Activity enhances dopaminergic long-duration response in Parkinson disease

Neurology

Volumn 78, Issue 15, 2012, Pages 1146-1149

  Kang, Un Jung ^a   Auinger, Peggy ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBIDOPA; LEVODOPA; PLACEBO;

ARTICLE; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DOSE RESPONSE; HANDEDNESS; HUMAN; LONG DURATION RESPONSE; MAJOR CLINICAL STUDY; MOTOR PERFORMANCE; PARKINSON DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); TASK PERFORMANCE; TREATMENT RESPONSE;

EID: 84860750238     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31824f8056     Document Type: Article

References (10)

1. Muenter MD, Tyce GM. L-dopa therapy of Parkinson's disease: Plasma L-dopa concentration, therapeutic response, and side effects. Mayo Clin Proc 1971;46:231-239.
2. Nutt JG, Carter JH, Van Houten L, Woodward WR. Short-and long-duration responses to levodopa during the first year of levodopa therapy. Ann Neurol 1997;42:349-355.
3. Beeler JA, Cao ZF, Kheirbek MA, et al. Dopaminedependent motor learning: Insight into levodopa's longduration response. Ann Neurol 2010;67:639-647.
4. Fahn S, Oakes D, Shoulson I, et al. Levodopa and the progression of Parkinson's disease. N Engl J Med 2004; 351:2498-2508.
5. Zappia M, Bosco D, Plastino M, et al. Pharmacodynamics of the long-duration response to levodopa in PD. Neurology 1999;53:557-560. (Pubitemid 29382051)
6. Nutt JG, Carter JH, Lea ES, Sexton GJ. Evolution of the response to levodopa during the first 4 years of therapy. Ann Neurol 2002;51:686-693. (Pubitemid 34568846)
7. Olanow CW, Rascol O, Hauser R, et al. A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N Engl J Med 2009;361:1268-1278.
8. Bezard E, Gross CE, Brotchie JM. Presymptomatic compensation in Parkinson's disease is not dopaminemediated. Trends Neurosci 2003;26:215-221. (Pubitemid 36412004)
9. Shen W, Flajolet M, Greengard P, Surmeier DJ. Dichotomous dopaminergic control of striatal synaptic plasticity. Science 2008;321:848-851.
10. Di Filippo M, Picconi B, Tantucci M, et al. Short-term and long-term plasticity at corticostriatal synapses: Implications for learning and memory. Behav Brain Res 2009; 199:108-118.