Mechanism of inactivation of ocriplasmin in porcine vitreous

Biophysical Chemistry

Volumn 165-166, Issue , 2012, Pages 30-38

  Aerts, Frans ^a   Noppen, Bernard ^a   Fonteyn, Laetitia ^a   Derua, Rita ^b   Waelkens, Etienne ^b   De Smet, Marc D ^c   Vanhove, Marc ^a  

^a ThromboGenics NV   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c Retina and Inflammation Service   (Switzerland)

Author keywords

Autolysis; Local or partial unfolding; Ocriplasmin; Posterior vitreous detachment; Symptomatic vitreomacular adhesion

Indexed keywords

ARGININE; CYSTEINE; LYSINE; OCRIPLASMIN; SUCROSE;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; AUTOLYSIS; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISULFIDE BOND; EXPERIMENTAL PIG; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; PROTEIN UNFOLDING; VITREOMACULAR ADHESION; VITREOUS BODY; VITREOUS BODY DETACHMENT; VITREOUS DISEASE;

AMINO ACID SEQUENCE; ANIMALS; BUFFERS; DISULFIDES; FIBRINOLYSIN; HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STABILITY; PROTEIN UNFOLDING; PROTEOLYSIS; SWINE; VITREOUS BODY;

SUS;

EID: 84860717476     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2012.03.002     Document Type: Article

References (32)

1. B.J. Backes, J.L. Harris, F. Leonetti, C.S. Craik, and J.A. Ellman Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin Nature Biotechnology 18 2000 187 193 (Pubitemid 30091180)
2. M.S. Benz, K.H. Packo, V. Gonzalez, S. Pakola, D. Bezner, J.A. Haller, and S.D. Schwartz A placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomy Ophthalmology 117 2010 791 797
3. O.G. Berg, and P.H. von Hippel Diffusion-controlled macromolecular interactions Annual Review of Biophysics Chemistry 14 1985 131 160
4. R.B. Bhisitkul Anticipation for enzymatic vitreolysis British Journal of Ophthalmology 85 2001 1 3
5. W. Chen, W. Mo, K. Sun, X. Huang, Y.L. Zhang, and H.Y. Song Microplasmin degrades fibronectin and laminin at vitreoretinal interface and outer retina during enzymatic vitrectomy Current Eye Research 34 2009 1057 1064
6. E.E. Clifton The use of plasmin in humans Annals of the New York Academy of Sciences 68 1957 209 229
7. M.D. de Smet, A. Gandorfer, P. Stalmans, M. Veckeneer, E. Feron, S. Pakola, and A. Kampik Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial Ophthalmology 116 2009 1349 1355
8. C. Dommke, O. Turschner, J.-M. Stassen, F. Van de Werf, H.R. Lijnen, and P. Verhamme Thrombolytic efficacy of recombinant human microplasmin in a canine model of copper coil-induced coronary artery thrombosis Journal of Thrombosis and Thrombolysis 30 2010 46 54
9. A. Gandorfer, E. Putz, U. Welge-Lüssen, M. Grüterich, M. Ulbig, and A. Kampik Ultrastructure of the vitreoretinal interface following plasmin assisted vitrectomy British Journal of Ophthalmology 85 2001 6 10 (Pubitemid 32060187)
10. A. Gandorfer, S. Priglinger, K. Schebitz, J. Hoops, M. Ulbig, J. Ruckhofer, G. Grabner, and A. Kampik Vitreoretinal morphology of plasmin-treated human eyes American Journal of Ophthalmology 133 2002 156 159 (Pubitemid 34076524)
11. A. Gandorfer, M. Rohleder, C. Sethi, D. Eckle, U. Welge-Lüssen, A. Kampik, P. Luthert, and D. Charteris Posterior vitreous detachment induced by microplasmin Investigative Ophthalmology and Visual Science 45 2004 641 647 (Pubitemid 38140525)
12. D.P. Han, G.W. Abrams, and T.M. Aaberg Surgical excision of the attached posterior hyaloid Archives of Ophthalmology 106 1998 998 1000
13. M. Hermel, W. Dailey, and M.K. Hartzer Efficacy of plasmin, microplasmin, and streptokinase-plasmin complex for the in vitro degradation of fibronectin and laminin - implications for vitreoretinal surgery Current Eye Research 35 2010 419 424
14. T. Hikichi, N. Yanagiya, M. Kado, J. Akiba, and A. Yoshida Posterior vitreous detachment induced by injection of plasmin and sulfur hexafluoride in the rabbit vitreous Retina 19 1999 55 58 (Pubitemid 30387541)
15. J. Jespersen, J. Gram, and T. Astrup The autodigestion of human plasmin follows a bimolecular mode of reaction subject to product inhibition Thrombosis Research 41 1986 395 404 (Pubitemid 16160343)
16. X. Li, X. Shi, and J. Fan Posterior vitreous detachment with plasmin in the isolated human eye Graefe's Archive for Clinical and Experimental Ophthalmology 240 2002 56 62 (Pubitemid 36075574)
17. F. Markwardt, H. Landmann, and P. Walsmann Comparative studies on the inhibition of trypsin, plasmin, and thrombin by derivatives of benzylamine and benzamidine European Journal of Biochemistry 6 1968 502 506
18. N. Nagai, E. Demarsin, B. Van Hoef, S. Wouters, D. Cingolani, Y. Laroche, and D. Collen Recombinant human microplasmin: production and potential therapeutic properties Journal of Thrombosis and Haemostasis 1 2003 307 313
19. T.F. O'Connor, P.G. Debenedetti, and J.D. Carbeck Stability of proteins in the presence of carbohydrates; experiments and modeling using scaled particle theory Biophysical Chemistry 127 2007 51 63
20. M.A. Parry, C. Fernandez-Catalan, A. Bergner, R. Huber, K.P. Hopfner, B. Schlott, K.H. Gührs, and W. Bode The ternary microplasmin-staphylokinase- microplasmin complex is a proteinase-cofactor-substrate complex in action Nature Structural Biology 5 1998 917 923 (Pubitemid 28467416)
21. N.K. Poddar, Z.A. Ansari, R.K. Brojen Singh, A.A. Moosavi-Movahedi, and F. Ahmad Effect of monomeric and oligomeric sugar osmolytes on DeltaGD, the Gibbs energy of stabilization of the protein at different pH values: is the sum effect of monosaccharide individually additive in a mixture? Biophysical Chemistry 138 2008 120 129
22. Z. Saadati, L. Asadi, and S. Larki Thermal stability of α-Lactalbumin in the presence of various sugars as osmolytes Journal of Physical and Theoretical Chemistry of Islamic Azad University of Iran 7 2010 165 172
23. J. Sebag Pharmacologic vitreolysis Retina 18 1998 1 3
24. G.-Y. Shi, and H.-L. Wu Differential autolysis of human plasmin at various pH levels Thrombosis Research 51 1988 355 364
25. P. Sriram, N. Kalogerakis, and L.A. Behie Experimental determination of the rate of autolysis of trypsin at 37 °C Biotechnology Techniques 10 1996 601 606
26. M.R. Stoner, D.A. Dale, P.J. Gualfetti, T. Becker, M.C. Manning, J.F. Carpenter, and T.W. Randolph Protease autolysis in heavy-duty liquid detergent formulations: effects of thermodynamic stabilizers and protease inhibitors Enzyme and Microbial Technology 34 2004 114 125 (Pubitemid 38045482)
27. M.T. Trese Enzymatic vitreous surgery Seminars in Ophthalmology 15 2000 116 121 (Pubitemid 30408044)
28. M.T. Trese Enzymatic-assisted vitrectomy Eye 16 2002 365 368 (Pubitemid 34845963)
29. J.F. Vander, and R. Kleiner A method for induction of posterior vitreous detachment during vitrectomy Retina 12 1992 172 173
30. T.C. Verstraeten, C. Chapman, M. Hartzer, B.S. Winkler, M.T. Trese, and G.A. Williams Pharmacologic induction of posterior vitreous detachment in the rabbit Archives d'Ophtalmologie 111 1993 849 854 (Pubitemid 23170602)
31. J. Whitefleet-Smith, E. Rosen, J. McLinden, V.A. Ploplis, M.J. Fraser, J.E. Tomlinson, J.W. McLean, and F.J. Castellino Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system Archives of Biochemistry and Biophysics 271 1989 390 399 (Pubitemid 19145383)
32. H.-L. Wu, G.-Y. Shi, and M.L. Bender Preparation and purification of microplasmin Proceedings of the National Academy of Sciences of the United States of America 84 1987 8292 8295