Visualization of Sex-dimorphic changes in the intestinal transcriptome of fabp2 gene-ablated mice

Journal of Nutrigenetics and Nutrigenomics

Volumn 5, Issue 1, 2012, Pages 45-55

  Sugiyama, Michael G ^a   Hobson, Luc ^a   Agellon, Al B ^b   Agellon, Luis B ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Fatty acid binding proteins; KEGG pathways; Lipid metabolism; Method; Sex differences; Small intestine; Transcriptome analysis

Indexed keywords

FATTY ACID BINDING PROTEIN 2; TRANSCRIPTOME; UNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE LOSS; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; SEX DIFFERENCE; SMALL INTESTINE; XENOBIOTIC METABOLISM;

ANIMALS; DOWN-REGULATION; FATTY ACID-BINDING PROTEINS; FEMALE; INTESTINES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SEX CHARACTERISTICS; TRANSCRIPTOME; UP-REGULATION;

MUS;

EID: 84860800403     PISSN: 16616499     EISSN: 16616758     Source Type: Journal    
DOI: 10.1159/000337193     Document Type: Article

References (39)

1. Sugiyama MG, Agellon LB: Sex differences in lipid metabolism and metabolic disease risk. Biochem Cell Biol 2012, DOI: 10.1139/o11-067.
2. Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L: Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J Exp Med 2007; 204: 321-330.
3. Jalouli M, Carlsson L, Ameen C, Linden D, Ljungberg A, Michalik L, Eden S, Wahli W, Oscarsson J: Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones. Endocrinology 2003; 144: 101-109.
4. Kadowaki K, Fukino K, Negishi E, Ueno K: Sex differences in PPARgamma expressions in rat adipose tissues. Biol Pharm Bull 2007; 30: 818-820.
5. Gatti DM, Zhao N, Chesler EJ, Bradford BU, Shabalin AA, Yordanova R, Lu L, Rusyn I: Sex-specific gene expression in the BXD mouse liver. Physiol Genomics 2010; 42: 456-468.
6. Lofgren S, Baldwin RM, Hiratsuka M, Lindqvist A, Carlberg A, Sim SC, Schulke M, Snait M, Edenro A, Fransson- Steen R, Terelius Y, Ingelman-Sundberg M: Generation of mice transgenic for human CYP2C18 and CYP2C19: characterization of the sexually dimorphic gene and enzyme expression. Drug Metab Dispos 2008; 36: 955-962.
7. Sakuma T, Masaki K, Itoh S, Yokoi T, Kamataki T: Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs. Mol Pharmacol 1994; 45: 228-236.
8. Scandlyn MJ, Stuart EC, Rosengren RJ: Sex-specific differences in CYP450 isoforms in humans. Expert Opin Drug Metab Toxicol 2008; 4: 413-424.
9. Yoon M, Jeong S, Nicol CJ, Lee H, Han M, Kim JJ, Seo YJ, Ryu C, Oh GT: Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism. Exp Mol Med 2002; 34: 481-488.
10. Jeong S, Yoon M: Inhibition of the actions of peroxisome proliferator-activated receptor alpha on obesity by estrogen. Obesity (Silver Spring) 2007; 15: 1430-1440.
11. Tai ES, bin Ali A, Zhang Q, Loh LM, Tan CE, Retnam L, El Oakley RM, Lim SK: Hepatic expression of PPARalpha, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner. FEBS Lett 2003; 546: 237-240.
12. Kawashima Y, Uy-Yu N, Kozuka H: Sex-related differences in the enhancing effects of perfluoro-octanoic acid on stearoyl-CoA desaturase and its influence on the acyl composition of phospholipid in rat liver. Comparison with clofibric acid and tiadenol. Biochem J 1989; 263: 897-904.
13. Agellon LB, Toth MJ, Thomson AB: Intracellular lipid binding proteins of the small intestine. Mol Cell Biochem 2002; 239: 79-82.
14. Richieri GV, Ogata RT, Zimmerman AW, Veerkamp JH, Kleinfeld AM: Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. Biochemistry 2000; 39: 7197-7204.
15. Vassileva G, Huwyler L, Poirier K, Agellon LB, Toth MJ: The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice. FASEB J 2000; 14: 2040-2046.
16. Agellon LB, Drozdowski L, Li L, Iordache C, Luong L, Clandinin MT, Uwiera RR, Toth MJ, Thomson AB: Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver. Biochim Biophys Acta 2007; 1771: 1283-1288.
17. Agellon LB, Li L, Luong L, Uwiera RR: Adaptations to the loss of intestinal fatty acid binding protein in mice. Mol Cell Biochem 2006; 284: 159-166.
18. Chomczynski P, Sacchi N: Single-step method of rna isolation by acid guanidinium thiocyanate phenol chloroform extraction. Analytical Biochemistry 1987; 162: 156-159.
19. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4: 249-264.
20. Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001; 98: 5116-5121.
21. Zhang B, Kirov S, Snoddy J: Webgestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res 2005; 33:W741-W748.
22. Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M: KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 2010; 38:D355-D360.
23. Sheardown SA, Duthie SM, Johnston CM, Newall AE, Formstone EJ, Arkell RM, Nesterova TB, Alghisi GC, Rastan S, Brockdorff N: Stabilization of Xist RNA mediates initiation of X chromosome inactivation. Cell 1997; 91: 99-107.
24. Ditton HJ, Zimmer J, Kamp C, Rajpert-De Meyts E, Vogt PH: The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control. Hum Mol Genet 2004; 13: 2333-2341.
25. Jensen MD: Gender differences in regional fatty acid metabolism before and after meal ingestion. J Clin Invest 1995; 96: 2297-2303.
26. Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga M: MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006; 116: 1494-1505.
27. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M: IKKbeta links inflammation to obesity-induced insulin resistance. Nat Med 2005; 11: 191-198.
28. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821-1830.
29. Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY: Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes 2001; 50: 69-76.
30. Rolf B, Oudenampsen-Kruger E, Borchers T, Faergeman NJ, Knudsen J, Lezius A, Spener F: Analysis of the ligand binding properties of recombinant bovine liver-type fatty acid binding protein. Biochim Biophys Acta 1995; 1259: 245-253.
31. Bunger M, van den Bosch HM, van der Meijde J, Kersten S, Hooiveld GJ, Muller M: Genome-wide analysis of PPARalpha activation in murine small intestine. Physiol Genomics 2007; 30: 192-204.
32. Mahan JT, Heda GD, Rao RH, Mansbach CM 2nd: The intestine expresses pancreatic triacylglycerol lipase: regulation by dietary lipid. Am J Physiol Gastrointest Liver Physiol 2001; 280:G1187-G1196.
33. Lagakos WS, Gajda AM, Agellon L, Binas B, Choi V, Mandap B, Russnak T, Zhou YX, Storch J: Different functions of intestinal and liver-type fatty acid-binding proteins in intestine and in whole body energy homeostasis. Am J Physiol Gastrointest Liver Physiol 2011; 300:G803-G814.
34. Baier LJ, Sacchettini JC, Knowler WC, Eads J, Paolisso G, Tataranni PA, Mochizuki H, Bennett PH, Bogardus C, Prochazka M: An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest 1995; 95: 1281-1287.
35. Formanack ML, Baier LJ: Variation in the FABP2 promoter affects gene expression: implications for prior association studies. Diabetologia 2004; 47: 349-351.
36. Damcott CM, Feingold E, Moffett SP, Barmada MM, Marshall JA, Hamman RF, Ferrell RE: Variation in the FABP2 promoter alters transcriptional activity and is associated with body composition and plasma lipid levels. Hum Genet 2003; 112: 610-616.
37. Helwig U, Rubin D, Klapper M, Li Y, Nothnagel M, Folsch UR, Doring F, Schreiber S, Schrezenmeir J: The association of fatty acid-binding protein 2 A54T polymorphism with postprandial lipemia depends on promoter variability. Metabolism 2007; 56: 723-731.
38. Li Y, Fisher E, Klapper M, Boeing H, Pfeiffer A, Hampe J, Schreiber S, Burwinkel B, Schrezenmeir J, Doring F: Association between functional FABP2 promoter haplotype and type 2 diabetes. Horm Metab Res 2006; 38: 300-307.
39. Geschonke K, Klempt M, Lynch N, Schreiber S, Fenselau S, Schrezenmeir J: Detection of a promoter polymorphism in the gene of intestinal fatty acid binding protein (I-FABP). Ann N Y Acad Sci 2002; 967: 548-553.