Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age

Archives of General Psychiatry

Volumn 69, Issue 5, 2012, Pages 499-505

  Boyle, Patricia A ^a,b   Buchman, Aron S ^a,b   Wilson, Robert S ^a,b   Yu, Lei ^a,b   Schneider, Julie A ^a,b   Bennett, David A ^a,b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CLINICAL EVALUATION; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; EPIDEMIOLOGICAL DATA; FEMALE; HUMAN; HYPOTHESIS; LINEAR REGRESSION ANALYSIS; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MOTIVATION; NEUROFIBRILLARY TANGLE; STRUCTURED INTERVIEW;

ADAPTATION, PSYCHOLOGICAL; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; COGNITION; COGNITION DISORDERS; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; NEUROPSYCHOLOGICAL TESTS; PSYCHOLOGICAL TESTS; QUALITY OF LIFE;

EID: 84860702602     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2011.1487     Document Type: Article

References (55)

1. Stern Y. Cognitive reserve. Neuropsychologia. 2009;47(10):2015-2028.
2. Fratiglioni L, Wang HX, Ericsson K, Maytan M, Winblad B. Influence of social network on occurrence of dementia: a community-based longitudinal study. Lancet. 2000;355(9212):1315-1319. (Pubitemid 30199003)
3. Scarmeas N, Stern Y. Cognitive reserve and lifestyle. J Clin Exp Neuropsychol. 2003;25(5):625-633. (Pubitemid 36808148)
4. Scarmeas N, Zarahn E, Anderson KE, Habeck CG, Hilton J, Flynn J, Marder KS, Bell KL, Sackeim HA, Van Heertum RL, Moeller JR, Stern Y. Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis. Arch Neurol. 2003;60(3):359-365. (Pubitemid 36314361)
5. Wilson RS, Schneider JA, Arnold SE, Bienias JL, Bennett DA. Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment. Arch Gen Psychiatry. 2007;64(10):1204-1212. (Pubitemid 47529345)
6. Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE. Education modifies the association of amyloid but not tangles with cognitive function. Neurology. 2005;65(6):953-955. (Pubitemid 41362153)
7. Bennett DA, Wilson RS, Schneider JA, Evans DA, Mendes de Leon CF, Arnold SE, Barnes LL, Bienias JL. Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology. 2003;60(12):1909-1915. (Pubitemid 36736005)
8. Rentz DM, Locascio JJ, Becker JA, Moran EK, Eng E, Buckner RL, Sperling RA, Johnson KA. Cognition, reserve, and amyloid deposition in normal aging. Ann Neurol. 2010;67(3):353-364.
9. Roe CM, Mintun MA, D'Angelo G, Xiong C, Grant EA, Morris JC. Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake. Arch Neurol. 2008;65(11):1467-1471.
10. Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS. The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol. 2006;5(5):406-412.
11. Frankl VE. Man's Search for Meaning. New York, NY: Washington Square Press, Simon & Schuster; 1963.
12. Friedman EM, Hayney MS, Love GD, Urry HL, Rosenkranz MA, Davidson RJ, Singer BH, Ryff CD. Social relationships, sleep quality, and interleukin-6 in aging women. Proc Natl Acad Sci U S A. 2005;102(51):18757-18762. (Pubitemid 43011299)
13. Abbott RA, Ploubidis GB, Huppert FA, Kuh D, Wadsworth ME, Croudace TJ. Psychometric evaluation and predictive validity of Ryff's Psychological Well-Being items in a UK birth cohort sample of women. Health Qual Life Outcomes. 2006;4:76. doi:10.1186/1477-7525-4-76. (Pubitemid 44741188)
14. Ryff CD, Singer B. Psychological well-being: meaning, measurement, and implications for psychotherapy research. Psychother Psychosom. 1996;65(1):14-23. (Pubitemid 26041204)
15. Ryff CD, Singer BH, Dienberg Love G. Positive health: connecting well-being with biology. Philos Trans R Soc Lond B Biol Sci. 2004;359(1449):1383-1394. (Pubitemid 39275377)
16. Hedberg P, Gustafson Y, Brulin C. Purpose in life among men and women aged 85 years and older. Int J Aging Hum Dev. 2010;70(3):213-229.
17. Phelan CH, Love GD, Ryff CD, Brown RL, Heidrich SM. Psychosocial predictors of changing sleep patterns in aging women: a multiple pathway approach. Psychol Aging. 2010;25(4):858-866.
18. Wood AM, Joseph S. The absence of positive psychological (eudemonic) wellbeing as a risk factor for depression: a ten year cohort study. J Affect Disord. 2010;122(3):213-217.
19. Gerstorf D, Lövdén M, Röcke C, Smith J, Lindenberger U. Well-being affects changes in perceptual speed in advanced old age: longitudinal evidence for a dynamic link. Dev Psychol. 2007;43(3):705-718.
20. Ryff CD, Dienberg Love G, Urry HL, Muller D, Rosenkranz MA, Friedman EM, Davidson RJ, Singer B. Psychological well-being and ill-being: do they have distinct or mirrored biological correlates? Psychother Psychosom. 2006;75(2):85-95.
21. Boyle PA, Buchman AS, Barnes LL, Bennett DA. Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in communitydwelling older persons. Arch Gen Psychiatry. 2010;67(3):304-310.
22. Boyle PA, Barnes LL, Buchman AS, Bennett DA. Purpose in life is associated with mortality among community-dwelling older persons. Psychosom Med. 2009;71(5):574-579.
23. Boyle PA, Buchman AS, Bennett DA. Purpose in life is associated with a reduced risk of incident disability among community-dwelling older persons. Am J Geriatr Psychiatry. 2010;18(12):1093-1102.
24. Bennett DA, Schneider JA, Buchman AS, Mendes de Leon C, Bienias JL, Wilson RS. The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology. 2005;25(4):163-175. (Pubitemid 41540657)
25. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 1984;34(7):939-944. (Pubitemid 14076461)
26. Bennett DA, Schneider JA, Aggarwal NT, Arvanitakis Z, Shah RC, Kelly JF, Fox JH, Cochran EJ, Arends D, Treinkman AD, Wilson RS. Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology. 2006;27(3):169-176. (Pubitemid 44651437)
27. Boyle PA, Wilson RS, Aggarwal NT, Tang Y, Bennett DA. Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline. Neurology. 2006;67(3):441-445. (Pubitemid 44214968)
28. Wilson RS, Barnes LL, Krueger KR, Hoganson G, Bienias JL, Bennett DA. Early and late life cognitive activity and cognitive systems in old age. J Int Neuropsychol Soc. 2005;11(4):400-407. (Pubitemid 41167177)
29. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-198.
30. Ryff CD, Keyes CL. The structure of psychological well-being revisited. J Pers Soc Psychol. 1995;69(4):719-727.
31. Barnes LL, Wilson RS, Bienias JL, de Leon CF, Kim HJ, Buchman AS, Bennett DA. Correlates of life space in a volunteer cohort of older adults. Exp Aging Res. 2007;33(1):77-93. (Pubitemid 44899925)
32. Wilson RS, Schneider JA, Bienias JL, Arnold SE, Evans DA, Bennett DA. Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons. Neurology. 2003;61(8):1102-1107. (Pubitemid 37461945)
33. Wilson RS, Arnold SE, Schneider JA, Li Y, Bennett DA. Chronic distress, agerelated neuropathology, and late-life dementia. Psychosom Med. 2007;69(1):47-53. (Pubitemid 46148364)
34. Wilson RS, Schneider JA, Boyle PA, Arnold SE, Tang Y, Bennett DA. Chronic distress and incidence of mild cognitive impairment. Neurology. 2007;68(24):2085-2092. (Pubitemid 46912126)
35. Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA. The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis. 2009;18(3):691-701.
36. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 2006;66(12):1837-1844. (Pubitemid 44049813)
37. Bennett DA. Postmortem indices linking risk factors to cognition: results from the Religious Order Study and the Memory and Aging Project. Alzheimer Dis Assoc Disord. 2006;20(3) (suppl 2):S63-S68. (Pubitemid 44265853)
38. SAS 9.2 Help and Documentation. Cary, NC: SAS Institute Inc; 2009.
39. Aizenstein HJ, Nebes RD, Saxton JA, Price JC, Mathis CA, Tsopelas ND, Ziolko SK, James JA, Snitz BE, Houck PR, Bi W, Cohen AD, Lopresti BJ, De Kosky ST, Halligan EM, Klunk WE. Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol. 2008;65(11):1509-1517.
40. Kemppainen NM, Aalto S, Karrasch M, Någren K, Savisto N, Oikonen V, Viitanen M, Parkkola R, Rinne JO. Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease. Ann Neurol. 2008;63(1):112-118. (Pubitemid 351240557)
41. Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, McDonald WC, Braak H, Petersen RC. Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol. 2003;62(11):1087-1095. (Pubitemid 37413820)
42. Mortimer JA, Borenstein AR, Gosche KM, Snowdon DA. Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression. J Geriatr Psychiatry Neurol. 2005;18(4):218-223. (Pubitemid 41736387)
43. Riley KP, Snowdon DA, Markesbery WR. Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol. 2002;51(5):567-577.
44. Rodrigue KM, Kennedy KM, Park DC. Beta-amyloid deposition and the aging brain. Neuropsychol Rev. 2009;19(4):436-450.
45. Roe CM, Xiong C, Grant E, Miller JP, Morris JC. Education and reported onset of symptoms among individuals with Alzheimer disease. Arch Neurol. 2008;65(1):108-111.
46. Jicha GA, Abner EL, Schmitt FA, Kryscio RJ, Riley KP, Cooper GE, Stiles N, Mendiondo MS, Smith CD, Van Eldik LJ, Nelson PT. Preclinical AD Workgroup staging: pathological correlates and potential challenges. Neurobiol Aging. 2012;33(3):622.e1-622.e16. doi:10.1016/j.neurobiolaging.2011.02.018.
47. Westerhof GJ, Bohlmeijer ET, van Beljouw IM, Pot AM. Improvement in personal meaning mediates the effects of a life review intervention on depressive symptoms in a randomized controlled trial. Gerontologist. 2010;50(4):541-549.
48. Pinquart M. Creating and maintaining purpose in life in old age: a meta-analysis. Ageing Int. 2002;27(2):90-114. doi:10.1007/s12126-002-1004-2.
49. McKnight PE, Kashdan TB. Purpose in life as a system that creates and sustains health and well-being: an integrative, testable theory. Rev Gen Psychol. 2009;13(3):242-251. doi:10.1037/a0017152.
50. Schmutte PS, Ryff CD. Personality and well-being: reexamining methods and meanings. J Pers Soc Psychol. 1997;73(3):549-559. (Pubitemid 127453808)
51. Martin RA, MacKinnon S, Johnson J, Rohsenow DJ. Purpose in life predicts treatment outcome among adult cocaine abusers in treatment. J Subst Abuse Treat. 2011;40(2):183-188.
52. Adolphs R. The neurobiology of social cognition. Curr Opin Neurobiol. 2001;11(2):231-239. (Pubitemid 32289412)
53. Adolphs R. The social brain: neural basis of social knowledge. Annu Rev Psychol. 2009;60:693-716.
54. Giannakopoulos PHF, Herrmann FR, Bussière T, Bouras C, Kövari E, Perl DP, Morrison JH, Gold G, Hof PR. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology. 2003;60(9):1495-1500. (Pubitemid 36559525)
55. Boyle PA, Wilson RS, Schneider JA, Bienias JL, Bennett DA. Processing resources reduce the effect of Alzheimer pathology on other cognitive systems. Neurology. 2008;70(17):1534-1542. (Pubitemid 351589507)