Sensitive detection of drug vapors using an ion funnel interface for secondary electrospray ionization mass spectrometry

Journal of Mass Spectrometry

Volumn 47, Issue 5, 2012, Pages 555-559

  Meier, Lukas ^a   Berchtold, Christian ^a   Schmid, Stefan ^a   Zenobi, Renato ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

biological samples; ion funnel; online mass spectrometry; secondary electrospray ionization; surface analysis

Indexed keywords

AMBIENT PRESSURES; ATENOLOL; BIOLOGICAL SAMPLES; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; ELECTROSPRAYS; GASPHASE; HEADSPACE ANALYSIS; ION FUNNELS; ONLINE MASS SPECTROMETRY; ORDERS OF MAGNITUDE; SALBUTAMOL; SENSITIVE DETECTION;

ELECTROSPRAY IONIZATION; LUNAR SURFACE ANALYSIS; MASS SPECTROMETRY; SURFACE ANALYSIS;

IONS;

ATENOLOL; CALCIUM OXIDE; COCAINE; SALBUTAMOL;

ARTICLE; BANANA; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; INTERFACE PRESSURE; ION FUNNEL INTERFACE; PRIORITY JOURNAL; VAPOR;

GASES; IONS; LIMIT OF DETECTION; PHARMACEUTICAL PREPARATIONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

CITRUS AURANTIIFOLIA;

EID: 84860781112     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.2982     Document Type: Article

References (27)

1. A. El-Faramawy, K. W. M. Siu, B. A. Thomson,. Efficiency of nano-electrospray ionization. J Am Soc Mass Spectrom 2005, 16, 1702.
2. R. D. Smith, J. A. Loo, C. G. Edmonds, C. J. Barinaga, H. R. Udseth,. New developments in biochemical mass spectrometry: electrospray ionization. Anal Chem 1990, 62, 882.
3. Ionoscan Sentinel II, Smiths Detection, Smiths Group, London, UK.
4. GE Entry Scan. General Electric Company, Fairfield, CT, USA.
5. A. O. Soubani, Noninvasive monitoring of oxygen and carbon dioxide. Am J Emerg Med 2001, 19, 141.
6. Carbon Monoxide Sensor, Futurlec, London, UK.
7. A. B. Kanu, P. Dwivedi, M. Tam, L. Matz, H. H. Hill,. Ion mobility-mass spectrometry. J Mass Spectrom 2008, 43, 1.
8. A. Hansel, A. Jordan, R. Holzinger, P. Prazeller, W. Vogel, W. Lindinger,. Proton transfer reaction mass spectrometry: on-line trace gas analysis at the ppb level. Int. J. Mass Spectrom. Ion Processes 1995, 149, 609.
9. N. G. Adams, D. Smith,. The Selected ion flow tube (SIFT): a technique for studying ion-neutral reactions. Int. J. Mass Spectrom. Ion Phys. 1976, 21, 349.
10. P. Španěl, D. Smith,. Progress in SIFT-MS: breath analysis and other applications. Mass Spectrom Rev 2011, 30, 236.
11. C. A. Mayhew, P. Sulzer, F. Petersson, S. Haidacher, A. Jordan, L. Märk, P. Watts, T. D. Märk,. Applications of proton transfer reaction time-of-flight mass spectrometry for the sensitive and rapid real-time detection of solid high explosives. Int. J. Mass Spectrom. 2010, 289, 58.
12. B. M. Ross,. Sub-parts per billion detection of trace volatile chemicals in human breath using selected ion flow tube mass spectrometry. BMC Research Notes 2008, 1, 41.
13. 2-· with a series of sesquiterpenes. Int. J. Mass Spectrom. 2008, 272, 137.
14. 16 monoterpenes. Int. J. Mass Spectrom. 2003, 228, 117.
15. S. Jürschik, P. Sulzer, F. Petersson, C. A. Mayhew, A. Jordan, B. Agarwal, S. Haidacher, H. Seehauser, K. Becker, T. D. Märk,. Proton transfer reaction mass spectrometry for the sensitive and rapid real-time detection of solid high explosives in air and water. Anal Bioanal Chem 2010, 398, 2813.
16. M. Tam, H. H. Hill,. Secondary electrospray ionization-ion mobility spectrometry for explosive vapor detection. Anal Chem 2004, 76, 2741.
17. W. E. Steiner, B. H. Clowers, P. E. Haigh, H. H. Hill,. Secondary ionization of chemical warfare agent stimulants: atmospheric pressure ion mobility time-of-flight mass spectrometry. Anal Chem 2003, 75, 6068.
18. C. Wu, W. F. Siems, H. Hill,. Secondary electrospray ionization ion mobility spectrometry/mass spectrometry of illicit drugs. Anal Chem 2000, 72, 396.
19. P. Martínez-Lozano, J. Rus, de la G. F. Mora, M. Hernández, de la J. F. Mora,. Secondary electrospray ionization (SESI) of ambient vapors for explosive detection at concentrations below parts per trillion. J Am Soc Mass Spectrom 2008, 20, 287.
20. Z. Takats, J. M. Wiseman, B. Gologan, R. G. Cooks,. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 2004, 306, 471.
21. Z. Takats, J. M. Wiseman, R. G. Cooks,. Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms, and applications in forensics, chemistry, and biology. J Mass Spectrom 2005, 40, 1261.
22. M. Yamashita, J. B. Fenn,. Electrospray Ionization source. Another variation on the free-jet theme. J Phys Chem 1984, 88, 4451.
23. R. T. Kelly, A. V. Tolmachev, J. S. Page, K. Tang, R. D. Smith,. The ion funnel: theory, implementations and applications. Mass Spectrom Rev 2010, 29, 294.
24. L. Meier, C. Berchtold, S. Schmid, R. Zenobi,. Extractive electrospray ionization mass spectrometry-enhanced sensitivity using an ion funnel. Anal Chem 2012, 84, 2076.
25. L. Meier, S. Schmid, C. Berchtold, R. Zenobi,. Contribution of liquid-phase and gas-phase ionization in extractive electrospray ionization mass spectrometry of primary amines. Eur. J. Mass Spectrom. 2011, 17, 345.
26. J. M. F. Nogueira, P. J. P. Fernandes, A. M. D. Nascimento,. Composition of volatiles of banana cultivars from Madeira island. Phytochem Anal 2003, 14, 87.
27. M. G. Chisholm, M. A. Wilson, G. M. Gaskey,. Characterization of aroma volatiles in key lime essential oils (Citrus aurantifolia Swingle). Flavour Fragance J. 2003, 18, 106.