-
1
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal, A., R. Siegel, E. Ward, Y. Hao, J. Xu & M. J. Thun: Cancer statistics, 2009. CA Cancer J Clin, 59, 225- 49 (2009)
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
2
-
-
33746485766
-
Epidermal growth factor receptor targeting in cancer
-
Mendelsohn, J. & J. Baselga: Epidermal growth factor receptor targeting in cancer. Semin Oncol, 33, 369-85 (2006)
-
(2006)
Semin Oncol
, vol.33
, pp. 369-385
-
-
Mendelsohn, J.1
Baselga, J.2
-
3
-
-
0028104202
-
Regulation of signal transduction and signal diversity by receptor oligomerization
-
Lemmon, M. A. & J. Schlessinger: Regulation of signal transduction and signal diversity by receptor oligomerization. Trends Biochem Sci, 19, 459-63 (1994)
-
(1994)
Trends Biochem Sci
, vol.19
, pp. 459-463
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
5
-
-
0027254425
-
Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type
-
Finkelstein, S. D., R. Sayegh, S. Christensen & P. A. Swalsky: Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type. Cancer, 71, 3827-38 (1993)
-
(1993)
Cancer
, vol.71
, pp. 3827-3838
-
-
Finkelstein, S.D.1
Sayegh, R.2
Christensen, S.3
Swalsky, P.A.4
-
6
-
-
0023256456
-
Prevalence of ras gene mutations in human colorectal cancers
-
Bos, J. L., E. R. Fearon, S. R. Hamilton, M. Verlaan-de Vries, J. H. van Boom, A. J. van der Eb & B. Vogelstein: Prevalence of ras gene mutations in human colorectal cancers. Nature, 327, 293-7 (1987)
-
(1987)
Nature
, vol.327
, pp. 293-297
-
-
Bos, J.L.1
Fearon, E.R.2
Hamilton, S.R.3
Verlaan-De Vries, M.4
Van Boom, J.H.5
Van Der Eb, A.J.6
Vogelstein, B.7
-
7
-
-
30644480321
-
Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: Results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study
-
Bazan, V., V. Agnese, S. Corsale, V. Calo, M. R. Valerio, M. A. Latteri, S. Vieni, N. Grassi, G. Cicero, G. Dardanoni, R. M. Tomasino, G. Colucci, N. Gebbia & A. Russo: Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study. Ann Oncol, 16 Suppl 4, iv50-55 (2005)
-
(2005)
Ann Oncol
, vol.16
, Issue.SUPPL. 4
-
-
Bazan, V.1
Agnese, V.2
Corsale, S.3
Calo, V.4
Valerio, M.R.5
Latteri, M.A.6
Vieni, S.7
Grassi, N.8
Cicero, G.9
Dardanoni, G.10
Tomasino, R.M.11
Colucci, G.12
Gebbia, N.13
Russo, A.14
-
8
-
-
51049092984
-
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy
-
Etienne-Grimaldi, M. C., J. L. Formento, M. Francoual, E. Francois, P. Formento, N. Renee, P. Laurent-Puig, M. Chazal, D. Benchimol, J. R. Delpero, C. Letoublon, D. Pezet, J. F. Seitz & G. Milano: K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy. Clin Cancer Res, 14, 4830-5 (2008)
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4830-4845
-
-
Etienne-Grimaldi, M.C.1
Formento, J.L.2
Francoual, M.3
Francois, E.4
Formento, P.5
Renee, N.6
Laurent-Puig, P.7
Chazal, M.8
Benchimol, D.9
Delpero, J.R.10
Letoublon, C.11
Pezet, D.12
Seitz, J.F.13
Milano, G.14
-
9
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
De Roock, W., H. Piessevaux, J. De Schutter, M. Janssens, G. De Hertogh, N. Personeni, B. Biesmans, J. L. Van Laethem, M. Peeters, Y. Humblet, E. Van Cutsem & S. Tejpar: KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol, 19, 508-15 (2008)
-
(2008)
Ann Oncol
, vol.19
, pp. 508-515
-
-
De Roock, W.1
Piessevaux, H.2
De Schutter, J.3
Janssens, M.4
De Hertogh, G.5
Personeni, N.6
Biesmans, B.7
Van Laethem, J.L.8
Peeters, M.9
Humblet, Y.10
Van Cutsem, E.11
Tejpar, S.12
-
10
-
-
34247278727
-
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
-
Di Fiore, F., F. Blanchard, F. Charbonnier, F. Le Pessot, A. Lamy, M. P. Galais, L. Bastit, A. Killian, R. Sesboue, J. J. Tuech, A. M. Queuniet, B. Paillot, J. C. Sabourin, F. Michot, P. Michel & T. Frebourg: Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br J Cancer, 96, 1166-9 (2007)
-
(2007)
Br J Cancer
, vol.96
, pp. 1166-1219
-
-
Di Fiore, F.1
Blanchard, F.2
Charbonnier, F.3
Le Pessot, F.4
Lamy, A.5
Galais, M.P.6
Bastit, L.7
Killian, A.8
Sesboue, R.9
Tuech, J.J.10
Queuniet, A.M.11
Paillot, B.12
Sabourin, J.C.13
Michot, F.14
Michel, P.15
Frebourg, T.16
-
11
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford, S., C. R. Garrett, N. J. Meropol, M. Basik, C. T. Harbison, S. Wu, T. W. Wong, X. Huang, C. H. Takimoto, A. K. Godwin, B. R. Tan, S. S. Krishnamurthi, H. A. Burris, 3rd, E. A. Poplin, M. Hidalgo, J. Baselga, E. A. Clark & D. J. Mauro: Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol, 25, 3230-7 (2007)
-
(2007)
J Clin Oncol
, vol.25
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
Basik, M.4
Harbison, C.T.5
Wu, S.6
Wong, T.W.7
Huang, X.8
Takimoto, C.H.9
Godwin, A.K.10
Tan, B.R.11
Krishnamurthi, S.S.12
Burris, H.A.13
Poplin III, E.A.14
Hidalgo, M.15
Baselga, J.16
Clark, E.A.17
Mauro, D.J.18
-
12
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
Lievre, A., J. B. Bachet, V. Boige, A. Cayre, D. Le Corre, E. Buc, M. Ychou, O. Bouche, B. Landi, C. Louvet, T. Andre, F. Bibeau, M. D. Diebold, P. Rougier, M. Ducreux, G. Tomasic, J. F. Emile, F. Penault-Llorca & P. Laurent-Puig: KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol, 26, 374-9 (2008)
-
(2008)
J Clin Oncol
, vol.26
, pp. 374-379
-
-
Lievre, A.1
Bachet, J.B.2
Boige, V.3
Cayre, A.4
Le Corre, D.5
Buc, E.6
Ychou, M.7
Bouche, O.8
Landi, B.9
Louvet, C.10
Andre, T.11
Bibeau, F.12
Diebold, M.D.13
Rougier, P.14
Ducreux, M.15
Tomasic, G.16
Emile, J.F.17
Penault-Llorca, F.18
Laurent-Puig, P.19
-
13
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
Benvenuti, S., A. Sartore-Bianchi, F. Di Nicolantonio, C. Zanon, M. Moroni, S. Veronese, S. Siena & A. Bardelli: Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res, 67, 2643-8 (2007)
-
(2007)
Cancer Res
, vol.67
, pp. 2643-2728
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Zanon, C.4
Moroni, M.5
Veronese, S.6
Siena, S.7
Bardelli, A.8
-
14
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lievre, A., J. B. Bachet, D. Le Corre, V. Boige, B. Landi, J. F. Emile, J. F. Cote, G. Tomasic, C. Penna, M. Ducreux, P. Rougier, F. Penault-Llorca & P. Laurent-Puig: KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res, 66, 3992-5 (2006)
-
(2006)
Cancer Res
, vol.66
, pp. 3992-4035
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
Boige, V.4
Landi, B.5
Emile, J.F.6
Cote, J.F.7
Tomasic, G.8
Penna, C.9
Ducreux, M.10
Rougier, P.11
Penault-Llorca, F.12
Laurent-Puig, P.13
-
15
-
-
19244366949
-
Phase i studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
-
Baselga, J., D. Pfister, M. R. Cooper, R. Cohen, B. Burtness, M. Bos, G. D'Andrea, A. Seidman, L. Norton, K. Gunnett, J. Falcey, V. Anderson, H. Waksal & J. Mendelsohn: Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol, 18, 904-14 (2000)
-
(2000)
J Clin Oncol
, vol.18
, pp. 904-914
-
-
Baselga, J.1
Pfister, D.2
Cooper, M.R.3
Cohen, R.4
Burtness, B.5
Bos, M.6
D'Andrea, G.7
Seidman, A.8
Norton, L.9
Gunnett, K.10
Falcey, J.11
Anderson, V.12
Waksal, H.13
Mendelsohn, J.14
-
16
-
-
0002823211
-
Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer) CRC) that expresses epidermal growth factor receptor (EGFR)
-
Saltz L, R. M., Hochster H, et al. : Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer) CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2001:20 (2001)
-
(2001)
Proc Am Soc Clin Oncol
, vol.2001
, pp. 20
-
-
Saltz, L.R.M.1
Hochster, H.2
-
17
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz, L. B., N. J. Meropol, P. J. Loehrer, Sr., M. N. Needle, J. Kopit & R. J. Mayer: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol, 22, 1201-8 (2004)
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1218
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer Sr., P.J.3
Needle, M.N.4
Kopit, J.5
Mayer, R.J.6
-
18
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham, D., Y. Humblet, S. Siena, D. Khayat, H. Bleiberg, A. Santoro, D. Bets, M. Mueser, A. Harstrick, C. Verslype, I. Chau & E. Van Cutsem: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med, 351, 337-45 (2004)
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
Bets, D.7
Mueser, M.8
Harstrick, A.9
Verslype, C.10
Chau, I.11
Van Cutsem, E.12
-
19
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer, C., I. Bondarenko, A. Makhson, J. T. Hartmann, J. Aparicio, F. de Braud, S. Donea, H. Ludwig, G. Schuch, C. Stroh, A. H. Loos, A. Zubel & P. Koralewski: Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol, 27, 663-71 (2009)
-
(2009)
J Clin Oncol
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
Hartmann, J.T.4
Aparicio, J.5
De Braud, F.6
Donea, S.7
Ludwig, H.8
Schuch, G.9
Stroh, C.10
Loos, A.H.11
Zubel, A.12
Koralewski, P.13
-
20
-
-
65649086838
-
Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: A multicentre two-part phase I/II study
-
Raoul, J. L., J. L. Van Laethem, M. Peeters, C. Brezault, F. Husseini, L. Cals, J. Nippgen, A. H. Loos & P. Rougier: Cetuximab in combination with irinotecan/5- fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: a multicentre two-part phase I/II study. BMC Cancer, 9, 112 (2009)
-
(2009)
BMC Cancer
, vol.9
, pp. 112
-
-
Raoul, J.L.1
Van Laethem, J.L.2
Peeters, M.3
Brezault, C.4
Husseini, F.5
Cals, L.6
Nippgen, J.7
Loos, A.H.8
Rougier, P.9
-
21
-
-
36749067866
-
Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer
-
Tabernero, J., E. Van Cutsem, E. Diaz-Rubio, A. Cervantes, Y. Humblet, T. Andre, J. L. Van Laethem, P. Soulie, E. Casado, C. Verslype, J. S. Valera, G. Tortora, F. Ciardiello, O. Kisker & A. de Gramont: Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer. J Clin Oncol, 25, 5225-32 (2007)
-
(2007)
J Clin Oncol
, vol.25
, pp. 5225-5232
-
-
Tabernero, J.1
Van Cutsem, E.2
Diaz-Rubio, E.3
Cervantes, A.4
Humblet, Y.5
Andre, T.6
Van Laethem, J.L.7
Soulie, P.8
Casado, E.9
Verslype, C.10
Valera, J.S.11
Tortora, G.12
Ciardiello, F.13
Kisker, O.14
De Gramont, A.15
-
22
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem, E., C. H. Kohne, E. Hitre, J. Zaluski, C. R. Chang Chien, A. Makhson, G. D'Haens, T. Pinter, R. Lim, G. Bodoky, J. K. Roh, G. Folprecht, P. Ruff, C. Stroh, S. Tejpar, M. Schlichting, J. Nippgen & P. Rougier: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med, 360, 1408-17 (2009)
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
Zaluski, J.4
Chang Chien, C.R.5
Makhson, A.6
D'Haens, G.7
Pinter, T.8
Lim, R.9
Bodoky, G.10
Roh, J.K.11
Folprecht, G.12
Ruff, P.13
Stroh, C.14
Tejpar, S.15
Schlichting, M.16
Nippgen, J.17
Rougier, P.18
-
23
-
-
44249111440
-
EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
-
Sobrero, A. F., J. Maurel, L. Fehrenbacher, W. Scheithauer, Y. A. Abubakr, M. P. Lutz, M. E. Vega- Villegas, C. Eng, E. U. Steinhauer, J. Prausova, H. J. Lenz, C. Borg, G. Middleton, H. Kroning, G. Luppi, O. Kisker, A. Zubel, C. Langer, J. Kopit & H. A. Burris, 3rd: EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol, 26, 2311-9 (2008)
-
(2008)
J Clin Oncol
, vol.26
, pp. 2311-2329
-
-
Sobrero, A.F.1
Maurel, J.2
Fehrenbacher, L.3
Scheithauer, W.4
Abubakr, Y.A.5
Lutz, M.P.6
Vega- Villegas, M.E.7
Eng, C.8
Steinhauer, E.U.9
Prausova, J.10
Lenz, H.J.11
Borg, C.12
Middleton, G.13
Kroning, H.14
Luppi, G.15
Kisker, O.16
Zubel, A.17
Langer, C.18
Kopit, J.19
Burris III, H.A.20
more..
-
24
-
-
55249109460
-
Relationship of efficacy with K-RAS status wild type versus mutant) in patients with irinotecan-refractory metastatic colorectal cancer (mCRC), treated with irinotecan(q2w) and escalating doses of cetuximab(q1w): The EVEREST experience (preliminary data)
-
Tejpar S, P. M., Humblet Y, et al: Relationship of efficacy with K-RAS status wild type versus mutant) in patients with irinotecan-refractory metastatic colorectal cancer (mCRC), treated with irinotecan(q2w) and escalating doses of cetuximab(q1w): The EVEREST experience (preliminary data). J Clin Oncol (2008)
-
(2008)
J Clin Oncol
-
-
Tejpar, S.P.M.1
Humblet, Y.2
-
25
-
-
34548147248
-
Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer
-
Hecht, J. R., A. Patnaik, J. Berlin, A. Venook, I. Malik, S. Tchekmedyian, L. Navale, R. G. Amado & N. J. Meropol: Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer. Cancer, 110, 980-8 (2007)
-
(2007)
Cancer
, vol.110
, pp. 980-988
-
-
Hecht, J.R.1
Patnaik, A.2
Berlin, J.3
Venook, A.4
Malik, I.5
Tchekmedyian, S.6
Navale, L.7
Amado, R.G.8
Meropol, N.J.9
-
26
-
-
34147103678
-
Openlabel phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
Van Cutsem, E., M. Peeters, S. Siena, Y. Humblet, A. Hendlisz, B. Neyns, J. L. Canon, J. L. Van Laethem, J. Maurel, G. Richardson, M. Wolf & R. G. Amado: Openlabel phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer. J Clin Oncol, 25, 1658-64 (2007)
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
Canon, J.L.7
Van Laethem, J.L.8
Maurel, J.9
Richardson, G.10
Wolf, M.11
Amado, R.G.12
-
27
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado, R. G., M. Wolf, M. Peeters, E. Van Cutsem, S. Siena, D. J. Freeman, T. Juan, R. Sikorski, S. Suggs, R. Radinsky, S. D. Patterson & D. D. Chang: Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol, 26, 1626- 34 (2008)
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
Van Cutsem, E.4
Siena, S.5
Freeman, D.J.6
Juan, T.7
Sikorski, R.8
Suggs, S.9
Radinsky, R.10
Patterson, S.D.11
Chang, D.D.12
-
28
-
-
84887823086
-
Panitumumab efficacy in patients with metastatic colorectal cancer with low or undetecTable levels or epidermal growth factor receptor: Final efficacy and K-RAS analysis
-
Hecht JR, M. E., Baranda J, et al: Panitumumab efficacy in patients with metastatic colorectal cancer with low or undetecTable levels or epidermal growth factor receptor: final efficacy and K-RAS analysis. Program and abstracts of the 2008 Gastrointestinal Cancers Symposium(GCS) (2008)
-
(2008)
Program and Abstracts of the 2008 Gastrointestinal Cancers Symposium(GCS)
-
-
Hecht, J.R.M.E.1
Baranda, J.2
-
29
-
-
35648941728
-
Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND- 2 study
-
Saltz, L. B., H. J. Lenz, H. L. Kindler, H. S. Hochster, S. Wadler, P. M. Hoff, N. E. Kemeny, E. M. Hollywood, M. Gonen, M. Quinones, M. Morse & H. X. Chen: Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND- 2 study. J Clin Oncol, 25, 4557-61 (2007)
-
(2007)
J Clin Oncol
, vol.25
, pp. 4557-4561
-
-
Saltz, L.B.1
Lenz, H.J.2
Kindler, H.L.3
Hochster, H.S.4
Wadler, S.5
Hoff, P.M.6
Kemeny, N.E.7
Hollywood, E.M.8
Gonen, M.9
Quinones, M.10
Morse, M.11
Chen, H.X.12
-
30
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
Hecht, J. R., E. Mitchell, T. Chidiac, C. Scroggin, C. Hagenstad, D. Spigel, J. Marshall, A. Cohn, D. McCollum, P. Stella, R. Deeter, S. Shahin & R. G. Amado: A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol, 27, 672-80 (2009)
-
(2009)
J Clin Oncol
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
Scroggin, C.4
Hagenstad, C.5
Spigel, D.6
Marshall, J.7
Cohn, A.8
McCollum, D.9
Stella, P.10
Deeter, R.11
Shahin, S.12
Amado, R.G.13
-
31
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol, J., M. Koopman, A. Cats, C. J. Rodenburg, G. J. Creemers, J. G. Schrama, F. L. Erdkamp, A. H. Vos, C. J. van Groeningen, H. A. Sinnige, D. J. Richel, E. E. Voest, J. R. Dijkstra, M. E. Vink-Borger, N. F. Antonini, L. Mol, J. H. van Krieken, O. Dalesio & C. J. Punt: Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med, 360, 563-72 (2009)
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
Rodenburg, C.J.4
Creemers, G.J.5
Schrama, J.G.6
Erdkamp, F.L.7
Vos, A.H.8
Van Groeningen, C.J.9
Sinnige, H.A.10
Richel, D.J.11
Voest, E.E.12
Dijkstra, J.R.13
Vink-Borger, M.E.14
Antonini, N.F.15
Mol, L.16
Van Krieken, J.H.17
Dalesio, O.18
Punt, C.J.19
-
32
-
-
57449095367
-
Wildtype BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio, F., M. Martini, F. Molinari, A. Sartore-Bianchi, S. Arena, P. Saletti, S. De Dosso, L. Mazzucchelli, M. Frattini, S. Siena & A. Bardelli: Wildtype BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol, 26, 5705-12 (2008)
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
Sartore-Bianchi, A.4
Arena, S.5
Saletti, P.6
De Dosso, S.7
Mazzucchelli, L.8
Frattini, M.9
Siena, S.10
Bardelli, A.11
-
33
-
-
20444374445
-
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
-
Samuels, Y., L. A. Diaz, Jr., O. Schmidt-Kittler, J. M. Cummins, L. Delong, I. Cheong, C. Rago, D. L. Huso, C. Lengauer, K. W. Kinzler, B. Vogelstein & V. E. Velculescu: Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell, 7, 561-73 (2005)
-
(2005)
Cancer Cell
, vol.7
, pp. 561-573
-
-
Samuels, Y.1
Diaz Jr., L.A.2
Schmidt-Kittler, O.3
Cummins, J.M.4
Delong, L.5
Cheong, I.6
Rago, C.7
Huso, D.L.8
Lengauer, C.9
Kinzler, K.W.10
Vogelstein, B.11
Velculescu, V.E.12
-
34
-
-
40949135397
-
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
-
Jhawer, M., S. Goel, A. J. Wilson, C. Montagna, Y. H. Ling, D. S. Byun, S. Nasser, D. Arango, J. Shin, L. Klampfer, L. H. Augenlicht, R. Perez-Soler & J. M. Mariadason: PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res, 68, 1953-61 (2008)
-
(2008)
Cancer Res
, vol.68
, pp. 1953-1961
-
-
Jhawer, M.1
Goel, S.2
Wilson, A.J.3
Montagna, C.4
Ling, Y.H.5
Byun, D.S.6
Nasser, S.7
Arango, D.8
Shin, J.9
Klampfer, L.10
Augenlicht, L.H.11
Perez-Soler, R.12
Mariadason, J.M.13
-
35
-
-
35348908314
-
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
-
Frattini, M., P. Saletti, E. Romagnani, V. Martin, F. Molinari, M. Ghisletta, A. Camponovo, L. L. Etienne, F. Cavalli & L. Mazzucchelli: PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer, 97, 1139-45 (2007)
-
(2007)
Br J Cancer
, vol.97
, pp. 1139-1145
-
-
Frattini, M.1
Saletti, P.2
Romagnani, E.3
Martin, V.4
Molinari, F.5
Ghisletta, M.6
Camponovo, A.7
Etienne, L.L.8
Cavalli, F.9
Mazzucchelli, L.10
-
36
-
-
66849140563
-
PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
-
Loupakis, F., L. Pollina, I. Stasi, A. Ruzzo, M. Scartozzi, D. Santini, G. Masi, F. Graziano, C. Cremolini, E. Rulli, E. Canestrari, N. Funel, G. Schiavon, I. Petrini, M. Magnani, G. Tonini, D. Campani, I. Floriani, S. Cascinu & A. Falcone: PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J Clin Oncol, 27, 2622-9 (2009)
-
(2009)
J Clin Oncol
, vol.27
, pp. 2622-2629
-
-
Loupakis, F.1
Pollina, L.2
Stasi, I.3
Ruzzo, A.4
Scartozzi, M.5
Santini, D.6
Masi, G.7
Graziano, F.8
Cremolini, C.9
Rulli, E.10
Canestrari, E.11
Funel, N.12
Schiavon, G.13
Petrini, I.14
Magnani, M.15
Tonini, G.16
Campani, D.17
Floriani, I.18
Cascinu, S.19
Falcone, A.20
more..
-
37
-
-
59049089201
-
PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
-
Perrone, F., A. Lampis, M. Orsenigo, M. Di Bartolomeo, A. Gevorgyan, M. Losa, M. Frattini, C. Riva, S. Andreola, E. Bajetta, L. Bertario, E. Leo, M. A. Pierotti & S. Pilotti: PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol, 20, 84-90 (2009)
-
(2009)
Ann Oncol
, vol.20
, pp. 84-90
-
-
Perrone, F.1
Lampis, A.2
Orsenigo, M.3
Di Bartolomeo, M.4
Gevorgyan, A.5
Losa, M.6
Frattini, M.7
Riva, C.8
Andreola, S.9
Bajetta, E.10
Bertario, L.11
Leo, E.12
Pierotti, M.A.13
Pilotti, S.14
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