLATION; ANTIAPOPTOTIC; ANTIBODY ENGINEERING; APOPTOTIC CELL DEATH; BREAST CANCER CELLS; CELL CYCLE; CELL PENETRATION; CELL-CYCLE ARREST; CYCLIND1; CYTOSOLS; DOWN-REGULATION; GENE SILENCING; LIVING CELL; SIGNALING PATHWAYS; SMALL INTERFERING RNA (SIRNA); UP-REGULATION;

CELL DEATH; GENETIC ENGINEERING; PHOSPHORYLATION; RNA;

CELL ENGINEERING;

4MH2; ANTINEOPLASTIC AGENT; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN BCL XL; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; ENZYME INHIBITION; GENE OVEREXPRESSION; GENE SILENCING; HER2 GENE; HUMAN; HUMAN CELL; HYDROLYSIS; INTERFERING TRANSBODY; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; TUMOR GENE; WESTERN BLOTTING;

EID: 84861079642     PISSN: 12268372     EISSN: 19763816     Source Type: Journal    
DOI: 10.1007/s12257-011-0609-2     Document Type: Article

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