The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Jeschke, Marc G ^a,b,d   Williams, Felicia N ^a,b   Finnerty, Celeste C ^a,b   Rodriguez, Noe A ^a,b   Kulp, Gabriela A ^a,b   Ferrando, Arny ^c   Norbury, William B ^a,b   Suman, Oscar E ^a,b   Kraft, Robert ^a,b   Branski, Ludwik K ^a,b   Al mousawi, Ahmed M ^a,b   Herndon, David N ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; KETOCONAZOLE; MUSCLE PROTEIN; PLACEBO; ACUTE PHASE PROTEIN; ANTIFUNGAL AGENT; CYTOKINE; STEROL 14ALPHA DEMETHYLASE INHIBITOR;

ARTICLE; BODY COMPOSITION; BODY SURFACE; BURN; BURN INFECTION; CHILD; CONTROLLED STUDY; DEBRIDEMENT; DRUG EFFECT; FEMALE; HUMAN; HYDROCORTISONE RELEASE; HYDROCORTISONE URINE LEVEL; HYPERCORTISOLISM; HYPERMETABOLISM; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SEPSIS; BIOSYNTHESIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; METABOLISM;

14-ALPHA DEMETHYLASE INHIBITORS; ACUTE-PHASE PROTEINS; ANTIFUNGAL AGENTS; BODY COMPOSITION; BURNS; CHILD; CYTOKINES; FEMALE; HUMANS; HYDROCORTISONE; INFLAMMATION; KETOCONAZOLE; MALE; METABOLISM; MUSCLE PROTEINS; PROSPECTIVE STUDIES;

EID: 84860996705     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035465     Document Type: Article

References (50)

1. Herndon DN, Tompkins RG, (2004) Support of the metabolic response to burn injury. Lancet 363: 1895-1902.
2. Wilmore DW, Aulick LH, (1978) Metabolic changes in burned patients. Surg Clin North Am 58: 1173-1187.
3. Wilmore DW, Long JM, Mason AD, Skreen RW, Pruitt BA, (1974) Catecholamines: mediator of the hypermetabolic response to thermal injury. Ann Surg 180: 653-669.
4. Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, et al. (2008) Pathophysiologic response to severe burn injury. Ann Surg 248: 387-401.
5. Norbury WB, Herndon DN, Branski LK, Chinkes DL, Jeschke MG, (2008) Urinary cortisol and catecholamine excretion after burn injury in children. J Clin Endocrinol Metab 93: 1270-1275.
6. Hasselgren PO, (1995) Muscle protein metabolism during sepsis. Biochem Soc Trans 23: 1019-1025.
7. Hasselgren PO, (1999) Glucocorticoids and muscle catabolism. Curr Opin Clin Nutr Metab Care 2: 201-205.
8. Ferrando AA, Wolfe RR, (2007) Restoration of hormonal action and muscle protein. Crit Care Med 35: S630-634.
9. Rhen T, Cidlowski JA, (2005) Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 353: 1711-1723.
10. Palmieri TL, Levine S, Schonfeld-Warden N, O'Mara MS, Greenhalgh DG, (2006) Hypothalamic-pituitary-adrenal axis response to sustained stress after major burn injury in children. J Burn Care Res 27: 742-748.
11. Loose DS, Kan PB, Hirst MA, Marcus RA, Feldman D, (1983) Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest 71: 1495-1499.
12. Pont A, Williams PL, Loose DS, Feldman D, Reitz RE, et al. (1982) Ketoconazole blocks adrenal steroid synthesis. Ann Intern Med 97: 370-372.
13. Boscaro M, Sonino N, Rampazzo A, Mantero F, (1987) Response of pituitary-adrenal axis to corticotrophin releasing hormone in patients with Cushing's disease before and after ketoconazole treatment. Clin Endocrinol (Oxf) 27: 461-467.
14. Engelhardt D, Dorr G, Jaspers C, Knorr D, (1985) Ketoconazole blocks cortisol secretion in man by inhibition of adrenal 11 beta-hydroxylase. Klin Wochenschr 63: 607-612.
15. The ARDS Network, (2000) Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 283: 1995-2002.
16. Annane D, Maxime V, Ibrahim F, Alvarez JC, Abe E, et al. (2006) Diagnosis of adrenal insufficiency in severe sepsis and septic shock. Am J Respir Crit Care Med 174: 1319-1326.
17. Gauglitz GG, Herndon DN, Kulp GA, Meyer WJ, Jeschke MG, (2009) Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn. J Clin Endocrinol Metab 94: 1656-1664.
18. Brillon DJ, Zheng B, Campbell RG, Matthews DE, (1995) Effect of cortisol on energy expenditure and amino acid metabolism in humans. Am J Physiol 268: E501-513.
19. Darmaun D, Matthews DE, Bier DM, (1988) Physiological hypercortisolemia increases proteolysis, glutamine, and alanine production. Am J Physiol 255: E366-373.
20. Ferrando AA, Stuart CA, Sheffield-Moore M, Wolfe RR, (1999) Inactivity amplifies the catabolic response of skeletal muscle to cortisol. J Clin Endocrinol Metab 84: 3515-3521.
21. Gore DC, Jahoor F, Wolfe RR, Herndon DN, (1993) Acute response of human muscle protein to catabolic hormones. Ann Surg 218: 679-684.
22. Van den Bossche H, Willemsens G, Cools W, Cornelissen F, Lauwers WF, et al. (1980) In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. Antimicrob Agents Chemother 17: 922-928.
23. Deuschle M, Lecei O, Stalla GK, Landgraf R, Hamann B, et al. (2003) Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans. Neuropsychopharmacology 28: 379-383.
24. Hobson KG, Havel PJ, McMurtry AL, Lawless MB, Palmieri TL, et al. (2004) Circulating leptin and cortisol after burn injury: loss of diurnal pattern. J Burn Care Rehabil 25: 491-499.
25. Molteni A, Warpeha RL, Brizio-Molteni L, Albertson DF, Kaurs R, (1979) Circadian rhythms of serum aldosterone, cortisol and plasma renin activity in burn injuries. Ann Clin Lab Sci 9: 518-523.
26. Cohen J, Venkatesh B, (2009) Assessment of tissue cortisol activity. Crit Care Resusc 11: 287-289.
27. O'Sullivan ST, Lederer JA, Horgan AF, Chin DH, Mannick JA, et al. (1995) Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg 222: 482-492.
28. Klein GL, Bi LX, Sherrard DJ, Beavan SR, Ireland D, et al. (2004) Evidence supporting a role of glucocorticoids in short-term bone loss in burned children. Osteoporos Int 15: 468-474.
29. De Coster R, Wouters W, Bruynseels J, (1996) P450-dependent enzymes as targets for prostate cancer therapy. J Steroid Biochem Mol Biol 56: 133-143.
30. DeFelice R, Johnson DG, Galgiani JN, (1981) Gynecomastia with ketoconazole. Antimicrob Agents Chemother 19: 1073-1074.
31. Tsigos C, Chrousos GP, (1996) Differential diagnosis and management of Cushing's syndrome. Annu Rev Med 47: 443-461.
32. Pirlich M, Biering H, Gerl H, Ventz M, Schmidt B, et al. (2002) Loss of body cell mass in Cushing's syndrome: effect of treatment. J Clin Endocrinol Metab 87: 1078-1084.
33. Barrow RE, Wolfe RR, Dasu MR, Barrow LN, Herndon DN, (2006) The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly. Ann Surg 243: 115-120.
34. Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR, (2001) Reversal of catabolism by beta-blockade after severe burns. N Engl J Med 345: 1223-1229.
35. Minifee PK, Barrow RE, Abston S, Desai M, Herndon DN, (1989) Improved myocardial oxygen utilization following propranolol infusion in adolescents with postburn hypermetabolism. J Pediatr Surg 24: 806-811.
36. Hart DW, Wolf SE, Zhang XJ, Chinkes DL, Buffalo MC, et al. (2001) Efficacy of a high-carbohydrate diet in catabolic illness. Crit Care Med 29: 1318-1324.
37. Greenhalgh DG, Saffle JR, Holmes JHt, Gamelli RL, Palmieri TL, et al. (2007) American Burn Association consensus conference to define sepsis and infection in burns. J Burn Care Res 28: 776-790.
38. Hart DW, Wolf SE, Chinkes DL, Gore DC, Mlcak RP, et al. (2000) Determinants of skeletal muscle catabolism after severe burn. Ann Surg 232: 455-465.
39. Jeschke MG, Chinkes DL, Finnerty CC, Przkora R, Pereira CT, et al. (2007) Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients. Crit Care Med 35: 579-583.
40. The Acute Respiratory Distress Syndrome Network, (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342: 1301-1308.
41. Finnerty CC, Herndon DN, Przkora R, Pereira CT, Oliveira HM, et al. (2006) Cytokine expression profile over time in severely burned pediatric patients. Shock 26: 13-19.
42. Mlcak RP, Jeschke MG, Barrow RE, Herndon DN, (2006) The influence of age and gender on resting energy expenditure in severely burned children. Ann Surg 244: 121-130.
43. Wolfe RR, Chinkes DL, (2005) Principles and Practice of Kinetic Analysis. New Jersey Wiley-Liss.
44. Barrow RE, Mlcak R, Barrow LN, Hawkins HK, (2004) Increased liver weights in severely burned children: comparison of ultrasound and autopsy measurements. Burns 30: 565-568.
45. Jeschke MG, Finnerty CC, Suman OE, Kulp G, Mlcak RP, et al. (2007) The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn. Ann Surg 246: 351-362.
46. Jeschke MG, Mlcak RP, Finnerty CC, Norbury WB, Gauglitz GG, et al. (2007) Burn size determines the inflammatory and hypermetabolic response. Crit Care 11: R90.
47. Przkora R, Barrow RE, Jeschke MG, Suman OE, Celis M, et al. (2006) Body composition changes with time in pediatric burn patients. J Trauma 60: 968-971.
48. Przkora R, Jeschke MG, Barrow RE, Suman OE, Meyer WJ, et al. (2005) Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment. Ann Surg 242: 384-391.
49. Hazinski MF, (1992) Cardiovascular disorders. In: Hazinski MF, editors. Nursing Care of the Critically Ill Child Second ed. St. Louis Mosby-Year Book pp. 117-394.
50. Jeschke MG, Micak RP, Finnerty CC, Herndon DN, (2007) Changes in liver function and size after a severe thermal injury. Shock 28: 172-177.