Discovery of novel A 3 adenosine receptor ligands based on chromone scaffold

Biochemical Pharmacology

Volumn 84, Issue 1, 2012, Pages 21-29

  Gaspar, Alexandra ^a   Reis, Joana ^a   Kachler, Sonja ^c   Paoletta, Silvia ^d   Uriarte, Eugenio ^a,b,c,d   Klotz, Karl Norbert ^c   Moro, Stefano ^d   Borges, Fernanda ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d UNIVERSITY OF PADOVA   (Italy)

Author keywords

Adenosine receptor ligand; Chromone scaffold; Drug discovery

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR AFFECTING AGENT; CARBOXYLIC ACID DERIVATIVE; CHROMONE CARBOXAMIDE DERIVATIVE; CHROMONE DERIVATIVE; LIGAND; N (3,4 DIMETHOXYPHENYL) 4 OXO 4H 1 BENZOPYRAN 2 CARBOXAMIDE; N (4 METHOXYPHENYL) 4 OXO 4H 1 BENZOPYRAN 2; N (4 METHOXYPHENYL) 4 OXO 4H 1 BENZOPYRAN 2 CARBOXAMIDE; N (4 METHOXYPHENYL) 4 OXO 4H 1 BENZOPYRAN 3 CARBOXAMIDE; N (43, DIMETHOXYPHENYL) 4 OXO 4H 1 BENZOPYRAN 3 CARBOXAMIDE; UNCLASSIFIED DRUG; ADENOSINE A3 RECEPTOR ANTAGONIST;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG DEVELOPMENT; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; ANIMAL; BINDING COMPETITION; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HAMSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; METHODOLOGY; MOLECULAR CLONING; MOLECULAR LIBRARY; RADIOASSAY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

ADENOSINE A3 RECEPTOR ANTAGONISTS; ANIMALS; BINDING, COMPETITIVE; CELL MEMBRANE; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; CHROMONES; CLONING, MOLECULAR; CRICETINAE; DRUG DISCOVERY; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A3; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84860664996     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.007     Document Type: Article

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