메뉴 건너뛰기




Volumn 4 E, Issue 1, 2012, Pages 12-22

Role of anti-EGFR target therapy in colorectal carcinoma

Author keywords

Cetuximab; Colorectal carcinoma; EGFR; Gene mutation; KRAS; Molecular medicine; Monoclonal antibody; Panitumumab; Review

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; K RAS PROTEIN; MONOCLONAL ANTIBODY; MUTANT PROTEIN; OXALIPLATIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSFORMING GROWTH FACTOR ALPHA; ANTINEOPLASTIC AGENT;

EID: 84860856668     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e357     Document Type: Article
Times cited : (7)

References (37)
  • 2
    • 33746485766 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in cancer
    • Mendelsohn, J. & J. Baselga: Epidermal growth factor receptor targeting in cancer. Semin Oncol, 33, 369-85 (2006)
    • (2006) Semin Oncol , vol.33 , pp. 369-385
    • Mendelsohn, J.1    Baselga, J.2
  • 3
    • 0028104202 scopus 로고
    • Regulation of signal transduction and signal diversity by receptor oligomerization
    • Lemmon, M. A. & J. Schlessinger: Regulation of signal transduction and signal diversity by receptor oligomerization. Trends Biochem Sci, 19, 459-63 (1994)
    • (1994) Trends Biochem Sci , vol.19 , pp. 459-463
    • Lemmon, M.A.1    Schlessinger, J.2
  • 5
    • 0027254425 scopus 로고
    • Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type
    • Finkelstein, S. D., R. Sayegh, S. Christensen & P. A. Swalsky: Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type. Cancer, 71, 3827-38 (1993)
    • (1993) Cancer , vol.71 , pp. 3827-3838
    • Finkelstein, S.D.1    Sayegh, R.2    Christensen, S.3    Swalsky, P.A.4
  • 7
    • 30644480321 scopus 로고    scopus 로고
    • Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: Results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study
    • Bazan, V., V. Agnese, S. Corsale, V. Calo, M. R. Valerio, M. A. Latteri, S. Vieni, N. Grassi, G. Cicero, G. Dardanoni, R. M. Tomasino, G. Colucci, N. Gebbia & A. Russo: Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study. Ann Oncol, 16 Suppl 4, iv50-55 (2005)
    • (2005) Ann Oncol , vol.16 , Issue.SUPPL. 4
    • Bazan, V.1    Agnese, V.2    Corsale, S.3    Calo, V.4    Valerio, M.R.5    Latteri, M.A.6    Vieni, S.7    Grassi, N.8    Cicero, G.9    Dardanoni, G.10    Tomasino, R.M.11    Colucci, G.12    Gebbia, N.13    Russo, A.14
  • 13
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • Benvenuti, S., A. Sartore-Bianchi, F. Di Nicolantonio, C. Zanon, M. Moroni, S. Veronese, S. Siena & A. Bardelli: Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res, 67, 2643-8 (2007)
    • (2007) Cancer Res , vol.67 , pp. 2643-2728
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Zanon, C.4    Moroni, M.5    Veronese, S.6    Siena, S.7    Bardelli, A.8
  • 16
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer) CRC) that expresses epidermal growth factor receptor (EGFR)
    • Saltz L, R. M., Hochster H, et al. : Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer) CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2001:20 (2001)
    • (2001) Proc Am Soc Clin Oncol , vol.2001 , pp. 20
    • Saltz, L.R.M.1    Hochster, H.2
  • 17
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz, L. B., N. J. Meropol, P. J. Loehrer, Sr., M. N. Needle, J. Kopit & R. J. Mayer: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol, 22, 1201-8 (2004)
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1218
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 20
    • 65649086838 scopus 로고    scopus 로고
    • Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: A multicentre two-part phase I/II study
    • Raoul, J. L., J. L. Van Laethem, M. Peeters, C. Brezault, F. Husseini, L. Cals, J. Nippgen, A. H. Loos & P. Rougier: Cetuximab in combination with irinotecan/5- fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: a multicentre two-part phase I/II study. BMC Cancer, 9, 112 (2009)
    • (2009) BMC Cancer , vol.9 , pp. 112
    • Raoul, J.L.1    Van Laethem, J.L.2    Peeters, M.3    Brezault, C.4    Husseini, F.5    Cals, L.6    Nippgen, J.7    Loos, A.H.8    Rougier, P.9
  • 24
    • 55249109460 scopus 로고    scopus 로고
    • Relationship of efficacy with K-RAS status wild type versus mutant) in patients with irinotecan-refractory metastatic colorectal cancer (mCRC), treated with irinotecan(q2w) and escalating doses of cetuximab(q1w): The EVEREST experience (preliminary data)
    • Tejpar S, P. M., Humblet Y, et al: Relationship of efficacy with K-RAS status wild type versus mutant) in patients with irinotecan-refractory metastatic colorectal cancer (mCRC), treated with irinotecan(q2w) and escalating doses of cetuximab(q1w): The EVEREST experience (preliminary data). J Clin Oncol (2008)
    • (2008) J Clin Oncol
    • Tejpar, S.P.M.1    Humblet, Y.2
  • 26
  • 28
    • 84887823086 scopus 로고    scopus 로고
    • Panitumumab efficacy in patients with metastatic colorectal cancer with low or undetecTable levels or epidermal growth factor receptor: Final efficacy and K-RAS analysis
    • Hecht JR, M. E., Baranda J, et al: Panitumumab efficacy in patients with metastatic colorectal cancer with low or undetecTable levels or epidermal growth factor receptor: final efficacy and K-RAS analysis. Program and abstracts of the 2008 Gastrointestinal Cancers Symposium(GCS) (2008)
    • (2008) Program and Abstracts of the 2008 Gastrointestinal Cancers Symposium(GCS)
    • Hecht, J.R.M.E.1    Baranda, J.2
  • 29
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND- 2 study
    • Saltz, L. B., H. J. Lenz, H. L. Kindler, H. S. Hochster, S. Wadler, P. M. Hoff, N. E. Kemeny, E. M. Hollywood, M. Gonen, M. Quinones, M. Morse & H. X. Chen: Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND- 2 study. J Clin Oncol, 25, 4557-61 (2007)
    • (2007) J Clin Oncol , vol.25 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.J.2    Kindler, H.L.3    Hochster, H.S.4    Wadler, S.5    Hoff, P.M.6    Kemeny, N.E.7    Hollywood, E.M.8    Gonen, M.9    Quinones, M.10    Morse, M.11    Chen, H.X.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.