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Volumn 14, Issue 5, 2012, Pages 325-332

Advances in cutaneous melanoma

Author keywords

BRAF mutation; Interferon; Ipilimumab; Melanoma; Vemurafenb

Indexed keywords

ALBUMIN; ALPHA2B INTERFERON; B RAF KINASE INHIBITOR; CANCER VACCINE; CARBOPLATIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DACARBAZINE; FOTEMUSTINE; GP100 VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; GSK 118436; IMATINIB; INTERFERON; INTERLEUKIN 2; IPILIMUMAB; MAGE A3 VACCINE; MONOCLONAL ANTIBODY; OX44 ANTIBODY; PACLITAXEL; PD 1 ANTIBODY; PEGINTERFERON; PEPTIDE VACCINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLACEBO; TEMOZOLOMIDE; TICILIMUMAB; TRAMETINIB; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG; UNINDEXED DRUG; VEMURAFENIB;

EID: 84860712037     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-012-0804-4     Document Type: Article
Times cited : (9)

References (62)
  • 1
    • 84857017872 scopus 로고    scopus 로고
    • Epidemiology of invasive cutaneous melanoma
    • MacKie RM, Hauschild A, Eggermont AM (2009) Epidemiology of invasive cutaneous melanoma. Ann Oncol 20[Suppl 6]:vi1-7
    • (2009) Ann Oncol , vol.20 , Issue.SUPPL. 6
    • MacKie, R.M.1    Hauschild, A.2    Eggermont, A.M.3
  • 2
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009 AJCC melanoma staging and classifi cation
    • Balch CM, Gershenwald JE, Soong SJ et al (2009) Final version of 2009 AJCC melanoma staging and classifi cation. J Clin Oncol 27:6199-6206
    • (2009) J Clin Oncol , vol.27 , pp. 6199-6206
    • Balch, C.M.1    Gershenwald, J.E.2    Soong, S.J.3
  • 4
    • 33845592531 scopus 로고    scopus 로고
    • NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: A study based on mutation screening by pyrosequencing
    • DOI 10.1097/01.cmr.0000232300.22032.86, PII 0000839020061200000001
    • Edlundh-Rose E, Egyhazi S, Omholt K et al (2006) NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing. Melanoma Res 16:471-478 (Pubitemid 44934704)
    • (2006) Melanoma Research , vol.16 , Issue.6 , pp. 471-478
    • Edlundh-Rose, E.1    Egyhazi, S.2    Omholt, K.3    Mansson-Brahme, E.4    Platz, A.5    Hansson, J.6    Lundeberg, J.7
  • 6
    • 0346728596 scopus 로고    scopus 로고
    • Determinants of BRAF mutations in primary melanomas
    • Maldonado JL, Fridlyand J, Patel H et al (2003) Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst 95:1878-1890
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1878-1890
    • Maldonado, J.L.1    Fridlyand, J.2    Patel, H.3
  • 7
    • 77949406203 scopus 로고    scopus 로고
    • Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure
    • Handolias D, Salemi R, Murray W et al (2010) Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure. Pigment Cell Melanoma Res 23:210-215
    • (2010) Pigment Cell Melanoma Res , vol.23 , pp. 210-215
    • Handolias, D.1    Salemi, R.2    Murray, W.3
  • 8
    • 78649700287 scopus 로고    scopus 로고
    • Frequent mutation of BAP1 in metastasizing uveal melanomas
    • Harbour JW, Onken MD, Roberson ED et al (2010) Frequent mutation of BAP1 in metastasizing uveal melanomas. Science 330:1410-1413
    • (2010) Science , vol.330 , pp. 1410-1413
    • Harbour, J.W.1    Onken, M.D.2    Roberson, E.D.3
  • 9
    • 77954601260 scopus 로고    scopus 로고
    • Site and timing of fi rst relapse in stage III melanoma patients: Implications for follow-up guidelines
    • Romano E, Scordo M, Dusza SW et al (2010) Site and timing of fi rst relapse in stage III melanoma patients: implications for follow-up guidelines. J Clin Oncol 28:3042-3047
    • (2010) J Clin Oncol , vol.28 , pp. 3042-3047
    • Romano, E.1    Scordo, M.2    Dusza, S.W.3
  • 10
    • 83355174079 scopus 로고    scopus 로고
    • Optimizing the frequency of follow-up visits for patients treated for localized primary cutaneous melanoma
    • Turner RM, Bell KJ, Morton RL et al (2011) Optimizing the frequency of follow-up visits for patients treated for localized primary cutaneous melanoma. J Clin Oncol 29:4641-4646
    • (2011) J Clin Oncol , vol.29 , pp. 4641-4646
    • Turner, R.M.1    Bell, K.J.2    Morton, R.L.3
  • 11
    • 0041409703 scopus 로고    scopus 로고
    • Does adjuvant interferon-α for high-risk melanoma provide a worthwhile benefit? A meta-analysis of the randomised trials
    • DOI 10.1016/S0305-7372(03)00074-4
    • Wheatley K, Ives N, Hancock B et al (2003) Does adjuvant interferon-alpha for high-risk melanoma provide a worthwhile benefi t? A meta-analysis of the randomised trials. Cancer Treat Rev 29:241-252 (Pubitemid 37069655)
    • (2003) Cancer Treatment Reviews , vol.29 , Issue.4 , pp. 241-252
    • Wheatley, K.1    Ives, N.2    Hancock, B.3    Gore, M.4    Eggermont, A.5    Suciu, S.6
  • 12
    • 77950576363 scopus 로고    scopus 로고
    • Interferon alpha adjuvant therapy in patients with high-risk melanoma: A systematic review and meta-analysis
    • Mocellin S, Pasquali S, Rossi CR, Nitti D (2010) Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis. J Natl Cancer Inst 102:493-501
    • (2010) J Natl Cancer Inst , vol.102 , pp. 493-501
    • Mocellin, S.1    Pasquali, S.2    Rossi, C.R.3    Nitti, D.4
  • 13
    • 0942300677 scopus 로고    scopus 로고
    • Interferon alpha as adjuvant postsurgical treatment of melanoma: A meta-analysis
    • DOI 10.1159/000075045
    • Pirard D, Heenen M, Melot C, Vereecken P (2004) Interferon alpha as adjuvant postsurgical treatment of melanoma: a meta-analysis. Dermatology 208:43-48 (Pubitemid 38142333)
    • (2004) Dermatology , vol.208 , Issue.1 , pp. 43-48
    • Pirard, D.1    Heenen, M.2    Melot, C.3    Vereecken, P.4
  • 14
    • 77649217618 scopus 로고    scopus 로고
    • Efficacy of low-dose interferon {alpha}2a 18 versus 60 months of treatment in patients with primary melanoma of >=1.5 mm tumor thickness: Results of a randomized phase III DeCOG trial
    • Hauschild A, Weichenthal M, Rass K et al (2010) Efficacy of low-dose interferon {alpha}2a 18 versus 60 months of treatment in patients with primary melanoma of >=1.5 mm tumor thickness: results of a randomized phase III DeCOG trial. J Clin Oncol 28:841-846
    • (2010) J Clin Oncol , vol.28 , pp. 841-846
    • Hauschild, A.1    Weichenthal, M.2    Rass, K.3
  • 16
    • 84655168007 scopus 로고    scopus 로고
    • Ulceration and stage are predictive of interferon efficacy in melanoma: Results of the phase III adjuvant trials EORTC 18952 and EORTC 18991
    • Eggermont AM, Suciu S, Testori A et al (2012) Ulceration and stage are predictive of interferon efficacy in melanoma: results of the phase III adjuvant trials EORTC 18952 and EORTC 18991. Eur J Cancer 48:218-225
    • (2012) Eur J Cancer , vol.48 , pp. 218-225
    • Eggermont, A.M.1    Suciu, S.2    Testori, A.3
  • 18
    • 78449242173 scopus 로고    scopus 로고
    • E4697: Phase III cooperative group study of yeast-derived granulocyte macrophage colony-stimulating factor (GM-CSF) versus placebo as adjuvant treatment of patients with completely resected stage III-IV melanoma
    • Lawson D, Lee S, Tarhini AA et al (2010) E4697: phase III cooperative group study of yeast-derived granulocyte macrophage colony-stimulating factor (GM-CSF) versus placebo as adjuvant treatment of patients with completely resected stage III-IV melanoma. In: Proc Am Soc Clin Oncol abs 8504
    • (2010) Proc Am Soc Clin Oncol Abs 8504
    • Lawson, D.1    Lee, S.2    Tarhini, A.A.3
  • 19
  • 20
    • 0034007555 scopus 로고    scopus 로고
    • Duration of survival for disseminated malignant melanoma: Results of a meta-analysis
    • Lee ML, Tomsu K, Von Eschen KB (2000) Duration of survival for disseminated malignant melanoma: results of a meta-analysis. Melanoma Res 10:81-92 (Pubitemid 30127833)
    • (2000) Melanoma Research , vol.10 , Issue.1 , pp. 81-92
    • Lee, M.L.1    Tomsu, K.2    Von Eschen, K.B.3
  • 21
    • 79958783120 scopus 로고    scopus 로고
    • Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: Fi nal results of a randomised phase III study (EORTC 18032)
    • Patel PM, Suciu S, Mortier L et al (2011) Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: fi nal results of a randomised phase III study (EORTC 18032). Eur J Cancer 47:1476-1483
    • (2011) Eur J Cancer , vol.47 , pp. 1476-1483
    • Patel, P.M.1    Suciu, S.2    Mortier, L.3
  • 23
    • 74549221384 scopus 로고    scopus 로고
    • A phase 2 clinical trial of nab-paclitaxel in previously treated and chemotherapy-naive patients with metastatic melanoma
    • Hersh EM, O'Day SJ, Ribas A et al (2010) A phase 2 clinical trial of nab-paclitaxel in previously treated and chemotherapy-naive patients with metastatic melanoma. Cancer 116:155-163
    • (2010) Cancer , vol.116 , pp. 155-163
    • Hersh, E.M.1    O'Day, S.J.2    Ribas, A.3
  • 24
    • 53949108399 scopus 로고    scopus 로고
    • Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): A trial coordinated by the Eastern Cooperative Oncology Group
    • Atkins MB, Hsu J, Lee S et al (2008) Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): a trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 26:5748-5754
    • (2008) J Clin Oncol , vol.26 , pp. 5748-5754
    • Atkins, M.B.1    Hsu, J.2    Lee, S.3
  • 25
    • 79953798396 scopus 로고    scopus 로고
    • A phase II trial of nab-paclitaxel (ABI- 007) and carboplatin in patients with unresectable stage IV melanoma: A North Central Cancer Treatment Group Study, N057E(1)
    • Kottschade LA, Suman VJ, Amatruda T 3rd et al (2011) A phase II trial of nab-paclitaxel (ABI- 007) and carboplatin in patients with unresectable stage IV melanoma: a North Central Cancer Treatment Group Study, N057E(1). Cancer 117: 1704-1710
    • (2011) Cancer , vol.117 , pp. 1704-1710
    • Kottschade, L.A.1    Suman, V.J.2    Amatruda Iii, T.3
  • 26
    • 70249083099 scopus 로고    scopus 로고
    • What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma?
    • Robert C, Ghiringhelli F (2009) What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma? Oncologist 14:848-861
    • (2009) Oncologist , vol.14 , pp. 848-861
    • Robert, C.1    Ghiringhelli, F.2
  • 27
    • 33644659256 scopus 로고    scopus 로고
    • Principles and use of anti-CTLA4 antibody in human cancer immunotherapy
    • DOI 10.1016/j.coi.2006.01.011, PII S0952791506000148, Lymphocyte Development / Tumor Immunology
    • Peggs KS, Quezada SA, Korman AJ, Allison JP (2006) Principles and use of anti-CTLA4 antibody in human cancer immunotherapy. Curr Opin Immunol 18:206-213 (Pubitemid 43327304)
    • (2006) Current Opinion in Immunology , vol.18 , Issue.2 , pp. 206-213
    • Peggs, K.S.1    Quezada, S.A.2    Korman, A.J.3    Allison, J.P.4
  • 28
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363: 711-723
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 29
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I et al (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364: 2517-2526
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 30
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok JD, Hoos A, O'Day S et al (2009) Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 15:7412-7420
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3
  • 31
    • 78449250123 scopus 로고    scopus 로고
    • Clinical development of the anti- CTLA-4 antibody tremelimumab
    • Ribas A (2010) Clinical development of the anti- CTLA-4 antibody tremelimumab. Semin Oncol 37:450-454
    • (2010) Semin Oncol , vol.37 , pp. 450-454
    • Ribas, A.1
  • 32
    • 78449239072 scopus 로고    scopus 로고
    • Phase II evaluation of tremelimumab (Treme) combined with high-dose interferon alpha-2b (HDI) for metastatic melanoma
    • Tarhini AA (2010) Phase II evaluation of tremelimumab (Treme) combined with high-dose interferon alpha-2b (HDI) for metastatic melanoma. In: Proc Am Soc Clin Oncol abs 8524
    • (2010) Proc Am Soc Clin Oncol Abs , pp. 8524
    • Tarhini, A.A.1
  • 33
    • 80052536175 scopus 로고    scopus 로고
    • New drugs in melanoma: It's a whole new world
    • Eggermont AM, Robert C (2011) New drugs in melanoma: it's a whole new world. Eur J Cancer 47:2150-2157
    • (2011) Eur J Cancer , vol.47 , pp. 2150-2157
    • Eggermont, A.M.1    Robert, C.2
  • 34
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I et al (2010) Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 28:3167-3175
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 35
    • 77957968556 scopus 로고    scopus 로고
    • PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas
    • Lee JT, Li L, Brafford PA et al (2010) PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas. Pigment Cell Melanoma Res 23:820-827
    • (2010) Pigment Cell Melanoma Res , vol.23 , pp. 820-827
    • Lee, J.T.1    Li, L.2    Brafford, P.A.3
  • 36
    • 77954376912 scopus 로고    scopus 로고
    • RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models
    • Yang H, Higgins B, Kolinsky K et al (2010) RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res 70:5518-5527
    • (2010) Cancer Res , vol.70 , pp. 5518-5527
    • Yang, H.1    Higgins, B.2    Kolinsky, K.3
  • 37
    • 79959776574 scopus 로고    scopus 로고
    • BRIM-2: An open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutationpositive metastatic melanoma
    • Ribas A (2010) BRIM-2: an open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutationpositive metastatic melanoma. In Proc Am Soc Clin Oncol abs 8509
    • (2010) Proc Am Soc Clin Oncol Abs , pp. 8509
    • Ribas, A.1
  • 38
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman JA, Kim K, Schuchter L et al (2012) Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Egl J Med 366:707-714
    • (2012) N Egl J Med , vol.366 , pp. 707-714
    • Sosman, J.A.1    Kim, K.2    Schuchter, L.3
  • 39
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507-2516
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 40
    • 77957350123 scopus 로고    scopus 로고
    • Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors
    • Kefford R (2010) Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors. In Proc Am Soc Clin Oncol abs 8503
    • (2010) Proc Am Soc Clin Oncol Abs , pp. 8503
    • Kefford, R.1
  • 41
    • 80051625929 scopus 로고    scopus 로고
    • Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profi ling
    • Wagle N, Emery C, Berger MF et al (2011) Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profi ling. J Clin Oncol 29:3085-3096
    • (2011) J Clin Oncol , vol.29 , pp. 3085-3096
    • Wagle, N.1    Emery, C.2    Berger, M.F.3
  • 42
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
    • Nazarian R, Shi H, Wang Q et al (2010) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468:973-977
    • (2010) Nature , vol.468 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3
  • 43
    • 78650309875 scopus 로고    scopus 로고
    • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
    • Johannessen CM, Boehm JS, Kim SY et al (2010) COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468:968-972
    • (2010) Nature , vol.468 , pp. 968-972
    • Johannessen, C.M.1    Boehm, J.S.2    Kim, S.Y.3
  • 44
    • 83455254767 scopus 로고    scopus 로고
    • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
    • Poulikakos PI, Persaud Y, Janakiraman M et al (2011) RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480:387-390
    • (2011) Nature , vol.480 , pp. 387-390
    • Poulikakos, P.I.1    Persaud, Y.2    Janakiraman, M.3
  • 45
    • 78650008177 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    • Villanueva J, Vultur A, Lee JT et al (2010) Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18:683-695
    • (2010) Cancer Cell , vol.18 , pp. 683-695
    • Villanueva, J.1    Vultur, A.2    Lee, J.T.3
  • 46
    • 84855302859 scopus 로고    scopus 로고
    • Intra- and inter-tumor heterogeneity of BRAF mutations in primary and metastatic melanoma
    • Yancovitz M, Litterman A, Yoon J et al (2012) Intra- and inter-tumor heterogeneity of BRAF mutations in primary and metastatic melanoma. PLoS One 7:e29336
    • (2012) PLoS One , vol.7
    • Yancovitz, M.1    Litterman, A.2    Yoon, J.3
  • 47
    • 80053154225 scopus 로고    scopus 로고
    • Phase I/II study to assess safety, pharmacokinetics, and effi cacy of the oral MEK 1/2 inhibitor GSK1120212 dosed in combination with the oral BRAF inhibitor GSK2118436
    • Infante J (2011) Phase I/II study to assess safety, pharmacokinetics, and effi cacy of the oral MEK 1/2 inhibitor GSK1120212 dosed in combination with the oral BRAF inhibitor GSK2118436. In Proc Am Soc Clin Oncol abs 8503
    • (2011) Proc Am Soc Clin Oncol Abs , pp. 8503
    • Infante, J.1
  • 48
    • 58149260596 scopus 로고    scopus 로고
    • KIT gene mutations and copy number in melanoma subtypes
    • Beadling C, Jacobson-Dunlop E, Hodi FS et al (2008) KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 14:6821-6828
    • (2008) Clin Cancer Res , vol.14 , pp. 6821-6828
    • Beadling, C.1    Jacobson-Dunlop, E.2    Hodi, F.S.3
  • 49
    • 79960708519 scopus 로고    scopus 로고
    • Phase II, openlabel, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplifi cation
    • Guo J, Si L, Kong Y et al (2011) Phase II, openlabel, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplifi cation. J Clin Oncol 29:2904-2909
    • (2011) J Clin Oncol , vol.29 , pp. 2904-2909
    • Guo, J.1    Si, L.2    Kong, Y.3
  • 50
    • 79958066836 scopus 로고    scopus 로고
    • KIT as a therapeutic target in metastatic melanoma
    • Carvajal RD, Antonescu CR, Wolchok JD et al (2011) KIT as a therapeutic target in metastatic melanoma. JAMA 305:2327-2334
    • (2011) JAMA , vol.305 , pp. 2327-2334
    • Carvajal, R.D.1    Antonescu, C.R.2    Wolchok, J.D.3
  • 51
    • 0028872887 scopus 로고
    • Randomized, surgical adjuvant clinical trial of recombinant interferon alfa-2a in selected patients with malignant melanoma
    • Creagan ET, Dalton RJ, Ahmann DL et al (1995) Randomized, surgical adjuvant clinical trial of recombinant interferon alfa-2a in selected patients with malignant melanoma. J Clin Oncol 13:2776-2783
    • (1995) J Clin Oncol , vol.13 , pp. 2776-2783
    • Creagan, E.T.1    Dalton, R.J.2    Ahmann, D.L.3
  • 54
    • 0035339880 scopus 로고    scopus 로고
    • High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of intergroup trial E1694/S9512/C509801
    • Kirkwood JM, Ibrahim JG, Sosman JA et al (2001) High-dose interferon alfa-2b signifi cantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801. J Clin Oncol 19:2370-2380 (Pubitemid 32391207)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.9 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3    Sondak, V.K.4    Agarwala, S.S.5    Ernstoff, M.S.6    Rao, U.7
  • 55
    • 84860733055 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose interferon alfa-2b for 4 weeks induction only in patients with intermediate and high-risk melanoma
    • Agarwala SS (2011) Randomized phase III trial of high-dose interferon alfa-2b for 4 weeks induction only in patients with intermediate and high-risk melanoma. In Proc Am Soc Clin Oncol abs 8505
    • (2011) Proc Am Soc Clin Oncol Abs , pp. 8505
    • Agarwala, S.S.1
  • 56
    • 70249145088 scopus 로고    scopus 로고
    • Prospective randomized multicenter adjuvant dermatologic cooperative oncology group trial of low-dose interferon alfa-2b with or without a modifi ed high-dose interferon alfa-2b induction phase in patients with lymph node-negative melanoma
    • Hauschild A, Weichenthal M, Rass K et al (2009) Prospective randomized multicenter adjuvant dermatologic cooperative oncology group trial of low-dose interferon alfa-2b with or without a modifi ed high-dose interferon alfa-2b induction phase in patients with lymph node-negative melanoma. J Clin Oncol 27:3496-3502
    • (2009) J Clin Oncol , vol.27 , pp. 3496-3502
    • Hauschild, A.1    Weichenthal, M.2    Rass, K.3
  • 57
    • 79151485188 scopus 로고    scopus 로고
    • Two different durations of adjuvant therapy with intermediate- dose interferon alfa-2b in patients with high-risk melanoma (Nordic IFN trial): A randomised phase 3 trial
    • Hansson J, Aamdal S, Bastholt L et al (2011) Two different durations of adjuvant therapy with intermediate- dose interferon alfa-2b in patients with high-risk melanoma (Nordic IFN trial): a randomised phase 3 trial. Lancet Oncol 12:144-152
    • (2011) Lancet Oncol , vol.12 , pp. 144-152
    • Hansson, J.1    Aamdal, S.2    Bastholt, L.3
  • 62
    • 0035883950 scopus 로고    scopus 로고
    • Effect of long-term adjuvant therapy with interferon alpha-2a in patients with regional node metastases from cutaneous melanoma: A randomised trial
    • DOI 10.1016/S0140-6736(01)06068-8
    • Cascinelli N, Belli F, MacKie RM et al (2001) Effect of long-term adjuvant therapy with interferon alpha-2a in patients with regional node metastases from cutaneous melanoma: a randomised trial. Lancet 358:866-869 (Pubitemid 32900567)
    • (2001) Lancet , vol.358 , Issue.9285 , pp. 866-869
    • Cascinelli, N.1    Belli, F.2    MacKie, R.M.3    Santinami, M.4    Bufalino, R.5    Morabito, A.6


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