Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood

Diabetes Care

Volumn 34, Issue 9, 2011, Pages 2061-2066

  Ortega Senovilla, Henar ^a   Schaefer Graf, Ute ^b   Meitzner, Katrin ^b   Abou Dakn, Michael ^b   Graf, Kristof ^c,d   Kintscher, Ulrich ^e   Herrera, Emilio ^a  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

^b St Joseph's Hospital   (Germany)

^c DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^d Jewish Hospital   (Germany)

^e DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FATTY ACID; FATTY ACID BINDING PROTEIN 4; GLUCOSE; GLYCEROL; INSULIN; LEPTIN; RETINOL BINDING PROTEIN 4; ADIPOCYTOKINE; FATTY ACID BINDING PROTEIN;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY ACID BLOOD LEVEL; FEMALE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MATERNAL BLOOD; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PROTEIN BLOOD LEVEL; PUERPERIUM; UMBILICAL CORD BLOOD; BLOOD; FETUS BLOOD; METABOLISM; PATHOPHYSIOLOGY; PREGNANCY;

ADIPOKINES; ADIPONECTIN; ADULT; DIABETES, GESTATIONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY ACID-BINDING PROTEINS; FEMALE; FETAL BLOOD; HUMANS; INSULIN; LEPTIN; PREGNANCY;

EID: 84860814671     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc11-0715     Document Type: Article

References (25)

1. Herrera E, Ortega H. Metabolism in Normal Pregnancy. In Textbook of Diabetes and Pregnancy. Second Edition. Hod M, Jovanovic L, Renzo GCd, Leiva A, Langer O, Eds. London, Informa Heath Care, 2008, p. 25-34
2. Leary J, Pettitt DJ, Jovanovic L. Gestational diabetes guidelines in a HAPO world. Best Pract Res Clin Endocrinol Metab 2010;24:673-685
3. Metzger BE, Lowe LP, Dyer AR, et al.;HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358:1991-2002
4. Robitaille J, Grant AM. The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus. Genet Med 2008;10:240-250 (Pubitemid 351544125)
5. Poulos SP, Hausman DB, Hausman GJ. The development and endocrine functions of adipose tissue. Mol Cell Endocrinol 2010;323:20-34
6. Coe NR, Bernlohr DA. Physiological properties and functions of intracellular fatty acid-binding proteins. Biochim Biophys Acta 1998;1391:287-306 (Pubitemid 28202126)
7. Smith AJ, Thompson BR, Sanders MA, Bernlohr DA. Interaction of the adipocyte fatty acid-binding protein with the hormone-sensitive lipase: regulation by fatty acids and phosphorylation. J Biol Chem 2007;282:32424-32432 (Pubitemid 350106440)
8. Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 1996;274:1377-1379 (Pubitemid 26391462)
9. Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 2000;141:3388-3396 (Pubitemid 32269028)
10. Xu A, Wang Y, Xu JY, et al. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem 2006;52:405-413
11. Tso AW, Xu A, Sham PC, et al. Serum adipocyte fatty acid binding protein as a newbiomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes Care 2007;30:2667-2672 (Pubitemid 47547818)
12. Kralisch S, Stepan H, Kratzsch J, et al. Serumlevels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus. Eur J Endocrinol 2009;160:33-38
13. Schaefer-Graf UM, Meitzner K, Ortega- Senovilla H, et al. Differences in the implications of maternal lipids on fetal metabolism and growth between gestational diabetes mellitus and control pregnancies. Diabet Med. In press
14. Schaefer-Graf UM, Graf K, Kulbacka I, et al. Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care 2008;31:1858-1863
15. Catalano PM, Tyzbir ED, Allen SR, McBean JH, McAuliffe TL. Evaluation of fetal growth by estimation of neonatal body composition. Obstet Gynecol 1992;79:46-50
16. Engl J, Ciardi C, Tatarczyk T, et al. A-FABP-a biomarker associated with the metabolic syndrome and/or an indicator of weight change? Obesity (Silver Spring) 2008;16:1838-1842
17. Geary M, Pringle PJ, Persaud M, et al. Leptin concentrations in maternal serum and cord blood: relationship to maternal anthropometry and fetal growth. Br J Obstet Gynaecol 1999;106:1054-1060 (Pubitemid 29457088)
18. Kuriyama H, Shimomura I, Kishida K, et al. Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes 2002;51:2915-2921
19. Hay WW Jr, Raju TN, Higgins RD, Kalhan SC, Devaskar SU. Knowledge gaps and research needs for understanding and treating neonatal hypoglycemia: workshop report from Eunice Kennedy Shriver National Institute of Child Health and Human Development. J Pediatr 2009;155:612-617
20. Herrera E, Ortega-Senovilla H. Disturbances in lipid metabolism in diabetic pregnancy - Are these the cause of the problem? Best Pract Res Clin Endocrinol Metab 2010;24:515-525
21. Retnakaran R, Hanley AJ, Raif N, Connelly PW, Sermer M, Zinman B. Reduced adiponectin concentration in women with gestational diabetes: a potential factor in progression to type 2 diabetes. Diabetes Care 2004;27:799-800 (Pubitemid 38280554)
22. Cortelazzi D, Corbetta S, Ronzoni S, et al. Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnancies.Clin Endocrinol (Oxf) 2007;66:447-453 (Pubitemid 46239308)
23. Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005;436:356-362 (Pubitemid 41065039)
24. Mazaki-Tovi S, Romero R, Vaisbuch E, et al. Retinol-binding protein 4: a novel adipokine implicated in the genesis of LGA in the absence of gestational diabetes mellitus. J Perinat Med 2010;38:147-155
25. Chan TF, Chen HS, Chen YC, et al. Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus. Reprod Sci 2007;14:169-174