Severe sepsis and its impact on outcome in elderly and very elderly patients admitted in intensive care unit

Journal of Intensive Care Medicine

Volumn 27, Issue 3, 2012, Pages 179-183

  Nasa, Prashant ^a   Juneja, Deven ^a   Singh, Omender ^a   Dang, Rohit ^a   Arora, Vikas ^a  

^a Max Super Speciality Hospital   (India)

Author keywords

elderly; mortality; organ support; severe sepsis

Indexed keywords

ABDOMINAL INFECTION; ADULT; AGE; AGED; APACHE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FISHER EXACT TEST; HOSPITAL ADMISSION; HUMAN; LUNG INFECTION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; POPULATION RESEARCH; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW; RISK; RISK FACTOR; STUDENT T TEST; TERTIARY HEALTH CARE; URINARY TRACT INFECTION;

ACADEMIC MEDICAL CENTERS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; APACHE; CRITICAL CARE; HUMANS; INDIA; INFECTION; INTENSIVE CARE UNITS; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PATIENT ADMISSION; PROSPECTIVE STUDIES; RENAL DIALYSIS; SEPSIS; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; SURVIVAL RATE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 84860733823     PISSN: 08850666     EISSN: 15251489     Source Type: Journal    
DOI: 10.1177/0885066610397116     Document Type: Review

References (29)

1. Anonymous. World population ageing: 1950-2050. Department of Economic and Social Affairs PD, United Nations, New York; 2001. http://www.un.org/esa/ population/publications/worldageing19502050/Accessed on September 30, 2010
2. Mitnitski AB, Mogilner AJ, MacKnight C, Rockwood K. The accumulation of deficits with age and possible invariants of aging. Sci World J. 2002 ; 2: 1816-1822
3. Carson SS. The epidemiology of critical illness in the elderly. Crit Care Clin. 2003 ; 19 (4). 605-617 (Pubitemid 37323349)
4. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003 ; 348 (16). 1546-1554 (Pubitemid 36437931)
5. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001 ; 29 (7). 1303-1310 (Pubitemid 32641789)
6. Destarac LA, Ely EW. Sepsis in older patients: an emerging concern in critical care. Advances in Sepsis. 2002 ; 2: 15-22
7. Gavazzi G, Krause KH. Ageing and infection. Lancet Infect Dis. 2002 ; 2 (11). 659-666 (Pubitemid 35265061)
8. Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med. 2006 ; 34 (1). 15-21 (Pubitemid 43032375)
9. Brun-Buisson C, Doyon F, Carlet J, et al. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. JAMA. 1995 ; 274 (12). 968-974
10. Tran DD, Groeneveld AB, Van der MJ, et al. Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit. Crit Care Med. 1990 ; 18 (5). 474-479 (Pubitemid 20164866)
11. Greenberg BM, Atmar RL, Stager CE, Greenberg SB. Bacteraemia in the elderly: predictors of outcome in an urban teaching hospital. J Infect. 2005 ; 50 (4). 288-295 (Pubitemid 40533366)
12. Regazzoni CJ, Zamora RJ, Petrucci E, et al. Hospital and 1-year outcomes of septic syndromes in older people: a cohort study. J Gerontol A Biol Sci Med Sci. 2008 ; 63 (2). 210-212 (Pubitemid 351738455)
13. McClelland RS, Fowler VG, Sanders LL, et al. Staphylococcus aureus bacteremia among elderly vs younger adult patients: comparison of clinical features and mortality. Arch Intern Med. 1999 ; 159 (11). 1244-1247 (Pubitemid 29269865)
14. Leibovici L, Pitlik SD, Konisberger H, Drucker M. Bloodstream infections in patients older than eighty years. Age Ageing. 1993 ; 22 (6). 431-442 (Pubitemid 23348151)
15. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis: the ACCP/SCCM Consensus Conference Committee, American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992 ; 101 (5 suppl). 1644-1655
16. Vosylius S, Sipylaite J, Ivaskevicius J. Determinants of outcome in elderly patients admitted to the intensive care unit. Age Ageing. 2005 ; 34 (2). 157-162 (Pubitemid 40331098)
17. Baine WB, Yu W, Summe JP. The epidemiology of hospitalization of elderly Americans for septicemia or bacteremia in 1991-1998: application of Medicare claims data. Ann Epidemiol. 2001 ; 11 (2). 118-126 (Pubitemid 32054778)
18. Girard TD, Ely EW. Bacteremia and sepsis in older adults. Clin Geriatr Med. 2007 ; 23 (3). 633-647 (Pubitemid 47053882)
19. Pawelec G, Solana R, Remarque E, Mariani E. Impact of aging on innate immunity. J Leukoc Biol. 1998 ; 64 (6). 703-712 (Pubitemid 28555382)
20. DeGaudio AR, Rinaldi S, Chelazzi C, Borracci T. Pathophysiology of sepsis in the elderly: clinical impact and therapeutic considerations. Curr Drug Targets. 2009 ; 10 (1). 60-70
21. Stephan F, Cheffi A, Bonnet F. Nosocomial infections and outcome of critically ill elderly patients after surgery. Anesthesiology. 2001 ; 94 (3). 407-414 (Pubitemid 32198446)
22. Chelluri L, Pinsky MR, Donahoe MP, et al. Long-term outcome of critically ill elderly patients requiring intensive care. JAMA. 1993 ; 269 (24). 3119-3123 (Pubitemid 23171708)
23. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med. 1999 ; 340 (3). 207-214 (Pubitemid 29063218)
24. Pittet D, Thievent B, Wenzel RP, Gurman G, Suter PM. Importance of pre-existing co-morbidities for prognosis of septicemia in critically ill patients. Intensive Care Med. 1993 ; 19 (5). 265-272 (Pubitemid 23265998)
25. Nierman DM, Schechter CB, Cannon LM, Meier DE. Outcome prediction model for very elderly critically ill patients. Crit Care Med. 2001 ; 29 (10). 1853-1859 (Pubitemid 32980391)
26. Kleinpell R, Ferrans C. Factors influencing intensive care unit survival for critically ill elderly patients. Heart Lung. 1998 ; 27 (5). 337-343 (Pubitemid 28465341)
27. Ely EW, Angus DC, Williams MD, Bates B, Qualy R, Bernard GR. Drotrecogin alfa (activated) treatment of older patients with severe sepsis. Clin Infect Dis. 2003 ; 37 (2). 187-195 (Pubitemid 36930348)
28. Lerolle N, Trinquart L, Bornstain C, et al. Increased intensity of treatment and decreased mortality in elderly patients in an intensive care unit over a decade. Crit Care Med. 2010 ; 38 (1). 59-64
29. Rosenberg AL. Recent innovations in intensive care unit risk-prediction models. Curr Opin Crit Care. 2002 ; 8 (4). 321-330