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Volumn 11, Issue 5, 2012, Pages 600-608

Diclofenac sodium 3% gel for the management of actinic keratosis: 10+ years of cumulative evidence of efficacy and safety

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD31 ANTIGEN; CD8 ANTIGEN; CYCLOOXYGENASE 2; DICLOFENAC; FLUOROURACIL; HYALURONIC ACID; IMIQUIMOD; PLACEBO;

EID: 84860891967     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (51)

References (53)
  • 2
    • 0037446974 scopus 로고    scopus 로고
    • A genetic explanation of slaughter's concept of field cancerization: Evidence and clinical implications
    • Braakhuis BJM, Tabor MP, Kummer JA, et al. A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res. 2003;63(8):1727-1730. (Pubitemid 36460827)
    • (2003) Cancer Research , vol.63 , Issue.8 , pp. 1727-1730
    • Braakhuis, B.J.M.1    Tabor, M.P.2    Kummer, J.A.3    Leemans, C.R.4    Brakenhoff, R.H.5
  • 5
    • 0035659622 scopus 로고    scopus 로고
    • Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses
    • DOI 10.1046/j.1365-4362.2001.01324.x
    • Wolf JE Jr, Taylor JR, Tschen E, Kang S. Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses. Int J Dermatol. 2001;40(11):709-713. (Pubitemid 34023642)
    • (2001) International Journal of Dermatology , vol.40 , Issue.11 , pp. 709-713
    • Wolf Jr., J.E.1    Taylor, J.R.2    Tschen, E.3    Kang, S.4
  • 6
    • 84860914187 scopus 로고    scopus 로고
    • Melville, NY: PharmaDerm; April
    • Solaraze [package insert] Melville, NY: PharmaDerm; April 2010.
    • (2010) Solaraze [Package Insert]
  • 7
    • 33845955389 scopus 로고    scopus 로고
    • Topical diclofenac in the treatment of actinic keratoses
    • DOI 10.1111/j.1365-4632.2007.03060.x
    • Merk HF. Topical diclofenac in the treatment of actinic keratoses. Int J Dermatol. 2007;46(1):12-18. (Pubitemid 46029719)
    • (2007) International Journal of Dermatology , vol.46 , Issue.1 , pp. 12-18
    • Merk, H.F.1
  • 8
    • 41149095173 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis
    • DOI 10.1111/j.1751-1097.2007.00261.x
    • Rundhaug JE, Fischer SM. Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis. Photochem Photobiol. 2008;84(2):322-329. (Pubitemid 351424030)
    • (2008) Photochemistry and Photobiology , vol.84 , Issue.2 , pp. 322-329
    • Rundhaug, J.E.1    Fischer, S.M.2
  • 9
    • 76749144682 scopus 로고    scopus 로고
    • Field treatment of actinic keratoses - Focus on COX-2-inhibitors
    • Ulrich M, Stockfleth E. Field treatment of actinic keratoses - focus on COX-2-inhibitors. Actas Dermosifilliogr. 2009;100(suppl 2):55-58.
    • (2009) Actas Dermosifilliogr , vol.100 , Issue.SUPPL. 2 , pp. 55-58
    • Ulrich, M.1    Stockfleth, E.2
  • 10
    • 0031843401 scopus 로고    scopus 로고
    • COX-2 expression is induced by UVB exposure in human skin: Implications for the development of skin cancer
    • DOI 10.1093/carcin/19.5.723
    • Buckman SY, Gresham A, Hale P, et al. COX-2 expression is induced by UVB exposure in human skin: Implications for the development of skin cancer. Carcinogenesis. 1998;19(5):723-729. (Pubitemid 28376760)
    • (1998) Carcinogenesis , vol.19 , Issue.5 , pp. 723-729
    • Buckman, S.Y.1    Gresham, A.2    Hale, P.3    Hruza, G.4    Anast, J.5    Masferrer, J.6    Pentland, A.P.7
  • 11
    • 10744231656 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: Implications for therapeutic approaches
    • An KP, Athar M, Tang X, et al. Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: Implications for therapeutic approaches. Photochem Photobiol. 2002;76(1):73-80.
    • (2002) Photochem Photobiol , vol.76 , Issue.1 , pp. 73-80
    • An, K.P.1    Athar, M.2    Tang, X.3
  • 13
    • 33646124246 scopus 로고    scopus 로고
    • Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis
    • Tjiu J-W, Liao Y-H, Lin S-J, et al. Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis. J Invest Dermatol. 2006;126(5):1143-1151.
    • (2006) J Invest Dermatol , vol.126 , Issue.5 , pp. 1143-1151
    • Tjiu, J.-W.1    Liao, Y.-H.2    Lin, S.-J.3
  • 14
    • 0035097541 scopus 로고    scopus 로고
    • Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis
    • Gallo O, Franchi A, Magnelli L, et al. Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. Neoplasia. 2001;3(1):53-61. (Pubitemid 32201610)
    • (2001) Neoplasia , vol.3 , Issue.1 , pp. 53-61
    • Gallo, O.1    Franchi, A.2    Magnelli, L.3    Sardi, I.4    Vannacci, A.5    Boddi, V.6    Chiarugi, V.7    Masini, E.8
  • 15
    • 8344275873 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: A paired immunohistochemical study of 35 cases
    • DOI 10.1111/j.1365-2133.2004.06214.x
    • Nijsten T, Colpaert CG, Vermeulen PB, et al. Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases. Br J Dermatol. 2004;151(4):837-845. (Pubitemid 39482118)
    • (2004) British Journal of Dermatology , vol.151 , Issue.4 , pp. 837-845
    • Nijsten, T.1    Colpaert, C.G.2    Vermeulen, P.B.3    Harris, A.L.4    Van Marck, E.5    Lambert, J.6
  • 16
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
    • Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 1995;83(3):493-501.
    • (1995) Cell , vol.83 , Issue.3 , pp. 493-501
    • Tsujii, M.1    DuBois, R.N.2
  • 18
    • 63149154973 scopus 로고    scopus 로고
    • Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction
    • Tjiu J-W, Chen J-S, Shun C-T, et al. Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction. J Invest Dermatol. 2009;129(4):1016-1025.
    • (2009) J Invest Dermatol , vol.129 , Issue.4 , pp. 1016-1025
    • Tjiu, J.-W.1    Chen, J.-S.2    Shun, C.-T.3
  • 19
    • 0034650771 scopus 로고    scopus 로고
    • Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis
    • Reddy BS, Hirose Y, Lubet R, et al. Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. Cancer Res. 2000;60(2):293-297. (Pubitemid 30070754)
    • (2000) Cancer Research , vol.60 , Issue.2 , pp. 293-297
    • Reddy, B.S.1    Hirose, Y.2    Lubet, R.3    Steele, V.4    Kelloff, G.5    Paulson, S.6    Seibert, K.7    Rao, C.V.8
  • 20
    • 27944450087 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the risk of actinic keratoses and squamous cell cancers of the skin
    • DOI 10.1016/j.jaad.2005.05.049, PII S0190962205023819
    • Butler GJ, Neale R, Green AC, et al. Nonsteroidal anti-inflammatory drugs and the risk of actinic keratoses and squamous cell cancers of the skin. J Am Acad Dermatol. 2005;53(6):966-972. (Pubitemid 41677321)
    • (2005) Journal of the American Academy of Dermatology , vol.53 , Issue.6 , pp. 966-972
    • Butler, G.J.1    Neale, R.2    Green, A.C.3    Pandeya, N.4    Whiteman, D.C.5
  • 21
    • 78650315025 scopus 로고    scopus 로고
    • Chemoprevention of nonmelanoma skin cancer with celecoxib: A randomized, double-blind, placebocontrolled trial
    • Elmets CA, Viner JL, Pentland AP, et al. Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebocontrolled trial. J Natl Cancer Inst. 2010;102(24):1835-1844.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.24 , pp. 1835-1844
    • Elmets, C.A.1    Viner, J.L.2    Pentland, A.P.3
  • 22
    • 81255189130 scopus 로고    scopus 로고
    • Modes of action of diclofenac 3%/hyaluronic acid 2.5% in the treatment of actinic keratosis
    • published online ahead of print May 20, doi: 10.1111/j.1610-0387.2011. 07700.x
    • Maltusch A, Röwert-Huber J, Matthies C, et al. Modes of action of diclofenac 3%/hyaluronic acid 2.5% in the treatment of actinic keratosis. J Dtsch Dermatol Ges. [published online ahead of print May 20, 2011]. doi: 10.1111/j.1610-0387.2011.07700.x.
    • (2011) J Dtsch Dermatol Ges
    • Maltusch, A.1    Röwert-Huber, J.2    Matthies, C.3
  • 23
    • 34247333077 scopus 로고    scopus 로고
    • The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti-inflammatory drugs (NSAIDs)
    • DOI 10.1111/j.1365-2133.2007.07856.x
    • Fecker LF, Stockfleth E, Nindl I, et al. The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti-inflammatory drugs (NSAIDs). Br J Dermatol. 2007;156(suppl 3):25-33. (Pubitemid 46632508)
    • (2007) British Journal of Dermatology , vol.156 , Issue.SUPPL. 3 , pp. 25-33
    • Fecker, L.F.1    Stockfleth, E.2    Nindl, I.3    Ulrich, C.4    Forschner, T.5    Eberle, J.6
  • 24
    • 77954692385 scopus 로고    scopus 로고
    • Enhanced death ligand-induced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid correlates with downregulation of c-FLIP
    • Fecker LF, Stockfleth E, Braun FK, et al. Enhanced death ligand-induced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid correlates with downregulation of c-FLIP. J Invest Dermatol. 2010;130(8):2098-2109.
    • (2010) J Invest Dermatol , vol.130 , Issue.8 , pp. 2098-2109
    • Fecker, L.F.1    Stockfleth, E.2    Braun, F.K.3
  • 25
    • 76349101673 scopus 로고    scopus 로고
    • Topical 3.0% diclofenac in 2.5% hyaluronic acid gel induces regression of cancerous transformation in actinic keratoses
    • Dirschka T, Bierhoff E, Pflugfelder A, Garbe C. Topical 3.0% diclofenac in 2.5% hyaluronic acid gel induces regression of cancerous transformation in actinic keratoses. J Eur Acad Dermatol Venereol. 2010;24(3):258-263.
    • (2010) J Eur Acad Dermatol Venereol , vol.24 , Issue.3 , pp. 258-263
    • Dirschka, T.1    Bierhoff, E.2    Pflugfelder, A.3    Garbe, C.4
  • 27
    • 33646204466 scopus 로고    scopus 로고
    • Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the treatment of actinic keratoses of the face and scalp
    • Smith SR, Morhenn VB, Piacquadio DJ. Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the treatment of actinic keratoses of the face and scalp. J Drugs Dermatol. 2006;5(2):156-159.
    • (2006) J Drugs Dermatol , vol.5 , Issue.2 , pp. 156-159
    • Smith, S.R.1    Morhenn, V.B.2    Piacquadio, D.J.3
  • 28
    • 0029563642 scopus 로고
    • The effect of hyaluronan on the in vitro deposition of diclofenac within the skin
    • Brown MB, Marriott C, Martin GP. The effect of hyaluronan on the in vitro deposition of diclofenac within the skin. Int J Tissue React. 1995;17(4):133-140. (Pubitemid 26048919)
    • (1995) International Journal of Tissue Reactions , vol.17 , Issue.4 , pp. 133-140
    • Brown, M.B.1    Marriott, C.2    Martin, G.P.3
  • 30
    • 0037325491 scopus 로고    scopus 로고
    • Topical diclofenac in hyaluronan gel for the treatment of solar keratoses
    • DOI 10.1046/j.1440-0960.2002.00635.x
    • Gebauer K, Brown P, Varigos G. Topical diclofenac in hyaluronan gel for the treatment of solar keratoses. Australas J Dermatol. 2003;44(1):40-43. (Pubitemid 36246421)
    • (2003) Australasian Journal of Dermatology , vol.44 , Issue.1 , pp. 40-43
    • Gebauer, K.1    Brown, P.2    Varigos, G.3
  • 31
    • 7644224775 scopus 로고    scopus 로고
    • Phase IV, openlabel assessment of the treatment of actinic keratosis with 3.0% diclofenac sodium topical gel (Solaraze)
    • Nelson C, Rigel D, Smith S, Swanson N, Wolf J. Phase IV, openlabel assessment of the treatment of actinic keratosis with 3.0% diclofenac sodium topical gel (Solaraze). J Drugs Dermatol. 2004;3(4):401-407.
    • (2004) J Drugs Dermatol , vol.3 , Issue.4 , pp. 401-407
    • Nelson, C.1    Rigel, D.2    Smith, S.3    Swanson, N.4    Wolf, J.5
  • 32
    • 77954279653 scopus 로고    scopus 로고
    • Long-term follow up of diclofenac sodium 3% in 2.5% hyaluronic acid gel for actinic keratosis: One-year evaluation
    • Nelson C, Rigel D. Long-term follow up of diclofenac sodium 3% in 2.5% hyaluronic acid gel for actinic keratosis: One-year evaluation. J Clin Aesthetic Dermatol. 2009;2(7):20-25.
    • (2009) J Clin Aesthetic Dermatol , vol.2 , Issue.7 , pp. 20-25
    • Nelson, C.1    Rigel, D.2
  • 34
    • 83955162958 scopus 로고    scopus 로고
    • Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hualuronic acid gel: A trial of the German Dermatologic Cooperative Oncology Group
    • published online ahead of print March 18, doi: 10.1111/j.1468-3083.2011. 04005.x
    • Pflugfelder A, Welter A, Leiter U, et al. Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hualuronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group. J Eur Acad Dermatol Vernereol. [published online ahead of print March 18, 2011. doi: 10.1111/j.1468-3083.2011.04005.x.
    • (2011) J Eur Acad Dermatol Vernereol
    • Pflugfelder, A.1    Welter, A.2    Leiter, U.3
  • 35
    • 78649416244 scopus 로고    scopus 로고
    • Diclofenac in hyaluronic acid gel: An alternative treatment for actinic cheilitis
    • Lima GS, da Silva GF, Gomes AP, de Araújo LM, Salum FG. Diclofenac in hyaluronic acid gel: An alternative treatment for actinic cheilitis. J Appl Oral Sci. 2010;18(5):533-537.
    • (2010) J Appl Oral Sci , vol.18 , Issue.5 , pp. 533-537
    • Lima, G.S.1    Da Silva, G.F.2    Gomes, A.P.3    De Araújo, L.M.4    Salum, F.G.5
  • 36
    • 34548863927 scopus 로고    scopus 로고
    • A single-arm, open-label efficacy and tolerability study of diclofenac sodium 3% gel for the treatment of actinic keratosis of the upper and lower lip
    • Nelson CG, Spencer J, Nelson CG Jr. A single-arm, open-label efficacy and tolerability study of diclofenac sodium 3% gel for the treatment of actinic keratosis of the upper and lower lip. J Drugs Dermatol. 2007;6(7):712-717.
    • (2007) J Drugs Dermatol , vol.6 , Issue.7 , pp. 712-717
    • Nelson, C.G.1    Spencer, J.2    Nelson Jr., C.G.3
  • 38
    • 84860914186 scopus 로고    scopus 로고
    • Topical diclofenac gel for the management of periocular actinic keratosis
    • published online ahead of print July 21
    • Batra R, Sundararajan S, Sandramouli S. Topical diclofenac gel for the management of periocular actinic keratosis. Ophthal Plast Reconstr Surg. [published online ahead of print July 21, 2011].
    • (2011) Ophthal Plast Reconstr Surg
    • Batra, R.1    Sundararajan, S.2    Sandramouli, S.3
  • 40
    • 45849132060 scopus 로고    scopus 로고
    • Comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% imiquimod cream in the treatment of actinic keratosis
    • DOI 10.1080/09546630701818870, PII 790392875
    • Kose O, Koc E, Erbil AH, Caliskan E, Kurumlu Z. Comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% imiquimod cream in the treatment of actinic keratosis. J Dermatol Treat. 2008;19(3):159-163. (Pubitemid 351882995)
    • (2008) Journal of Dermatological Treatment , vol.19 , Issue.3 , pp. 159-163
    • Kose, O.1    Koc, E.2    Erbil, A.H.3    Caliskan, E.4    Kurumlu, Z.5
  • 41
    • 79959352251 scopus 로고    scopus 로고
    • Comparison of topical 3% diclofenac sodium gel and 5% imiquimod cream for the treatment of actinic keratoses
    • published online ahead of print March 21, doi: 10.1111/j.1365-2230.2010. 03999.x
    • Akarsu S, Aktan Ş, Atahan A, et al. Comparison of topical 3% diclofenac sodium gel and 5% imiquimod cream for the treatment of actinic keratoses. Clin Exp Dermatol. [published online ahead of print March 21, 2011]. doi: 10.1111/j.1365-2230.2010.03999.x.
    • (2011) Clin Exp Dermatol
    • Akarsu, S.1    Aktan, Ş.2    Atahan, A.3
  • 42
    • 34247359625 scopus 로고    scopus 로고
    • Treatment of multiple actinic keratoses with topical diclofenac 3% gel in organ transplant recipients: A series of six cases
    • DOI 10.1111/j.1365-2133.2007.07864.x
    • Ulrich C, Hackethal M, Ulrich M, et al. Treatment of multiple actinic keratoses with topical diclofenac 3% gel in organ transplant recipients: A series of six cases. Br J Dermatol. 2007;156(suppl 3):40-42. (Pubitemid 46632515)
    • (2007) British Journal of Dermatology , vol.156 , Issue.SUPPL. 3 , pp. 40-42
    • Ulrich, C.1    Hackethal, M.2    Ulrich, M.3    Howorka, A.4    Forschner, T.5    Sterry, W.6    Stockfleth, E.7
  • 43
    • 77954697873 scopus 로고    scopus 로고
    • Results of a randomized, placebo-controlled safety and efficacy study of topical diclofenac 3% gel in organ transplant patients with multiple actinic keratoses
    • Ulrich C, Johannsen A, Rowert-Huber J, Ulrich M, Sterry W, Stockfleth E. Results of a randomized, placebo-controlled safety and efficacy study of topical diclofenac 3% gel in organ transplant patients with multiple actinic keratoses. Eur J Dermatol. 2010;20(4):1-7.
    • (2010) Eur J Dermatol , vol.20 , Issue.4 , pp. 1-7
    • Ulrich, C.1    Johannsen, A.2    Rowert-Huber, J.3    Ulrich, M.4    Sterry, W.5    Stockfleth, E.6
  • 44
    • 52449126834 scopus 로고    scopus 로고
    • Diclofenac sodium 3% gel in the treatment of actinic keratoses postcryosurgery
    • Berlin JM, Rigel DS. Diclofenac sodium 3% gel in the treatment of actinic keratoses postcryosurgery. J Drugs Dermatol. 2008;7(7):669-673.
    • (2008) J Drugs Dermatol , vol.7 , Issue.7 , pp. 669-673
    • Berlin, J.M.1    Rigel, D.S.2
  • 45
    • 57349151103 scopus 로고    scopus 로고
    • Topical diclofenac 3% gel plus cryotherapy for treatment of multiple and recurrent actinic keratoses
    • Mastrolonardo M. Topical diclofenac 3% gel plus cryotherapy for treatment of multiple and recurrent actinic keratoses. Clin Exp Dermatolog. 2009;34(1):33-35.
    • (2009) Clin Exp Dermatolog , vol.34 , Issue.1 , pp. 33-35
    • Mastrolonardo, M.1
  • 46
    • 75849118834 scopus 로고    scopus 로고
    • Treatment of actinic keratoses on the dorsum of the hands: ALA-PDT versus diclofenac 3% gel followed by ALA-PDT. A placebo-controlled, double-blind, pilot study
    • Van Der Geer S, Krekels GAM. Treatment of actinic keratoses on the dorsum of the hands: ALA-PDT versus diclofenac 3% gel followed by ALA-PDT. A placebo-controlled, double-blind, pilot study. J Dermatol Treat. 2009;20(5):259-265.
    • (2009) J Dermatol Treat , vol.20 , Issue.5 , pp. 259-265
    • Van Der Geer, S.1    Krekels, G.A.M.2
  • 48
    • 27744588722 scopus 로고    scopus 로고
    • Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: A meta-analysis of the recent studies
    • DOI 10.1007/s00403-005-0601-9
    • Pirard D, Vereecken P, Mélot C, Heenen M. Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: A meta-analysis of the recent studies. Arch Dermatol Res. 2005;297(5):185-189. (Pubitemid 41618696)
    • (2005) Archives of Dermatological Research , vol.297 , Issue.5 , pp. 185-189
    • Pirard, D.1    Vereecken, P.2    Melot, C.3    Heenen, M.4
  • 49
    • 33646177310 scopus 로고    scopus 로고
    • Mechanisms of action of new treatment modalities for actinic keratosis
    • Berman B, Villa AM, Ramirez CC. Mechanisms of action of new treatment modalities for actinic keratosis. Journal of drugs in dermatology : JDD. 2006;5(2):167-173.
    • (2006) Journal of Drugs in Dermatology: JDD , vol.5 , Issue.2 , pp. 167-173
    • Berman, B.1    Villa, A.M.2    Ramirez, C.C.3
  • 50
    • 84860907176 scopus 로고    scopus 로고
    • Diclofenac gel in the treatment of actinic keratoses
    • Nelson CG. Diclofenac gel in the treatment of actinic keratoses. Ther Clin Risk Management. 2011;7:207-2011.
    • (2011) Ther Clin Risk Management , vol.7 , pp. 207-2011
    • Nelson, C.G.1
  • 51
    • 84860895784 scopus 로고    scopus 로고
    • Chadds Ford, PA: Endo Pharmaceuticals Inc; October
    • Voltaren [package insert]. Chadds Ford, PA: Endo Pharmaceuticals Inc; October 2009.
    • (2009) Voltaren [Package Insert]
  • 52
    • 84860914188 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. fda.gov/ Safety/MedWatch/ SafetyInformation/SafetyAlertsforHumanMedical-Products/ucm193047.htm. Updated December 5, Accessed September 27, 2011
    • U.S. Food and Drug Administration. Safety: Voltaren gel (diclofenac sodium topical gel) 1% - hepatic effects labeling changes. fda.gov/ Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedical-Products/ ucm193047.htm. Updated December 5, 2009. Accessed September 27, 2011.
    • (2009) Safety: Voltaren Gel (Diclofenac Sodium Topical Gel) 1% - Hepatic Effects Labeling Changes
  • 53
    • 0029072301 scopus 로고
    • Angiostasis and vascular regression in chronic granulomatous inflammation induced by diclofenac in combination with hyaluronan in mice
    • Alam CAS, Seed MP, Willoughby DA. Angiostasis and vascular regression in chronic granulomatous inflammation induced by diclofenac in combination with hyaluronan in mice. J Pharm Pharmacol. 1995;47(5):407-411.
    • (1995) J Pharm Pharmacol , vol.47 , Issue.5 , pp. 407-411
    • Alam, C.A.S.1    Seed, M.P.2    Willoughby, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.