The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: Analysis of 51 519 consecutive validated samples

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 119, Issue 7, 2012, Pages 824-831

  Yeh, P ^a   Emary, K ^a   Impey, L ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Acidaemia; encephalopathy; neonatal death; pH; seizure

Indexed keywords

ACIDEMIA; ADVERSE OUTCOME; APGAR SCORE; ARTERIAL PH; ARTICLE; BLOOD GAS ANALYSIS; BLOOD PH; BRAIN DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DEATH; DELIVERY; FETUS MONITORING; GESTATIONAL AGE; HOSPITAL ADMISSION; HUMAN; INTRAPARTUM CARE; LIVE BIRTH; MAJOR CLINICAL STUDY; MORBIDITY; NEWBORN; NEWBORN CARE; NEWBORN DISEASE; NEWBORN MORTALITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SEIZURE; UMBILICAL ARTERY; VALIDATION STUDY;

ACIDOSIS; ANOXIA; APGAR SCORE; BLOOD GAS ANALYSIS; BRAIN DISEASES; FETAL BLOOD; HUMANS; HYDROGEN-ION CONCENTRATION; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; PATIENT ADMISSION; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SEIZURES; UMBILICAL ARTERIES;

EID: 84861035758     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2012.03335.x     Document Type: Article

References (26)

1. Nelson KB,. What proportion of cerebral palsy is related to birth asphyxia? J Pediatr 1988; 112: 572-4.
2. National Collaborating Centre for Women's and Children's Health. Intrapartum Care: Care of Healthy Women and Their Babies During Childbirth. Clinical Guideline. London: RCOG Press, 2007.
3. Royal College of Obstetricians and Gynaecologists: Clinical Effectiveness Support Unit. The Use of Electronic Fetal Monitoring: The Use and Interpretation of Cardiotocography in Intrapartum Fetal Surveillance. Evidence-based Clinical Guideline No. 8. London: RCOG, 2001.
4. Malin GL, Morris RK, Khan KS,. Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis. BMJ 2010; 340: c1471. DOI:.
5. Goldaber KG, Gilstrap LC, Leveno KJ, Dax JS, McIntire DD,. Pathological fetal acidemia. Obstet Gynecol 1991; 78: 1103-6.
6. MacLennan A,. A template for defining a causal relation between acute intrapartum events and cerebral palsy: international consensus statement. BMJ 1999; 319: 1054-9. (Pubitemid 29476439)
7. Victory R, Penava D, da Silva O, Natale R, Richardson B,. Umbilical cord pH and base excess values in relation to adverse outcome events for infants delivering at term. Am J Obstet Gynecol 2004; 191: 2021-8. (Pubitemid 39601508)
8. Westgate J, Garibaldi JM, Greene KR,. Umbilical cord blood gas analysis at delivery: a time for quality data. Br J Obstet Gynaecol 1994; 101: 1054-63. (Pubitemid 24376867)
9. Pin TW, Eldridge B, Galea MP,. A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy. Eur J Paediatr Neurol 2009; 13: 224-34.
10. Graham EM, Ruis KA, Hartman AL, Northington FJ, Fox HE,. A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 2008; 199: 587-95.
11. Westgate JA, Bennet L, Branbyn C, Williams CE, Gunn AJ,. Plymouth randomized trial of cardiotocogram for intrapartum monitoring in 2400 cases. Am J Obstet Gynecol 1993; 169: 1151-60.
12. Impey L, Greenwood C, MacQuillan K, Reynolds M, Sheil O,. Fever in labour and neonatal encephalopathy: a prospective cohort study. BJOG 2001; 108: 594-7. (Pubitemid 33646499)
13. Williams KP, Singh A,. The correlation of seizures in newborn infants with significant acidosis at birth with umbilical artery cord gas values. Obstet Gynecol 2002; 100: 557-60. (Pubitemid 35246145)
14. Wu YW, Escobar GJ, Grether JK, Croen LA, Greene JD, Newman TB,. Chorioamnionitis and cerebral palsy in term and near-term infants. JAMA 2003; 290: 2677-84. (Pubitemid 37475595)
15. Goodwin TM, Belai I, Hernandez P, Durand M, Paul RH,. Asphyxial complications in the term newborn with severe umbilical acidemia. Am J Obstet Gynecol 1992; 167: 1506-12. (Pubitemid 23009277)
16. Kro G, Yli B, Rasmussen S, Noren H, Amer-Wahlin I, Didrik Saugstad O, et al., A new tool for the validation of umbilical cord acid-base data. BJOG 2010; 117: 1544-52.
17. Badawi N, Kurinczuk J, Keogh JM, Alessandri LM, O'Sullivan F, Burton PR, et al., Intrapartum risk factors for newborn encephalopathy: The Western Australian case-control study. BMJ 1998; 317: 1554-8. (Pubitemid 28550235)
18. Ikeda T, Murata Y, Quilligan EJ, Parer JT, Theunissen IM, Cifuentes P, et al., Fetal heart rate patterns in post asphyxiated fetal lambs with brain. Am J Obstet Gynecol 1998; 179: 1329-37. (Pubitemid 28533796)
19. Hermansen MC,. The acidosis paradox: asphyxial brain injury without coincident academia. Dev Med Child Neurol 2003; 45: 353-6. (Pubitemid 36469396)
20. Dennis J, Johnson A, Mutch L, Yudkin P, Johnson P,. Acid-base status at birth and neurodevelopmental outcome at four and one-half years. Am J Obstet Gynecol 1998; 161: 213-20.
21. Stanley F, Blair E, Alberman E,. Cerebral Palsies: Epidemiology and Causal Pathways. Cambridge: Cambridge University Press, 2000.
22. Lieberman E, Eichenwald E, Mathur G, Richardson D, Heffner L, Cohen A,. Intrapartum fever and unexplained seizures in term infants. Pediatrics 2000; 106: 983.
23. Grether JK, Nelson KB,. Maternal infection and cerebral palsy in infants of normal birth weight. JAMA 1997; 278: 207-11. (Pubitemid 27339585)
24. Petrova A, Demissie K, Rhoads GG, Smulian JC, Marcella S, Ananth CV,. Association of maternal fever during labor with neonatal and infant morbidity and mortality. Obstet Gynecol 2001; 98: 1152-4. (Pubitemid 34075351)
25. Impey LW, Greenwood CE, Black RS, Yeh PS, Sheil O, Doyle P,. The relationship between intrapartum maternal fever and neonatal acidosis as risk factors for neonatal encephalopathy. Am J Obstet Gynecol 2008; 198: 49.e1-6.
26. Nelson KB, Grether JK,. Potentially asphyxiating conditions and spastic cerebral palsy in infants of normal birth weight. Am J Obstet Gynecol 1998; 179: 507-13. (Pubitemid 28413392)