CTGFsiRNA ameliorates retinal cells apoptosis in streptozotocin-induced diabetic rats

International Journal of Ophthalmology

Volumn 3, Issue 2, 2010, Pages 120-124

  Yang, Hong Wei ^a   Chen, Xiao Long ^a   Liu, Zhe Li ^a   Liu, Jie ^a   Bu, Li Min ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; CTGF; Diabetes; Retina

Indexed keywords

EID: 84860907513     PISSN: 22223959     EISSN: 22274898     Source Type: Journal    
DOI: 10.3980/j.issn.2222-3959.2010.02.06     Document Type: Article

References (35)

1. Abu El-Asrar AM, Dralands L, Missotten L, Al-Jadaan IA, Geboes K. Expression ofapoptosis markers in the retinas of human subjects with diabetes. Invest Ophthalmol Vis Sci. 2004;45(8): 2760-2766. [PubMed]
2. Hudson BI, Schmidt AM. RAGE: a novel target for drug intervention in diabetic vascular disease. Pharm Res. 2004;21(7): 1079-1086. [PubMed]
3. Barile GR, Pachydaki SI, Tan SR, Lee SE, Donmoyer CM, Ma W, Rong LL, Buciarelli LG, Wendt T, Hong H, Hudson BI, Qu W, WeinbergAD,Yan SF, SchmidtAM. The RAGE axis in early diabetic retinopathy. Invest Ophthalmol Vis Sci. 2005;46(8): 2916-2924. [PubMed]
4. Caldwell RB, Bartoli M, Behzadian MA, El-Remessy AE, Al-Shabrawey M, Platt DH, Liou GI, Caldwell RW. Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress. Curr Drug Targets. 2005;6(4): 511-524. [PubMed]
5. Kita T, Hata Y, KanoK, Miura M, NarkaoS, Noda Y, Shimokawa H, Ishibashi T. Transforming growth factor-132 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes andtherapeutic potential of Rhokinase inhibitor. Diabetes. 2007;56(1): 231-238. [PubMed]
6. Park SH, Park JW, Park SJ, Kim KY, Chung JW, Chun MH, Oh SJ. Apoptotic death of photoreceptors in the streptozotocininduced diabetic rat retina. Diabetologia. 2003;46: 1260-1268. [PubMed]
7. Barber AJ, Antonetti DA, Gardner TW. Alteredexpression of retinal occludin andglial fibrillary acidic protein in experimental diabetes: the Penn State Retina Research Group. Invest Ophthalmol Vis Sci. 2000;41: 3561-3568. [PubMed]
8. Behl Y, Krothapalli P, Desta T, DiPiazza A, Roy S, Graves Elf. Diabetes-enhancedtumor necrosis factor-ctproduction promotes apoptosis andtheloss of retinal microvascular cells in typel andtype 2 models of diabetic retinopathy. Am J Pathol. 2008;172(5): 1411-1418. [PMCfree article] [PubMed]
9. Park SH, Park JW, Park SJ, Kim KY, Chung JW, Chun MH, Oh SJ. Apoptotic death of photoreceptors in the streptozotocininduced diabetic rat retina. Diabetologia. 2003;46(9): 1260-1268. [PubMed]
10. .KradyJK,BasuA,Allen CM,XuY,LaNoueKF,GardnerTW,Levison SW. Minocyclinereducesproinflammatory cytokine expression, m icrogl ial activation, and caspase-3 activation in a rodent m odd of diabetic retinopathy. Diabetes. 2005;54(5): 1559-1565. [PubMed]
11. Liu H, Yang R, Tinner B, Choudhry A, Schutze N, Chaqour B. Cysteine-rich protein 61 andconnectivetissue growth factor induce deadhesion andanoikis of retinal pericytes. Endocrinology. 2008;149(4): 1666-1677. [PubMedj
12. Van Setten G, Berglin L, Blalock TD, Schultz G. Detection of connective tissue growth factor in subretinal fluid following retinal detachment: possible contribution tosubretinal scar formation, preliminary results. Ophthalmic Res. 2005;37(6): 289-292. [PubMed]
13. Zhou XD, Xiong MM, Tan FK, GuoXJ, Arnett FC. SPARC, an upstream regulator of connective tissue growth factor in response totransforming growth factor 1 stimulation. Arthritis Rheum. 2006;54(12): 3885-3889. [PubMed]
14. Zhou X, Tan FK, GuoX, Wallis D, Milewicz DM, Xue S, Arnett FC. Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor in cultured normal human fibroblasts. Arthritis Rheum. 2005;52(1): 257-261. [PubMed]
15. Aranda J, Rivera JC, Jeziorski MC, Riesgo-Escovar J, Nava G, López-Barrera F, Quiróz-MercadoH, Berger P, Martinez de la Escalera G, Clapp CR. Prolactins are natural inhibitors of angiogenesis in the retina. Invest Ophthalmol Vis Sci. 2005;46(8): 2947-2953. [PubMed]
16. Reich SJ, Fosnot J, Kuroki A, Tang W, Yang X, MaguireAM, Bennett J, TolentinoMJ. Small interfering RNA (5iRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis. 2003;9(5): 210-21b. [PubMed]
17. Kim B, Tang Q, Biswas PS, Xu J, Schiffelers RM, Xie FY, Ansari AM, Scaria PV, Woodle MC, Lu P, Rouse BT. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. Am J Pathol. 2004;165(6): 2177-2185. [PMCfree article] [PubMed]
18. Twigg SM, Cooper ME. Thetime has cometotarget connective tissue growth factor in diabetic complications. Diabetologia. 2004;47(6): 965-968. [PubMed]
19. Gaucher D, Chiappore JA, Pâques M, Simonutti M, Boitard C, Sahel JA, Massin P, Picaud S. Microglial changes occur without neural cell death in diabetic retinopathy. Vision Res. 2007;47(5): 612-623. [PubMed]
20. Gastinger MJ, Singh RS, BarberAJ. Loss of cholinergicanddopaminergicamacrinecells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas. Invest Ophthalmol Vis Sci. 2006;47(7): 3143-3150. [PubMed]
21. Varkonyi TT, PetoT, Degi R, Lengyel C, Janàky M, Kempler P, Lonovics J. Impairment of visual evokedpotentials: an early central manifestation of diabetic neu ropathy? Diabetes Care. 2002;25(9): 1661-1662. [PubMed]
22. Ozdek S, LonnevilleY H, Onol M, Yetkin I, Hasanreiso-lu BB. Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry. Eye. 2002;16(6): 761-765. [PubMed]
23. Han Y, Bearse MA, Jr, Schneck ME, Barez S, Jacobsen CH, Adams AJ. Multifocal electroretinogram delays predict sites of subsequent diabetic retinopathy. Invest Ophthalmol Vis Sci. 2004;45(3): 948-954. [PubMed]
24. Tikellis C, Cooper ME, Twigg SM. Connectivetissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibition. Endocrinology. 2004;145(2): 860-866. [PubMed]
25. Kuiper EJ, WitmerAN, Klaassen I, Oliver N, Goldschmeding R, Schlingemann RO. Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina. Br J Ophthalmol. 2004;88(8): 1082-1087. [PMCfree article] [PubMed]
26. Suzuma K, Naruse K, Suzuma I, Takahara N, Ueki K, Aiello LP, King GL. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flti, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem. 2000;275(52): 40725-40731. [PubMed]
27. Lorenzi M, Gerhardinger C. Early cellular andmolecular changes inducedby diabetes in the retina. Diabetologia. 2001;44(7): 791-804. [PubMed]
28. Hishikawa K, Nakaki T, Fujii T. Connectivetissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells. Eur J Pharmacol. 2000;392: 19-22. [PubMed]
29. Liu H, Yang R, Tinner B, Choudhry A, Schutze N, Chaqour B. Cysteine-rich protein 61 and connective tissue growth factor induce deadhesion andanoikis of retinal pericytes. Endocrinology. 2008;149(4): 1666-1677. [PubMed]
30. Gardner TW,Antonetti DA, BarberAJ, LaNoue KF, Levison SW. Diabetic retinopathy: morethan meets the eye. Surv Ophthalmol. 2002;47: 253-262. [PubMed]
31. Layton C.J, Chidlow G, Casson RJ, Wood JP, Graham M, Osborne N N. Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat. Invest Ophthalmol Vis Sci. 2005;46(8): 2878-2885. [PubMed]
32. BarberAJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27(2): 283-290. [PubMed]
33. Joussen AM, Poulaki V, Mitsiades N, Cai WY, Suzuma I, Pak J, Ju ST, Rook SL, Esser P, Mitsiades CS, Kirchhof B, Adamis AP, AielloLP. Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes. FASEBJ. 2003;17(1): 76-78. [PubMed]
34. ShimoT, Nakanishi T, Nishida T, Asano M, Sasaki A, Kanyama M, Kuboki T, Matsumura T, Takigawa M. Involvement of CFGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis. Oncology. 2001;61(4): 315-322. [PubMed]
35. Cooper ME, Bonnet F, Oldfield M, Jandeleit-Dahm K. Mechanisms of diabetic vasculopathy: an overview. Am J Hypertens. 2001;14: 475-486. [PubMed]