Upregulation of HLA-G in JEG-3 cells by dexamethasone and hydrocortisone

Archives of Gynecology and Obstetrics

Volumn 285, Issue 1, 2012, Pages 7-14

  Akhter, Ariz ^b   Das, Vinita ^b   Naik, Sita ^a   Faridi, Rehan Mujeeb ^a   Pandey, Amita ^b   Agrawal, Suraksha ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^b CSSMU   (India)

Author keywords

Glucocorticoids; HLA G; JAR; JEG 3; K 562; Trophoblast

Indexed keywords

DEXAMETHASONE; HLA G ANTIGEN; HYDROCORTISONE; MESSENGER RNA; GLUCOCORTICOID;

ARTICLE; CARCINOMA CELL; CELL LINE; CELL STRAIN; CELL STRAIN JAR; CELL STRAIN JEG 3; CELL STRAIN K 562; CHORIOCARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ERYTHROLEUKEMIA CELL; FLOW CYTOMETRY; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HLA G GENE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENETICS; METABOLISM; TROPHOBLAST;

CELL LINE; DEXAMETHASONE; FEMALE; GENE EXPRESSION; GLUCOCORTICOIDS; HLA-G ANTIGENS; HUMANS; HYDROCORTISONE; TROPHOBLASTS; UP-REGULATION;

EID: 84860827699     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-011-1880-3     Document Type: Article

References (22)

1. OK Fuzzi B, Rizzo R, Criscuoli L et al (2002) HLAG expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy. Eur J Immunol 32:311-315
2. OK McMaster MT, Librach CL, Zhou Y et al (1995) Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. J Immunol 154:3771-3778
3. OK Paul P, Cabestre FA, Ibrahim EC et al (2000) Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells. Hum Immunol 61:1138-1149
4. OK Kitano T, Iizasas H, Hwang IW, Hirose Y, Morita T, Maeda T et al (1988) Conditionally immortalized syncytiotrophoblast cell lines as new tools for study of blood-placenta barrier. Biol Pharm Bull 27:753-759
5. OK Apline JD, Sattar A, Mould AP (2002) Variant choriocarcinoma (BeWo) cells that differ in adhesion and migration on Wbronectin display conserved patterns of integrin expression. J Cell Sci 103:435-444
6. Drexler HG (2000) The leukemia-lymphoma cell line facts book. Academic Press, San Diego
7. OK Klein HO, Adler D, Doering M, Klein PJ, Lennartz KJ (1976) Investigations on pharmacologic induction of partial synchronization of tumor cell proliferation: its relevance for cytostatic therapy. Cancer Treat Rep 60(12):1959-1979
8. Andersson LC, Gahmberg CG, Teerenhovi L, Vuopio P (1979) Glycophorin A as a cell surface marker of early erythroid differentiation in acute leukemia. Int J Cancer 24(6):717-720 (Dec 15)
9. OK Moreau P, Faure O, Lefebvre S, Ibrahim EC, Brien MO, Gourand L, Dausset J, Carosella ED, Paul P (2001) Glucocorticoid hormones upregulate levels of HLA-G transcripts in trophoblasts. Transplant Proc 33:2277-2280
10. OK Carosella ED, Moreau P, Lemaoult J et al (2008) HLA-G: from biology to clinical benefits. Trends Immunol 29:125-132
11. Marchal-Bras-Goncalves R, Rouas-Freiss N, Connan F et al (2001) A soluble HLA-G protein that inhibits natural killer cellmediated cytotoxicity. Transplant Proc 33:2355-2359
12. OK Aldrich CL, Stephenson MD, Karrison T, Odem RR, Branch DW, Scott JR, Schreiber JR, Ober C (2001) HLA-G genotype and pregnancy outcome in couples with unexplained recurrent miscarriage. Mol Hum Reprod 7:1167-1172
13. OK Ober C, Billstrand C, Kuldanek S, Tan Z (2006) The miscarriageassociated HLA-G-725G allele influences transcription rates in JEG-3 cells. Hum Reprod 21:1743-1748
14. Szekeres-Bartho J, Szekeres J (1992) Immunosuppression by progesterone in pregnancy. CRC Press, Boca Raton
15. OK Almawi WY, Melemedjian OK, Rieder MJ (1999) An alternate mechanism of glucocorticoid anti-proliferative effect: promotion of a Th2 cytokine-secreting profile. Clin Transplant 13:65-74
16. OK Lee N, Malacko AR, Ishitani A, Chen MC, Bajorath J, Marquardt H, Geraghty DE (1995) The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association. Immunity 3:591-600
17. OK Blaschitz A, Juch H, Volz A, Hutter H, Daxboeck C, Desoye G (2005) The soluble pool of HLA-G produced by human trophoblast does not contain the intro 4-derived peptide. Mol Hum Reprod 11:699-710
18. Bainbridge DR, Ellis S, Sarget IL (2000) The short forms of HLAG are unlikely to play a role in pregnancy because they are not expressed at the cell surface. J Reprod Immunol 47:1-16
19. OK Ulbrecht M, Maier S, Hofmeister C, Falk CS, Brooks AG, McMaster MT et al (2004) Truncated HLA-G isoforms are retained in the endoplasmic reticulum and insuficiently provide HLA-E ligands. Hum Immunol 65:200-208
20. OK Ven VD, Skrabin KS, Engels G, Krebs D (1998) HLA-G polymorphisms and allele frequencies in Caucasians. Hum Immunol 59:302
21. OK Yie S, Li L, Li G, Xiao R, Librach C (2006) Progestrone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitro. Hum Reprod 21:46-51
22. OK Moreau P, Moullot G, Rousseau P, Marcou C, Dausset J, Carosella D (2002) HLA-G gene repression is reversed by demethylation. Proc Natl Acad Sci USA 3:1191-1196