Knee chondral injuries: Clinical treatment strategies and experimental models

Injury

Volumn 43, Issue 6, 2012, Pages 694-705

  Vaquero, Javier ^a   Forriol, Francisco ^b  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

Biotechnology; Cartilage; Chondrocyte transplantation; Microfracture; Osteochondral

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CHONDROITIN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; FIBRIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 18; FIBROBLAST GROWTH FACTOR 2; GELATIN; GROWTH DIFFERENTIATION FACTOR 5; HYALURONIC ACID; OSTEOGENIC PROTEIN 1; POLYDIOXANONE; POLYETHYLENEIMINE; POLYGLACTIN; POLYGLYCOLIC ACID; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT OSTEOGENIC PROTEIN 1; SOMATOMEDIN C; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ALLOGRAFT; ARTHROSCOPIC DEBRIDEMENT; ARTHROSCOPY; ARTICULAR CARTILAGE; BIOCOMPATIBILITY; BIODEGRADABLE IMPLANT; CHONDROCYTE IMPLANTATION; CHONDROPROTECTION; CLINICAL EVALUATION; DIAGNOSTIC ACCURACY; EXPERIMENTAL MODEL; GENE THERAPY; HUMAN; JOINT DEGENERATION; KNEE INJURY; KNEE PAIN; KNEE SURGERY; MICROFRACTURE; MOSAICPLASTY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATELLA; PRIORITY JOURNAL; REVIEW; SHEEP; STEM CELL TRANSPLANTATION; TIBIA; TISSUE REPAIR; TREATMENT INDICATION;

ANIMALS; ARTHROSCOPY; CARTILAGE, ARTICULAR; CHONDROCYTES; DEBRIDEMENT; GOATS; HUMANS; KNEE INJURIES; KNEE JOINT; MAGNETIC RESONANCE IMAGING; MICE; MODELS, ANIMAL; OSSEOINTEGRATION; SHEEP; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TREATMENT OUTCOME;

EID: 84860744986     PISSN: 00201383     EISSN: 18790267     Source Type: Journal    
DOI: 10.1016/j.injury.2011.06.033     Document Type: Review

References (137)

1. J.A. Buckwalter, and H.J. Mankin Articular cartilage, part II: generation and osteoarthrosis, repair, regeneration and transplantation J Bone Joint Surg Am 79 1997 612 632
2. J.E. Bekkers, M. Inklaar, and D.B.F. Saris Treatment selection in articular cartilage lesions of the knee. A systematic review Am J Sports Med 37 2009 148 155
3. A. Aroen, S. Loken, S. Heir, E. Alvik, A. Ekeland, and O.G. Granlund Articular cartilage lesions in 993 consecutive knee arthroscopies Am J Sports Med 32 2004 211 215 (Pubitemid 38141444)
4. M. Brittberg, and C.S. Winalski Evaluation of cartilage injuries and repair J Bone Joint Surg Am 85-A Suppl. 2 2003 58 69 (Pubitemid 36535046)
5. W.W. Curl, J. Krome, E.S. Gordon, J. Rushing, B.P. Smith, and G.G. Poehling Cartilage injuries: a review of 31.516 knee arthroscopies Arthroscopy 13 1997 456 460 (Pubitemid 27344113)
6. K. Hjelle, E. Solheim, T. Strand, R. Muri, and M. Brittberg Articular cartilage defects in 1000 knees arthroscopies Arthroscopy 18 2002 730 734 (Pubitemid 36114627)
7. W. Widuchowski, J. Widuchowski, and T. Trzaska Articular cartilage defects: study of 25,124 knee arthroscopies Knee 14 2007 177 182 (Pubitemid 46695821)
8. L.J. Micheli, J.B. Moseley, A.F. Anderson, J.E. Browne, C. Erggelet, and R. Arciero Articular cartilage defects of the distal femur in children and adolescents: treatment with autologous chondrocyte implantation J Pediatr Orthop 26 2006 455 460 (Pubitemid 44384908)
9. B.J. Cole, C. Pascual-Garrido, and R.C. Grumet Surgical management of articular cartilage defects in the knee J Bone Joint Surg Am 91-A 2009 1778 1790
10. T.S. de Windt, J.E. Bekkers, L.B. Creemers, W.J.A. Dhert, and D.B.F. Saris Patient profiling in cartilage regeneration. Prognostic factors determining success of treatment for cartilage defects Am J Sports Med 39 Suppl. 1 2009 S58 S62
11. P. Niemeyer, J.M. Pestka, P.C. Kreuz, C. Erggelet, H. Schmal, and N.P. Südkamp Characteristic complications after autologous chondrocyte implantation for cartilage defects of the knee joint Am J Sports Med 36 2008 2091 2099
12. K. Zaslav, B. Cole, Brewster, T. DeBerardino, J. Farr, and P. Fowler A prospective study of autologous chondrocyte implantation in patients with failed prior treatment for articular cartilage defect of the knee: results of the Study of the treatment of Articular Repair (STAR) clinical trial Am J Sports Med 37 2009 42 55
13. G. Knutsen, L. Engebretsen, T.C. Ludvigsen, J.O. Drogset, T. Grontvedt, and E. Solheim Autologous chondrocyte implantation compared with microfracture in the knee: a randomized trial J Bone Joint Surg (Am) 86-A 2004 455 464 (Pubitemid 38269014)
14. D.B. Saris, J. Vanlauwe, J. Victor, K.F. Almqvist, R. Verdonk, and J. Bellemans Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized trial versus microfracture Am J Sports Med 36 2008 235 246
15. R. Gudas, R.J. Kalesinskas, V. Kimtys, E. Stankevicius, V. Toilusis, and G. Bernotavicius A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes Arthroscopy 21 2005 1066 1075 (Pubitemid 41323870)
16. J.C. Childers, and S.C. Ellwood Partial chondrectomy and subchondral bone drilling for chondromalacia Clin Orthop Relat Res 144 1979 114 120
17. J.R. Steadman, K.K. Briggs, and J.J. Rodrigo Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up Arthroscopy 19 2003 477 484 (Pubitemid 36560399)
18. D.B. Saris, J. Vanlauwe, J. Victor, K.F. Almqvist, R. Verdonk, and J. Bellemans Treatment of symptomatic cartilage defects of the knee. Characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture Am J Sports Med 37 Suppl. 1 2009 11 19
19. K. Mithoefer, R.J. Williams 3rd, R.F. Warren, H.G. Potter, C.R. Spock, and E.C. Jones The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study J Bone Joint Surg Am 87 A 2005 1911 1920 (Pubitemid 41279120)
20. P.C. Kreuz, M.R. Steinwachs, C. Erggelet, S.J. Krause, S.J. Konrad, and M. Uhl Results after microfracture of full-thickness chondral defects in different compartments in the knee Osteoarthritis Cartilage 14 2006 1119 1125 (Pubitemid 44490314)
21. F. Forriol Growth factors in cartilage and meniscus repair Injury, Int J Care Injured 40 Suppl. 2009 S12 S16
22. E. Merchan, and E. Galindo Arthroscopic-guided surgery versus nonoperative treatment for limited degenerative arthritis of the femorotibial joint in patients over 50 years of age. A prospective comparative study Arthroscopy 9 1993 663 667 (Pubitemid 24004160)
23. J.B. Moseley, K. O'Malley, N.J. Petersen, T.J. Menke, B.A. Brody, and D.H. Kuykendall A controlled trial of arthroscopic surgery for osteoarthritis of the knee N Engl J Med 347 2002 81 88 (Pubitemid 34753477)
24. M.J.S. Hubbard Articular debridement versus washout for degeneration of medial femoral condyle J Bone Joint Surg Br 78-B 1996 217 219
25. F.A. Barber, and N.G. Iwasko Treatment of grade III femoral chondral lesions: mechanical chondroplasty versus monopolar radiofrequency probe Arthroscopy 22 2006 1312 1317 (Pubitemid 44854411)
26. M. Lotz Cytokines in cartilage injury and repair Clin Orthop Relat Res 391 Suppl. 2001 108 115
27. K.H. Pridie A method of resurfacing osteoarthritic knee joints J Bone Joint Surg (Br) 41-B 1959 618 619
28. J.R. Steadman, W.G. Rodkey, and K.K. Briggs Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation, and outcomes J Knee Surg 15 2002 170 176
29. J.R. Steadman, B.S. Miller, S. Karas, T. Schlegel, K. Briggs, and R. Hawkins The microfracture technique in the treatment of chondral lesions of the knee in National Football League players J Knee Surg 2 2003 83 86
30. T. Minas, and S. Nehrer Current concepts in the treatment of articular cartilage defects Orthopedics 20 1997 525 538 (Pubitemid 27255622)
31. S. Wakitani, A. Kawaguchi, Y. Tokuhara, and K. Takaoka Present status of and future direction for articular cartilage repair J Bone Miner Metab 26 2008 115 122 (Pubitemid 351317128)
32. H. Koga, L. Engebretsen, J.E. Brinchmann, T. Muneta, and I. Sekiya Mesenchymal stem cell-based therapy for cartilage repair: a review Knee Surg Sports Traumatol Arthrosc 17 2009 1289 1297
33. K. Mithoefer, T. McAdams, R.J. Williams, P.C. Kreuz, and B.R. Mandelbaum Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis Am J Sports Med 37 2009 2053 2063
34. C. Hoemann, M. Hurtig, E. Rossomacha, J. Sun, A. Chevrier, and M. Shive Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects J Bone Joint Surg (Am) 87-A 2005 2671 2686 (Pubitemid 41748291)
35. H. Chen, J. Sun, C. Hoemann, V. Lascau-Coman, W. Ouyang, and M. McKee Drilling and microfracture lead to different bone structure and necrosis during bone-marrow stimulation for cartilage repair J Orthop Res 27 2009 1432 1438
36. D.L. Cerynik, G.E. Lewullis, B.C. Joves, M.P. Palmer, and J.A. Tom Outcomes of microfracture in professional basketball players Knee Surg Sports Traumatol Arthrosc 17 2009 1135 1139
37. E. Solheim, J. Oyen, J. Hegna, O.K. Austgulen, T. Harlem, and T. Strand Microfracture treatment of single or multiple articular cartilage defects of the knee: a 5-year median follow-up of 110 patients Knee Surg Sports Traumatol Arthrosc 18 2010 504 508
38. K. Mithoefer, K. Hambly, S. Della Villa, H. Silvers, and B.R. Mandelbaum Return to sports participation after articular cartilage repair in the knee Am J Sports Med 37 Suppl. 1 2009 167 176
39. D. van Assche, F. Staes, D. van Caspel, J. Vanlauwe, J. Bellemans, and D.B. Saris Autologous chondrocyte implantation versus microfracture for knee cartilage injury: a prospective randomized trial, with 2-year follow-up Knee Surg Sports Traumatol Arthrosc 18 2010 486 495
40. J.S. Huntley, J.M. McBirnie, A.H. Simpson, and A.C. Hall Cutting-edge design to improve cell viability in osteochondral grafts Osteoarthritis Cartilage 13 2005 665 671 (Pubitemid 41025119)
41. L. Hangody, G. Kish, Z. Kárpáti, I. Szerb, and I. Udvarhelyi Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylar articular defects Knee Surg Sport Traumatol Arthrosc 5 1997 262 267 (Pubitemid 127541076)
42. G. Kordás, J.S. Szabó, and L. Hangody Primary stability of osteochondral grafts used in mosaicplasty Arthroscopy 22 2006 414 421
43. R.P. Jakob, T. Franz, E. Gautier, and P. Mainil-Varlet Autologous osteochondral grafting in the knee: indication, results and reflections Clin Orthop Relat Res 401 2002 170 184 (Pubitemid 34832848)
44. R.A. Whiteside, R.P. Jakob, U.P. Wyss, and P. Mainil-Varlet Impact loading of articular cartilage during transplantation of osteochondral autograft J Bone Joint Surg (Br) 87-B 2005 1285 1291 (Pubitemid 41387575)
45. G. Bentley, L. Biant, R. Carrington, M. Akmal, A. Goldberg, and A. Williams A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee J Bone Joint Surg (Br) 85-B 2003 223 230 (Pubitemid 36410545)
46. U. Horas, D. Pelinkovic, G. Herr, T. Aigner, and R. Schnettler Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial J Bone Joint Surg (Am) 85-A 2003 185 192 (Pubitemid 36538777)
47. L. Hangody, and P. Füles Autologous osteochondral mosaicplasty for the treatment of full thickness defects of weight-bearing joints: ten years of experimental and clinical experience J Bone Joint Surg (Am) 85-A Suppl. 2 2003 25 32 (Pubitemid 36535042)
48. J.G. Lane, W.L. Tontz, S.T. Ball, J.B. Massie, A.C. Chen, and W.C. Bae A morphologic, biochemical and biomechanical assessment of short-term effects of osteochondral autograft plug transfer in a animal model Arthroscopy 17 2001 856 863
49. S.G. Pearce, M.B. Hurtig, R. Clarnette, and M. Kalra An investigation of 2 techniques for optimizing joint surface congruency using multiple cylindrical osteochondral autografts Arthroscopy 17 2001 50 55
50. B. Dozin, M. Malpeli, R. Cancedda, P. Bruzzi, S. Calcagno, and L. Molfetta Comparative evaluation of autologous chondrocyte implantation and mosaicplasty: a multicentered randomized clinical trial Clin J Sport Med 15 2005 220 226
51. R. Gudas, E. Stankevicius, E. Monastyreckiene, D. Pranys, and R.J. Kalesinskas Osteochondral autologous transplantation versus microfracture for the treatment of articular cartilage defects in the knee joint in athletes Knee Surg Sports Traumatol Arthrosc 14 2006 834 842 (Pubitemid 44598184)
52. R. Gudas, R. Simonaityte, E. Cekanauskas, and R. Tamosiunas A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children J Pediatr Orthop 29 2009 741 748
53. B.M. Mc Goveran, K.P. Pritzker, N. Shasha, J. Price, and A.E. Gross Long-term chondrocyte viability in a fresh osteochondral allograft J Knee Surg 15 2002 97 100
54. R.J. Beaver, M. Mahomed, D. Backstein, A. Davis, D.J. Zukor, and A.E. Gross Fresh osteochondral allografts for post-traumatic defects in the knee. A survivorship analysis J Bone Joint Surg Br 74-B 1992 105 110
55. A.E. Gross, W. Kim, F. Las Heras, D. Backstein, O. Safir, and K.P.H. Pritzker Fresh osteochondral allografts for posttraumatic knee defects: long-term followup Clin Orthop Relat Res 466 2008 1863 1870
56. L. Micheli, C. Curtis, and N. Shervin Articular cartilage repair in the adolescent athlete: is autologous chondrocyte implantation the answer? Clin J Sport Med 16 2006 465 470 (Pubitemid 44900729)
57. M.R. Carmont, R. Carey-Smith, A. Saithna, M. Dhillon, P. Thompson, and T. Spalding Delayed incorporation of a TruFit plug: perseverance is recommended Arthroscopy 25 2009 810 814
58. K. Hambly, V. Bobic, B. Wondrasch, D. van Assche, and S. Marlovits Autologous chondrocyte implantation postoperative care and rehabilitation Am J Sports Med 34 2006 1020 1038 (Pubitemid 43725772)
59. M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, E. Sjogren-Jansson, and L. Peterson Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation N Eng J Med 331 1994 889 895 (Pubitemid 24299869)
60. M. Brittberg, L. Peterson, E. Sjogren-Jansson, T. Tallheden, and A. Lindhal Articular engineering with autologous chondrocyte transplantation. A review of recent developments J Bone Joint Surg Am 85 A Suppl. 3 2003 109 115 (Pubitemid 36951121)
61. M. Ochi, Y. Uchio, K. Kawasaki, S. Wakitani, and J. Iwasa Transplantation of cartilage-like tissue made by engineering in the treatment of cartilage defects of the knee J Bone Joint Surg (Br) 84-B 2002 571 578 (Pubitemid 34578510)
62. M. Marcacci, M. Berruto, D. Brocchetta, A. Delcogliano, D. Ghinelli, and A. Gobbi Articular cartilage engineering with Hyalograft C: 3-year clinical results Clin Orthop Relat Res 435 2005 96 105 (Pubitemid 40798651)
63. A.H. Gomoll, Probst Ch, J. Farr, B.J. Cole, and T. Minas Use of a type I/III bilayer collagen membrane decreases reoperation rates for symptomatic hypertrophy after autologous chondrocyte implantation Am J Sports Med 38 Suppl. 1 2009 20 23
64. M. Manfredini, F. Zerbinati, A. Gildone, and R. Faccini Autologous chondrocyte implantation: a comparison between an open periosteal covered and an arthroscopic matrix-guided technique Acta Orthop Belg 73 2007 207 218
65. W. Bartlett, J.A. Skinner, C.R. Gooding, R.W.J. Carrington, A.M. Flanagan, and T.W.R. Briggs Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee J Bone Joint Surg (Br) 87-B 2005 640 645 (Pubitemid 40711636)
66. C.M. Hettrich, D. Crawford, and S.A. Rodeo Cartilage repair: third-generation cell-based technologies - basic science, surgical techniques, clinical outcomes Sports Med Arthrosc 16 2008 230 235
67. M.W. Kessler, G. Ackerman, J.S. Dines, and D. Grande Emerging technologies and fourth generation issues in cartilage repair Sports Med Arthrosc 16 2008 246 254
68. L. Peterson, T. Minas, M. Brittberg, A. Nilsson, E. Janssan, and A. Lindahl Two to nine year outcomes after autologous chondrocyte transplantation of the knee Clin Orthop Relat Res 374 2000 212 234 (Pubitemid 30263488)
69. M. Brittberg Autologous chondrocyte implantation - technique and long-term follow-up Injury 39 Suppl. 1 2008 S40 S49
70. T. Minas, A.H. Gomoll, S. Solhpour, R. Rosenberger, Probst Ch, and T. Bryant Autologous chondrocyte implantation for joint preservation in patients with early osteoarthritis Clin Orthop Relat Res 468 2010 147 157
71. G. Knutsen, J.O. Drogset, L. Engebretsen, T. Grantvedt, V. Isksen, and T.C. Ludvigsen A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years J Bone Joint Surg Am 89 A 2007 2105 2112 (Pubitemid 47606154)
72. E. Basad, B. Ishaque, G. Bachmann, H. Stürz, and J. Steinmeyer Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a two years randomized study Knee Surg Sports Traumatol Arthrosc 18 2010 519 527
73. B.R. Mandelbaum, J.E. Browne, F. Fu, L. Micheli, J. Mosely Jr., and C. Erggelet Articular cartilage lesions of the knee Am J Sport Med 26 1998 853 861 (Pubitemid 28555164)
74. J.B. Moseley, A.F. Anderson, J.E. Browne, B.R. Mandelbaum, L.J. Micheli, and F. Fu Long-term durability of autologous chondrocyte implantation: a multicenter, observational study in US patients Am J Sports Med 38 2010 238 246
75. J. Iwasa, L. Engebretsen, Y. Shima, and M. Ochi Clinical application of scaffolds for cartilage tissue engineering Knee Surg Sports Traumatol Arthrosc 17 2009 561 577
76. N. Tran-Khanh, C.D. Hoemann, M.D. McKee, J.E. Henderson, and M.D. Buschmann Aged bovine chondrocytes display a diminished capacity to produce a collagen-rich, mechanically functional cartilage extracellular matrix J Orthop Res 23 2005 1354 1362 (Pubitemid 41554668)
77. C.A. Acosta, I. Izal, P. Ripalda, A.L. Douglas-Price, and F. Forriol Gene expression and proliferation analysis in young, aged, and osteoarthritic sheep chondrocytes effect of growth factor treatment J Orthop Res 24 2006 2087 2094 (Pubitemid 44717971)
78. C.A. Acosta, I. Izal, P. Ripalda, and F. Forriol Cell viability and protein composition in cryopreserved cartilage Clin Orthop Relat Res 460 2007 234 239 (Pubitemid 47056503)
79. H.J. Mankin, H. Dorfman, L. Lippiello, and A. Zarins Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips: II. Correlation of morphology with biochemical and metabolic data J Bone Joint Surg (Am) 53-A 1971 523 537
80. S.W. O'Driscoll, F.W. Keeley, and R.B. Salter The chondrogenic potential of free autologous periosteal grafts for biological resurfacing of major full-thickness defects in Joint surfaces under the influence of continuous passive motion. An experimental investigation in the Rabbit J Bone Joint Surg (Am) 68-A 1986 1017 1035 (Pubitemid 17180051)
81. S. Pineda, A. Pollack, S. Stevenson, V. Goldberg, and A. Caplan A semiquantitative scale for histologic trading of articular cartilage repair Acta Anat (Basel) 143 1992 335 340
82. K.P.H. Pritzker, S. Gay, S.A. Jimenez, K. Ostergaard, J.P. Pelletier, and P. Revell Osteoarthritis cartilage histopathology: trading and staging Osteoarthritis Cartilage 14 2006 13 29 (Pubitemid 43034086)
83. P. Mainil-Varlet, T. Aigner, M. Brittberg, P. Bullough, A. Hollander, and E. Hunzinker Histological assessment of cartilage repair: a report by the histology endpoint committee of the International Cartilage Repair Society (ICRS) J Bone Joint Surg (Am) 85-A Suppl. 2 2003 45 57 (Pubitemid 36535045)
84. A. Chevrier, C. Hoemann, J. Sun, and M. Buschmann Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects Osteoarthritis Cartilage 15 2007 316 327
85. C.D. Hoemann, G. Chen, C. Marchand, N. Tran-Khanh, M. Thibault, and A. Chevrier Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages Am J Sports Med 38 2010 1845 1856
86. M. Blanke, H.D. Carl, P. Klinger, B. Swoboda, F. Hennig, and K. Gelse Transplanted chondrocytes inhibit endochondral ossification within cartilage repair tissue Calcif Tissue Int 85 2009 421 433
87. E. Filová, F. Jelínek, M. Handl, A. Lytvynets, M. Rampichová, and F. Varga Novel composite hyaluronan/type I collagen/fibrin scaffold enhances repair of osteochondral defect in rabbit knee J Biomed Mater Res B Appl Biomater 87 2008 415 424
88. C.R. Lee, A.J. Grodzinsky, H.P. Hsu, and M. Spector Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model J Orthop Res 21 2003 272 281 (Pubitemid 36322547)
89. A. Funayama, Y. Niki, H. Matsumoto, S. Maeno, T. Yatabe, and H. Morioka Repair of full-thickness articular cartilage defects using injectable type II collagen gel embedded with cultured chondrocytes in a rabbit model J Orthop Sci 13 2008 225 232 (Pubitemid 351799210)
90. C. Willers, J. Chen, D. Wood, J. Xu, and M.H. Zheng Autologous chondrocyte implantation with collagen bioscaffold for the treatment of osteochondral defects in rabbits Tissue Eng 11 2005 1065 1076 (Pubitemid 41321409)
91. Y. Liu, F. Chen, W. Liu, L. Cui, Q. Shang, and W. Xia Repairing large porcine full-thickness defects of articular cartilage using autologous chondrocyte-engineered cartilage Tissue Eng 8 2002 709 721 (Pubitemid 34857806)
92. Y.C. Kuo, and I.N. Ku Application of polyethyleneimine-modified scaffolds to the regeneration of cartilaginous tissue Biotechnol Prog 25 2009 1459 1467
93. H. Fan, H. Liu, R. Zhu, X. Li, Y. Cui, and Y. Hu Comparison of chondral defects repair with in vitro and in vivo differentiated mesenchymal stem cells Cell Transplant 16 2007 823 832 (Pubitemid 351448258)
94. O. Pulliainen, A.I. Vasara, M.M. Hyttinen, V. Tiitu, P. Valonen, and M. Kellomäki Poly-l-d-lactic acid scaffold in the repair of porcine knee cartilage lesions Tissue Eng 13 2007 1347 1355 (Pubitemid 46986734)
95. M. Płończak, J. Czubak, and J. Kawiak Repair of articular cartilage defects with cultured chondrocytes on polysulphonic membrane: experimental studies in rabbits Transplant Proc 38 2006 312 313
96. M. Rudert, U. Wilms, M. Hoberg, and C.J. Wirth Cell-based treatment of osteochondral defects in the rabbit knee with natural and synthetic matrices: cellular seeding determines the outcome Arch Orthop Trauma Surg 125 2005 598 608
97. G.T. Köse, F. Korkusuz, A. Ozkul, Y. Soysal, T. Ozdemir, and C. Yildiz Tissue engineered cartilage on collagen and PHBV matrices Biomaterials 26 2005 5187 5197 (Pubitemid 40387841)
98. E. Kon, M. Delcogliano, G. Filardo, M. Fini, G. Giavaresi, and S. Francioli Orderly osteochondral regeneration in a sheep model using a novel nano-composite multilayered biomaterial J Orthop Res 28 2010 116 124
99. M. Kayakabe, S. Tsutsumi, H. Watanabe, Y. Kato, and K. Takagishi Transplantation of autologous rabbit BM-derived mesenchymal stromal cells embedded in hyaluronic acid gel sponge into osteochondral defects of the knee Cytotherapy 8 2006 343 353 (Pubitemid 44269673)
100. P.B. Lin, L.J. Ning, Q.Z. Lian, Z. Xia, Y. Xin, and B.H. Sen A study on repair of porcine articular cartilage defects with tissue-engineered cartilage constructed in vivo by composite scaffold materials Ann Plast Surg 65 2010 430 436
101. J.H. Lee, K.V. Prakash, Y.H. Pengatteeri, S.E. Park, H.S. Koh, and C.W. Han Chondrocyte apoptosis in the regenerated articular cartilage after allogenic chondrocyte transplantation in the rabbit knee J Bone Joint Surg (Br) 89-B 2007 977 983 (Pubitemid 47322803)
102. T. Mimura, S. Imai, M. Kubo, E. Isoya, K. Ando, and N. Okumura A novel exogenous concentration-gradient collagen scaffold augments full-thickness articular cartilage repair Osteoarthritis Cartilage 16 2008 1083 1091
103. F. Chang, T. Ishii, T. Yanai, H. Mishima, H. Akaogi, and T. Ogawa Repair of large full-thickness articular cartilage defects by transplantation of autologous uncultured bone-marrow-derived mononuclear cells J Orthop Res 26 2008 18 26
104. H. Chiang, C.J. Liao, Y.H. Wang, H.Y. Huang, C.N. Chen, and C.H. Hsieh Comparison of articular cartilage repair by autologous chondrocytes with and without in vitro cultivation Tissue Eng Part C Methods 16 2010 291 300
105. F. Forriol, U.G. Longo, E. Alvarez, S. Campi, P. Ripalda, and C. Rabitti Scanty integration of osteochondral allografts cryopreserved at low temperatures with dimethyl sulfoxide Knee Surg Sports Traumatol Arthrosc 2010
106. J.G. Lane, R.M. Healey, A.C. Chen, R.L. Sah, and D. Amiel Can osteochondral grafting be augmented with microfracture in an extended-size lesion of articular cartilage? Am J Sports Med 38 2010 1316 1323
107. T. Tanaka, H. Komaki, M. Chazono, and K. Fujii Use of a biphasic graft constructed with chondrocytes overlying a beta-tricalcium phosphate block in the treatment of rabbit osteochondral defects Tissue Eng 11 2005 331 339 (Pubitemid 40515200)
108. S.R. Frenkel, G. Bradica, J.H. Brekke, S.M. Goldman, K. Ieska, and P. Issack Regeneration of articular cartilage - evaluation of osteochondral defect repair in the rabbit using multiphasic implants Osteoarthritis Cartilage 13 2005 798 807 (Pubitemid 41263938)
109. J. Xie, Z. Han, M. Naito, A. Maeyama, S.H. Kim, and Y.H. Kim Articular cartilage tissue engineering based on a mechano-active scaffold made of poly(l-lactide-co-epsilon-caprolactone): in vivo performance in adult rabbits J Biomed Mater Res B Appl Biomater 94 2010 80 88
110. J.C. Schagemann, C. Erggelet, H.W. Chung, A. Lahm, H. Kurz, and E.H. Mrosek Cell-laden and cell-free biopolymer hydrogel for the treatment of osteochondral defects in a sheep model Tissue Eng Part A 15 2009 75 82
111. T. Kamarul, L. Selvaratnam, T. Masjuddin, S. Ab-Rahim, C. Ng, and K.Y. Chan Autologous chondrocyte transplantation in the repair of full-thickness focal cartilage damage in rabbits J Orthop Surg (Hong Kong) 16 2008 230 236
112. A. Jubel, J. Andermahr, G. Schiffer, J. Fischer, K.E. Rehm, and M.J. Stoddart Transplantation of de novo scaffold-free cartilage implants into sheep knee chondral defects Am J Sports Med 36 2008 1555 1564 (Pubitemid 352019466)
113. P.R. Boopalan, S. Sathishkumar, S. Kumar, and S. Chittaranjan Rabbit articular cartilage defects treated by allogenic chondrocyte transplantation Int Orthop 30 2006 357 361
114. A.I. Vasara, M.M. Hyttinen, O. Pulliainen, M.J. Lammi, J.S. Jurvelin, and L. Peterson Immature porcine knee cartilage lesions show good healing with or without autologous chondrocyte transplantation Osteoarthritis Cartilage 14 2006 1066 1074 (Pubitemid 44309418)
115. L. De Girolamo, G. Bertolini, M. Cervellin, G. Sozzi, and P. Volpi Treatment of chondral defects of the knee with one step matrix-assisted technique enhanced by autologous concentrated bone marrow: in vitro characterisation of mesenchymal stem cells from iliac crest and subchondral bone Injury 41 2010 1172 1177
116. H. Alfaqeh, M.Y. Norhamdan, K.H. Chua, H.C. Chen, B.S. Aminuddin, and B.H. Ruszymah Cell based therapy for osteoarthritis in a sheep model: gross and histological assessment Med J Malaysia 63 Suppl. A 2008 37 38
117. D. Mrugala, C. Bony, N. Neves, L. Caillot, S. Fabre, and D. Moukoko Phenotypic and functional characterisation of ovine mesenchymal stem cells: application to a cartilage defect model Ann Rheum Dis 67 2008 288 295 (Pubitemid 351281260)
118. G. Zhou, W. Liu, L. Cui, X. Wang, T. Liu, and Y. Cao Repair of porcine articular osteochondral defects in non-weightbearing areas with autologous bone marrow stromal cells Tissue Eng 12 2006 3209 3221 (Pubitemid 44846425)
119. M.B. Schmidt, E.H. Chen, and S.E. Lynch A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair Osteoarthritis Cartilage 14 2006 403 412
120. M. Hurtig, S. Chubinskaya, J. Dickey, and D. Rueger BMP-7 protects against progression of cartilage degeneration after impact injury J Orthop Res 27 2009 602 611
121. M. Nawata, S. Wakitani, H. Nakaya, A. Tanigami, T. Seki, and Y. Nakamura Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage Arthritis Rheum 52 2005 155 163 (Pubitemid 40129244)
122. N.K. Singh, G.R. Singh, Amarpal, P. Kinjavdekar, A.K. Sharma, and T.R. Mohanty Articular cartilage repair with autografting under the influence of insulin-like growth factor-1 in rabbits J Vet Med A Physiol Pathol Clin Med 54 2007 210 218 (Pubitemid 46633353)
123. H. Mizuta, S. Kudo, E. Nakamura, Y. Otsuka, K. Takagi, and Y. Hiraki Active proliferation of mesenchymal cells prior to the chondrogenic repair response in rabbit full-thickness defects of articular cartilage Osteoarthritis Cartilage 12 2004 586 596 (Pubitemid 38950269)
124. E.E. Moore, A.M. Bendele, D.L. Thompson, A. Littau, K.S. Waggie, and B. Reardon Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis Osteoarthritis Cartilage 13 2005 623 631 (Pubitemid 40867862)
125. T. Nishida, S. Kubota, S. Kojima, T. Kuboki, K. Nakao, and T. Kushibiki Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor) J Bone Miner Res 19 2004 1308 1319 (Pubitemid 41094373)
126. R. Katayama, S. Wakitani, N. Tsumaki, Y. Morita, I. Matsushita, and R. Gejo Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow Rheumatology (Oxford) 43 2004 980 985 (Pubitemid 39144444)
127. H. Madry, G. Kaul, M. Cucchiarini, U. Stein, D. Zurakowski, and K. Remberger Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I) Gene Ther 12 2005 1171 1179 (Pubitemid 41136311)
128. A.J. Nixon, L.A. Fortier, J. Williams, and H. Mohammed Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites J Orthop Res 17 1999 475 487 (Pubitemid 29383606)
129. J.H. Che, Z.R. Zhang, G.Z. Li, W.H. Tan, X.D. Bai, and F.J. Qu Application of tissue-engineered cartilage with BMP-7 gene to repair knee joint cartilage injury in rabbits Knee Surg Sports Traumatol Arthrosc 18 2010 496 503
130. C. Hidaka, L.R. Goodrich, C.T. Chen, R.F. Warren, R.G. Crystal, and A.J. Nixon Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7 J Orthop Res 21 2003 573 583 (Pubitemid 36758199)
131. D.A. Grande, J. Mason, E. Light, and D. Dines Stem cells as platforms for delivery of genes to enhance cartilage repair J Bone Joint Surg (Am) 85-A Suppl. 2 2003 111 116 (Pubitemid 36535053)
132. L. Lin, C. Zhou, X. Wei, Y. Hou, L. Zhao, and X. Fu Articular cartilage repair using dedifferentiated articular chondrocytes and bone morphogenetic protein 4 in a rabbit model of articular cartilage defects Arthritis Rheum 58 2008 1067 1075 (Pubitemid 351564008)
133. K. Gelse, C. Mühle, K. Knaup, B. Swoboda, M. Wiesener, and F. Hennig Chondrogenic differentiation of growth factor-stimulated precursor cells in cartilage repair tissue is associated with increased HIF-1alpha activity Osteoarthritis Cartilage 16 2008 1457 1465
134. I. Izal, C.A. Acosta, P. Ripalda, M. Zaratiegui, J. Ruiz, and F. Forriol IGF-1 gene therapy to protect articular cartilage in a rat model of joint damage Arch Orthop Trauma Surg 128 2008 239 247 (Pubitemid 351167220)
135. G. Kaul, M. Cucchiarini, D. Arntzen, D. Zurakowski, M.D. Menger, and D. Kohn Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo J Gene Med 8 2006 100 111 (Pubitemid 43169386)
136. M. Cucchiarini, H. Madry, C. Ma, T. Thurn, D. Zurakowski, and M.D. Menger Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2 Mol Ther 12 2005 229 238 (Pubitemid 41025092)
137. R.A. Magnussen, W.A. Dunn, J.L. Carey, and K.P. Spindler Treatment of focal articular cartilage defects in knee Clin Orthop Relat Res 466 2008 952 962