Safety and efficacy of Tien-Hsien Liquid Practical in patients with refractory metastatic breast cancer: A randomized, double-blind, placebo-controlled, parallel-group, phase IIa trial

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Kuo, Wen Hung ^a   Yao, Chien An ^a   Lin, Chih Hui ^b   Chang, King Jen ^a,c  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b Gerent Biotech Co Ltd   (Taiwan)

^c CHENG CHING GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; HERBACEOUS AGENT; TIEN HSIEN LIQUID PRACTICAL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST METASTASIS; CHINESE MEDICINE; COGNITION; CONSTIPATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; EMOTION; FATIGUE; FEMALE; FOLLOW UP; HEALTH STATUS; HUMAN; IMMUNOMODULATION; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; PHASE 2 CLINICAL TRIAL; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PRURITUS; QUALITY OF LIFE; REFRACTORY METASTATIC BREAST CANCER;

EID: 84861059890     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/803239     Document Type: Article

References (30)

1. Jemal A., Bray F., Center M. M., Ferlay J., Ward E., Forman D., Global cancer statistics CA Cancer Journal for Clinicians 2011 61 2 69 90
2. Cardoso F., Castiglione M., Locally recurrent or metastatic breast cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up Annals of Oncology 2009 20 supplement 4 iv15 iv18
3. Taiwan Cancer Registry, http://tcr.cph.ntu.edu.tw/uploadimages/ Top201020cancer20in20Taiwan202008.pdf
4. Roché H., Vahdat L. T., Treatment of metastatic breast cancer: second line and beyond Annals of Oncology 2011 22 5 1000 1010
5. Fernndez Y., Cueva J., Palomo A. G., Ramos M., de Juan A., Calvo L., Garca-Mata J., Garca-Teijido P., Pelez I., Garca-Estévez L., Novel therapeutic approaches to the treatment of metastatic breast cancer Cancer Treatment Reviews 2010 36 1 33 42
6. Chia J. S., Du J. L., Hsu W. B., Sun A., Chiang C. B., Wang W. B., Inhibition of metastasis, angiogenesis, and tumor growth by chinese herbal cocktail Tien-Hsien Liquid BMC Cancer 2010 10 175
7. Yao C.-J., Yang C.-M., Chuang S.-E., Lai T.-Y., Yan J.-L., Liu C.-Y., Chen S.-W., Yan K.-H., Lai G.-M., Targeting PML-RAR and oncogenic signaling pathways by chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells Evidence-Based Complementary and Alternative Medicine 2011 2011 11
8. Chan K. K., Yao T. J., Jones B., Zhao J. F., Ma F. K., Leung C. Y., Lau S. K., Yip M. W., Ngan H. Y.S., The use of chinese herbal medicine to improve quality of life in women undergoing chemotherapy for ovarian cancer: a double-blind placebo-controlled randomized trial with immunological monitoring Annals of Oncology 2011 22 10 2241 2249
9. Sun A., Chia J. S., Chiang C. P., Hsuen S. P., Du J. L., Wu C. W., Wang W. B., The chinese herbal medicine Tien-Hsien liquid inhibits cell growth and induces apoptosis in a wide variety of human cancer cells Journal of Alternative and Complementary Medicine 2005 11 2 245 256 (Pubitemid 40647159)
10. Boon H., Stewart M., Kennard M. A., Gray R., Sawka C., Brown J. B., McWilliam C., Gavin A., Baron R. A., Aaron D., Haines-Kamka T., Use of complementary/alternative medicine by breast cancer survivors in Ontario: prevalence and perceptions Journal of Clinical Oncology 2000 18 13 2515 2521 (Pubitemid 30432516)
11. Richardson M. A., Sanders T., Palmer J. L., Greisinger A., Singletary S. E., Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology Journal of Clinical Oncology 2000 18 13 2505 2514 (Pubitemid 30432515)
12. Shen J., Andersen R., Albert P. S., Wenger N., Glaspy J., Cole M., Shekelle P., Use of complementary/alternative therapies by women with advanced-stage breast cancer BMC Complementary and Alternative Medicine 2002 2 1, article no. 8 8
13. Gerber B., Scholz C., Reimer T., Briese V., Janni W., Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review Breast Cancer Research and Treatment 2006 95 3 199 209
14. Sun A., Chia J. S., Wang W. B., Chiang C. P., Immunomodulating effects of "Tien-Hsien liquid" on peripheral blood mononuclear cells and T-lymphocytes from patients with recurrent aphthous ulcerations American Journal of Chinese Medicine 2004 32 2 221 234 (Pubitemid 39011016)
15. Sun A., Chia J. S., Wang W. B., Chiang C. P., Tien-hsien liquid can modulate antigen-stimulated cytokine production by T-cells isolated from patients with recurrent aphthous ulcerations American Journal of Chinese Medicine 2005 33 4 559 571 (Pubitemid 41194617)
16. Svensson H., Hatschek T., Johansson H., Einbeigi Z., Brandberg Y., Health-related quality of life as prognostic factor for response, progression-free survival, and survival in women with metastatic breast cancer. Medical Oncology. In press
17. Chen L. C., Wang B. R., Chou Y. C., Tien J. H., Drug utilization pattern of chinese herbal medicines in a general hospital in Taiwan Pharmacoepidemiology and Drug Safety 2005 14 9 651 657 (Pubitemid 41358702)
18. Ernst E., Herbal medicines put into context British Medical Journal 2003 327 7420 881 882 (Pubitemid 37289958)
19. Mok T. S., Yeo W., Johnson P. J., Hui P., Ho W. M., Lam K. C., Xu M., Chak K., Chan A., Wong H., Mo F., Zee B., A double-blind placebo-controlled randomized study of chinese herbal medicine as complementary therapy for reduction of chemotherapy-induced toxicity Annals of Oncology 2007 18 4 768 774 (Pubitemid 46523283)
20. Li C. Q., He L. C., Dong H. Y., Jin J. Q., Screening for the anti-inflammatory activity of fractions and compounds from atractylodes macrocephala koidz Journal of Ethnopharmacology 2007 114 2 212 217
21. [No authors listed], Astragalus membranaceus. Monograph Alternative Medicine ReviewA Journal of Clinical Therapeutics 2003 8 1 72 77
22. Kim Y.-H., Choo S.-J., Ryoo I.-J., Ahn J.-S., Yoo I.-D., Eudesmanolides from taraxacum mongolicum and their inhibitory effects on the production of nitric oxide Archives of Pharmacal Research 2011 34 1 37 41
23. Ros J.-L., Chemical constituents and pharmacological properties of poria cocos Planta Medica 2011 77 7 681 691
24. Ran X., Ma L., Peng C., Zhang H., Qin L.-P., Ligusticum chuanxiong Hort: a review of chemistry and pharmacology Pharmaceutical Biology 2011 49 11 1180 1189
25. Gao D., Li Q., Li Y., Liu Z., Fan Y., Liu Z., Zhao H., Li J., Han Z., Antidiabetic and antioxidant effects of oleanolic acid from Ligustrum lucidum ait in alloxan-induced diabetic rats Phytotherapy Research 2009 23 9 1257 1262
26. Sun Y. X., Immunological adjuvant effect of awater-soluble polysaccharide, CPP, from the roots of codonopsis pilosula on the immune responses to ovalbumin in mice Chemistry and Biodiversity 2009 6 6 890 896
27. Ko B.-S., Jang J. S., Hong S. M., Sung S. R., Lee J. E., Lee M. Y., Jeon W. K., Park S., Changes in components, glycyrrhizin and glycyrrhetinic acid, in raw glycyrrhiza uralensis fisch, modify insulin sensitizing and insulinotropic actions Bioscience, Biotechnology and Biochemistry 2007 71 6 1452 1461 (Pubitemid 47012031)
28. Lin J., Wei L., Xu W., Hong Z., Liu X., Peng J., Effect of hedyotis diffusa willd extract on tumor angiogenesis Molecular Medicine Reports 2011 4 6 1283 1288
29. Wong C. K., Leung K. N., Fung K. P., Choy Y. M., The immunostimulating activities of anti-tumor polysaccharides from pseudostellaria heterophylla Immunopharmacology 1994 28 1 47 54 (Pubitemid 24199276)
30. He W., Chan L. Y., Zeng G., Daly N. L., Craik D. J., Tan N., Isolation and characterization of cytotoxic cyclotides from viola philippica Peptides 2011 32 8 1719 1723