Hypothermia as a treatment for birth asphyxia

Clinical Obstetrics and Gynecology

Volumn 50, Issue 3, 2007, Pages 624-635

  Shankaran, Seetha ^a,c   Laptook, Abbot R ^b  

^a WAYNE STATE UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

Encephalopathy; Hypothermia; Hypoxia ischemic; Neuroprotection

Indexed keywords

BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; COOLING; EVALUATION; EVIDENCE BASED MEDICINE; FOLLOW UP; HUMAN; HYPOTHERMIA; HYPOXIC ISCHEMIC ENCEPHALOPATHY; NEUROPROTECTION; PERINATAL ASPHYXIA; REVIEW;

ASPHYXIA NEONATORUM; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; PROGNOSIS; TREATMENT OUTCOME;

EID: 34548417609     PISSN: 00099201     EISSN: None     Source Type: Journal    
DOI: 10.1097/GRF.0b013e31811eba5e     Document Type: Review

References (54)

1. Gunn AJ. Cerebral hypothermia for prevention of brain injury following perinatal asphyxia. Curr Opin Pediatr. 2000;12:111-115.
2. Vanucci RC, Perlman JM. Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics. 1997;100:1004-1014.
3. Roberston CMT, Finer NN, Grace MGA. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Pediatr. 1989;114:753-760.
4. Shankaran S, Woldt E, Koepke T, et al. Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev. 1991;25:135-148.
5. Nelson KB. The epidemiology of cerebral palsy in term infants. Ment Retard Dev Disabil Res Rev. 2002;8:146-150.
6. Volpe JJ. Hypoxic-ischemic encephalopathy: intrauterine assessment. In: Volpe JJ, ed. Neurology of the Newborn. Philadelphia, PA: WB Saunders Co; 2000:277-295.
7. Lorek A, Takei Y, Cady EB, et al. Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1994;36:699-706.
8. Laptook AR, Corbett RJ, Arencibia-Mireles O, et al. Glucose-associated alterations in ischemic brain metabolism of neonatal piglets. Stroke. 1992;23:1504-1511.
9. Johnston MV, Trescher WH, Ishida A, et al. Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatr Res. 2001;49:735-741.
10. Siesjo BK, Bengtsson F. Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis. J Cereb Blood Flow Metab. 1989;9:127-140.
11. Fellman V, Raivio KO. Reperfusion injury as the mechanism of brain damage after perinatal asphyxia. Pediatr Res. 1997;41:599-606.
12. Liu XH, Kwon D, Schielke GP, et al. Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage. J Cereb Blood Flow Metab. 1999;19:1099-1108.
13. Mehmet H, Yue X, Squier MV, et al. Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult. Neurosci Lett. 1994;181:121-125.
14. Tan WK, Williams CE, During MJ, et al. Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep. Pediatr Res. 1996;39:791-797.
15. Gluckman PD, Guan J, Williams C, et al. Asphyxial brain injury - the role of the IGF system. Mol Cell Endocrinol. 1998;140:95-99.
16. Gunn AJ, Gunn TR, de Haan HH, et al. Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest. 1997;99:248-256.
17. Gunn AJ, Gunn TR, Gunning MI, et al. Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep. Pediatrics. 1998;102: 1098-1106.
18. Gunn AJ, Bennet L, Gunning MI, et al. Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr Res. 1999;46:274-280.
19. Peeters C, van Bel F. Pharmacotherapeutical reduction of post-hypoxic-ischemic brain injury in the newborn. Biol Neonate. 2001;79:274-280.
20. Gluckman PD, Pinal CS, Gunn AJ. Hypoxic-ischemic brain injury in the newborn: pathophysiology and potential strategies for intervention. Semin Neonatol. 2001;6:109-120.
21. Liu Y, Barks JD, Xu G, et al. Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke. 2004;35:1460-1465.
22. Sfaello I, Baud O, Arzimanoglou A, et al. Topiramate prevents excitotoxic damage in the newborn rodent brain. Neurobiol Dis. 2005;20:837-848.
23. Montero EF, Abrahao MS, Koike MK, et al. Intestinal ischemia and reperfusion injury in growing rats: hypothermia and N-acetylcysteine modulation. Microsurgery. 2003;23:517-521.
24. Jatana M, Singh I, Singh AK, et al. Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res. 2006;59:684-689.
25. 1H magnetic resonance spectroscopy. Pediatr Res. 1995;38:919-925.
26. Thoresen M, Satas S, Puka-Sundvall M, et al. Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins. Neuroreport. 1997;8:3359-3362.
27. Edwards AD, Yue X, Squier MV, et al. Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. Biochem Biophys Res Commun. 1995;217:1193-1199.
28. Fukuda H, Tomimatsu T, Watanabe N, et al. Post-ischemic hypothermia blocks caspase-3 activation in the newborn rat brain after hypoxia-ischemia. Brain Res. 2001;910:187-191.
29. Bergstedt K, Hu BR, Wieloch T. Postischaemic changes in protein synthesis in the rat brain: effects of hypothermia. Exp Brain Res. 1993;95:91-99.
30. Globus MY, Busto R, Lin B, et al. Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem. 1995;65:1250-1256.
31. Goss JR, Styren SD, Miller PD, et al. Hypothermia attenuates the normal increase in interleukin 1 beta RNA and nerve growth factor following traumatic brain injury in the rat. J Neurotrauma. 1995;12:159-167.
32. Thoresen M, Penrice J, Lorek A, et al. Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res. 1995;37:667-670.
33. Wagner BP, Nedelcu J, Martin E. Delayed postischemic hypothermia improves long-term behavioral outcome after cerebral hypoxia-ischemia in neonatal rats. Pediatr Res. 2002;51:354-360.
34. Taylor DL, Mehmet H, Cady EB, et al. Improved neuroprotection with hypothermia delayed by 6 hours following cerebral hypoxia-ischemia in the 14-day-old rat. Pediatr Res. 2002;51:13-19.
35. Nelson KB, Ellenberg JH. The asymptomatic newborn and risk of cerebral palsy. Am J Dis Child. 1987;141:1333-1335.
36. Freeman JM, Nelson KB. Intrapartum asphyxia and cerebral palsy. Pediatrics. 1988;82:240-249.
37. Goldaber KG, Gilstrap LC III, Leveno KJ, et al. Pathologic fetal acidemia. Obstet Gynecol. 1991;78:1103-1107.
38. Perlman JM, Tack ED. Renal injury in the asphyxiated newborn infant: relationship to neurologic outcome. J Pediatr. 1988;113:875-879.
39. American Academy of Pediatrics and American College of Obstetricians and Genecologists. Care of the neonate. In: Gilstrap LC, OH W, eds. Guidelines for Perinatal Care-5th edition. Elk Grove Village, IL: American Academy of Pediatrics; 2002:187-235.
40. Grether JK, Nelson KB. Maternal infection and cerebral palsy in infants of normal birth weight. JAMA. 1997;278:207-211.
41. Shalak LF, Laptook AR, Jafri HS, et al. Clinical chorioamnionitis, elevated cytokines, and brain injury in term infants. Pediatrics. 2002;110:673-680.
42. Gunn AJ, Gluckman PD, Gunn TR. Selective head cooling in newborn infants after perinatal asphyxia: a safety study. Pediatrics. 1998;102:885-892.
43. Azzopardi D, Robertson NJ, Cowan FM, et al. Pilot study of treatment with whole body hypothermia for neonatal encephalopathy. Pediatrics. 2000;106:684-694.
44. Thoresen M, Whitelaw A. Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy. Pediatrics. 2000;106:92-99.
45. Shankaran S, Laptook A, Wright LL, et al. Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants. Pediatrics. 2002;110:377-385.
46. Debillon T, Daoud P, Durand P, et al. Whole-body cooling after perinatal asphyxia: a pilot study in term neonates. Dev Med Child Neurol. 2003;45:17-23.
47. Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy: safety outcomes. Pediatr Neurol. 2005;32:18-24.
48. Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol. 2005;32:11-17.
49. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365:663-670.
50. Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353:1574-1584.
51. Higgins RD, Raju TN, Perlman J, et al. Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop. J Pediatr. 2006;148:170-175.
52. Ambalavanan N, Carlo W, Shankaran S, et al. Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy. Pediatrics. 2006;118:2084-2093.
53. Shah PS, Beyene J, To T, et al. Postasphyxial hypoxic-ischemic encephalopathy in neonates. Outcome prediction rule within 4 hours of birth. Arch Pediatr Adolesc Med. 2006;160:729-736.
54. Laptook AR, Shalak L, Corbett RJ. Differences in brain temperature and cerebral blood flow during selective head versus whole-body cooling. Pediatrics. 2001;108:1103-1110.