Local anaesthetics and their adjuncts

Hatch and Sumner's Textbook of Paediatric Anaesthesia Third Edition

Volumn , Issue , 2003, Pages 211-225

  Mazoit, Jean Xavier ^a   Lönnqvist, Per Arne ^b  

^a BICÊTRE HOSPITAL   (France)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84860786228     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (112)

1. Bösenberg AT, Thomas J, Cronje L et al. Pharmacokinetics and efficacy of ropivacaine for continuous epidural infusion in neonates and infants. Paediatr Anaesth 2005; 15(9): 739-49.
2. Hager H, Marhofer P, Sitzwohl C et al. Caudal clonidine prolongs analgesia from caudal S(+)-ketamine in children. Anesth Analg 2002; 94(5): 1169-72.
3. Lerman J, Nolan J, Eyres R et al. Efficacy, safety, and pharmacokinetics of levobupivacaine with and without fentanyl after continuous epidural infusion in children: a multicenter trial. Anesthesiology 2003; 99(5): 1166-74.
4. Mazoit JX, Dalens BJ. Pharmacokinetics of local anaesthetics in infants and children. Clin Pharmacokinet 2004; 43: 17-32.
5. Mazoit JX, Decaux A, Bouaziz H, Edouard A. Comparative ventricular electrophysiologic effect of racemic bupivacaine, levobupivacaine, and ropivacaine on the isolated rabbit heart. Anesthesiology 2000; 93: 784-92.
6. Denson DD, Mazoit JX. Physiology and pharmacology of local anesthetics. In: Sinatra RS. Acute pain mechanisms and management. St Louis, MO: Mosby, 1992: 124-39.
7. Cartwright PD, Fyhr P. The manufacture and storage of local anesthetics. Reg Anesth 1988; 13: 1-12.
8. Mazoit JX, Dalens BJ. Pharmacokinetics of local anaesthetics in infants and children. Clin Pharmacokinet 2004; 43: 17-32.
9. Tucker GT, Boyes RN, Bridenbaugh PO, Moore DC. Binding of anilide-type local anesthetics in human plasma. I. Relationships between binding, physicochemical properties, and anesthetic activity. Anesthesiology 1970; 33: 287-303.
10. Denson DD, Coyle DE, Thompson GA, Myers JA. Alpha1-acid glycoprotein and albumin in human serum bupivacaine binding. Clin Pharmacol Ther 1984; 35: 409-15.
11. Mazoit JX, Denson DD, Samii K. Pharmacokinetics of bupivacaine following caudal anesthesia in infants. Anesthesiology 1988; 68: 387-91.
12. Booker PD, Taylor C, Saba G. Perioperative changes in alpha1-acid glycoprotein concentrations in infants undergoing major surgery. Br J Anaesth 1996; 76: 365-8.
13. Meunier JF, Goujard E, Dubousset AM et al. Pharmacokinetics of bupivacaine after continuous epidural infusion in infants with and without biliary atresia. Anesthesiology 2001; 95: 87-95.
14. Sitbon P, Laffon M, Lesage V et al. Lidocaine plasma concentrations in pediatric patients after providing airway topical anesthesia from a calibrated device. Anesth Analg 1996; 82: 1003-6.
15. Taddio A, Ohlsson A, Einarson TR et al. Systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics 1998; 101: E1.
16. Russell SC, Doyle E. A risk-benefit assessment of topical percutaneous local anaesthetics in children. Drug Safety 1997; 16: 279-87.
17. Wachi A, Kudo S, Sato K. Characteristics of cerebrospinal fluid circulation in infants as detected with MR velocity imaging. Child Nerv Syst 1995; 11: 227-30.
18. Higuchi H, Adachi Y, Kazama T. 2004; Factors affecting the spread and duration of epidural anesthesia with ropivacaine. Anesthesiology 101: 451-60.
19. Burm AGL. Clinical pharmacokinetics of epidural and spinal anesthesia. Clin Pharmacokinet 1989; 16: 283-311.
20. Lonnqvist PA, Westrin P, Larsson BA et al. Ropivacaine pharmacokinetics after caudal block in 1-8-year-old children. Br J Anaesth 2000; 85: 506-11.
21. Chalkiadis GA, Eyres RL, Cranswick N et al. Pharmacokinetics of levobupivacaine 0.25% following caudal administration in children under 2 years of age. Br J Anaesth 2004; 92: 218-22.
22. van Obbergh LJ, Roelants FA, Veyckemans F, Verbeeck RK. In children, the addition of epinephrine modifies the pharmacokinetics of ropivacaine injected caudally. Can J Anaesth 2003; 50: 593-8.
23. Flandin-Blety C, Barrier G. Accidents following extradural analgesia in children. The results of a retrospective study. Paediatric Anaesth 1995; 5: 41-46.
24. Gantenbein M, Attolini L, Bruguerolle B et al. Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3 A. Drug Metab Dispos 2000; 28: 383-5.
25. Arlander E, Ekstrom G, Alm C et al. Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4. An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors. Clin Pharmacol Ther 1998; 64: 484-91.
26. Hines RN, McCarver DG. The ontogeny of human drugmetabolizing enzymes: phase I oxidative enzymes. J Pharm Exp Ther 2002; 300: 355-60.
27. Hansen TG, Ilett KF, Reid C et al. Caudal ropivacaine in infants: population pharmacokinetics and plasma concentrations. Anesthesiology 2001; 94: 579-584.
28. Rapp HJ, Molnar V, Austin S et al. September; Ropivacaine in neonates and infants: a population pharmacokinetic evaluation following single caudal block. Paediatr Anaesth 2004; 14: 724-32.
29. Bosenberg AT, Thomas J, Cronje L et al. Pharmacokinetics and efficacy of ropivacaine for continuous epidural infusion in neonates and infants. Paediatr Anaesth 2005; 15: 739-49.
30. McCann ME, Sethna NF, Mazoit JX et al. The pharmacokinetics of epidural ropivacaine in infants and young children. Anesth Analg 2001; 93: 893-7.
31. Luz G, Wieser C, Innerhofer P et al. Free and total bupivacaine plasma concentrations after continuous epidural anaesthesia in infants and children. Paediatr Anaesth 1998; 8: 473-8.
32. Wulf H, Peters C, Behnke H. The pharmacokinetics of caudal ropivacaine 0.2% in children. A study of infants aged less than 1 year and toddlers aged 1-5 years undergoing inguinal hernia repair. Anaesthesia 2000; 55: 757-60.
33. Catterall WA. Molecular mechanisms of gating and drug block of sodium channels. Novartis Found Symp 2002; 241: 206-18.
34. Longobardo M, Delpon E, Caballero R et al. Structural determinants of potency and stereoselective block of hKv1.5 channels induced by local anesthetics. Mol Pharmacol 1998; 54: 162-9.
35. Gonzalez T, Arias C, Caballero R et al. Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block. Br J Pharmacol 2002; 137: 1269-79.
36. 2+ channels? Br J Anaesth 1997; 78: 185-8.
37. 2+ release channel of skeletal and cardiac muscles. Anesthesiology 1999; 90: 835-43.
38. Vabnick I, Novakovic SD, Levinson SR et al. The clustering of axonal sodium channels during development of the peripheral nervous system. J Neurosci 1996; 16: 4914-22.
39. Rasband MN, Trimmer JS. Developmental clustering of ion channels at and near the node of Ranvier. Dev Biol 2001; 236: 5-16.
40. Raymond SA, Thalhammer JG, Strichartz GR. Axonal excitability. endogenous and exogenous modulation. In: Dimitrijevic R, ed. Altered sensation and pain. Recent achievement in restorative neurology, Vol. 3 Basel: Karger, 1990.
41. Benzon HT, Strichartz GR, Gissen AJ et al. Developmental neurophysiology of mammalian peripheral nerves and agerelated differential sensitivity to local anaesthetics. Br J Anaesth 1988; 61: 754-60.
42. Kohane DS, Sankar WN, Shubina M et al. Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. Anesthesiology 1998; 89: 1199-208.
43. Booth D, Evans DJ. Anticonvulsants for neonates with seizures. Cochrane Database Syst Rev 2004; (4): CD004218.
44. de La Coussaye J, Brugada J, Allessie MA. Electrophysiologic and arrhythmogenic effects of bupivacaine. A study with high-resolution ventricular epicardial mapping in rabbit hearts. Anesthesiology 1992; 77: 32-41.
45. Mazoit JX, Decaux A, Bouaziz H, Edouard A. Comparative ventricular electrophysiologic effect of racemic bupivacaine, levobupivacaine, and ropivacaine on the isolated rabbit heart. Anesthesiology 2000; 93: 784-92.
46. Simon L, Kariya N, Edouard A et al. Effect of bupivacaine on the isolated rabbit heart: developmental aspect on ventricular conduction and contractility. Anesthesiology 2004; 101: 937-44.
47. Iida H, Watanabe Y, Dohi S, Ishiyama T. Direct effects of ropivacaine and bupivacaine on spinal pial vessels in canine. Assessment with closed spinal window technique. Anesthesiology 1997; 87: 75-81.
48. Burke D, Joypaul V, Thomson MF. Circumcision supplemented by dorsal penile nerve block with 0.75% ropivacaine: A complication. Reg Anesth Pain Med 2000; 25: 424-7.
49. Vladimirov M, Nau C, Mok WM, Strichartz G. Potency of bupivacaine stereoisomers tested in vitro and in vivo. biochemical, electrophysiological, and neurobehavioral studies. Anesthesiology 2000; 93: 744-55.
50. Groban L, Deal DD, Vernon JC et al. Does local anesthetic stereoselectivity or structure predict myocardial depression in anesthetized canines? Reg Anesth Pain Med 2002; 27: 460-8.
51. Odoom JA, Sturk A, Dokter PWC et al. The effects of bupivacaine and pipecoloxylidide on platelet function in vitro. Acta Anaesthesiol Scand 1989; 33: 385-8.
52. Hollmann MW, Gross A, Jelacin N, Durieux ME. Local anesthetic effects on priming and activation of human neutrophils. Anesthesiology 2001; 95: 113-22.
53. Beloeil H, Asehnoune K, Moine P et al. Bupivacaine’s action on the carrageenan-induced inflammatory response in mice: cytokine production by leukocytes after ex-vivo stimulation. Anesth Analg 2005; 100: 1081-6.
54. Leduc C, Gentili ME, Estebe JP et al. Inhibition of peroxidation by local anesthetic in an inflammatory rat model with carrageenan. Anesth Analg 2002; 95: 992-6.
55. Rowbotham MC, Reisner-Keller LA, Fields HL. Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurology 1991; 41: 1024-8.
56. Linchitz RM, Raheb JC. Subcutaneous infusion of lidocaine provides effective pain relief for CRPS patients. Clin J Pain 1999; 15: 67-72.
57. Dadure C, Motais F, Ricard C et al. Continuous peripheral nerve blocks at home for treatment of recurrent complex regional pain syndrome I in children. Anesthesiology 2005; 102: 387-91.
58. Freedman JM, De-Kun I, Drasner K et al. Transient neurologic symptoms after spinal anesthesia. Anesthesiology 1998; 89: 633-41.
59. Newman RJ, Radda GK. The myotoxicity of bupivacaine, a 31P NMR investigation. Br J Pharmacol 1983; 79: 395-9.
60. 2+ regulation in murine skeletal muscle fibers. Anesthesiology 2005; 102: 793-8.
61. Sztark F, Nouette-Gaulain K, Malgat M et al. Absence of stereospecific effects of bupivacaine isomers on heart mitochondrial bioenergetics. Anesthesiology 2000; 93: 456-62.
62. Murat I, Esteve C, Montay G et al. Pharmacokinetics and cardiovascular effects of bupivacaine during epidural anesthesia in children with Duchenne muscular dystrophy. Anesthesiology 1987; 67: 249-52.
63. Brown DL, Ransom DM, Hall JA et al. Regional anesthesia and local anesthetic-induced systemic toxicity. seizure frequency and accompanying cardiovascular changes. Anesth Analg 1995; 81: 321-8.
64. Klein SM, Pierce T, Rubin Y et al. Successful resuscitation after ropivacaine-induced ventricular fibrillation. Anesth Analg 2003; 97: 901-3.
65. Huet O, Eyrolle LJ, Mazoit JX, Ozier YM. Cardiac arrest after injection of ropivacaine for posterior lumbar plexus blockade. Anesthesiology 2003; 99: 1451-3.
66. Weinberg G. Lipid rescue resuscitation from local anaesthetic cardiac toxicity. Toxicol Rev 2006; 25: 139-45.
67. Sanders JC. Paediatric regional anaesthesia, a survey of practice in the United Kingdom. Br J Anaesth 2002; 89: 707-10.
68. Lonnqvist PA. Adjuncts to caudal block in children - Quo vadis? Br J Anaesth 2005; 95: 431-3.
69. Wolf AR, Hughes D, Hobbs AJ, Prys-Roberts C. Combined morphine-bupivacaine caudals for reconstructive penile surgery in children: systemic absorption of morphine and postoperative analgesia. Anaesth Intens Care 1991; 19: 17-21.
70. Attia J, Ecoffey C, Sandouk P et al. Epidural morphine in children: pharmacokinetics and CO2 sensitivity. Anesthesiology 1986; 65: 590-4.
71. Nicholas DG, Yaster M, Lynn AM et al. Disposition and respiratory effects of intrathecal morphine in children. Anesthesiology 1993; 79: 73-8.
72. Manach A, Estebe JP, le Naoures A Bentue-Ferre D et al. Determination of fentanyl in the plasma during caudal anesthesia in children. Cah d’anesthesiol 1987; 35: 409-11.
73. Lejus C, Schwoerer D, Furic I et al. Fentanyl versus sufentanil: plasma concentrations during continuous epidural postoperative infusion in children. Br J Anaesth 2000; 85: 615-17.
74. Ivani G, Bergendahl HT, Lampugnani E et al. Plasma levels of clonidine following epidural bolus injection in children. Acta Anaesthesiol Scand 1998; 42: 306-11.
75. Krane EJ, Tyler DC, Jacobson LE. The dose-response of caudal morphine in children. Anesthesiology 1989; 71: 48-52.
76. Rosen KR, Rosen DA. Caudal epidural morphine for control of pain following open heart surgery in children. Anesthesiology 1989; 70: 418-21.
77. Campbell FA, Yentis SM, Fear DW, Bissonnette B. Analgesic efficacy and safety of a caudal bupivacaine-fentanyl mixture in children. Can J Anaesth 1992; 39: 661-4.
78. Constant I, Gall O, Gouyet L et al. Addition of clonidine or fentanyl to local anaesthetics prolongs the duration of surgical analgesia after single shot caudal block in children. Br J Anaesth 1998; 80: 294-8.
79. Baris S, Karakaya D, Kelsaka E et al. Comparison of fentanyl-bupivacaine or midazolam-bupivacaine mixtures with plain bupivacaine for caudal anaesthesia in children. Paediatr Anaesth 2003; 13: 126-31.
80. Khan FA, Memon GA, Kamal RS. Effect of route of buprenorphine on recovery and postoperative analgesic requirement in paediatric patients. Paediatr Anaesth 2002; 12: 786-90.
81. Benlabed M, Ecoffey C, Levron JC et al. Analgesia and ventilatory response to CO2 following epidural sufentanil in children. Anesthesiology 1987; 67: 948-51.
82. Kokki H, Ruuskanen A, Karvinen M. Comparison of epidural pain treatment with sufentanil-ropivacaine infusion with and without epinephrine in children. Acta Anaesthesiol Scand 2002; 46: 647-53.
83. Kart T, Walther-Larsen S, Svejborg TF et al. Comparison of continuous epidural infusion of fentanyl and bupivacaine with intermittent epidural administration of morphine for postoperative pain management in children. Acta Anaesthesiol Scand 1997; 41: 461-5.
84. Lejus C, Surbled M, Schwoerer D et al. Postoperative epidural analgesia with bupivacaine and fentanyl: hourly pain assessment in 348 paediatric cases. Paediatr Anaesth 2001; 11: 327-32.
85. Lerman J, Nolan J, Eyres R et al. Efficacy, safety, and pharmacokinetics of levobupivacaine with and without fentanyl after continuous epidural infusion in children: a multicenter trial. Anesthesiology 2003; 99: 1166-74.
86. Berde CB. Epidural analgesia in children. Can J Anaesth 1994; 41: 555-60.
87. Lonnqvist PA, Ivani G, Moriarty T. Use of caudal-epidural opioids in children: still state of the art or the beginning of the end? Paediatr Anaesth 2002; 12: 747-9.
88. Lloyd-Thomas AR, Howard RF. A pain service for children. Paediatr Anaesth 1994; 4: 3-15.
89. Lee JJ, Rubin AP. Comparison of a bupivacaine-clonidine mixture with plain bupivacaine for caudal analgesia in children. Br J Anaesth 1994; 72: 258-62.
90. Jamali S, Monin S, Begon C et al. Clonidine in pediatric caudal anesthesia. Anesth Analg 1994; 78: 663-6.
91. Ivani G, De Negri P, Conio A et al. Ropivacaine-clonidine combination for caudal blockade in children. Acta Anaesthesiol Scandi 2000; 44: 446-9.
92. Nishina K, Mikawa K, Shiga M, Obara H. Clonidine in paediatric anaesthesia. Paediatr Anaesth 1999; 9: 187-202.
93. De Negri P, Ivani G, Visconti C et al. The dose-response relationship for clonidine added to a postoperative continuous epidural infusion of ropivacaine in children. Anesth Analg 2001; 93: 71-76.
94. Bergendahl HTG, Lonnqvist PA, De Negri P et al. Increased postoperative arterial blood pressure stability with continuous epidural infusion of clonidine in children. Anesth Analg 2002; 95: 1121-2.
95. Cook B, Grubb DJ, Aldridge LA, Doyle E. Comparison of the effects of adrenaline, clonidine and ketamine on the duration of caudal analgesia produced by bupivacaine in children. Br J Anaesth 1995; 75: 698-701.
96. Semple D, Findlow D, Aldridge LM, Doyle E. The optimal dose of ketamine for caudal epidural blockade in children. Anaesthesia 1996; 51: 1170-2.
97. Panjabi N, Prakash S, Gupta P, Gogia AR. Efficacy of three doses of ketamine with bupivacaine for caudal analgesia in pediatric inguinal herniotomy. Reg Anesth Pain Med 2004; 29: 28-31.
98. Naguib M, Sharif AM, Seraj M et al. Ketamine for caudal analgesia in children: comparison with caudal bupivacaine. Br J Anaesth 1991; 67: 559-64.
99. Marhofer P, Krenn CG, Plochl W et al. S(+)-ketamine for caudal block in paediatric anaesthesia. Br J Anaesth 2000; 84: 341-5.
100. Hager H, Marhofer P, Sitzwohl C et al. Caudal clonidine prolongs analgesia from caudal S(+)-ketamine in children. Anesth Analg 2002; 94: 1169-72.
101. Passariello M, Almenrader N, Canneti A et al. Caudal analgesia in children: S(+)-ketamine vs. S(+)-ketamine plus clonidine. Paediatr Anaesth 2004; 14: 851-5.
102. Malinovsky JM, Servin F, Cozian A et al. Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children. Br J Anaesth 1996; 77: 203-7.
103. Gall O, Aubineau JV, Berniere J et al. Analgesic effect of low-dose intrathecal morphine after spinal fusion in children. Anesthesiology 2001; 94: 447-52.
104. Harris MM, Kahana MD, Park TS. Intrathecal morphine for postoperative analgesia in children after selective dorsal root rhizotomy. Neurosurgery 1991; 28: 519-22.
105. Jones SE, Beasley JM, Macfarlane DW et al. Intrathecal morphine for postoperative pain relief in children. Br J Anaesth 1984; 56: 137-40.
106. Suominen PK, Ragg PG, McKinley DF et al. Intrathecal morphine provides effective and safe analgesia in children after cardiac surgery. Acta Anaesthesiol Scand 2004; 48: 875-2.
107. Tobias JD, Mateo C, Ferrer MJ et al. Intrathecal morphine for postoperative analgesia following repair of frontal encephaloceles in children: comparison with intermittent, ondemand dosing of nalbuphine. J Clin. Anesth 1997; 9: 280-4.
108. Hammer GB, Ramamoorthy C, Cao H et al. Postoperative analgesia after spinal blockade in infants and children undergoing cardiac surgery. Anesth Analg 2005; 100: 1283-8.
109. Kaabachi O, Ben Rajeb A, Mebazaa M et al. Spinal anesthesia in children: comparative study of hyperbaric bupivacaine with or without clonidine. Ann Fr Anesth Reanim 2002; 21: 617-21.
110. Rochette A, Raux O, Troncin R et al. Clonidine prolongs spinal anesthesia in newborns: a prospective dose-ranging study. Anesth Analg 2004; 98: 56-9.
111. Ivani G, Conio A, De Negri P et al. Spinal vs peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine-clonidine mixture when administered as a caudal or ilioinguinal-iliohypogastric nerve blockade for inguinal surgery in children. Paediatr Anaesth 2002; 12: 680-4.
112. Giannoni C, White S, Enneking FK, Morey T. Ropivacaine with or without clonidine improves pediatric tonsillectomy pain. Arch Otolaryngol Head Neck Surg 2001; 127: 1265-70.