Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity

Toxicology and Applied Pharmacology

Volumn 261, Issue 2, 2012, Pages 189-195

  Kong, Bo ^a   Csanaky, Iván L ^a   Aleksunes, Lauren M ^c   Patni, Meghan ^a   Chen, Qi ^a   Ma, Xiaochao ^a   Jaeschke, Hartmut ^a   Weir, Scott ^a,b   Broward, Melinda ^a,b   Klaassen, Curtis D ^a,b   Guo, Grace L ^a,b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS CANCER CENTER   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

ANIT; Cholestasis; Gender; Hepatotoxicity; High fat diet; Mrp2

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BILIRUBIN; GLUTATHIONE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BILIARY EXCRETION; CHOLESTASIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG TRANSPORT; FEMALE; HISTOPATHOLOGY; LIPID DIET; LIVER INJURY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RNA ISOLATION; SEX DIFFERENCE;

1-NAPHTHYLISOTHIOCYANATE; ANIMALS; BILE; DIET, HIGH-FAT; FEMALE; LIVER; MALE; MICE; MICE, INBRED C57BL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; SEX CHARACTERISTICS;

MUS; RODENTIA;

EID: 84861000288     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.04.001     Document Type: Article

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