Five choice serial reaction time performance in the Hdh Q92 mouse model of Huntington's disease

Brain Research Bulletin

Volumn 88, Issue 2-3, 2012, Pages 163-170

  Trueman, R C ^a   Dunnett, S B ^a   Jones, L ^b   Brooks, S P ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

5 Choice serial reaction time task; 9 Hole box; Attention; Hdh Q92 mouse; Huntington's disease; Knock in; Operant tests

Indexed keywords

HUNTINGTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENTION; FEMALE; FIVE CHOICE SERIAL REACTION TIME TASK; HISTOLOGY; HUNTINGTON CHOREA; INSTRUMENTAL CONDITIONING; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REACTION TIME; STIMULUS; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ATTENTION; CHOICE BEHAVIOR; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; FEMALE; GENE KNOCK-IN TECHNIQUES; HUNTINGTON DISEASE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; REACTION TIME; ROTAROD PERFORMANCE TEST;

EID: 84860836044     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2011.10.019     Document Type: Article

References (38)

1. Aron A.R., Sahakian B.J., Robbins T.W. Distractibility during selection-for-action: differential deficits in Huntington's disease and following frontal lobe damage. Neuropsychologia 2003, 41:1137-1147.
2. Q92/Q92 mouse line. Brain Res. Bull. 2011.
3. Brooks S., Higgs G., Jones L., Dunnett S.B. Longitudinal analysis of the behavioural phenotype in Hdh(Q92) Huntington's disease knock-in mice. Brain Res. Bull. 2010.
4. Couette M., Bachoud-Levi A.C., Brugieres P., Sieroff E., Bartolomeo P. Orienting of spatial attention in Huntington's disease. Neuropsychologia 2008, 46:1391-1400.
5. de la Monte S.M., Vonsattel J.P., Richardson E.P. Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease. J. Neuropathol. Exp. Neurol. 1988, 47:516-525.
6. DiFiglia M., Sapp E., Chase K.O., Davies S.W., Bates G.P., Vonsattel J.P., Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 1997, 277:1990-1993.
7. Georgiou N., Bradshaw J.L., Phillips J.G., Bradshaw J.A., Chiu E. The Simon effect and attention deficits in Gilles de la Tourette's syndrome and Huntington's disease. Brain 1995, 118(Pt 5):1305-1318.
8. Gutekunst C.A., Li S.H., Yi H., Mulroy J.S., Kuemmerle S., Jones R., Rye D., Ferrante R.J., Hersch S.M., Li X.J. Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology. J. Neurosci. 1999, 19:2522-2534.
9. Humby T., Wilkinson L., Dawson G. Assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. Curr. Protoc. Neurosci. 2005, (Chapter 8 Unit).
10. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983. Huntington's Disease Collaborative Research Group.
11. Jeste D.V., Barban L., Parisi J. Reduced Purkinje cell density in Huntington's disease. Exp. Neurol. 1984, 85:78-86.
12. Kremer H.P., Roos R.A., Dingjan G.M., Bots G.T., Bruyn G.W., Hofman M.A. The hypothalamic lateral tuberal nucleus and the characteristics of neuronal loss in Huntington's disease. Neurosci. Lett. 1991, 132:101-104.
13. Lange H., Thorner G., Hopf A., Schroder K.F. Morphometric studies of the neuropathological changes in choreatic diseases. J. Neurol. Sci. 1976, 28:401-425.
14. Lawrence A.D., Sahakian B.J., Rogers R.D., Hodge J.R., Robbins T.W. Discrimination, reversal, and shift learning in Huntington's disease: mechanisms of impaired response selection. Neuropsychologia 1999, 37:1359-1374.
15. Menalled L.B. Knock-in mouse models of Huntington's disease. NeuroRx 2005, 2:465-470.
16. Muir J.L., Everitt B.J., Robbins T.W. The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task. Cereb. Cortex 1996, 6:470-481.
17. Penney J.B., Young A.B. Speculations on the functional anatomy of basal ganglia disorders. Annu. Rev. Neurosci. 1983, 6:73-94.
18. Posner M.I. Orienting of attention. Q. J. Exp. Psychol. 1980, 32:3-25.
19. Posner M.I. Cognitive neuropsychology and the problem of selective attention. Electroencephalogr. Clin. Neurophysiol. Suppl. 1987, 39:313-316.
20. Ramaswamy S., McBride J.L., Kordower J.H. Animal models of Huntington's disease. ILAR J. 2007, 48:356-373.
21. Robbins T.W. The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl) 2002, 163:362-380.
22. Robbins T.W., Everitt B.J., Marston H.M., Wilkinson J., Jones G.H., Page K.J. Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes. Behav. Brain Res. 1989, 35:221-240.
23. Robbins T.W., Muir J.L., Killcross A.S., Pretsell D. Methods for assessing attention and stimulus control in the rat. Behavioural Neuroscience: A Practical Approach 1993, vol. 1:13-47. Oxford University Press, Oxford.
24. Rogers R.D., Baunez C., Everitt B.J., Robbins T.W. Lesions of the medial and lateral striatum in the rat produce differential deficits in attentional performance. Behav. Neurosci. 2001, 115:799-811.
25. Roon-Mom W.M., Hogg V.M., Tippett L.J., Faull R.L. Aggregate distribution in frontal and motor cortex in Huntington's disease brain. Neuroreport 2006, 17:667-670.
26. Sathasivam K., Woodman B., Mahal A., Bertaux F., Wanker E.E., Shima D.T., Bates G.P. Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients. Hum. Mol. Genet. 2001, 10:2425-2435.
27. Sieradzan K.A., Mechan A.O., Jones L., Wanker E.E., Nukina N., Mann D.M. Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein. Exp. Neurol. 1999, 156:92-99.
28. Sotrel A., Paskevich P.A., Kiely D.K., Bird E.D., Williams R.S., Myers R.H. Morphometric analysis of the prefrontal cortex in Huntington's disease. Neurology 1991, 41:1117-1123.
29. Spargo E., Everall I.P., Lantos P.L. Neuronal loss in the hippocampus in Huntington's disease: a comparison with HIV infection. J. Neurol. Neurosurg. Psychiatry 1993, 56:487-491.
30. Sprengelmeyer R., Lange H., Homberg V. The pattern of attentional deficits in Huntington's disease. Brain 1995, 118(Pt 1):145-152.
31. Tellez-Nagel I., Vidal M., Rojas M.P., Guiloff R. Electron microscopic observations in a cerebral biopsy of huntington's chorea. Proceedings of the 6th International Congress of Neuropathology 1970, 1055-1056.
32. Trueman R.C., Brooks S.P., Dunnett S.B. Implicit learning in a serial choice visual discrimination task in the operant 9-hole box by intact and striatal lesioned mice. Behav. Brain Res. 2005, 159:313-322.
33. Trueman R.C., Brooks S.P., Jones L., Dunnett S.B. The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease. Eur. J. Neurosci. 2007, 25:551-558.
34. Trueman R.C., Brooks S.P., Jones L., Dunnett S.B. Time course of choice reaction time deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease in the operant serial implicit learning task (SILT). Behav. Brain Res. 2008, 189:317-324.
35. Trueman R.C., Brooks S.P., Jones L., Dunnett S.B. Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease. Behav. Brain Res. 2009, 203:215-222.
36. Trueman R.C., Jones L., Dunnett S.B., Brooks S.P. Early onset deficits on the delayed alternation task in the Hdh(Q92) knock-in mouse model of Huntington's disease. Brain Res. Bull. 2011.
37. Vonsattel J.P., Myers R.H., Stevens T.J., Ferrante R.J., Bird E.D., Richardson E.P. Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 1985, 44:559-577.
38. Wheeler V.C., Auerbach W., White J.K., Srinidhi J., Auerbach A., Ryan A., Duyao M.P., Vrbanac V., Weaver M., Joyner A.L., MacDonald M.E. Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse. Hum. Mol. Genet. 1999, 8:115-122.